Img_2115.jpeg_thumb90

Loreto Andrea Abusleme Ramos

Assistant Professor

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


- Oral microbiome and host-microbial interactions in health, common disease and rare monogenic disorders - Development of Th17 cells at the oral mucosa - Oral murine microbiome as a model to understand microbial dysbiosis associated with disease

Educación

  •  Cirujano-Dentista, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Master in Periodontology, UNIVERSIDAD DE CHILE. Chile, 2012
  •  PhD in Oral microbial immunity, UNIVERSITY OF MARYLAND. Estados Unidos, 2017

Experiencia Académica

  •   Ayudante Part Time

    UNIVERSIDAD DE CHILE

    Dentistry

    Santiago, Chile

    2009 - 2012

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Dentistry

    Santiago, Chile

    2012 - A la fecha

  •   PhD student Full Time

    UNIVERSITY OF MARYLAND

    Baltimore, Estados Unidos

    2013 - 2017

  •   PhD student and post-doctoral fellow Full Time

    NATIONAL INSTITUTE OF HEALTH

    Bethesda, Estados Unidos

    2013 - 2018

Experiencia Profesional

  •   Dentist Part Time

    Private practice

    Santiago, Chile

    2009 - 2012

  •   Associate Investigator (Clinical) Part Time

    National Institutes of Health

    Bethesda, Estados Unidos

    2013 - 2018

Premios y Distinciones

  •   Premio Academia Alfonso Leng

    UNIVERSIDAD DE CHILE

    Chile, 2009

    Beca para estudios de Magíster en Cs. Odontológicas, Facultad de Odontología, Universidad de Chile

  •   Hatton Unilever Senior Award IADR Chilean Division

    International Association for Dental Research

    Brasil, 2012

    Award given to compete for the chilean division for the worldwide Hatton Award as best research work at IADR Chilean division meeting

  •   Best Master's Student

    UNIVERSIDAD DE CHILE

    Chile, 2012

    Best master student of year 2012 according to academic performance and thesis work

  •   FARE Award 2018

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos, 2017

    The Fellows Award for Research Excellence (FARE), began in 1995 to recognize the outstanding scientific research performed by intramural postdoctoral fellows at NIH.

  •   NIH Summer Research Mentor Award

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos, 2018

    The NIH Summer Mentor Award program provides for a centrally funded summer intern to qualified graduate students, postdocs and fellows.

  •   AADR Hatton Award Finalist

    International Association for Dental Research

    Estados Unidos, 2018

    The American Association for Dental Research (AADR) is entitled to send qualified individuals to compete in the 2018 IADR Unilever Hatton Competition and Awards. These individuals will be selected on the basis of an oral presentation competition to be held at the AADR Annual Meeting & Exhibition. The competition is designed for junior investigators (junior, senior and post-doctoral) who exhibit potential for a productive career in dental research. Mentors are strongly urged to support and select a project for the competition that is original, well-planned, and carefully executed.


 

Article (27)

A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen
Editorial: Oral Microbiome and Inflammation Connection to Systemic Health
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
Microbial signatures of health, gingivitis, and periodontitis
Establishment and Stability of the Murine Oral Microbiome
Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome
A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans
Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis
Transcriptional signature primes human oral mucosa for rapid wound healing
IL-17: overview and role in oral immunity and microbiome
On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier
Oral Microbiome Characterization in Murine Models
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis
Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
A 17-year old patient with DOCK8 deficiency, severe oral HSV-1 and aggressive periodontitis - A case of virally induced periodontitis?
Host response mechanisms in periodontal diseases
Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors
Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology
Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss
Influence of DNA extraction on oral microbial profiles obtained via 16S rRNA gene sequencing
The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation
Transplantation-Associated Long-Term Immunosuppression Promotes Oral Colonization by Potentially Opportunistic Pathogens without Impacting Other Members of the Salivary Bacteriome
Genotipificación de los genes rgpA y kgp que codifican para las gingipaínas de Porphyromonas gingivalis
Interleukin-21 Expression and Its Association With Proinflammatory Cytokines in Untreated Chronic Periodontitis Patients
Using high throughput sequencing to explore the biodiversity in oral bacterial communities
Genotipificación de Porphyromonas gingivalis en pacientes con periodontitis

BookWhole (1)

T Helper 17 Cells as Pathogenic Drivers of Periodontitis

Proyecto (4)

Role of Th17 mediated inflammation in promoting subgingival microbial dysbiosis during periodontitis
BIOLOGICAL PLAQUE CONTROL IN PERIODONTAL DISEASES=> UNDERSTANDING VARIABILITY OF MICROBIOME/IMMUNE RESPONSE AND IMPLEMENTATION OF A CONVENTIONAL PERIODONTAL TREATMENT COMBINED WITH PROBIOTICS.
Oral Microbial and Immunological Characterization of Patients with Immune Dysfunction
THE TH17 VS. TREG IMBALANCE IN THE PATHOGENESIS OF PERIODONTITIS=> NEW APPROACH FOR DICHOTOMY TH1 VS. TH2.

Review (1)

Host-Pathogen Interactions in Progressive Chronic Periodontitis
29
Loreto Abusleme

Assistant Professor

Oral pathology and medicine

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

12
Nicolás Dutzan

Associate Professor

Facultad de Odontología

Universidad de Chile

Santiago, Chile

5
Jorge Gamonal

Académico

Odontología Conservadora

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

5
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Jorge Gamonal

PROFESOR TITULAR

ODONTOLOGIA CONSERVADORA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

3
Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

1
Fermín González

Profesor Asociado

universidad de chile

Santiago, Chile

1
Denisse Bravo

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

1
Timo Sorsa

Visiting Professor of Oral Biology

Institute of Dentistry

Karolinska Institutet

Stockholm, Suecia