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Andrea Leonor Calixto Mohor

Full professor

Universidad de Valparaíso

Valparaiso, Chile

Líneas de Investigación


The role of microbial metabolites and small RNAs on life history traits such as neuronal survival after injury and transgenerational behavior. We study the mechanisms underlying heritable adaptations using the nematode C. elegans as a model organism.

Educación

  •  Biological Sciences, COLUMBIA UNIVERSITY. Estados Unidos, 2009
  •  Molecular Neuroscience, COLUMBIA UNIVERSITY. Estados Unidos, 2006
  •  Microbiology, UNIVERSIDAD DE LA HABANA. Cuba, 1997

Experiencia Académica

  •   Postdoctoral Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Chile

    2009 - 2012

  •   Assistant Professor Full Time

    Universidad Mayor

    Ciencias

    Santiago, Chile

    2012 - A la fecha

  •   Investigador Asociado Other

    UNIVERSIDAD DE VALPARAISO

    Centro Interdisciplinario de Neurociencia de Valparaiso (CINV)

    Valparaiso, Chile

    2015 - A la fecha

  •   Principal Investigator Full Time

    Centro Interdisciplinario de Neurociencia de Valparaiso

    Valparaiso, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Graduate Student Full Time

    Columbia University

    New York, Estados Unidos

    2002 - 2008

  •   Postdoctoral Researcher Full Time

    P. Universidad Catolica de Chile

    Santiago de Chile, Chile

    2009 - 2012

  •   Assistant Professor Full Time

    Universidad Mayor

    Santiago de Chile, Chile

    2012 - 2019

  •   Investigadora Principal Full Time

    Centro Interdisciplinario de Neurociencia de Valparaiso

    Valparaiso, Chile

    2016 - A la fecha

Formación de Capital Humano


Mentoring of Postdoctoral investigators
Florence Gutzwiller, University of Manchester, Postdoctoral researcher (2017-2018)
Victor Antonio Garcia, UNAM Postdoctoral researcher (2014-2016)
Federico Camicia, UBA Postdoctoral researcher (2014-2015)
Ivan Neira, Universidad de Sao Paulo, Postdoctoral researcher (2009-2012)

Mentoring of Doctoral Students
Carolaing Gabaldon, Doctorado en Genomica Integrativa, Universidad Mayor (2015-2020)
Marcela Legue, Doctorado en Genomica Integrativa, Universidad Mayor (2015-2020)
Arles Urrutia, Doctorado en Genomica Integrativa, Universidad Mayor (2016-2020)
Scarlett Delgado, Doctorado en Neurociencia, Universidad de Valparaiso (2017-
Blanca Aguila, Doctorado en Ciencias mencion Microbiologia, Universidad de Chile (2020-

Mentoring of Masters Students
MFernanda Palominos, Ms Sc.Biological Sciences Program Universidad de Chile (2013-2014)
Mauricio Caneo, Ms Sc Biomedical Sciences Program Universidad de Valparaiso (2013-2016)
Daniela Ponce, Magister en Ciencia de la Ingenieria Mencion Quimica, Universidad de Chile (2014-2017)

Mentoring of Undergraduate Students
Andres Fuentes, Undergraduate Biotechnology, Universidad Mayor (2012-2014)
Bernardo Pollak, Undergraduate Biochemistry, Universidad Catolica (2009-2011)
Sebastian Urquiza, Undergraduate Biotechnology, Universidad Mayor (2018-2020)
Romina Valenzuela, Undergraduate Biotechnology, Universidad Mayor (2019-
Javiera Roman, Undergraduate Biotechnology, Universidad Mayor (2020-
Tomas Canepa, Undergraduate Biotechnology, Universidad Mayor (2020-


Difusión y Transferencia


Teaching and Organization of the following International Courses:

Small Brains Big Ideas Plus. Las Cruces, Chile. April, 2019
Small Brains Big Ideas Plus. Las Cruces, Chile. November 2016
Neural Systems and Behavior. Woodshole Massachusetts. July 2014.
Small Brains Big Ideas Plus. Santiago/Valparaiso October 2014
Small Brains Big Ideas Plus. Santiago/Valparaiso November 2012
Small Brains Big Ideas Plus. Santiago/Valparaiso November 2010

Organization of the First Latinamerican C. elegans Meeting
Pasteur Institute, Montevideo, Uruguay, February, 2017.

Organization of the Second Latinamerican C. elegans Meeting
Rosario,Santa Fe, Argentina , February, 2020.

Organization of the Third Latinamerican C. elegans Meeting
Valparaiso, Chile, March 2022.

Diffusion
Tertulias Porteñas: (http://centex.cl/somos-lo-que-comemos-regresan-a-centex-las-tertulias-portenas/)
Programas de Radio: Radio pauta (10 de Enero, 2019). La Invencion del Futuro, conduce Alejandro Alaluf (https://youtu.be/bHSOPn5CreI)

In the press:
Diario el Mercurio de Valparaiso (3 de Enero, 2019) "Usan gusanos para estudiar posible tratamiento contra el Alzheimer" (http://www.mercuriovalpo.cl/impresa/2019/01/03/full/cuerpo-principal/3/)
Diario Hoy por hoy "Cientificos investigan la regeneracion de neuronas con gusanos" (http://www.hoyxhoy.cl/2019/01/07/full/cuerpo-principal/6/)
Diadio Las Ultimas Noticias "Investigadora descubre como gusanos heredan mecanismos de defensa a su descendencia" (http://www.lun.com/Pages/NewsDetail.aspx?dt=2017-12-26&PaginaId=32&bodyid=0)
El Mercurio de Valparaiso (http://www.mercuriovalpo.cl/impresa/2018/04/19/full/cuerpo-principal/27/)


Premios y Distinciones

  •   National Prize of the Academy osf Sciences of Cuba

    Academia de Ciencias de Cuba

    Cuba, 1998

    National Scientific Prize

  •   Conicyt Doctorate Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 1998

    Doctorate CONICYT Fellowship

  •   Columbia Unversity Felowship

    COLUMBIA UNIVERSITY

    Estados Unidos, 2002

    Fellowship for Graduate Work

  •   Fondecyt Postdoctoral Fellowship

    FONDO NACIONAL DE CIENCIA,TECNOLOGIA E INNOVACION

    Chile, 2009

    Psotdoctoral Fellowsip for studies in neuronal degeneration and RNAi


 

Article (18)

Cross-kingdom RNA interactome in a paradigm of host defense against pathogens in C. elegans
The Heritability of Behaviors Associated With the Host Gut Microbiota
Bacterially produced metabolites protect C. elegans neurons from degeneration
Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243
Quantification of Bacteria Residing in Caenorhabditis elegans Intestine
Diapause induces functional axonal regeneration after necrotic insult in C. elegans
Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis
Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis
RNA language in Caenorhabditis elegans and bacteria interspecies communication and memory
Worm corpses affect quantification of dauer recovery.
Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in Caenorhabditis elegans
FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C-elegans embryogenesis
Life without Food and the Implications for Neurodegeneration
Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss
Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans
Enhanced neuronal RNAi in C. elegans using SID-1
Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

BookWhole (1)

Use of C. elegans Diapause to Study Transgenerational Responses to Pathogen Infection

Proyecto (9)

Discovery of neuroprotective bacterial metabolites and their mechanism of action in C. elegans
Functional innovations under energy constraints and the evolution of animal diapause.
Desarrollo de Consorcios Bacterianos para el tratamiento de enfermedades neurodegenerativas.
Development of computational methods for the determination of causal-condition specific gene regulatory networks
Analysis of gene regulatory networks that modulate behavior upon bacterial pathogenesis
DIAPAUSE FORMATION SIGNALED BY THE RNAI MACHINERY AS A NOVEL INNATE DEFENSE MECHANISM AGAINST BACTERIAL PATHOGENS.
The Neuronal network initiative. Understanding Differential neuronal vulnerability in neurological diseases
Millennium Institute Interdisciplinary Center of Neuroscience of Valparaíso – CINV
DISCOVERY OF NEURONAL ROLES FOR GENES THAT CAUSE LETHALITY IN C.ELEGANS USING RNA INTERFERENCE.
21
Andrea Calixto

Full professor

Neuroscience

Universidad de Valparaíso

Valparaiso, Chile

1
Glauben Landskron

Postdoctoral Researcher Fondecyt 3190931

Academic Direction

Clinica Las Condes

Santiago, Chile

1
Jonas Chnaiderman

Profesor Asociado

Instituto de Ciencias Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
KAREN DUBOIS

Postdoctoral fellow Fondef IDeA ID17I10064 IDI17

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Francisco Chávez

Profesor Asistente

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
María Fernanda Palominos

Estudiante de Doctorado

Instituto de Neurociencia

Universidad de Valparaíso

Valparaiso, Chile