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Mauricio Alejandro Sáez Venegas

Profesor Asistente

Universidad Mayor

Santiago, Chile

Líneas de Investigación


Epigenética. Complejo Represivo Polycomb 2 en maduración del Sistema Nervioso. Control de la Expresión Génica en neuronas. Neurociencias.

Educación

  •  Biología Molecular y Celular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2011
  •  Bioquímica, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD MAYOR

    Ciencias

    Santiago, Chile

    2018 - A la fecha

  •   Profesor Invitado Other

    PONTIFICIA UNIVERSIDAD JAVERIANA

    Medicina

    Bogotá, Chile

    2017 - 2017

Experiencia Profesional

  •   Investigador Postdoctoral Full Time

    Centro de Investigaciones Biomedicas de Belvitge

    Barcelona, España

    2011 - 2014

  •   Investigador Posdoctoral Full Time

    Centro de Investigaciones Biomédicas, Universidad Andrés Bello

    Santiago, Chile

    2014 - 2017

  •   Asistente de Investigación Full Time

    Instituto de Bioquímica, Universidad Austral de Chile

    Valdivia, Chile

    2011 - 2011

  •   Research Associated Full Time

    H. Institute for Human Genomics, University of Miami

    Miami, Estados Unidos

    2009 - A la fecha

  •   Asisente de Investigación Full Time

    Centro de Estudios Científicos

    Valdivia, Chile

    2006 - 2008

  •   Profesor Asistente Full Time

    Centro de Genómica y Bioinformática, Universidad Mayor

    Santiago, Chile

    2018 - A la fecha


 

Article (9)

Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice

Jorge-Torres, Olga C.; Szczesna, Karolina; Roa, Laura; Casal, Carme; Gonzalez-Somermeyer, Louisa; Soler, Marta; Velasco, Cecilia D.; Segundo, Pablo Martinez-San; Petazzi, Paolo; Saez, Mauricio A.; et al.

Article ISI
CELL REPORTS  (2018)

Mutations in JMJD1C are involved in Rett syndrome and intellectual disability

Fernandez-Rodriguez, Juana; Moutinho, Catia; Sanchez-Mut, Jose V.; Gomez, Antonio; Vidal, Enrique; Lopez-Serra, Paula; Lucariello, Mario; Lorden, Patricia; de la Caridad, Olga J.; Gelpi, Josep L.; et al.

Article ISI
GENETICS IN MEDICINE  (2016)

Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus

Rojas, Adriana

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS  (2016)

Whole exome sequencing of Rett syndrome-like patients reveals the mutational diversity of the clinical phenotype

Vidal, Silvia; Saez, Mauricio; Pineda, Merce; Dalfo, Esther; Jurado, Paola

Article ISI
HUMAN GENETICS  (2016)

Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes (vol 10, e0123693, 2015)

de Paz, Martinez A.; Sanchez-Mut, J., V; Samitier-Marti, M.; Petazzi, P.; Szczesna, K.

Article ISI
PLOS ONE  (2015)

Improvement of the Rett Syndrome Phenotype in a Mecp2 Mouse Model Upon Treatment with Levodopa and a Dopa-Decarboxylase Inhibitor

de la Caridad, Olga; Artuch-Iriberri, Rafael; Molero-Luis, Marta; Vidal, August

Article ISI
NEUROPSYCHOPHARMACOLOGY  (2014)

Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

Kerr, B; Soto C J; Saez, M; Abrams A.; Walz, K; Young J.I.

Article ISI SCOPUS
European Journal of Human Genetics  (2012)

Defective body-weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice

Kerr, B; Alvarez-Saavedra, M; Saez, MA; Saona, A

Article ISI SCOPUS
HUMAN MOLECULAR GENETICS  (2008)

Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis

Alvarez-Saavedra, M; Saez, MA; Kang, D; Zoghbi, HY

Article ISI SCOPUS
HUMAN MOLECULAR GENETICS  (2007)

Abstract (1)

PRC2-Ezh1 mediates transcription of hippocampal genes.

Saez, MA

Abstract ISI
 (2017)

ConferencePoster (2)

Study of the relationship between H3K27 acetylation levels and transcriptional changes associate with CRE promoters in Huntington Disease model

Arancibia-Opazo, Sandra; Sáez-Venegas, Mauricio

ConferencePoster
 (2019)

Ezh1 (a member of Polycomb Repressive Complex 2) associated transcription in the hippocampus

Saez, Mauricio; van Zundert, Brigitte; Montecino, Martin

ConferencePoster
 

1
Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

1
Jessica Soto

tesista de postgrado

Nutrición

Universidad de Chile

santiago, Chile

12
Mauricio Sáez

Profesor Asistente

Centro de Genómica y Bioinformática

Universidad Mayor

Santiago, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile