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Loreto Andrea Abusleme Ramos

Assistant Professor

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

- Oral microbiome and host-microbial interactions in health, common disease and rare monogenic disorders - Development of Th17 cells at the oral mucosa - Oral murine microbiome as a model to understand microbial dysbiosis associated with disease

Cirujano-Dentista, UNIVERSIDAD DE CHILE. Chile, 2009
Master in Periodontology, UNIVERSIDAD DE CHILE. Chile, 2012
PhD in Oral microbial immunity, UNIVERSITY OF MARYLAND. Estados Unidos, 2017

Ayudante Part Time

UNIVERSIDAD DE CHILE

Dentistry

Santiago, Chile

2009 - 2012
Assistant Professor Full Time

UNIVERSIDAD DE CHILE

Dentistry

Santiago, Chile

2012 - A la fecha
PhD student Full Time

UNIVERSITY OF MARYLAND

Baltimore, Estados Unidos

2013 - 2017
PhD student and post-doctoral fellow Full Time

NATIONAL INSTITUTE OF HEALTH

Bethesda, Estados Unidos

2013 - 2018

Dentist Part Time

Private practice

Santiago, Chile

2009 - 2012
Associate Investigator (Clinical) Part Time

National Institutes of Health

Bethesda, Estados Unidos

2013 - 2018

Premio Academia Alfonso Leng

UNIVERSIDAD DE CHILE

Chile, 2009

Beca para estudios de Magíster en Cs. Odontológicas, Facultad de Odontología, Universidad de Chile
Hatton Unilever Senior Award IADR Chilean Division

International Association for Dental Research

Brasil, 2012

Award given to compete for the chilean division for the worldwide Hatton Award as best research work at IADR Chilean division meeting
Best Master's Student

UNIVERSIDAD DE CHILE

Chile, 2012

Best master student of year 2012 according to academic performance and thesis work
FARE Award 2018

NATIONAL INSTITUTES OF HEALTH (NIH)

Estados Unidos, 2017

The Fellows Award for Research Excellence (FARE), began in 1995 to recognize the outstanding scientific research performed by intramural postdoctoral fellows at NIH.
NIH Summer Research Mentor Award

NATIONAL INSTITUTES OF HEALTH (NIH)

Estados Unidos, 2018

The NIH Summer Mentor Award program provides for a centrally funded summer intern to qualified graduate students, postdocs and fellows.
AADR Hatton Award Finalist

International Association for Dental Research

Estados Unidos, 2018

The American Association for Dental Research (AADR) is entitled to send qualified individuals to compete in the 2018 IADR Unilever Hatton Competition and Awards. These individuals will be selected on the basis of an oral presentation competition to be held at the AADR Annual Meeting & Exhibition. The competition is designed for junior investigators (junior, senior and post-doctoral) who exhibit potential for a productive career in dental research. Mentors are strongly urged to support and select a project for the competition that is original, well-planned, and carefully executed.


A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen Hoare, Anilei; Wang, Hui; Meethil, Archana; Abusleme, Loreto; Hong, Bo-Young; Moutsopoulos, Niki M.; Marsh, Philip D.; Hajishengallis, George; Diaz, Patricia I. Article ISI ISME JOURNAL (2021)
Editorial: Oral Microbiome and Inflammation Connection to Systemic Health Abusleme, Loreto; Morandini, Ana Carolina; Hashizume-Takizawa, Tomomi; Sahingur, Sinem Esra Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier Silva, Lakmali M.; Doyle, Andrew D.; Greenwell-Wild, Teresa; Dutzan, Nicolas; Tran, Collin L.; Abusleme, Loreto; Juang, Lih Jiin; Leung, Jerry; Chun, Elizabeth M.; Lum, Andrew G.; Agler, Cary S.; Zuazo, Carlos E.; Sibree, Megan; Jani, Priyam; Kram, Vardit; Martin, Daniel; Moss, Kevin; Lionakis, Michail S.; Castellino, Francis J.; Kastrup, Christian J.; Flick, Matthew J.; Divaris, Kimon; Bugge, Thomas H.; Moutsopoulos, Niki M. Article ISI SCIENCE (2021)
Microbial signatures of health, gingivitis, and periodontitis Abusleme, Loreto; Hoare, Anilei; Hong, Bo-Young; Diaz, Patricia, I Article ISI PERIODONTOLOGY 2000 (2021)
Establishment and Stability of the Murine Oral Microbiome Abusleme, L.; O'Gorman, H.; Dutzan, N.; Greenwell-Wild, T.; Moutsopoulos, N. M. Article ISI JOURNAL OF DENTAL RESEARCH (2020)
Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome Peluso G.; Tian E.; Abusleme L.; Munemasa T.; Mukaibo T.; Hagen K.G.T. Article ISI SCOPUS (2020)
A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans Dutzan N.; Kajikawa T.; Abusleme L.; Greenwell-Wild T.; Zuazo C.E.; Ikeuchi T.; Brenchley L.; Abe T.; Hurabielle C.; Martin D.; Morell R.J.; Freeman, A. F.; Lazarevic V.; Trinchieri G.; Diaz P.I.; Holland, S. M.; Belkaid Y.; Hajishengallis G.; Moutsopoulos N.M. Article ISI SCOPUS Science Translational Medicine (2018)
Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis Abusleme L.; Diaz, PI; Freeman, AF; Greenwell-Wild, T; Brenchley, L; Desai, JV; Ng, WI; Holland, SM; Lionakis, MS; Segre, JA; Kong, HH; Moutsopoulos, NM Article ISI SCOPUS JCI INSIGHT (2018)
Transcriptional signature primes human oral mucosa for rapid wound healing Iglesias-Bartolome, Ramiro; Uchiyama, Akihiko; Molinolo, Alfredo A.; Abusleme, Loreto; Brooks, Stephen R.; Callejas-Valera, Juan Luis; Edwards, Dean; Doci, Colleen; Asselin-Labat, Marie-Liesse; Onaitis, Mark W.; Moutsopoulos, Niki M.; Gutkind, J. Silvio; Morasso, Maria I. Article ISI SCIENCE TRANSLATIONAL MEDICINE (2018)
IL-17: overview and role in oral immunity and microbiome Abusleme, L.; Moutsopoulos, N. M. Article ISI ORAL DISEASES (2017)
On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier Dutzan, Nicolas; Abusleme, Loreto; Bridgeman, Hayley; Greenwell-Wild, Teresa; Zangerle-Murray, Tamsin; Fife, Mark E.; Bouladoux, Nicolas; Linley, Holly; Brenchley, Laurie; Wemyss, Kelly; Calderon, Gloria; Hong, Bo-Young; Break, Timothy J.; Bowdish, Dawn M. E.; Lionakis, Michail S.; Jones, Simon A.; Trinchieri, Giorgio; Diaz, Patricia I.; Belkaid, Yasmine; Konkel, Joanne E.; Moutsopoulos, Niki M. Article ISI IMMUNITY (2017)
Oral Microbiome Characterization in Murine Models Abusleme, Loreto; Hong, Bo-Young; Hoare, Anilei; Konkel, Joanne E.; Diaz, Patricia I.; Moutsopoulos, Niki M. Article ISI BIO-PROTOCOL (2017)
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis Konig, Maximilian F.; Abusleme, Loreto; Reinholdt, Jesper; Palmer, Robert J.; Teles, Ricardo P.; Sampson, Kevon; Rosen, Antony; Nigrovic, Peter A.; Sokolove, Jeremy; Giles, Jon T.; Moutsopoulos, Niki M.; Andrade, Felipe Article ISI SCIENCE TRANSLATIONAL MEDICINE (2016)
Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome Falcone, E. Liana; Abusleme, Loreto; Swamydas, Muthulekha; Lionakis, Michail S.; Ding, Li; Hsu, Amy P.; Zelazny, Adrian M.; Moutsopoulos, Niki M.; Kuhns, Douglas B.; Deming, Clay; Quinones, Mariam; Segre, Julia A.; Bryant, Clare E.; Holland, Steven M. Article ISI MICROBIOME (2016)
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network Dutzan, Nicolas; Abusleme, Loreto; Konkel, Joanne E.; Moutsopoulos, Niki M. Article ISI JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)
A 17-year old patient with DOCK8 deficiency, severe oral HSV-1 and aggressive periodontitis - A case of virally induced periodontitis? Betts, K.; Abusleme, L.; Freeman, A. F.; Sarmadi, M.; Fahle, G.; Pittaluga, S.; Cuellar-Rodriguez, J.; Hickstein, D.; Holland, S. M.; Su, H.; Moutsopoulos, N. M. Article ISI JOURNAL OF CLINICAL VIROLOGY (2015)
Host response mechanisms in periodontal diseases Silva N.; Abusleme L.; Bravo D.; Dutzan N.; Garcia-Sesnich, J; Vernal, R; Hernandez, M.; Gamonal, J Article ISI SCOPUS Journal of Applied Oral Science (2015)
Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors Sales, K. U.; Friis, S.; Abusleme, L.; Moutsopoulos, N. M.; Bugge, T. H. Article ISI ONCOGENE (2015)
Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology Moutsopoulos, Niki M.; Chalmers, Natalia I.; Barb, Jennifer J.; Abusleme, Loreto; Greenwell-Wild, Teresa; Dutzan, Nicolas; Paster, Bruce J.; Munson, Peter J.; Fine, Daniel H.; Uzel, Gulbu; Holland, Steven M. Article ISI PLOS PATHOGENS (2015)
Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss Moutsopoulos, Niki M.; Konkel, Joanne; Sarmadi, Mojgan; Eskan, Mehmet A.; Wild, Teresa; Dutzan, Nicolas; Abusleme, Loreto; Zenobia, Camille; Hosur, Kavita B.; Abe, Toshiharu; Uzel, Gulbu; Chen, WanJun; Chavakis, Triantafyllos; Holland, Steven M.; Hajishengallis, George Article ISI SCIENCE TRANSLATIONAL MEDICINE (2014)
Influence of DNA extraction on oral microbial profiles obtained via 16S rRNA gene sequencing Abusleme L.; Hong, BY; Dupuy, AK; Strausbaugh, LD; Diaz, PI Article ISI SCOPUS JOURNAL OF ORAL MICROBIOLOGY (2014)
The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation Abusleme L.; Dupuy, AK; Dutzan N.; Silva N.; Burleson, JA; Strausbaugh, LD; Gamonal, J; Diaz, PI Article ISI SCOPUS ISME Journal (2013)
Transplantation-Associated Long-Term Immunosuppression Promotes Oral Colonization by Potentially Opportunistic Pathogens without Impacting Other Members of the Salivary Bacteriome Diaz, PI; Hong, BY; Frias-Lopez, J; Dupuy, AK; Angeloni, M.; Abusleme L.; Terzi, E; Ioannidou, E; Strausbaugh, LD; Dongari-Bagtzoglou, A Article ISI SCOPUS Clinical and Vaccine Immunology (2013)
Genotipificación de los genes rgpA y kgp que codifican para las gingipaínas de Porphyromonas gingivalis Abusleme L.; Blanc V.; Leon, R; Gamonal, J; Silva N. Article SCIELO REVISTA CLINICA DE PERIODONCIA, IMPLANTOLOGIA Y REHABILITACION ORAL (2012)
Interleukin-21 Expression and Its Association With Proinflammatory Cytokines in Untreated Chronic Periodontitis Patients Dutzan N.; Vernal, R; Vaqué J.P.; Garcia-Sesnich, J; Hernandez, M.; Abusleme L.; Dezerega, A; Gutkind J.S.; Gamonal, J Article ISI SCOPUS Journal of Periodontology (2012)
Using high throughput sequencing to explore the biodiversity in oral bacterial communities Diaz P.I.; Dupuy, A. K.; Abusleme L.; Reese B.; Obergfell C.; Choquette, L.; Dongari-Bagtzoglou, A; Peterson, D. E.; Terzi, E; Strausbaugh, L. D. Article ISI SCOPUS Molecular Oral Microbiology (2012)
Genotipificación de Porphyromonas gingivalis en pacientes con periodontitis Abusleme L, Pozo P Article Revista Clínica de Periodoncia, Implantología y Rehabilitación Oral (2009)


T Helper 17 Cells as Pathogenic Drivers of Periodontitis Dutzan N.; Abusleme L. BookWhole ISI SCOPUS MAJOR DEPRESSIVE DISORDER: RETHINKING AND UNDERSTANDING RECENT DISCOVERIES (2019)


Role of Th17 mediated inflammation in promoting subgingival microbial dysbiosis during periodontitis Abusleme, Loreto Andrea Proyecto (2018)
BIOLOGICAL PLAQUE CONTROL IN PERIODONTAL DISEASES=> UNDERSTANDING VARIABILITY OF MICROBIOME/IMMUNE RESPONSE AND IMPLEMENTATION OF A CONVENTIONAL PERIODONTAL TREATMENT COMBINED WITH PROBIOTICS. FONDECYT (1130570) Proyecto 2013-2017 Coinvestigador(a)
Oral Microbial and Immunological Characterization of Patients with Immune Dysfunction NIH (NCT01568697) Proyecto 2013-2018 Coinvestigador(a)
THE TH17 VS. TREG IMBALANCE IN THE PATHOGENESIS OF PERIODONTITIS=> NEW APPROACH FOR DICHOTOMY TH1 VS. TH2. FONDECYT (1090046) Proyecto 2009-2013 Tesista


Host-Pathogen Interactions in Progressive Chronic Periodontitis Hernandez, M.; Dutzan N.; Garcia-Sesnich, J; Abusleme L.; Dezerega, A; Silva N.; Gonzalez, FE; Vernal, R; Sorsa, T.; Gamonal, J Review ISI SCOPUS JOURNAL OF DENTAL RESEARCH (2011)