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Hugo Cesar Olguin Marin

Profesor Asociado

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Muscle regeneration, satellite cells, adult stem cells, the ubiquitin-proteasome system, skeletal muscle growth, myogenesis

Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002

Profesor Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Chile

2009 - A la fecha

Profesor Asociado Full Time

Pontificia Universidad Católica de Chile

Chile

2017 - A la fecha

DIRECCIÓN DE TESIS DE MAGISTER, PREGRADO O DE TÍTULOS PROFESIONALES (terminadas)
Sebastían Perez González
Efecto de Angiotensina 1-7 sobre la capacidad miogénica en Células Satélites adultas. Tutor, Dr. Claudio Cabello, UNAB; Co-tutor, Hugo Olguín (FCB-UC)
Ingeniería en Biotecnología Molecular, Universidad de Chile
Enero 19, 2017

Phamela Abarzúa
Evaluation of the effect of fiber morphology and the presence of decorin in the cellular response of myoblasts on polymer fiber scaffolds obtained by electrospinning. Tutor, Dra. Loreto Valenzuela (ING-UC); Co-tutor, Hugo Olguin (FCB-UC)
Magister Ingeniería, Pontificia Universidad Católica de Chile
Septiembre 20, 2016

Cristina Padilla
Biocompatibility studies of chitosan/poly(OTE) blends as a scaffold to maintain myoblast regeneration potential in vitro. Tutor, Dra. Loreto Valenzuela (ING-UC); Co-tutor, Hugo Olguin (FCB-UC)
Magister Ingeniería, Pontificia Universidad Católica de Chile
Junio 9, 2016

Natalia González
Fosforilación de Pax7 en progenitores musculares adultos. Tutor, Hugo Olguín.
Bioquímico, Pontificia Universidad Católica de Chile
Mayo 8, 2014

DIRECCIÓN DE TESIS DE DOCTORADO (terminadas)
Fabián Montecino
Rol de c-Abl en miogénesis y regeneración muscular. Tutor, Hugo Olguín; Cotutor, Alejandra Alvarez
Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Junio 12, 2020

Felipe Cabezas
Estudio del requerimiento de Nedd4-1 en la miogénesis de los progenitores musculares y la regeneración del músculo esquelético. Tutor, Hugo Olguín
Universidad y Grado Académico Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Fecha defensa/ obtención Diciembre 10, 2019

Eduardo de la Vega
Usp7 desubiquitinase regulates early differentiation of adult muscle progenitors. Tutor, Hugo Olguín.
Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Marzo 19, 2019

Francisco Bustos
Regulación de la estabilidad del factor de transcripción Pax7 mediada por Nedd4 y su papel en la función de progenitores musculares adultos. Tutor, Hugo Olguín.
Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile
Enero 21, 2015


USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors de la Vega E.; GonzÃ¡lez N.; Cabezas F.; Montecino F.; Blanco N.; OlguÃn H. Article ISI SCOPUS FEBS Journal (2020)
Chitosan/poly-octanoic acid 2-thiophen-3-yl-ethyl ester blends as a scaffold to maintain myoblasts regeneration potential in vitro Padilla, Cristina; Ramos, Andrea; González, Natalia; Isaacs, Mauricio; Zacconi, Flavia; Olguín, Hugo C.; Valenzuela, Loreto M. Article ISI SCOPUS JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)
Improving myoblast differentiation on electrospun poly(Îµ-caprolactone) scaffolds. Abarzúa-Illanes, Phammela N; Padilla, Cristina; Ramos, Andrea; Isaacs, Mauricio; Ramos-Grez, Jorge; Olguín, Hugo C; Valenzuela, Loreto M Article Journal of biomedical materials research. Part A (2017)
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas Morales M.G.; Abrigo, J; Acuna M.J.; Santos R.A.; Bader M.; Brandan, E.; Simon F.; Olguin, H; cabrera, D; Cabello-Verrugio C. Article ISI SCOPUS DMM Disease Models and Mechanisms (2016)
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. Morales, María Gabriela; Abrigo, Johanna; Acuña, María José; Santos, Robson A; Bader, Michael; Brandan, Enrique; Simon, Felipe; Olguin, Hugo; Cabrera, Daniel; Cabello-Verrugio, Claudio Article Disease models & mechanisms (2016)
Ck2-Dependent Phosphorylation Is Required to Maintain Pax7 Protein Levels in Proliferating Muscle Progenitors. González, Natalia; Moresco, James J; Cabezas, Felipe; de la Vega, Eduardo; Bustos, Francisco; Yates, John R; Olguín, Hugo C Article PloS one (2016)
Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Contreras, Osvaldo; Rebolledo, Daniela L; Oyarzún, Juan Esteban; Olguín, Hugo C; Brandan, Enrique Article Cell and tissue research (2016)
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism Morales, MG; Olguin, H; Di CApua G; Brandan, E.; Simon F.; Cabello-Verrugio, C Article ISI SCOPUS Clinical Science (2015)
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism. Morales, María Gabriela; Olguín, Hugo; Di Capua, Gabriella; Brandan, Enrique; Simon, Felipe; Cabello-Verrugio, Claudio Article Clinical science (London, England : 1979) (2015)
NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors. Bustos, Francisco; de la Vega, Eduardo; Cabezas, Felipe; Thompson, James; Cornelison, D D W; Olwin, Bradley B; Yates, John R; Olguín, Hugo C Article Stem cells (Dayton, Ohio) (2015)
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling Acuña MJ; Pessina P; Olguin, H; cabrera, D; Vio, CP; Bader M.; Munoz-Canoves, P; Santos RA; Cabello-Verrugio, C; Brandan, E. Article ISI HUMAN MOLECULAR GENETICS (2014)
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling Acuna, MJ; Pessina, P; Olguin, H; Cabrera, D; Vio, CP; Bader, M; Munoz-Canoves, P; Santos, RA; Cabello-Verrugio, C; Brandan, E Article HUMAN MOLECULAR GENETICS (2014)
Marking the tempo for myogenesis: Pax7 and the regulation of muscle stem cell fate decisions. Olguín, HC; Pisconti, A Article Journal of Cellular and Molecular Medicine (2012)
PAX7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD. Olguín, HC; Patzlaf, NE; Olwin, B Article JOURNAL OF CELLULAR BIOCHEMISTRY (2011)
Regulation of Pax7 protein levels by caspase-3 and proteasome activity in differentiating myoblasts. Olguín, HC Article BIOLOGICAL RESEARCH (2011)
Syndecan-3 and Notch cooperate in regulating adult myogenesis. Pisconti, A.; Cornelison, DD; Olguín, HC; Antwine, TL; Olwin, B Article JOURNAL OF CELL BIOLOGY (2010)
Reciprocal inhibition between Pax7 and MRFs modulates myogenic cell fate determination Olguín, H.C; Yang, Z; Tapscott, S.J; Olwin, B.B Article JOURNAL OF CELL BIOLOGY (2007)
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation Casar, JC; Cabello-Verrugio, C; Olguin, H; Aldunate, R; Inestrosa, NC; Brandan, E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2004)
Increased Expression of Heparan Sulfate Proteoglycans in Skeletal Muscle Regeneration: Relevance of Syndecan-3 Casar, JC; Cabello-Verrugio, C; Olguín, H; Aldunate, R; Inestrosa, NC; Brandan, E Article JOURNAL OF CELL SCIENCE (2004)
Pax-7 up-regulation inhibits myogenesis and cell cycle progression to promote satellite cell quiescence Olguín, H.C; Olwin, B.B Article DEVELOPMENTAL BIOLOGY (2004)
Inhibition of myoblast migration, via decorin expression, is critical for normal skeletal muscle differentiation Olguín, H; Santander, C; Brandan E; Brandena E; Brandan, E Article DEVELOPMENTAL BIOLOGY (2003)
Expression and localization of proteoglycans during limb myogenic activation Olguín, H; Brandan, E Article DEVELOPMENTAL DYNAMICS (2001)
Expression and localization of proteoglycans during limb myogenic activation Olguin, H; Brandan, E. Article ISI DEVELOPMENTAL DYNAMICS (2001)
Chitosan/ poly-octanoic acid 2-thiophen-3-yl-ethyl ester blends as a scaffold to maintain myoblasts regeneration potential in vitro Padilla, Cristina; Ramos, Andrea; González, Natalia; Isaacs, Mauricio; Zacconi, Flaviañ; Olguín, Hugo C.; Valenzuela, Loreto. Article JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (0)


Decorin is required to maintain committed skeletal muscle cell population grouped allowing normal differentiation in vivo Olguin, H; Brandan, E. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2002)


INTERPLAY BETWEEN UBIQUITIN LIGASE NEDD4 AND UBIQUITIN PROTEASE USP7 REGULATE MUSCLE STEM CELL FUNCTION. FONDECYT (1170975) Proyecto 2017-2020 Inv. Responsable
Electrotherapeutics for Musculoskeletal Tissue Repair & Regeneration UC Chile and Columbia SEAS Collaborative Engineering Research Seed Grant Program (NA) Proyecto 2016-2017 Inv. Principal
Comportamiento mecanobiológico de células bajo la rotación controlada de nanocilindros magnéticos en su interior. Proyectos de Investigación Interdisciplinarios, CIEN-UC CIEN-UC (NA) Proyecto 2015-2016 Coinvestigador(a)
PARTICIPATION OF MESENCHYMAL PROGENITORS IN THE INITIATION OF SKELETAL MUSCLE FIBROSIS=> EFFECT OF TGFBETA/CTGF/PDGF AND CO-FACTORS ON FIBROBLASTSâ€™ ABILITY TO MODULATE MYOGENESIS FONDECYT (1150106) Proyecto 2015-2019 Coinvestigador(a)
Anti-atrophic role of Angiotensin 1-7 on skeletal muscle AFM-Telethon (Francia) (AFM 16670) Proyecto 2013-2014 Coinvestigador(a)
Post-translational control of transcription factor Pax7 and the gulation of muscle progenitor cell fate FONDECYT (1130631) Proyecto 2013-2016 Inv. Responsable
Development of polymeric scaffold for muscle tissue engineering and repair. Vicerectoria de Investigación UC (Investigación Interdisciplinaria Nº43/2011) Proyecto 2011-2013 Inv. Responsable
Post-translational regulation of Pax7 function in myogenic progenitors Vicerectoria de Investigación UC (Proyecto Límite, Nº17/2010) Proyecto 2010-2011 Inv. Principal
Regulation of Pax7 function through PKC and CaMKII dependent signaling Vicerectoria de Investigación UC (Proyecto de Inicio; Nº20/2009) Proyecto 2009-2010 Inv. Principal
Pax7 role in satellite cell self-renewal Muscular Dystrophy Association (Development Grant, MDA3928) Proyecto 2005-2007 Inv. Principal
Mechanisms that activate skeletal muscle differentiation=> proteoglycans and the regulation of embryonic myogenesis FONDEF (299086) Proyecto 1999-2001 Inv. Responsable