Man

Luis Ignacio Cortínez Fernández

DIVISIÓN DE ANESTESIOLOGÍA, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Anestesia Regional; Farmacología Clínica; Dolor; HIPERALGESIA POSTOPERATORIA; FARMACOLOGIA CLINICA; Dolor Agudo y cronico; Hiperalgesia postoperatoria; autoinmunidad; Farmacología clínica; Monitorización de profundidad anestésica

Educación

  •  Medico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1991
  •  Anestesiologo, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
  •  Anestesiologia, DUKE UNIVERSITY. Estados Unidos, 2003

 

Article (48)

Differential frontal alpha oscillations and mechanisms underlying loss of consciousness: a comparison between slow and fast propofol infusion rates
Nebulization of Vancomycin Provides Higher Lung Tissue Concentrations than Intravenous Administration in Ventilated Female Piglets with Healthy Lungs
Liver transplantation: development, learning curve and results after the first 300 cases
Advances in pharmacokinetic modeling=> target controlled infusions in the obese.
Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients
Effect-Site Target-Controlled Infusion in the Obese: Model Derivation and Performance Assessment
Evidence of hysteresis in propofol pharmacodynamics
Modeling the pharmacokinetics and pharmacodynamics of sevoflurane using compartment models in children and adults
Pharmacokinetics of levobupivacaine with epinephrine in transversus abdominis plane block for postoperative analgesia after Caesarean section
Propofol pharmacokinetic and pharmacodynamic profile and its electroencephalographic interaction with remifentanil in children.
Comparison of the Cortínez and the Schnider models with a targeted effect-site TCI of 3 mcg/ml in biophase in healthy volunteers.
Comparison of the Cortínez and the Schnider models with a targeted effect-site TCI of 3 mcg/ml in biophase in healthy volunteers [Comparación del modelo de Cortínez y de Schnider en perfusión de propofol controlada por objetivo de 3 mcg/ml, a biofase, en
Levobupivacaine absorption pharmacokinetics with and without epinephrine during TAP block=> analysis of doses based on the associated risk of local anaesthetic toxicity.
Rocuronium pharmacokinetics and pharmacodynamics in the adductor pollicis and masseter muscles
Dexmedetomidine pharmacokinetics in the obese
Dexmedetomidine-ketamine combination and caudal block for superficial lower abdominal and genital surgery in children.
Effect of acute arterial hypertension on morphine requirements and postsurgical pain
In response.
A general purpose pharmacokinetic model for propofol.
Performance of Propofol Target-Controlled Infusion Models in the Obese=> Pharmacokinetic and Pharmacodynamic Analysis
What is the ke0 and what does it tell me about propofol?
Absorption characteristics of epidural levobupivacaine with adrenaline and clonidine in children
Effect of intravenous fluid therapy on postoperative vomiting in children undergoing tonsillectomy.
The effective effect-site propofol concentration for induction in morbidly obese patients using total body weight with a new pharmacokinetic model.
Evaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index(dagger)
The Effective Effect-Site Propofol Concentration for Induction and Intubation with Two Pharmacokinetic Models in Morbidly Obese Patients Using Total Body Weight
Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans.
Obesity does not influence the onset and offset of sevoflurane effect as measured by the hysteresis between sevoflurane concentration and bispectral index.
Performance evaluation of paediatric propofol pharmacokinetic models in healthy young children
Transesophageal echocardiography to monitor fluid administration during the perioperative period
Predictive ability of propofol effect-site concentrations during fast and slow infusion rates
Predictive ability of propofol effect-site concentrations during fast and slow infusion rates.
Propofol consumption and recovery times after bispectral index or cerebral state index guidance of anaesthesia.
Prospective evaluation of the time to peak effect of propofol to target the effect site in children
Pulse Contour Analysis and Transesophageal Echocardiography=> A Comparison of Measurements of Cardiac Output During Laparoscopic Colon Surgery
The volume of lactated Ringer's solution required to maintain preload and cardiac index during open and laparoscopic surgery.
Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years
Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years.
The Dynamic Relationship Between End-Tidal Sevoflurane Concentrations, Bispectral Index, and Cerebral State Index in Children
The influence of age on the dynamic relationship between end-tidal sevoflurane concentrations and bispectral index.
Remifentanil requirements during propofol administration to block the somatic response to skin incision in children and adults
Effect site concentrations of propofol producing hypnosis in children and adults=> comparison using the bispectral index
Changes in hematocrit based on incremental blood sampling=> mathematical models perform poorly
Target-controlled infusion of remifentanil or fentanyl during extra-corporeal shock-wave lithotripsy
Dexmedetomidine pharmacodynamics: Part I - Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers
Dexmedetomidine pharmacodynamics: Part II - Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers
Remifentanil requirements during sevoflurane administration to block somatic and cardiovascular responses to skin incision in children and adults
No clinical evidence of acute opioid tolerance after remifentanil-based anaesthesia

Note (1)

Sedation in obese patients [Sedación en obesos]

Proyecto (2)

THE EFFECT OF OBESITY IN DEXMEDETOMIDINE METABOLIC CLEARANCE
DEVELOPMENT OF INTEGRATED PHARMACOKINETIC (PK) PHARMACODYNAMIC (PD) MODELS TO ADMINISTER INTRAVENOUS ANESTHETICS IN OBESE PATIENTS
16
Luis Cortínez

DIVISIÓN DE ANESTESIOLOGÍA, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

3
Victor Contreras

Director y Gestor de Proyectos

Anestesiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Martin Dib

Jefe Programa de Trasplantes UC

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandro Delfino

Profesor Asociado

Escuela de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marcia Corvetto

Profesor Asociado

Anestesiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
José Egaña

Profesor Asistente

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

1
Ranganatha Sitaram

Associate Professor and Director of Laboratory of Brain-Machine Interfaces and Neuromodulation

Institute for Biological and Medical Engineering, and Department of Psychiatry

Pontificia Universidad Católica de Chile

Santiago, Chile

1
María Elgueta

Médico Anestesiólogo

HOSPITAL CLINICO PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Fernando Altermatt

Profesor Asociado

Anestesiología

DIVISIÓN DE ANESTESIOLOGÍA, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Pablo Sepúveda

Staff

Pabellón

Hospital San José de Osorno

Osorno, Chile