Man

CAROLINA VALCK CALDERÓN

ASSISTANT PROFESSOR

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


INMUNOGENETICA E INMUNOQUIMICA DEL SISTEMA DEL SISTEMA DEL COMPLEMENTO; CALRETICULINA, ANGIOGENESIS, TUMORES; Enfermedad de Chagas; Sistema del Complemento; Parasitologia; Cancer; Inmuno-parasitologia de la Enfermedad de Chagas; Angiogenesis Tumoral

Educación

  •  PhD BIOMEDICAL SCIENCES, UNIVERSIDAD DE CHILE. Chile, 2010
  •  BIOCHEMIST, UNIVERSIDAD DE CHILE. Chile, 2002

Experiencia Académica

  •   ASSISTANT PROFESSOR Full Time

    UNIVERSIDAD DE CHILE

    MEDICINE

    SANTIAGO, Chile

    2011 - A la fecha

Experiencia Profesional

  •   LABORATORY TECHNICIAN Full Time

    FONDECYT PROJECT 1010930

    SANTIAGO, Chile

    2001 - 2005

  •   CO-INVESTIGATOR Full Time

    FONDECYT PROJECT 1050133

    SANTIAGO, Chile

    2005 - 2009

  •   CO-INVESTIGATOR Other

    FONDECYT PROJECT 1095095

    SANTIAGO, Chile

    2009 - 2013

  •   CO-INVESTIGATOR Other

    PIA - ACT 112

    SANTIAGO, Chile

    2009 - 2012

  •   CO-INVESTIGATOR Other

    PIA - C11S02

    SANTIAGO, Chile

    2012 - 2014

  •   CO-INVESTIGATOR Other

    FONDECYT PROJECT 1130099

    SANTIAGO, Chile

    2013 - A la fecha

  •   PRINCIPAL INVESTIGATOR Full Time

    FONDECYT PROJECT 11110519

    SANTIAGO, Chile

    2011 - A la fecha

Formación de Capital Humano


NOT APPLICABLE


Premios y Distinciones

  •   AWARD FOR FIRST PLACE IN SCIENTIFIC WORK

    SOCIEDAD CHILENA DE PARASITOLOGIA

    Chile

    FIRST PLACE IN XIII JORNADAS ANUALES DE PARASITOLOGÍA


 

Article (24)

In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin Promotes Immunogenicity and Phagocytosis
Structural bases that underline Trypanosoma cruzi calreticulin proinfective, antiangiogenic and antitumor properties
The interactions of parasite calreticulin with initial complement components: Consequences in immunity and virulence
Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis.
Exogenous Calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their internalization into mammal host cells
Exogenous Calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their internalization into mammal host cells.
Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies.
Deficiency in Mannose-Binding Lectin-Associated Serine Protease-2 Does Not Increase Susceptibility to Trypanosoma cruzi Infection
Is it all That Bad When Living with an Intracellular Protozoan? The Role of Trypanosoma cruzi Calreticulin in Angiogenesis and Tumor Growth.
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin.
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with LFicolin.
Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages
The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta
Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity
Antiangiogenic and Antitumor Effects of Trypanosoma cruzi Calreticulin
Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens
Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin
Trypanosoma cruzi calreticulin: a possible role in Chagas' disease autoimmunity.
Trypanosoma cruzi calreticulin=> A possible role in Chagas' disease autoimmunity
An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis
F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement
The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi
PARASITE CALRETICULIN: POSSIBLE ROLES IN THE PARASITE/HOST INTERFACE

Abstract (6)

Exogenous calreticulin, incorporated onto non-infective Trypanosoma cruzi epimastigotes, promotes their internalization into mammal hosts cells
Trypanosoma cruzi calreticulin (TcCRT) modulates infection in human placental chorionic villi explants
C1 interaction with Trypanosoma cruzi calreticulin mediates ex vivo infection of human placenta
Trypanosoma cruzi calreticulin inhibits the classical pathway of complement activation in Gallus gallus
Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin
Trypanosoma cruzi calreticulin, a virulence factor that binds C1/C1q on the parasite surface

Proyecto (8)

TRYPANOSOMA CRUZI CALRETICULIN, BY VIRTUE OF ITS ANTI-ANGIOGENIC PROPERTIES, INHIBITS TUMOR GROWTH IN EXPERIMENTAL MODELS
Visión molecular sobre cómo los parásitos evaden la inmunidad del hospedero=> caracterización estructural y funcional de las interacciones entre colágenos defensivos solubles y Calreticulina de Trypanosoma cruzi
SOME MOLECULAR BASIS OF THE DIFFERENTIAL BEHAVIOR OF THE AVIAN AND THE HUMAN COMPLEMENT SYSTEMS, IN THE CONTEXT OF TRYPANOSOMA CRUZI AGGRESSION
"Trypanosoma cruzi Calreticulin=> Interplay with the Complement System and Angiogenesis"
Advanced Center for Training and Research in the Design of Pharmacological and Immunological Strategies for the Control of Parasitic and Neoplastic Aggressions
Trypanosoma cruzi Calreticulin=> Interplay with the Complement System and Angiogenesis
CALRETICULINA DE TRYPANOSOMA CRUZI EN LA RELACION HOSPEDERO / PARASITO=> ROLES EN EL SISTEMA DE COMPLEMENTO, AUTOINMUNIDAD Y ANGIOGENESIS
ROL DE CALRETICULINA DE TRYPANOSOMA CRUZI EN LA MODULACION DE INTERACCIONES HUESPED/PARASITO

Review (5)

Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis
Is it all that bad when living with an intracellular protozoan?The role of Trypanosoma cruzi calreticulin in angiogenesis and tumor growth
Roles of Trypanosoma cruzi calreticulin in parasite-host interactions and in tumor growth
Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay
Role of calreticulin from parasites in its interaction with vertebrate hosts
37
CAROLINA VALCK

ASSISTANT PROFESSOR

IMMUNOLOGY DISCIPLINARY PROGRAM

UNIVERSIDAD DE CHILE

Santiago, Chile

28
GALIA RAMIREZ

PROFESOR ASISTENTE

DEPARTAMENTO DE MEDICINA PREVENTIVA ANIMAL

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

16
LORENA AGUILAR

Assistant Professor

Animal Pathology

Faculty of Veterinary Medicine and Livestock Sciences, University of Chile

Santiago, Chile

14
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

9
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

8
Ismael Maldonado

Asistente de Investigación

Inmunología

Universidad de Chile

Santiago, Chile

7
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

4
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

2
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

2
pedro cattan

full professor

ciencias biologicas animales

UNIVERSIDAD DE CHILE; FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

santiago, Chile

1
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Lopez

Profesor Asociado

Facultad de Ciencias Veterinarias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Hector Hidalgo

profesor, invetigador, director del laboratorio

Patologia Animal

Universidad de Chile

Santiago, Chile

1
Jaime Peña

Coordinador de Prácticas y Titulación

Universidad Autónoma de Chile

Temuco, Chile

1
Alvaro Olivera

Principal Investigator and Assistant Professor

Chemical Engineering and Biotechnology

UNIVERSIDAD DE CHILE

Santiago, Chile