Man

Gladys Sofia Tapia Opazo

Academica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


estrés oxidativo y señalización celular; hepatoprotección y daño por isquemia/reperfusión; mecanismos de preacondicionamiento hepático; estrès oxidativo hepàtico y activaciòn redox de la expresiòn gènica; Mecanismos de preacondicionamiento hepàticos inducidos por hormona tiroìdea,; Mecanismos de preacondicionamiento hepàtico inducidos por hierro y àcidos grasos poli-insaturados omega-3; Inducción del estrés oxidativo por hormona tiroídea; Preacondicionamiento hepático por hormona tiroídea; Mecanismos de preacondicionamiento hepático

Educación

  •  Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Profesor asistente 44 horas semanales

    Universidad de Chile

    Santiago, Chile

    Sin Información - Sin Información

  •   Profesora Asociada Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1985 - 2020

Experiencia Profesional

  •   Academico Full Time

    Universidad de Chile

    Santiago, Chile

    1985 - A la fecha


 

Article (39)

Role of dietary α- and γ-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model.
Rosa Mosqueta Oil Prevents Oxidative Stress and Inflammation through the Upregulation of PPAR-alpha and NRF2 in C57BL/6J Mice Fed a High-Fat Diet.
A combined iron and thyroid hormone protocol suppresses ischemia-reperfusion injury in rat livers
N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-alpha upregulation and NF-kappa B DNA binding abrogation
Insulin-Dependent H2O2 Production Is Higher in Muscle Fibers of Mice Fed with a High-Fat Diet
Prevention of liver steatosis through fish oil supplementation: correlation of oxidative stress with insulin resistance and liver fatty acid content
Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol
Bioconversion of alpha-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with alpha-linolenic acid-rich oils
N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis
Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol
Liver preconditioning induced by iron in a rat model of ischemia/reperfusion
N-3 PUFA Supplementation Triggers PPAR-alpha Activation and PPAR-alpha/NF-kappa B Interaction: Anti-Inflammatory Implications in Liver Ischemia-Reperfusion Injury
Delayed Ischemic Preconditioning Protects Against Liver Ischemia-Reperfusion Injury In Vivo
Kupffer-cell activity is essential for thyroid hormone rat liver preconditioning
Protection against in vivo liver ischemia-reperfusion injury by n-3 long-chain polyunsaturated fatty acids in the rat
Liver NF-?B and AP-1 DNA binding in obese patients
Liver NF-kappa B and AP-1 DNA Binding in Obese Patients
Upregulation of liver inducible nitric oxide synthase following thyroid hormone preconditioning: suppression by N-acetylcysteine
Causal role of oxidative stress in liver preconditioning by thyroid hormone in rats
Involvement of Kupffer cell-dependent signaling in T-3-induced hepatocyte proliferation in vivo
Thyroid hormone calorigenesis and mitochondrial redox signaling: upregulation of gene expression
Thyroid hormone preconditioning: Protection against ischemia-reperfusion liver injury in the rat
The acute-phase response of the liver in relation to thyroid hormone-induced redox signaling
The role of thyroid hormone calorigenesis in the redox regulation of gene expression
Early histological and functional effects of chronic copper exposure in rat liver
Redox regulation of thyroid hormone-induced Kupffer cell-dependent I kappa B-alpha phosphorylation in relation to inducible nitric oxide synthase expression
Redox up-regulated expression of rat liver manganese superoxide dismutase and Bcl-2 by thyroid hormone is associated with inhibitor of kappa B-alpha phosphorylation and nuclear factor-kappa B activation
Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappa B cytokine gene expression, and liver injury in the rat
Effects of acute lindane intoxication and thyroid hormone administration in relation to nuclear factor-kappa B activation, tumor necrosis factor-alpha expression, and Kupffer cell function in the rat
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Kupffer cell stimulation in the isolated perfused rat liver triggers nuclear factor-kappa B DNA binding activity
Oxidative stress-mediated hepatotoxicity of iron and copper: Role of Kupffer cells
Thyroid hormone-induced oxidative stress triggers nuclear factor-kappa b activation and cytokine gene expression in rat liver
Increases in tumor necrosis factor-alpha in response to thyroid hormone-induced liver oxidative stress in the rat
Influence of C-phycocyanin on hepatocellular parameters related to liver oxidative stress and Kupffer cell functioning
Vitamin E but not 17 beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant
Effects of iron overload and lindane intoxication in relation to oxidative stress, Kupffer cell function, and liver injury in the rat
Influence of aging on Kupffer cell respiratory activity in relation to particle phagocytosis and oxidative stress parameters in mouse liver
Iron-induced changes in nitric oxide and superoxide radical generation in rat liver after lindane or thyroid hormone treatment

Abstract (7)

Changes in hepatic levels of PPAR-alpha, ACOX and CAT-1 in the prevention of hight fat diet iinduced steatosis
Enhancement in liver nuclear factor-KB (NF-KB) and activator protein 1 (AP-1) DNA binding in obese patients with non-alcoholic fatty liver disease
Chronic copper overload: Kupffer cell function and NF-kappa B activity
Oxidative stress in preeclampsia. Possible relevance of plasma oxidative stress indexes in the early prediction of preeclampsia
Activation of NF kappa B in carbon infusion activated liver macrophages
Liver oxidative stress and tumor necrosis factor-alpha (TNF-alpha) in response to thyroid hormone administration
Redox regulation of liver NF-kappa B after thyroid hormone administration

ConferencePaper (1)

Activation of nuclear factor KB and TNF-alpha response to thyroid hormone-induced liver oxidative stress

EditorialMaterial (1)

Effect of iron overload on liver nitric oxide (NO) generation in hyperthyroid rats

Proyecto (6)

Hepatoprotective mechanisms of Rosa rubiginosa oil (Rosa moaqueta) in preconditioning against eschemia reperfusion injury in healthy and steatotic liver and prevention of liver steatosis=> role of Nrf2, PPAR-alpha,
Mecanismos moleculares asociados al preacondicionamiento hepático por la hormona tiroidea y los ácidos grasos poliinsaturados omega-3
Preacondicionamiento por isquemia-reperfusión y hormona tiroidea como mecanismo de protección del daño por isquemia-reperfusión en el hígado
Adaptación de la expresión genica del hígado en el estrés oxidativo hipertoroídeo=> señalización de supervivencia y proliferación celular
Rol de las células de Kupffer en la injuria hepatocelular. Relación entre estrés oxidativo y balance entre citoquinas pro y anti inflamatorias.
Hepatotoxicidad asociada a la interacción de mecanismos pro oxidativos=> rol de las células de Kupffer.

Review (2)

Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron
Thyroid hormone-induced oxidative stress in rodents and humans: A comparative view and relation to redox regulation of gene expression
55
Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

15
Virginia Fernández

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ICBM, PROGRAMA DE FARMACOLOGÌA

Santiago, Chile

11
Pamela Romanque

Residente

Imagenología

Hospital Clínico Universidad de Chile

Santiago, Chile

8
Rodrigo Valenzuela

Profesor Asociado

Nutrición

Universidad de Chile

Santiago, Chile

6
Berta Espinosa

Assistant Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

4
Amanda D'Espessailles

Investigadora Postdoctoral

Instituto de Ciencias de a Salud

Universidad de O'Higgins

Rancagua, Chile

4
Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

4
Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

3
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

2
Jessica Zuñiga

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

2
Alexis Diaz

PhD stundent

Fisiología

universidad de Chile

Santiago, Chile

2
Leonardo Gaete

Assistant Profesor

ICBM

University of Chile

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Lilia Masson

Presidenta

UNIVERSIDAD DE CHILE

santiago, Chile

1
Cristian Campos

Entrenamiento Post Doctorado

Fisiología

Universidad de Chile

Santiago, Chile

1
Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
PAULINA PETTINELLI

Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carlos Valenzuela

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
César Osorio

Associate Professor

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile