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Gladys Sofia Tapia Opazo

Academica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

estrÃ©s oxidativo y seÃ±alizaciÃ³n celular; hepatoprotecciÃ³n y daÃ±o por isquemia/reperfusiÃ³n; mecanismos de preacondicionamiento hepÃ¡tico; estrÃƒÂ¨s oxidativo hepÃƒÂ tico y activaciÃƒÂ²n redox de la expresiÃƒÂ²n gÃƒÂ¨nica; Mecanismos de preacondicionamiento hepÃƒÂ ticos inducidos por hormona tiroÃƒÂ¬dea,; Mecanismos de preacondicionamiento hepÃƒÂ tico inducidos por hierro y ÃƒÂ cidos grasos poli-insaturados omega-3; InducciÃ³n del estrÃ©s oxidativo por hormona tiroÃdea; Preacondicionamiento hepÃ¡tico por hormona tiroÃdea; Mecanismos de preacondicionamiento hepÃ¡tico

Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2009

Profesor asistente 44 horas semanales

Universidad de Chile

Santiago, Chile

Sin Información - Sin Información
Profesora Asociada Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1985 - 2020

Academico Full Time

Universidad de Chile

Santiago, Chile

1985 - A la fecha


Role of dietary α- and γ-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model. Tapia G, Silva D; Romero N, Pettinelli P; Dossi CG, de Miguel M Article NUTRITION (2018)
Rosa Mosqueta Oil Prevents Oxidative Stress and Inflammation through the Upregulation of PPAR-alpha and NRF2 in C57BL/6J Mice Fed a High-Fat Diet. González-Mañán D, D'Espessailles A; Dossi CG, San Martín M; Mancilla RA, Tapia GS. Article J Nutr. (2017)
A combined iron and thyroid hormone protocol suppresses ischemia-reperfusion injury in rat livers Pedemonte, JC; Vargas R.; Castillo V.; Hodali, T.; Gutierrez S. ; Tapia, G; Castillo I.; Videla LA.; Fernández V. Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2015)
N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-alpha upregulation and NF-kappa B DNA binding abrogation Tapia, G; Valenzuela R.; Espinosa, A.; Romanque, P.; Dossi, C; Gonzalez-Manan, D; Videla LA.; D'Espessailles A. Article ISI SCOPUS MOLECULAR NUTRITION & FOOD RESEARCH (2014)
Insulin-Dependent H2O2 Production Is Higher in Muscle Fibers of Mice Fed with a High-Fat Diet Espinosa, A.; Campos C.; Diaz-Vegas, A; Galgani, JE; Juretic, N; Osorio-Fuentealba, C; Bucarey, JL; Tapia, G; Valenzuela R.; Contreras-Ferrat, A; Llanos P.; Jaimovich E. Article ISI SCOPUS international journal of mole (2013)
Prevention of liver steatosis through fish oil supplementation: correlation of oxidative stress with insulin resistance and liver fatty acid content Espinosa, A.; Valenzuela R.; Gonzalez-Manan, D; D'Espessailles A.; Gormaz, JG; Barrera C.; Tapia, G Article ISI SCOPUS ARCHIVOS LATINOAMERICANOS DE NUTRICION (2013)
Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol Fernández V.; Vargas R.; Castillo V.; Cadiz, N; Bastias, D.; Roman, S; Tapia, G; Videla LA. Article ISI SCOPUS The Scientific World Journal (2013)
Bioconversion of alpha-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with alpha-linolenic acid-rich oils Gonzalez-Manan, D; Tapia, G; Gormaz J.G.; D'Espessailles A.; Espinosa, A.; Masson L.; Varela, P; Valenzuela A.; Valenzuela R. Article ISI SCOPUS Food and Function (2012)
N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis Valenzuela R.; Espinosa, A.; Gonzalez-Manan, D; D'Espessailles A.; Fernández V.; Videla, L.A.; Tapia, G Article ISI SCOPUS PLOS ONE (2012)
Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol Mardones, M; Valenzuela R.; Romanque, P.; Covarrubias, N; Anghileri F.; Fernández V.; Videla, L.A.; Tapia, G Article ISI SCOPUS Journal of Nutritional Biochemistry (2012)
Liver preconditioning induced by iron in a rat model of ischemia/reperfusion Galleano, M; Tapia, G; Puntarulo, S; Varela, P; Videla LA.; Fernández V. Article ISI SCOPUS Life Sciences (2011)
N-3 PUFA Supplementation Triggers PPAR-alpha Activation and PPAR-alpha/NF-kappa B Interaction: Anti-Inflammatory Implications in Liver Ischemia-Reperfusion Injury Zuñiga J; Cancino, M.; Medina, F; Varela, P; Vargas R.; Tapia, G; Videla LA.; Fernández V. Article ISI SCOPUS PLOS ONE (2011)
Delayed Ischemic Preconditioning Protects Against Liver Ischemia-Reperfusion Injury In Vivo Romanque, P.; Diaz A.; Tapia, G; Uribe-Echevarria, S; Videla LA.; Fernández V. Article ISI SCOPUS Transplantation Proceedings (2010)
Kupffer-cell activity is essential for thyroid hormone rat liver preconditioning Tapia, G; Santibáñez C.; Farías J.; Fuenzalida, G; Varela, P; Videla LA.; Fernández V. Article ISI SCOPUS Molecular and Cellular Endocrinology (2010)
Protection against in vivo liver ischemia-reperfusion injury by n-3 long-chain polyunsaturated fatty acids in the rat ZÃºÃ±iga J.; Venegas, F; Villarreal M.; NÃºÃ±ez D.; ChandÃa M.; Valenzuela R.; Tapia, G; Varela, P; Videla, L.A.; FernÃ¡ndez V. Article ISI SCOPUS Free Radical Research (2010)
Liver NF-?B and AP-1 DNA binding in obese patients Videla, L.A.; Tapia, G; Rodrigo R.; Pettinelli P.; Haim, D; Santibaez C.; Araya A.V.; Smok, G; Csendes, A; Gutierrez, L.; Rojas J.; Castillo J.; Korn, O; Maluenda F; Díaz J.C.; Rencoret G.; Poniachik, J Article OBESITY (2009)
Liver NF-kappa B and AP-1 DNA Binding in Obese Patients Videla LA.; Tapia, G; Rodrigo R.; Pettinelli P.; Haim, D; Santibáñez C.; Araya, AV; Smok, G; Csendes, A; Gutierrez, L.; Rojas J.; Castillo J.; Korn, O; Maluenda F; Diaz, JC; Rencoret G.; Poniachik, J Article ISI SCOPUS OBESITY (2009)
Upregulation of liver inducible nitric oxide synthase following thyroid hormone preconditioning: suppression by N-acetylcysteine Fernández V.; Tapia, G; Varela, P; Cornejo P.; Videla LA. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2009)
Causal role of oxidative stress in liver preconditioning by thyroid hormone in rats Fernández V.; Tapia, G; Varela, P; Gaete, L; Vera, G; Mora, C.; Vial, MT; Videla LA. Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2008)
Involvement of Kupffer cell-dependent signaling in T-3-induced hepatocyte proliferation in vivo Fernández V.; Reyes, S; Bravo S.; sepulveda, r; Romanque, P.; Santander, G.; Castillo I.; Varela, P; Tapia, G; Videla LA. Article ISI SCOPUS BIOLOGICAL CHEMISTRY (2007)
Thyroid hormone calorigenesis and mitochondrial redox signaling: upregulation of gene expression Videla LA.; Fernández V.; Tapia, G; Varela, P Article ISI SCOPUS FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Thyroid hormone preconditioning: Protection against ischemia-reperfusion liver injury in the rat Fernández V.; Castillo I.; Tapia, G; Romanque, P.; Uribe-Echevarria, S; Uribe M.; Cartier-Ugarte, D; Santander, G.; Vial, MT; Videla LA. Article ISI SCOPUS HEPATOLOGY (2007)
The acute-phase response of the liver in relation to thyroid hormone-induced redox signaling Tapia, G; Fernández V.; Pino C.; Ardiles, R; Videla LA. Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2006)
The role of thyroid hormone calorigenesis in the redox regulation of gene expression Varela, P; Tapia, G; Fernández V.; Videla LA. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2006)
Early histological and functional effects of chronic copper exposure in rat liver Cisternas, FA; Tapia, G; Arredondo M.; Cartier-Ugarte, D; Romanque, P.; Sierralta WD; Vial, MT; Videla LA.; Araya M. Article ISI SCOPUS BIOMETALS (2005)
Redox regulation of thyroid hormone-induced Kupffer cell-dependent I kappa B-alpha phosphorylation in relation to inducible nitric oxide synthase expression Fernández V.; Tapia, G; Varela, P; Videla LA. Article ISI SCOPUS FREE RADICAL RESEARCH (2005)
Redox up-regulated expression of rat liver manganese superoxide dismutase and Bcl-2 by thyroid hormone is associated with inhibitor of kappa B-alpha phosphorylation and nuclear factor-kappa B activation Fernández V.; Tapia, G; Varela, P; Castillo I.; Mora, C.; Moya, F; Orellana M.; Videla LA. Article ISI SCOPUS JOURNAL OF ENDOCRINOLOGY (2005)
Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappa B cytokine gene expression, and liver injury in the rat Videla LA.; Tapia, G; Varela, P; Cornejo P.; Guerrero, J; Israel, Y; Fernández V. Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2004)
Effects of acute lindane intoxication and thyroid hormone administration in relation to nuclear factor-kappa B activation, tumor necrosis factor-alpha expression, and Kupffer cell function in the rat Valencia, C; Cornejo P.; Romanque, P.; Tapia, G; Varela, P; Videla LA.; Fernández V. Article ISI SCOPUS TOXICOLOGY LETTERS (2004)
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients Videla LA.; Rodrigo R.; Orellana M.; Fernández V.; Tapia, G; Quinones, L; Varela, N; Contreras, J.; Lazarte, R; Csendes, A; Rojas J.; Maluenda F; Burdiles, P; Diaz, JC; Smok, G; Thielemann, L; Poniachik, J Article ISI SCOPUS CLINICAL SCIENCE (2004)
Kupffer cell stimulation in the isolated perfused rat liver triggers nuclear factor-kappa B DNA binding activity Romanque, P.; Tapia, G; Videla LA. Article ISI SCOPUS REDOX REPORT (2003)
Oxidative stress-mediated hepatotoxicity of iron and copper: Role of Kupffer cells Videla LA.; Fernández V.; Tapia, G; Varela, P Article ISI BIOMETALS (2003)
Thyroid hormone-induced oxidative stress triggers nuclear factor-kappa b activation and cytokine gene expression in rat liver Tapia, G; Fernández V.; Varela, P; Cornejo P.; Guerrero, J; Videla LA. Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2003)
Increases in tumor necrosis factor-alpha in response to thyroid hormone-induced liver oxidative stress in the rat Fernández V.; Videla LA.; Tapia, G; Israel, Y Article ISI SCOPUS FREE RADICAL RESEARCH (2002)
Influence of C-phycocyanin on hepatocellular parameters related to liver oxidative stress and Kupffer cell functioning Remirez D.; Fernández V.; Tapia, G; González R.; Videla LA. Article ISI SCOPUS INFLAMMATION RESEARCH (2002)
Vitamin E but not 17 beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant Muñoz FJ.; Opazo C.; Gil-Gomez G.; Tapia, G; Fernández V.; Valverde, MA; Inestrosa, NC Article ISI JOURNAL OF NEUROSCIENCE (2002)
Effects of iron overload and lindane intoxication in relation to oxidative stress, Kupffer cell function, and liver injury in the rat Junge, B; Carrion, Y; Bosco C.; Galleano, M; Puntarulo, S; Tapia, G; Videla LA. Article ISI TOXICOLOGY AND APPLIED PHARMACOLOGY (2001)
Influence of aging on Kupffer cell respiratory activity in relation to particle phagocytosis and oxidative stress parameters in mouse liver Videla, L.A.; Tapia, G; Fernández V. Article SCOPUS REDOX REPORT (2001)
Iron-induced changes in nitric oxide and superoxide radical generation in rat liver after lindane or thyroid hormone treatment Cornejo P.; Tapia, G; Puntarulo, S; Galleano, M; Videla LA.; Fernández V. Article ISI SCOPUS TOXICOLOGY LETTERS (2001)


Changes in hepatic levels of PPAR-alpha, ACOX and CAT-1 in the prevention of hight fat diet iinduced steatosis Tapia, G; Varela, P; Escudero, D; Hasson D.; González D; DEspessailles, A; Valenzuela R.; Barrera C. Abstract ISI FEBS JOURNAL (2012)
Enhancement in liver nuclear factor-KB (NF-KB) and activator protein 1 (AP-1) DNA binding in obese patients with non-alcoholic fatty liver disease Poniachik, J; Santibáñez C.; Haim, D; Tapia, G; Araya J.; Rodrigo R.; Araya, V; Csendes, A; Burdiles, R; Castillo J.; Díaz, J; Maluenda F; Korn, O; Gutierrez, L.; Rojas J.; Rencoret G.; Ibarra, J; Videla, L Abstract ISI JOURNAL OF HEPATOLOGY (2008)
Chronic copper overload: Kupffer cell function and NF-kappa B activity Cartier, D; Tapia, G; Romanque, P.; Araya M.; Videla LA. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2004)
Oxidative stress in preeclampsia. Possible relevance of plasma oxidative stress indexes in the early prediction of preeclampsia Fernández V.; Rodrigo R.; Bosco C.; Barja P.; Tapia, G; Parra,M Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2004)
Activation of NF kappa B in carbon infusion activated liver macrophages Romanque, P.; Cornejo P.; Tapia, G; Fernández V.; Videla LA. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2003)
Liver oxidative stress and tumor necrosis factor-alpha (TNF-alpha) in response to thyroid hormone administration Fernández V.; Tapia, G; Cornejo P.; Schon, M; Israel, Y; Videla LA. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2002)
Redox regulation of liver NF-kappa B after thyroid hormone administration Cornejo P.; Guerrero, J; Fernández V.; Tapia, G; Videla LA. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2002)


Activation of nuclear factor KB and TNF-alpha response to thyroid hormone-induced liver oxidative stress Fernández V.; Tapia, G; Cornejo P.; Guerrero, J; Israel, Y; Videla LA. ConferencePaper ISI XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL (2002)


Effect of iron overload on liver nitric oxide (NO) generation in hyperthyroid rats Cornejo P.; Tapia, G; Sepúlveda, A.; Videla LA.; Fernández V. EditorialMaterial ISI BIOMETALS (2003)


Hepatoprotective mechanisms of Rosa rubiginosa oil (Rosa moaqueta) in preconditioning against eschemia reperfusion injury in healthy and steatotic liver and prevention of liver steatosis=> role of Nrf2, PPAR-alpha, FONDECYT (1140547) Proyecto 2014-2018 Inv. Principal
Mecanismos moleculares asociados al preacondicionamiento hepático por la hormona tiroidea y los ácidos grasos poliinsaturados omega-3 FONDECYT (1080039) Proyecto 2008-2011 Coinvestigador(a)
Preacondicionamiento por isquemia-reperfusión y hormona tiroidea como mecanismo de protección del daño por isquemia-reperfusión en el hígado FONDECYT (1050131) Proyecto 2005-2008 Coinvestigador(a)
Adaptación de la expresión genica del hígado en el estrés oxidativo hipertoroídeo=> señalización de supervivencia y proliferación celular FONDECYT (1030499) Proyecto 2003-2006 Coinvestigador(a)
Rol de las células de Kupffer en la injuria hepatocelular. Relación entre estrés oxidativo y balance entre citoquinas pro y anti inflamatorias. FONDECYT (1000887) Proyecto 2000-2003 Coinvestigador(a)
Hepatotoxicidad asociada a la interacción de mecanismos pro oxidativos=> rol de las células de Kupffer. FONDECYT (1970300) Proyecto 1997-2000 Coinvestigador(a)


Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron FernÃ¡ndez V.; Tapia, G; Videla, L.A. Review SCOPUS World Journal of Hepatology (2012)
Thyroid hormone-induced oxidative stress in rodents and humans: A comparative view and relation to redox regulation of gene expression Fernández V.; Tapia, G; Varela, P; Romanque, P.; Cartier-Ugarte, D; Videla LA. Review ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY PHARMACOLOGY (2006)

Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Virginia Fernández

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ICBM, PROGRAMA DE FARMACOLOGÌA

Santiago, Chile

Pamela Romanque

Residente

Imagenología

Hospital Clínico Universidad de Chile

Santiago, Chile

Rodrigo Valenzuela

Profesor Asociado

Nutrición

Universidad de Chile

Santiago, Chile

Berta Espinosa

Full Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

Amanda D'Espessailles

Investigadora Postdoctoral

Instituto de Ciencias de a Salud

Universidad de O'Higgins

Rancagua, Chile

Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

IVAN CASTILLO

Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Jessica Zuñiga

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

Leonardo Gaete

Assistant Profesor

ICBM

University of Chile

Santiago, Chile

Alexis Diaz

PhD stundent

Fisiología

universidad de Chile

Santiago, Chile

Juan Gormaz

UNIVERSIDAD DE CHILE

Santiago, Chile

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

Lilia Masson

Presidenta

UNIVERSIDAD DE CHILE

santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Carlos Valenzuela

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

PAULINA PETTINELLI

Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

Cristian Campos

Entrenamiento Post Doctorado

Fisiología

Universidad de Chile

Santiago, Chile

Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

César Osorio

Associate Professor

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

Gladys Sofia Tapia Opazo

Líneas de Investigación

Educación

Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

Profesor asistente 44 horas semanales

Profesora Asociada Full Time

Experiencia Profesional

Academico Full Time

Article (39)

Abstract (7)

ConferencePaper (1)

EditorialMaterial (1)

Proyecto (6)

Hepatoprotective mechanisms of Rosa rubiginosa oil (Rosa moaqueta) in preconditioning against eschemia reperfusion injury in healthy and steatotic liver and prevention of liver steatosis=> role of Nrf2, PPAR-alpha,

Mecanismos moleculares asociados al preacondicionamiento hepático por la hormona tiroidea y los ácidos grasos poliinsaturados omega-3

Preacondicionamiento por isquemia-reperfusión y hormona tiroidea como mecanismo de protección del daño por isquemia-reperfusión en el hígado

Adaptación de la expresión genica del hígado en el estrés oxidativo hipertoroídeo=> señalización de supervivencia y proliferación celular

Rol de las células de Kupffer en la injuria hepatocelular. Relación entre estrés oxidativo y balance entre citoquinas pro y anti inflamatorias.

Hepatotoxicidad asociada a la interacción de mecanismos pro oxidativos=> rol de las células de Kupffer.

Review (2)