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Raul Rene Araya Secchi

Docente Investigador

Universidad San Sebastián

Santiago, Chile

Utilización de modelamiento y simulación computacional1) Estudios estructurales y biofísicos de proteínas piezoeléctricas para el desarrollo bio-sensores y bio-materiales y 2) Diseño racional de aptámeros para aplicaciones en nanobiosensores.

Doctor en Biotecnologia, UNIVERSIDAD ANDRES BELLO. Chile, 2013
Licenciado en Ingenieria en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2004
Ingeniero en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2008

Postdoctoral Fellow Full Time

OHIO STATE UNIVERSITY

College of Arts and Sciences

Columbus, Ohio, Estados Unidos

2013 - 2017
Postodoctoral Researcher Full Time

UNIVERSITY OF COPENHAGEN

Faculty of Science

Copenhagen, Dinamarca

2017 - 2020
Docente Investigador Full Time

UNIVERSIDAD SAN SEBASTIAN

Facultad de Ingeniería y Tecnología

Santiago, Chile

2021 - A la fecha

Pelotonia Postdoctoral Fellowship

Pelotonia

Estados Unidos, 2014

La Beca (Fellowship) postdoctoral otorgada por The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute (OSUCCC – James) otorga fondos para que investigadores postdoctorales realicen investigación de alto nivel en busca de curas para el cáncer. En mi caso, recibi finaciamiento para mi proyecto relacionado a investigaciones de biología estructural y biofísica en proteínas de la familia de las cadherinas (FATs and DCHs) relacionadas con metastasis.
Beca de Doctorado Nacional

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2009

Beca para estudios de doctorado en Chile, dirigido a estudiantes de excelencia, chilenos/as o extranjeros, con o sin permanencia definitiva en Chile, en todas las áreas del conocimiento, para iniciar o continuar en programas acreditados (Ley N° 20.129) e impartidos por universidades chilenas, por un plazo máximo de cuatro años.


Functional characterization of the ATPase-like activity displayed by a catalytic amyloid Castillo-Caceres, Claudio; Duran-Meza, Eva; Nova, Esteban; Araya-Secchi, Raul; Monasterio, Octavio; Diaz-Espinoza, Rodrigo Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception Choudhary, Deepanshu; Narui, Yoshie; Neel, Brandon L.; Wimalasena, Lahiru N.; Klanseck, Carissa F.; De-la-Torre, Pedro; Chen, Conghui; Araya-Secchi, Raul; Tamilselvan, Elakkiya; Sotomayor, Marcos Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity Hendus-Altenburger, Ruth; Vogensen, Jens; Pedersen, Emilie Skotte; Luchini, Alessandra; Araya-Secchi, Raul; Bendsoe, Anne H.; Prasad, Nanditha Shyam; Prestel, Andreas; Cardenas, Marite; Pedraz-Cuesta, Elena; Arleth, Lise; Pedersen, Stine F.; Kragelund, Birthe B. Article ISI COMMUNICATIONS BIOLOGY (2020)
Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters Park, Mi Seul; Araya-Secchi, Raul; Brackbill, James A.; Phan, Hong-Duc; Kehling, Audrey C.; Abd El-Wahab, Ekram W.; Dayeh, Daniel M.; Sotomayor, Marcos; Nakanishi, Kotaro Article ISI MOLECULAR CELL (2019)
A Mechanically Weak Extracellular Membran-Adjacent Domain Induces Dimerization of Protocadherin-15 De-la-Torre, Pedro; Choudhary, Deepanshu; Araya-Secchi, Raul; Narui, Yoshie; Sotomayor, Marcos Article ISI BIOPHYSICAL JOURNAL (2018)
Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance Jaiganesh, Avinash; Narui, Yoshie; Araya-Secchi, Raul; Sotomayor, Marcos Article ISI COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)
An elastic element in the protocadherin-15 tip link of the inner ear Araya-Secchi, Raul; Neel, Brandon L.; Sotomayor, Marcos Article ISI NATURE COMMUNICATIONS (2016)
Exploring the Membrane Potential of Simple Dual-Membrane Systems as Models for Gap-Junction Channels Escalona Y.; Garate J.A.; Araya-Secchi R; Huynh T.; Zhou R.; Pérez-Acle T. Article ISI SCOPUS Biophysical Journal (2016)
Characterization of a Novel Water Pocket Inside the Human Cx26 Hemichannel Structure Araya-Secchi R; Perez-Acle, T; Kang, SG; Huynh T.; Bernardin A; Escalona Y.; Garate, JA; Martínez AD; Garcia, IE; Sáez JC; Zhou R. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2014)
Dual Inhibitory Pathways of Metallofullerenol Gd@C 82 (OH) 22 on Matrix Metalloproteinase-2: Molecular insight into drug-like nanomedicine Kang S.-G.; Araya-Secchi R.; Wang D.; Wang, B; Huynh T.; Zhou R. Article ISI SCOPUS SCIENTIFIC REPORTS (2014)
Molecular Dynamics Simulations of Cx26-Wt and Deafness Related Mutants M34A, A40G and V37I Araya-Secchi, Raul; Lagos, Carlos F.; Abarca, Fernando; Martinez, Agustin D.; Perez-Acle, Tomas Article ISI BIOPHYSICAL JOURNAL (2012)
Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione Lagos, C. F.; Araya-Secchi R.; Thomas P.; Perez-Acle, T; Tapia, R.A.; Salas, C. O. Article ISI SCOPUS JOURNAL OF MOLECULAR MODELING (2012)
Molecular dynamics study of the archaeal aquaporin AqpM Araya-Secchi R.; Garate J.A.; Perez-Acle, T; Holmes, D.S. Article ISI SCOPUS BMC GENOMICS (2011)
An eleven amino acid residue deletion expands the substrate specificity of acetyl xylan esterase II (AXE II) from Penicillium purpurogenum Colombres M.; Garate, JA; Lagos, CF; Araya-Secchi R.; Norambuena P.; Quiroz, S.; Larrondo, L; Perez-Acle, T; Eyzaguirre, J Article ISI SCOPUS JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2008)
Computational modeling study of functional microdomains in cannabinoid receptor type 1 González A; Duran, LS; Araya-Secchi R.; Garate, JA; Pessoa-Mahana, CD; Lagos, CF; Perez-Acle, T Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)


Protein function in extremely acidic conditions: Molecular simulations of a predicted aquaporin and a potassium channel in Acidithiobacillus ferrooxidans Duarte F.; Holmes D.S.; Araya-Secchi R.; Perez-Acle T.; Gonzalez W.; Gonzalez-Nilo D. ConferencePaper ISI SCOPUS ADVANCED MATERIALS RESEARCH (2009)