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Luis Ignacio Cortínez Fernández

Profesor Titular

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Anestesia Regional; FarmacologÃia Clinica; Dolor; HIPERALGESIA POSTOPERATORIA; FARMACOLOGIA CLINICA; Dolor Agudo y cronico; Hiperalgesia postoperatoria; autoinmunidad; Farmacología clínica; Monitorización de profundidad anestésica

Educación

  •  Medico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1991
  •  Anestesiologo, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
  •  Anestesiologia, DUKE UNIVERSITY. Estados Unidos, 2003

Experiencia Académica

  •   Profesor Titular Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    1997 - A la fecha

Experiencia Profesional

  •   Anestesiologo Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    1997 - A la fecha

Formación de Capital Humano


Profesor Investigador que ha convocado a diversos alumnos para los proyectos de investigación que he liderado.


Difusión y Transferencia


Modelamiento TCI Propofol Eleveld
Modelamiento TCI Propofol Obesos



 

Article (36)

Determination of dose for neuromuscular blocking drugs

Cortinez, L. Ignacio; Anderson, Brian J.

Article ISI SCOPUS
Paediatric Anaesthesia  (2024)

Dexmedetomidine dosing for procedural sedation in children and adults: We can do better

Morse, James D.; Cortinez, L. Ignacio

Article ISI SCOPUS
Paediatric Anaesthesia  (2024)

Latin American Surgical Outcomes Study in Paediatrics (LASOS-Peds): study protocol and statistical analysis plan for a multicentre international observational cohort study

Quintao, Vinicius Caldeira; de Sousa, Gabriel Soares; Torborg, Alexandra; Vieira, Alexandra; Consonni, Francesco; Rodrigues, Samuel; Proenca, Julia; Carlos, Ricardo Vieira; Clemente, Marcella; Alonso, Nivaldo; et al.

Article ISI SCOPUS
BMJ Open  (2024)

Pharmacokinetics of Methadone in Adult Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Salas, Wibaldo; Cortinez, Luis I.; Rolle, Augusto; Lopez, Rodrigo; Elgueta, Maria Francisca; Godoy, Cesar; Giordano, Ady; Contreras, Victor; Anderson, Brian

Article
ANESTHESIA AND ANALGESIA  (2024)

Physiologic time and anesthesia

Anderson, Brian J.; Cortinez, L. Ignacio

Article ISI SCOPUS
Paediatric Anaesthesia  (2024)

Sugammadex dose in infants

Cortinez, L. Ignacio; Anderson, Brian J.

Article ISI
PEDIATRIC ANESTHESIA  (2024)

The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients

Morales, Sebastian; Wendel-Garcia, Pedro D.; Ibarra-Estrada, Miguel; Jung, Christian; Castro, Ricardo; Retamal, Jaime; Cortinez, Luis I.; Severino, Nicolas; Kiavialaitis, Greta Emilia; Ospina-Tascon, Gustavo; et al.

Article ISI SCOPUS
Critical Care  (2024)

Intraoperative electroencephalographic marker of preoperative frailty: A prospective cohort study

Benavides, Javiera; Morales, Maria I.; Caldron, Natalia

Article ISI SCOPUS
Journal of Clinical Anesthesia  (2023)

Pharmacokinetic-pharmacodynamic modeling before clinical study



Article ISI SCOPUS
Paediatric Anaesthesia  (2023)

Levobupivacaine plasma concentrations following repeat caudal anesthetics

Frawley, Geoff; Ignacio Cortinez, Luis; Anderson, Brian J.; Bjorksten, Andrew; King, Sebastian

Article ISI
PEDIATRIC ANESTHESIA  (2022)

The effect of age on electroencephalogram measures of anesthesia hypnosis: A comparison of BIS, Alpha Power, Lempel-Ziv complexity and permutation entropy during propofol induction

Biggs, Daniela; Pedemonte, Juan C. C.; Cortinez, Luis I. I.

Article ISI
Frontiers in Aging Neuroscience  (2022)

Brain activity complexity has a nonlinear relation to the level of propofol sedation



Article ISI
BRITISH JOURNAL OF ANAESTHESIA  (2021)

Estimation of the Loading Dose for Target-Controlled Infusion of Dexmedetomidine. Reply to Eleveld et al. Comment on "Morse et al. A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults. J. Clin. Med. 2020, 9, 3480"

Morse, James D.; Cortinez, L. Ignacio; Anderson, Brian J.

Article ISI
JOURNAL OF CLINICAL MEDICINE  (2021)

Harnessing remifentanil adverse effects

Cortinez, Luis Ignacio; Anderson, Brian J.

Article ISI
PEDIATRIC ANESTHESIA  (2021)

Information gleaned from naloxone non-compartment pharmacokinetic estimates

Cortinez, Luis I.; Anderson, Brian J.

Article ISI
PEDIATRIC ANESTHESIA  (2021)

Prediction of levobupivacaine concentrations in neonates and infants following neuraxial rescue blocks

Frawley, Geoff; Ignacio Cortinez, Luis; Anderson, Brian J.

Article ISI
PEDIATRIC ANESTHESIA  (2021)

A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine

Chamadia, Shubham; Pedemonte, Juan C.; Hobbs, Lauren E.; Deng, Hao; Nguyen, Sarah; Cortinez, Luis I.; Akeju, Oluwaseun

Article ISI
ANESTHESIOLOGY  (2020)

A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults

Morse, James D.; Cortinez, L. Ignacio; Anderson, Brian J.

Article ISI
JOURNAL OF CLINICAL MEDICINE  (2020)

Differential frontal alpha oscillations and mechanisms underlying loss of consciousness: a comparison between slow and fast propofol infusion rates

Egana, J. I.; Sanchez Corzo, A.; Sitaram, R

Article ISI SCOPUS
ANAESTHESIA  (2020)

Impact of the COVID-19 pandemic on anaesthesia trainees and their training

Sneyd, John R.; Mathoulin, Sophie E.; O'Sullivan, Ellen P.; So, Vincent C.; Roberts, Fiona R.; Paul, Aaron A.; Cortinez, Luis I.; Ampofo, Russell S.; Miller, Caitlynn J.; Balkisson, Maxine A.

Article ISI
BRITISH JOURNAL OF ANAESTHESIA  (2020)

Living Donor Liver Transplantation for Imatinib-Resistant Gastrointestinal Stromal Tumor Liver Metastases: A New Therapeutic Option in Transplant Oncology

Garrido, Marcelo; Dib, Martin; Torres, Javiera; Guerra, Juan F.; Fernandes, Eduardo; Martinez, Jorge A.

Article ISI
LIVER TRANSPLANTATION  (2020)

Nebulization of Vancomycin Provides Higher Lung Tissue Concentrations than Intravenous Administration in Ventilated Female Piglets with Healthy Lungs

de Mello Morais, Cristiane Luchesi; Leandro Nascimento, Jorge Willian; Ribeiro, Aline Correa; Ignacio Cortinez, Luis; Carvalho Carmona, Maria Jose; Ramos Maia, Debora Rothstein; Monsel, Antoine; Costa Auler, Jose Otavio, Jr.; Rouby, Jean-Jacques; Otsuki, Denise Aya

Article ISI
ANESTHESIOLOGY  (2020)

Liver transplantation: development, learning curve and results after the first 300 cases

Pattillo, JC; Cortinez, L; Dib, M

Article ISI
REVISTA MEDICA DE CHILE  (2019)

Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients

Rolle, A; Anderson, BJ; Quezada, N; Solari, S; Allende, F; Contreras, V; Oliveros, AM; Ibacache, M

Article ISI SCOPUS
BRITISH JOURNAL OF ANAESTHESIA  (2018)

Effect-Site Target-Controlled Infusion in the Obese: Model Derivation and Performance Assessment

Cottin, P; Anderson, BJ

Article ISI
ANESTHESIA AND ANALGESIA  (2018)

Modeling the pharmacokinetics and pharmacodynamics of sevoflurane using compartment models in children and adults

Anderson, BJ

Article ISI SCOPUS
PEDIATRIC ANESTHESIA  (2018)

Pharmacokinetics of levobupivacaine with epinephrine in transversus abdominis plane block for postoperative analgesia after Caesarean section

Lacassie, HJ; Corvetto, MA

Article ISI SCOPUS
BRITISH JOURNAL OF ANAESTHESIA  (2018)

Propofol pharmacokinetic and pharmacodynamic profile and its electroencephalographic interaction with remifentanil in children.

Fuentes, Ricardo; Cortinez, L. Ignacio; Contreras, Victor; Ibacache, Mauricio; Anderson, Brian J.

Article ISI SCOPUS
Paediatric Anaesthesia  (2018)

Rocuronium pharmacokinetics and pharmacodynamics in the adductor pollicis and masseter muscles

Vega, EA; Solari, S; Cortínez, LI

Article ISI SCOPUS
ACTA ANAESTHESIOLOGICA SCANDINAVICA  (2016)

Dexmedetomidine pharmacokinetics in the obese

Cortinez, L; Anderson, BJ; Holford, NHG; Puga, V; De La Fuente N.; Auad, H; Solari, S; Allende, FA; Ibacache, M

Article ISI SCOPUS
European Journal of Clinical Pharmacology  (2015)

Evaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index(dagger)

Altermatt, FR; Solari, S; Guerra, I; Munoz H.R.; Cortínez, LI

Article ISI SCOPUS
British Journal of Anaesthesia  (2012)

The Effective Effect-Site Propofol Concentration for Induction and Intubation with Two Pharmacokinetic Models in Morbidly Obese Patients Using Total Body Weight

Elgueta, MF; Donoso M.T.; Cortínez, LI; Munoz H.R.

Article ISI SCOPUS
Anesthesia and Analgesia  (2012)

Transesophageal echocardiography to monitor fluid administration during the perioperative period

Concha, M; Mertz, V; Cortinez, L; Zúñiga, A; Pinedo, G

Article ISI
REVISTA MEDICA DE CHILE  (2011)

Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model

Anderson, BJ; Penna, A; Olivares, L; Holford, NHG; Struys, MMRF; Sepúlveda, P

Article ISI SCOPUS
British Journal of Anaesthesia  (2010)

Dexmedetomidine pharmacodynamics: Part I - Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers

Young C.C.; Somma, J; Cortínez, LI; Sum-Ping S.T.

Article SCOPUS
ANESTHESIOLOGY  (2004)

Dexmedetomidine pharmacodynamics: Part II - Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers

Cortínez, LI; Young, C; MacLeod D.; Somma, J; Sum-Ping S.T.

Article SCOPUS
ANESTHESIOLOGY  (2004)

Note (1)

Sedation in obese patients [Sedación en obesos]

Cortínez, LI

Note SCOPUS
Revista Mexicana de Anestesiologia  (2014)

Proyecto (1)

Analyzing the neuroprotective effect of dexmedetomidine in terms of preserving brain functional connectivity in elderly patients after major surgery

Cortinez, Luis I.; Contreras, Victor; Carrasco, Marcela P.; Ibacache, Mauricio

Proyecto
 (2021)

Review (8)

Modeling and Simulations in Latin-American Generic Markets: Perspectives from Chilean Local Industry, Regulatory Agency, and Academia

García, Mauricio A.; Paulos, Claudio; Vinales, Manuel Ibarra; Michelet, Robin; Cabrera-Perez, Miguel Angel; Aceituno, Alexis; Bone, Michelle; Ibacache, Mauricio; Cortinez, Luis Ignacio; Guzmán, Marcelo

Review ISI SCOPUS
Molecular Pharmaceutics  (2024)

Pediatric anesthesiology in Brazil, Chile, and Mexico

Quintao, Vinicius Caldeira; Concha, Mario; Arguello, Lina Andrea Sarmiento; Cavallieri, Silvana; Cortinez, Luis I.; de Sousa, Gabriel Soares; Clemente, Marcella Marino Malavazzi; Carlos, Ricardo Vieira; Rodriguez, Juan Manuel; Gutierrez, Karla; et al.

Review ISI SCOPUS
Paediatric Anaesthesia  (2024)

Considerations for Intravenous Anesthesia Dose in Obese Children: Understanding PKPD

Morse, James Denzil; Cortinez, Luis Ignacio; Anderson, Brian Joseph

Review ISI SCOPUS
Journal of Clinical Medicine  (2023)

Perioperative Acetaminophen Dosing in Obese Children

Anderson, Brian Joseph; Cortinez, Luis Ignacio

Review ISI SCOPUS
Children  (2023)

Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice

Morse, James D.; Ignacio Cortinez, Luis; Anderson, Brian J.

Review ISI
JOURNAL OF CLINICAL MEDICINE  (2022)

Propofol context-sensitive decrement times in children

Morse, James D.; Cortinez, Luis Ignacio; Meneely, Stephen; Anderson, Brian J.

Review ISI
PEDIATRIC ANESTHESIA  (2022)

Pharmacokinetic concepts for dexmedetomidine target-controlled infusion pumps in children

Morse, James D.; Cortinez, Luis Ignacio; Anderson, Brian J.

Review ISI
PEDIATRIC ANESTHESIA  (2021)

Pharmacokinetic and pharmacodynamic considerations of general anesthesia in pediatric subjects

Morse J.D.

Review ISI SCOPUS
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY  (2020)

1
Marcela Carrasco

Profesor Asociado

Medicina

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
José Egaña

Profesor Asistente

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

46
Luis Cortínez

Profesor Titular

DIVISIÓN DE ANESTESIOLOGÍA

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Sandra Solari

Profesor Clinico Asociado

Laboratorios Clinicos

Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fernando Altermatt

Profesor Asociado

Anestesiología

DIVISIÓN DE ANESTESIOLOGÍA, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
María Elgueta

Médico Anestesiólogo

HOSPITAL CLINICO PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Nicolás Quezada

Adjunct Researcher

Digestive Surgery

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jaime Retamal

Profesor Asociado

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

1
Marcia Corvetto

Profesor Asociado

Anestesiología

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Victor Contreras

Director y Gestor de Proyectos

Anestesiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Eduardo Kattan

Profesor Asistente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Martin Inzunza

Fellow simulación

Cirugía

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ranganatha Sitaram

Associate Professor and Director of Laboratory of Brain-Machine Interfaces and Neuromodulation

Institute for Biological and Medical Engineering, and Department of Psychiatry

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Juan Pedemonte

Profesor Asistente

Anestesiologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mauricio García

Assistant Professor

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Gonzalo Boncompte

Researcher

Anestesiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Riveros

Residente

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Martin Dib

Jefe Programa de Trasplantes UC

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandro Delfino

Profesor Asociado

Escuela de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Pablo Sepúveda

Staff

Pabellón

Hospital San José de Osorno

Osorno, Chile

1
Vicente Medel

Lead Investigator

Latin American Brain Health Institute (BrainLat)

Universidad Adolfo Ibánez

Santiago, Chile

1
Miguel Cabrera

Académico

Departamento de Ciencias Farmacéuticas

Universidad Católica del Norte

Antofagasta, Chile

1
Daniela Biggs

Residente

Anestesiología

Pontificia Universidad Católica de Chile

Santiago, Chile