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Luis Ignacio Cortínez Fernández

DIVISIÓN DE ANESTESIOLOGÍA, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Anestesia Regional; FarmacologÃa ClÃnica; Dolor; HIPERALGESIA POSTOPERATORIA; FARMACOLOGIA CLINICA; Dolor Agudo y cronico; Hiperalgesia postoperatoria; autoinmunidad; FarmacologÃa clÃnica; MonitorizaciÃ³n de profundidad anestÃ©sica

Medico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1991
Anestesiologo, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
Anestesiologia, DUKE UNIVERSITY. Estados Unidos, 2003


Differential frontal alpha oscillations and mechanisms underlying loss of consciousness: a comparison between slow and fast propofol infusion rates Sepulveda, P.; Cortinez, L. I.; Irani, M.; Egana, J. I.; Contreras, V.; Sanchez Corzo, A.; Acosta, I.; Sitaram, R. Article ISI SCOPUS ANAESTHESIA (2020)
Nebulization of Vancomycin Provides Higher Lung Tissue Concentrations than Intravenous Administration in Ventilated Female Piglets with Healthy Lungs de Mello Morais, Cristiane Luchesi; Leandro Nascimento, Jorge Willian; Ribeiro, Aline Correa; Ignacio Cortinez, Luis; Carvalho Carmona, Maria Jose; Ramos Maia, Debora Rothstein; Monsel, Antoine; Costa Auler, Jose Otavio, Jr.; Rouby, Jean-Jacques; Otsuki, Denise Aya Article ISI ANESTHESIOLOGY (2020)
Liver transplantation: development, learning curve and results after the first 300 cases Guerra, JF; Quezada, JL; Cancino, A; Arrese, M; Wolff, R; Benitez, C; Pattillo, JC; Gana, JC; Concha, M; Cortinez, L; Vera, M; Miranda, P; Rubilar, F; Troncoso, A; Briceno, E; Dib, M.; Jarufe, N; Martinez, J Article ISI REVISTA MEDICA DE CHILE (2019)
Advances in pharmacokinetic modeling=> target controlled infusions in the obese. Cortínez, Luis I; Anderson, Brian J Article Current opinion in anaesthesiology (2018)
Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients Rolle, A; Paredes, S; Cortinez, LI; Anderson, BJ; Quezada, N; Solari, S; Allende, F; Torres, J; Cabrera, D; Contreras, V; Carmona, J; Ramirez, C; Oliveros, AM; Ibacache M. Article ISI SCOPUS BRITISH JOURNAL OF ANAESTHESIA (2018)
Effect-Site Target-Controlled Infusion in the Obese: Model Derivation and Performance Assessment Cortinez, LI; Sepulveda, P; Rolle, A; Cottin, P; Guerrini, A; Anderson, BJ Article ISI ANESTHESIA AND ANALGESIA (2018)
Evidence of hysteresis in propofol pharmacodynamics Sepulveda, PO; Carrasco, E; Tapia, LF; Ramos, M; Cruz, F; Conget, P; Olivares, QFB; Cortinez, I Article ANAESTHESIA (2018)
Modeling the pharmacokinetics and pharmacodynamics of sevoflurane using compartment models in children and adults Cortinez, LI; Anderson, BJ Article ISI SCOPUS PEDIATRIC ANESTHESIA (2018)
Pharmacokinetics of levobupivacaine with epinephrine in transversus abdominis plane block for postoperative analgesia after Caesarean section Lacassie HJ; Rolle, A; Cortinez, LI; Solari, S; Corvetto, MA; Altermatt, FR Article ISI SCOPUS BRITISH JOURNAL OF ANAESTHESIA (2018)
Propofol pharmacokinetic and pharmacodynamic profile and its electroencephalographic interaction with remifentanil in children. Fuentes, Ricardo; Cortínez, L Ignacio; Contreras, Victor; Ibacache, Mauricio; Anderson, Brian J. Article ISI SCOPUS Paediatric Anaesthesia (2018)
Comparison of the CortÃnez and the Schnider models with a targeted effect-site TCI of 3 mcg/ml in biophase in healthy volunteers. Frederico Avendaño, C; Cortínez, L I; Ramírez-Paesano, C R Article Revista espanola de anestesiologia y reanimacion (2016)
Comparison of the Cortínez and the Schnider models with a targeted effect-site TCI of 3 mcg/ml in biophase in healthy volunteers [Comparación del modelo de Cortínez y de Schnider en perfusión de propofol controlada por objetivo de 3 mcg/ml, a biofase, en Frederico Avendaño C., Cortínez L.I. Article REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION (2016)
Levobupivacaine absorption pharmacokinetics with and without epinephrine during TAP block=> analysis of doses based on the associated risk of local anaesthetic toxicity. Miranda, P; Corvetto, M A; Altermatt, Fernando R; Araneda, A; Echevarría, G C; Cortínez, L I Article European journal of clinical pharmacology (2016)
Rocuronium pharmacokinetics and pharmacodynamics in the adductor pollicis and masseter muscles Vega E.A.; Ibacache M.E.; Anderson B.J.; Holford N.H.G.; Nazar C.E.; Solari, S; Allende F.A.; Cortínez L.I. Article ISI SCOPUS Acta Anaesthesiologica Scandinavica (2016)
Dexmedetomidine pharmacokinetics in the obese Cortinez, L; Anderson, BJ; Holford, NHG; Puga, V; De La Fuente N.; Auad, H; Solari, S; Allende, FA; Ibacache M. Article ISI SCOPUS European Journal of Clinical Pharmacology (2015)
Dexmedetomidine-ketamine combination and caudal block for superficial lower abdominal and genital surgery in children. Ibacache, Mauricio E; Muñoz, Hernán R; Fuentes, Ricardo; Cortínez, Luis I Article Paediatric anaesthesia (2015)
Effect of acute arterial hypertension on morphine requirements and postsurgical pain Delfino, AE; de la Fuente, N; Echevarria, GC; Altermatt, FR; Cortinez, LI Article Journal of Clinical Anesthesia (2015)
In response. Eleveld, Douglas J; Proost, Johannes H; Absalom, Anthony R; Cortínez, Luis I; Struys, Michel M R F Article Anesthesia and analgesia (2015)
A general purpose pharmacokinetic model for propofol. Eleveld, Douglas J; Proost, Johannes H; Cortínez, Luis I; Absalom, Anthony R; Struys, Michel M R F Article Anesthesia and analgesia (2014)
Performance of Propofol Target-Controlled Infusion Models in the Obese=> Pharmacokinetic and Pharmacodynamic Analysis Cortinez, LI; de la Fuente, N; Eleveld, DJ; Oliveros A., Crovari; F, Sepúlveda P.; Ibacache, M; Solari, S Article Anesthesia and Analgesia (2014)
What is the ke0 and what does it tell me about propofol? Cortínez, L I Article Anaesthesia (2014)
Absorption characteristics of epidural levobupivacaine with adrenaline and clonidine in children Chalkiadis, GA; Abdullah, F; Bjorksten, AR; Clarke A., Cortinez; LI, Udayasiri; S, Anderson Article Paediatric Anaesthesia (2013)
Effect of intravenous fluid therapy on postoperative vomiting in children undergoing tonsillectomy. Elgueta, M F; Echevarría, G C; De la Fuente, N; Cabrera, F; Valderrama, A; Cabezón, R; Muñoz, H R; Cortinez, L I Article British journal of anaesthesia (2013)
The effective effect-site propofol concentration for induction in morbidly obese patients using total body weight with a new pharmacokinetic model. de la Fuente, Natalia F; Puga, Valentina A; Cortínez, Luis I; Muñoz, Hernán R Article Anesthesia and analgesia (2013)
Evaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index(dagger) Altermatt F.R.; Bugedo D.A.; Delfino A.E.; Solari, S; Guerra, I.; Munoz H.R.; Cortínez L.I. Article ISI SCOPUS British Journal of Anaesthesia (2012)
The Effective Effect-Site Propofol Concentration for Induction and Intubation with Two Pharmacokinetic Models in Morbidly Obese Patients Using Total Body Weight Echevarria G.C.; Elgueta M.F.; Donoso M.T.; Bugedo D.A.; Cortínez L.I.; Munoz H.R. Article ISI SCOPUS Anesthesia and Analgesia (2012)
Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans. Echevarría, G; Elgueta, F; Fierro, C; Bugedo, D; Faba, G; Iñiguez-Cuadra, R; Muñoz, H R; Cortínez, L I Article British journal of anaesthesia (2011)
Obesity does not influence the onset and offset of sevoflurane effect as measured by the hysteresis between sevoflurane concentration and bispectral index. Cortínez, Luis I; Gambús, Pedro; Trocóniz, Iñaki F; Echevarría, Ghislaine; Muñoz, Hernán R Article Anesthesia and analgesia (2011)
Performance evaluation of paediatric propofol pharmacokinetic models in healthy young children Sepúlveda P., Cortinez; LI, Sáez C.; Penna, A; Solari, S; Guerra, I.; Absalom, AR Article British Journal of Anaesthesia (2011)
Transesophageal echocardiography to monitor fluid administration during the perioperative period Concha M.; Mertz, V; Cortinez, L; Zuniga, A; Pinedo, G Article ISI REVISTA MEDICA DE CHILE (2011)
Predictive ability of propofol effect-site concentrations during fast and slow infusion rates Sepulveda, PO; Cortinez, LI; Recart, A; Munoz, HR Article Acta Anaesthesiologica Scandinavica (2010)
Predictive ability of propofol effect-site concentrations during fast and slow infusion rates. Sepúlveda, P O; Cortínez, L I; Recart, A; Muñoz, H R Article Acta anaesthesiologica Scandinavica (2010)
Propofol consumption and recovery times after bispectral index or cerebral state index guidance of anaesthesia. Delfino, A E; Cortinez, L I; Fierro, C V; Muñoz, H R Article British journal of anaesthesia (2009)
Prospective evaluation of the time to peak effect of propofol to target the effect site in children Munoz, HR; Leon, PJ; Fuentes, RS; Echevarria, GC; Cortinez, LI Article ACTA ANAESTHESIOLOGICA SCANDINAVICA (2009)
Pulse Contour Analysis and Transesophageal Echocardiography=> A Comparison of Measurements of Cardiac Output During Laparoscopic Colon Surgery Concha, MR; Mertz, VF; Cortinez, LI; Gonzalez, KA; Butte, JM Article ANESTHESIA AND ANALGESIA (2009)
The volume of lactated Ringer's solution required to maintain preload and cardiac index during open and laparoscopic surgery. Concha, Mario R; Mertz, Verónica F; Cortínez, Luis I; González, Katya A; Butte, Jean M; López, Francisco; Pinedo, George; Zúñiga, Alvaro Article Anesthesia and analgesia (2009)
Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years Cortinez, LI; Fuentes R., Solari; S, Ostermann; P, Vega M.; Munoz, HR Article ANESTHESIA AND ANALGESIA (2008)
Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years. Cortínez, Luis I; Fuentes, Ricardo; Solari, Sandra; Ostermann, Paola; Vega, Miguel; Muñoz, Hernán R Article Anesthesia and analgesia (2008)
The Dynamic Relationship Between End-Tidal Sevoflurane Concentrations, Bispectral Index, and Cerebral State Index in Children Fuentes R., Cortinez; LI, Struys; MMRF, Delfino A.; Munoz, H Article ANESTHESIA AND ANALGESIA (2008)
The influence of age on the dynamic relationship between end-tidal sevoflurane concentrations and bispectral index. Cortínez, Luis I; Trocóniz, Iñaki F; Fuentes, Ricardo; Gambús, Pedro; Hsu, Yung-Wei; Altermatt, Fernando; Muñoz, Hernán R Article Anesthesia and analgesia (2008)
Remifentanil requirements during propofol administration to block the somatic response to skin incision in children and adults Munoz, HR; Cortinez, LI; Ibacache, ME; Altermatt, FR Article ANESTHESIA AND ANALGESIA (2007)
Effect site concentrations of propofol producing hypnosis in children and adults=> comparison using the bispectral index Munoz, HR; Cortinez, LI; Ibacache, ME; Leon, PJ Article ACTA ANAESTHESIOLOGICA SCANDINAVICA (2006)
Changes in hematocrit based on incremental blood sampling=> mathematical models perform poorly Cortinez, LI; Somma, J; Robertson, KM; Keifer, JC; Wright, DR; Hsu, YW; MacLeod, DB; Moretti, EW Article CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE (2005)
Target-controlled infusion of remifentanil or fentanyl during extra-corporeal shock-wave lithotripsy Cortinez, LI; Munoz, HR; De La Fuente R., Acuña D.; Dagnino, JA Article EUROPEAN JOURNAL OF ANAESTHESIOLOGY (2005)
Dexmedetomidine pharmacodynamics: Part I - Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers Hsu Y.-W.; Robertson K.M.; Keifer J.C.; Moretti E.W.; Young C.C.; Wright D.R.; MacLeod D.B.; Somma, J; Cortínez L.I.; Sum-Ping S.T. Article SCOPUS ANESTHESIOLOGY (2004)
Dexmedetomidine pharmacodynamics: Part II - Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers Cortínez L.I.; Hsu Y.-W.; Young, C; Keifer J.C.; MacLeod D.; Robertson K.M.; Wright D.R.; Moretti E.W.; Somma, J; Sum-Ping S.T. Article SCOPUS ANESTHESIOLOGY (2004)
Remifentanil requirements during sevoflurane administration to block somatic and cardiovascular responses to skin incision in children and adults Munoz, HR; Cortinez, LI; Altermatt, FR; Dagnino, JA Article ANESTHESIOLOGY (2002)
No clinical evidence of acute opioid tolerance after remifentanil-based anaesthesia Cortinez, LI; Brandes, V; Munoz, HR; Guerrero, ME; Mur, M Article BRITISH JOURNAL OF ANAESTHESIA (2001)


Sedation in obese patients [Sedación en obesos] Cortínez L.I. Note SCOPUS Revista Mexicana de Anestesiologia (2014)


THE EFFECT OF OBESITY IN DEXMEDETOMIDINE METABOLIC CLEARANCE FONDECYT (1150197) Proyecto 2015-2018 Inv. Responsable
DEVELOPMENT OF INTEGRATED PHARMACOKINETIC (PK) PHARMACODYNAMIC (PD) MODELS TO ADMINISTER INTRAVENOUS ANESTHETICS IN OBESE PATIENTS FONDECYT (1120583) Proyecto 2012-2014 Inv. Responsable