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Marcos Rodrigo Mancilla Espinoza

Director Cientifico

ADL Diagnostic Chile Ltda

Puerto Montt, Chile

Patogenicidad bacteriana; Genómica; Microbiología

Profesor Ad Honorem Part Time

UNIVERSIDAD AUSTRAL DE CHILE

2013 - 2015
Investigador asociado Part Time

UNIVERSIDAD AUSTRAL DE CHILE

2012 - 2015
Profesor Asociado Part Time

UNIVERSIDAD DE NAVARRA

2009 - 2011

Técnico analista

Fundación Chile

Chile

1999 - 1999
Bioquímico

Aqua Health Chile S.A.

Chile

2000 - 2001
Asistente investigación

Universidad Austral de Chile

Chile

2001 - 2002
Analista laboratorio

Aquatic Health

Chile

2002 - 2002
Asistente investigación

Universidad Austral de Chile

Chile

2002 - 2003
Estudiante doctorado

Universidad Austral de Chile

Chile

2003 - 2008
Profesor Adjunto

Universidad Austral de Chile

Chile

2008 - 2009
Postdoc Full Time

Universidad de Navarra

Pamplona, España

2009 - 2012
Investigador Asociado Full Time

Universidad Austral de Chile

Valdivia, Chile

2012 - 2013
Director Cientifico Full Time

ADL Diagnostic Chile Ltda

Puerto Montt, Chile

2014 - A la fecha


In evolution's unending race: ancestral STING sensors in Salmo salar mediate intracellular bacterial detection and programmed cell death through evolutionarily conserved pathways Yanez, AJ; Beltran, JF; Barrientos, CA; Soto-Rauch, G; Aguilar, M; Isla, A; Flores-Martin, SN; Yañez, FT; Yuivar, Y; Ojeda, A; et al. Article ISI SCOPUS Frontiers in Immunology (2025)
Major antigenic differences in Aeromonas salmonicida isolates correlate with the emergence of a new strain causing furunculosis in Chilean salmon farms Mancilla, M; Ojeda, A; Yuivar, Y; Grandon, M.; Grothusen H.; Oyarzun, M; Bisquertt, A; Ugalde, JA; Fuentes, F; Ibarra, P; et al. Article ISI SCOPUS Frontiers in Cellular and Infection Microbiology (2025)
Modulation of immune response and tissue repair mechanisms in the gill filaments of Atlantic salmon (Salmo salar) affected by complex gill disease (CGD) in a marine open sea-cage environment Vidal, Mabel; Santillan-Araneda, Maria Jesus; Rivera, Alexis; Goldstein, Merari; Reyes-Cerpa, Sebastian; Mancilla, Marcos; Bustos, Patricio; Vallejos-Vidal, Eva; Reyes-Lopez, Felipe E. Article ISI SCOPUS Fish and Shellfish Immunology (2025)
Discovery and Characterization of the ddx41 Gene in Atlantic Salmon: Evolutionary Implications, Structural Functions, and Innate Immune Responses to Piscirickettsia salmonis and Renibacterium salmoninarum Infections Barrientos, Claudia A.; Aguilar, Marcelo; Ojeda, Adriana; Ibieta, Pablo; Mancilla, Marcos Article ISI SCOPUS International Journal of Molecular Sciences (2024)
Complete Lipopolysaccharide of Piscirickettsia salmonis Is Required for Full Virulence in the Intraperitoneally Challenged Atlantic Salmon, Salmo salar, Model Herrera Valeska; Olavarria, Nicole; Almarza, Oscar; Mancilla, Marcos Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)
Use of antimicrobials in Chilean Salmon farming: Facts, myths and perspectives Mancilla, Marcos; Miranda, Claudio D. Article ISI REVIEWS IN AQUACULTURE (2022)
Florfenicol and oxytetracycline susceptibility patterns in Chilean isolates of Tenacibaculum dicentrarchi: An emerging pathogen for farmed salmonids Mancilla, Marcos Article ISI JOURNAL OF FISH DISEASES (2021)
Proposed protocol for performing MIC testing to determine the antimicrobial susceptibility ofRenibacterium salmoninarumin Chilean salmon farms Mancilla, Marcos Article ISI JOURNAL OF FISH DISEASES (2020)
Commentary: A Novel and Validated Protocol for Performing MIC Tests to Determine the Susceptibility of Piscirickettsia salmonis Isolates to Florfenicol and Oxytetracycline Mancilla, Marcos Article ISI SCOPUS Frontiers in Microbiology (2018)
First complete genome sequence of piscine orthoreovirus variant 3 infecting coho salmon (Oncorhynchus kisutch) farmed in southern Chile Bohle H.; Bustamante, F; Montecinos K. Article WOS-ESCI SCOPUS Genome Announcements (2018)
Isolation, Functional Characterization and Transmissibility of p3PS10, a Multidrug Resistance Plasmid of the Fish Pathogen Piscirickettsia salmonis Grandon, Maritza; Villalobos-Gonzalez, Juan; Bohle, Harry; Mancilla, Marcos Article ISI SCOPUS Frontiers in Microbiology (2018)
The mutagenesis of a type IV secretion system locus of Piscirickettsia salmonis leads to the attenuation of the pathogen in Atlantic salmon, Salmo salar Mancilla, M; Grandon, M.; Navas, E. Article ISI SCOPUS JOURNAL OF FISH DISEASES (2018)
Comparative Pan-Genome Analysis of Piscirickettsia salmonis Reveals Genomic Divergences within Genogroups Nourdin-Galindo, Guillermo; Molina, Cristian F.; Espinoza-Rojas, Daniela A. Article ISI SCOPUS Frontiers in Cellular and Infection Microbiology (2017)
Prevalence, geographic distribution and phenotypic differences of Piscirickettsia salmonis EM-90-like isolates. Saavedra, J; Hernandez, N; Osses, A; Castillo, A; Cancino, A; Grothusen, H; Navas, E; Henriquez, P; Bohle, H; Bustamante, F; Bustos, P; Mancilla, M Article Journal of fish diseases (2017)
The Genome Sequence of an Oxytetracycline-Resistant Isolate of the Fish Pathogen Piscirickettsia salmonis Harbors a Multidrug Resistance Plasmid. Bohle, Harry; Henríquez, Patricio; Grothusen, Horst; Navas, Esteban; Bustamante, Fernando; Bustos, Patricio; Mancilla, Marcos Article Genome announcements (2017)
Comprehensive antibiotic susceptibility profiling of Chilean Piscirickettsia salmonis field isolates Patricio Henriquez; Melanie Kaiser; Harry Bohle; Patricio Bustos; Marcos Mancilla Article Journal of Fish Diseases (2016)
First Complete Genome Sequence of Tenacibaculum dicentrarchi, an Emerging Bacterial Pathogen of Salmonids Horst Grothusen; Alejandro Castillo; Patricio Henriquez; Esteban Navas; Harry Bohle; Carolina Araya; Fernando Bustamante; Patricio Bustos; Marcos Mancilla Article Genome Announcements (2016)
Smooth to rough dissociation in Brucella: the missing link to virulence Marcos Mancilla Article Frontiers in Cellular and Infection Microbiology (2016)
Polymorphism in gyrA is associated to quinolones resistance in Chilean Piscirickettsia salmonis field isolates Patricio Henriquez; Harry Bohle; Fernando Bustamante; Patricio Bustos; Marcos Mancilla Article Journal of Fish Diseases (2015)
Comparative Genome Analysis of Two Isolates of the Fish Pathogen Piscirickettsia salmonis from Different Hosts Reveals Major Differences in Virulence-Associated Secretion Systems Harry Bohle; Patricio Henriquez; Horst Grothusen; Esteban Navas; Alvaro Sandoval; Fernando Bustamante; Patricio Bustos; Marcos Mancilla Article Genome Announcements (2014)
Draft Genome Sequence of the Fish Pathogen Yersinia ruckeri Strain 37551, Serotype O1b, Isolated from Diseased, Vaccinated Atlantic Salmon (Salmo salar) in Chile Esteban Navas; Harry Bohle; Patricio Henriquez; Horst Grothusen; Fernando Bustamante; Patricio Bustos; Marcos Mancilla Article Genome Announcements (2014)
Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine Marcos Mancilla; Maria Jesus Grillo; Maria Jesus de Miguel; Igancio Lopez Goni; Beatriz San Roman; Ana Zabalza Barangua Article Veterinary Research (2013)
Site-specific DNA Recombinases and Genetic Stabilization of Vaccines Marcos Mancilla Article Enzime Engineering (2013)
The spontaneous excision of the O-polysaccharide wbkA glycosyltransferase gene is a cause of dissociation of smooth to rough Brucella colonies Marcos Mancilla; Clara Marín; José María Blasco; Ana María Zárraga; Ignacio López-Goñi; Ignacio Moriyón Article Journal of Bacteriology (2012)
Identification of new IS711 insertion sites in Brucella abortus field isolates Marcos Mancilla; Marcos Ulloa; Ignacio Lopez-Goni; Ignacio Moriyon Article BMC MICROBIOLOGY (2011)
Genomic island-2 is an unstable genetic element contributing to Brucella lipopolysaccharide spontaneous smooth-to-rough dissociation Marcos Mancilla; Ignacio López-Goñi; Ignacio Moriyón; Ana María Zárraga Article Journal of Bacteriology (2010)
Genotypes of Brucella abortus field isolates from different geographical regions of Chile Genotipos de aislados de campo de Brucella abortus de distintas regiones geográficas de Chile Marcos Mancilla; Minie Villarroel; Maria Esther Saldias; Jaime Soto Article Archivos de Medicina Veterinaria (2008)


Desarrollo de una vacuna viva avirulenta contra la enfermedad bacteriana del riñón (BKD) basada en mutantes nutricionales de Renibacterium salmoninarum CORFO INNOVA (18IDAE-90504) Proyecto 2018-2020 Director(a)
Desarrollo de un kit LPS-ELISA para el seguimiento de la respuesta inmune contra Piscirickettsia salmonis CORFO INNOVA (16ITE1-71014) Proyecto 2017-2018 Director(a)
Elaboración de una vacuna viva atenuada contra el SRS y diseño de una estrategia integral para su aplicación CORFO INNOVA (17PIDE-80700) Proyecto 2017-2020 Subdirector(a)
Obtención de cepas atenuadas de Piscirickettsia salmonis por métodos genéticos y selección de candidatos para vacunas vivas contra la Piscirickettsiosis CORFO INNOVA (15ITE1-45434) Proyecto 2016-2017 Director(a)
Desarrollo, validación y aplicación diagnóstica de un ensayo no fenotípico para predecir la resistencia a antimicrobianos de Piscirickettsia salmonis CORFO INNOVA (14IDL2-30005) Proyecto 2014-2016 Director(a)
Contribution of Horizontal Gene Transfer to the Pathogenicity of Brucella microorganisms FONDECYT (11130347) Proyecto 2013-2015 Inv. Principal
Optimización y validación de kit de PCR tiempo real para el diagnóstico de tuberculosis animal en sangre y leche CORFO INNOVA (CORFO INNOVA 12IDL2-12974) Proyecto 2012-2014 Investigador(a)
Recombinación sitio-específica catalizada por integrasas/recombinasas de islas genómicas como mecanismo de atenuación de la patogenicidad de Brucella abortus Proyecto DID-UACh (S-2009-33) Proyecto 2009-2011 Inv. Principal
Genomic and phenotypic analysis of the Brucella virulence and its application to the development of new vaccines and diagnostic tools Proyecto investigación UE (Universidad de Navarra) (AGL2008-04514-C03-01) Proyecto 2008-2011 Investigador(a)