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Pablo Andrés Castro Córdova

Investigador Postdoctoral

Universidad de Los Andes

Santiago, Chile

Estudio mejoramiento metábolico de células inmune.

Ingeniero en Biotecnología, Universidad Andrés Bello. Chile, 2016
Licenciatura en Biotecnología, Universidad Andrés Bello. Chile, 2014
Doctorado en Biotecnología, Universidad Andrés Bello. Chile, 2020
Biotecnología, Universidad Andrés Bello. Chile, 2016

Docente Part Time

Universidad Andrés Bello

Ciencias de la Vida

Santiago, Chile

2014 - 2015

Personal técnico y/o de apoyo - FONDEF CA13I10077 Full Time

Universidad Andrés Bello

Santiago, Chile

2015 - 2016
Tesista pregrado/magister - FONDECYT REGULAR 1151025 Full Time

Universidad Andrés Bello

Santiago, Chile

2014 - 2015
Investigador - FONDEF IDEA ID16|10038 Part Time

Universidad Andrés Bello

Santiago, Chile

2017 - 2018
Investigador Joven - NCN17_093 - Núcleo Milenio Biología de Microbiota Intestinal Full Time

Universidad Andrés Bello

Santiago, Chile

2021 - 2021
Director alterno - NCN17_093 -Núcleo Milenio Biología de Microbiota Intestinal Full Time

Universidad Andrés Bello

Santiago, Chile

2021 - 2022
Investigador Postdoctoral Full Time

Universidad de los Andes

Santiago, Chile

2022 - A la fecha

Mejor graduado

UNIVERSIDAD ANDRES BELLO

Chile, 2020

Premio al mejor graduado 2020 de Programas de Doctorado Universidad Andrés Bello. Vicerrectoría de Investigación y Doctorado
Excelencia Académica

UNIVERSIDAD ANDRES BELLO

Chile, 2017

Premio a la Excelencia Académica en el programa de Ingeniería en Biotecnología año 2017


Editorial: Mechanism of colonization and persistence of gut commensal microbiota and pathogens Castro-Cordova, Pablo; Pizarro-Guajardo, Marjorie; Romero-Rodriguez, Alba Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions Castro-Cordova, Pablo; Otto-Medina, Macarena; Montes-Bravo, Nicolas; Brito-Silva, Christian; Lacy, D. Borden; Paredes-Sabja, Daniel Article ISI INFECTION AND IMMUNITY (2023)
Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection Castro-Córdova, P; Mora-Uribe, P; Reyes-Ramírez, R; Cofré-Araneda, G; Orozco-Aguilar, J; Brito-Silva, C; Mendoza-León, M; Kuehne, S; Minton, N; Pizarro-Guajardo, M; Paredes-Sabja, Article NATURE COMMUNICATIONS (2021)
Using a ligate intestinal loop mouse model to investigate Clostridioides difficile adherence to the intestinal mucosa in aged mice Castro-Córdova, P; Mendoza-León, M; Paredes-Sabja, D Article PLoS One (2021)
Effect of antibiotic to induce Clostridioides difficile- susceptibility and infectious strain in a mouse model of Clostridioides difficile infection and recurrence Castro-Córdova, P; Díaz-Yáñez, F; Muñoz- Miralles, J; Gil, F; Paredes-Sabja, D Article ANAEROBE (2020)
Induction of a Specific Humoral Immune Response by Nasal Delivery of Bcla2ctd of Clostridioides difficile Maia, Ana R; Reyes-Ramírez, R; Pizarro- Guajardo, M; Saggese, A; Castro-Córdova, P; Isticato, R; Ricca, E; Paredes-Sabja, D; Baccigalupi, L Article (2020)
Clostridium difficile exosporium cysteine-rich proteins are essential for the morphogenesis of the exosporium layer, spore resistance, and affect C. difficile pathogenesis Paulina Calderón-Romero, Pablo Castro-Córdova; Rodrigo Reyes-Ramirez, Mauro Milano-Céspedes; Enzo Guerrero-Araya, Marjorie Pizarro-Guajardo; Valeria Olguín-Araneda, Fernando Gil Article Plos Pathogen (2018)
Indomethacin increases severity of Clostridium difficile infection in mouse model Juan Muñoz-Miralles, Bruno C Trindade; Pablo Castro-Córdova, Ingrid L Bergin; Leslie A Kirk, Fernando Gil; David M Aronoff, Daniel Paredes-Sabja Article Future Microbiology (2018)
Characterization of the Adherence of Clostridium difficile Spores=> The Integrity of the Outermost Layer Affects Adherence Properties of Spores of the Epidemic Strain R20291 to Components of the Intestinal Mucosa Paola Mora-Uribe, Camila Miranda-Cárdenas; Pablo Castro-Córdova, Fernando Gil; Ivan Calderon, Juan Fuentes; Paula Rodas, Saeed Banawas; Mahfuzur Sarker, Daniel Paredes-Sabja Article Frontiers in Cellular and Infection Microbiology (2016)
Ultrastructural variability of the exosporium layer of Clostridium difficile spores Pizarro-Guajardo, M; Calderón-Romero P.; Castro-Córdova P; Mora-Uribe, P; Paredes-Sabja D. Article ISI SCOPUS Applied and Environmental Microbiology (2016)
Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes Ángela Plaza-Garrido, Camila Miranda-Cárdenas; Pablo Castro-Córdova, Valeria Olguín- Araneda; Glenda Cofré-Araneda, Cristian Hernández-Rocha; Robert Carman, Patricio Ibáñez; Warren N. Fawley, Mark H. Wilcox; Fernando Gil, Iván L. Calderón; Juan A. Fuentes, Ana María Guzmán-Durán; Manuel Alvarez-Lobos, Daniel Paredes-Sabja Article Anaerobe (2015)
Protein composition of the outermost exosporium-like layer of Clostridium difficile 630 spores Fernando Díaz-González, Mauro Milano; Valeria Olguin-Araneda, Jaime Pizarro-Cerda; Pablo Castro-Córdova, Shin-Chen Tzeng; Claudia S. Maier, Mahfuzur R. Sarker Article Journal of Proteomics (2015)


Method and pharmacological composition for the prevention of recurrent infections caused by Clostridium difficile Daniel Paredes-Sabja; Pablo Castro-Córdova Patent (2020)
Composition based on nystatin and vancomycin nanoparticles for the treatment of Clostridioides difficile infection and prevention of recurrence Daniel Paredes-Sabja; Pablo Castro-Córdova; Carolina Otero Patent

Pablo Castro

Investigador Postdoctoral

Universidad de Los Andes

Santiago, Chile

Paulina Calderón

Investigador Principal

Biome Therapeutics

Santiago, Chile

Marjorie Pizarro

Asistente de Investigacion

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Pablo Andrés Castro Córdova

Líneas de Investigación

Educación

Ingeniero en Biotecnología, Universidad Andrés Bello. Chile, 2016

Licenciatura en Biotecnología, Universidad Andrés Bello. Chile, 2014

Doctorado en Biotecnología, Universidad Andrés Bello. Chile, 2020

Biotecnología, Universidad Andrés Bello. Chile, 2016

Experiencia Académica

Docente Part Time

Experiencia Profesional

Personal técnico y/o de apoyo - FONDEF CA13I10077 Full Time

Tesista pregrado/magister - FONDECYT REGULAR 1151025 Full Time

Investigador - FONDEF IDEA ID16|10038 Part Time

Investigador Joven - NCN17_093 - Núcleo Milenio Biología de Microbiota Intestinal Full Time

Director alterno - NCN17_093 -Núcleo Milenio Biología de Microbiota Intestinal Full Time

Investigador Postdoctoral Full Time

Premios y Distinciones

Mejor graduado

Excelencia Académica

Article (12)

Editorial: Mechanism of colonization and persistence of gut commensal microbiota and pathogens

Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions

Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection

Using a ligate intestinal loop mouse model to investigate Clostridioides difficile adherence to the intestinal mucosa in aged mice

Effect of antibiotic to induce Clostridioides difficile- susceptibility and infectious strain in a mouse model of Clostridioides difficile infection and recurrence

Induction of a Specific Humoral Immune Response by Nasal Delivery of Bcla2ctd of Clostridioides difficile

Clostridium difficile exosporium cysteine-rich proteins are essential for the morphogenesis of the exosporium layer, spore resistance, and affect C. difficile pathogenesis

Indomethacin increases severity of Clostridium difficile infection in mouse model

Characterization of the Adherence of Clostridium difficile Spores=> The Integrity of the Outermost Layer Affects Adherence Properties of Spores of the Epidemic Strain R20291 to Components of the Intestinal Mucosa

Ultrastructural variability of the exosporium layer of Clostridium difficile spores

Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes

Protein composition of the outermost exosporium-like layer of Clostridium difficile 630 spores

Patent (2)

Method and pharmacological composition for the prevention of recurrent infections caused by Clostridium difficile

Composition based on nystatin and vancomycin nanoparticles for the treatment of Clostridioides difficile infection and prevention of recurrence

Pablo Castro

Paulina Calderón

Marjorie Pizarro