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Cristian Antonio Hernández Rocha

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Inflammatory Bowel Disease (Crohn's disease and ulcerative colitis) Microbiome Transcriptome Biomarkers Clostridium difficile Infections

Educación

  •  Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 2003
  •  Specialist in Internal Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
  •  Specialist in Gastroenterology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
  •  Advanced Inflammatory Bowel Disease Fellow, UNIVERSITY OF TORONTO. Chile

Experiencia Académica

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2014 - A la fecha

Experiencia Profesional

  •   Gastroenterologist Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2012 - A la fecha

  •   Advanced Inflammatory Bowel Disease Fellow Full Time

    Mount Sinai Hospital

    Toronto, Canada

    2018 - 2020

  •   Gastroenterology Fellow Full Time

    Pontificia Universidad Catolica of Chile

    Santiago, Chile

    2010 - 2012

  •   Internal Medicine Resident Full Time

    Pontificia Universidad Catolica of Chile

    Santiago, Chile

    2007 - 2010

  •   Community Physician, Law No 19,664. Rural Medical Doctor Full Time

    Ministry of Health, Chile

    Chile

    2003 - A la fecha

Formación de Capital Humano


- 2015-2016. Director of thesis to qualify for the professional title of Master of Biotechnology. Valentina Camilli Santiago. Universidad Andrés Bello. "Rol del receptor GPBAR-1 en la gravedad de la infección causada por Clostridium difficile". URL: http://repositorio.unab.cl/xmlui/handle/ria/4449
-2015-2016. Director of thesis to qualify for the professional title of Master of Biotechnology. Constanza Galilea Solar. Universidad Andrés Bello. "Evaluación de la correlación entre un polimorfismo en GPBAR1 y la gravedad clínica de la infección por clostridium difficile". URL: http://repositorio.unab.cl/xmlui/handle/ria/3992
- 2014-2015 Director of thesis to qualify for the professional title of gastroenterologist. Rodrigo Irarrazaval. Efecto de la vitamina D en un modelo murino de infección por Clostridium difficile
-2014-2015. Director of thesis to qualify for the professional title of Biotechnology. Edgar Montiel Muñoz. Universidad de Antofagasta. "Rol del receptor GPBAR-1 en la gravedad de la infección asociada a Clostridium difficile”.


Premios y Distinciones

  •   Young Investigator. Dr. Jaime Chesta Award

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2015

    Young Investigator with Projection in Basic and Clinical Research (Gastoenterology)

  •   Best Scientific Abstract from Gastroenterology Fellow. Dr. Iván Marinovic Award

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2015

    Best Scientific Abstract from Gastroenterology Fellow, XLII Annual meeting of Chilean Society of Gastroenterology. “Effect of vitamin D in a mouse model of Clostridium difficile infection”. Dr. Cristian Hernández was the supervisor of Dr. Rodrigo Irarrazaval

  •   Best Scientific Abstract XLI Annual meeting of Chilean Society of Gastroenterology. Award Saval Laboratory

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2014

    Best Scientific Abstract XLI Annual meeting of Chilean Society of Gastroenterology, “High frequency of PNPLA3 rs738409 (I148M) polymorphism in the Chilean population: association with non-alcoholic fatty liver disease risk and histological severity”

  •   CIHR/CAG Fellowship Award

    Canadian Institutes of Health Research/Canadian Association of Gastroenterology

    Chile, 2018

    CIHR (Institute of Nutrition, Metabolism and Diabetes (INMD)) ’s Health Research Training Strategy aims to equip research trainees so that they emerge from their training as scientific, professional, or organizational leaders within and beyond the health research enterprise


 

Article (23)

Combined histo-endoscopic remission but not endoscopic healing alone in ulcerative colitis is associated with a mucosal transcriptional profile resembling healthy mucosa
A role for CXCR3 ligands as biomarkers of post-operative Crohn's disease recurrence
Integrative analysis of colonic biopsies from inflammatory bowel disease patients identifies an interaction between microbial bile-acid inducible gene abundance and human Angiopoietin-like 4 gene expression
Colonoscopy-guided therapy for the prevention of post-operative recurrence of Crohn’s disease
JAK inhibitors: current position in treatment strategies for use in inflammatory bowel disease
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease
Experiencia de educación continua en línea en gastroenterología para médicos no especialistas
Claves prácticas para un trasplante de microbiota fecal por colonoscopía en infección por Clostridium difficile recurrente. Experiencia en un centro universitario
Management of severe ulcerative colitis An up-to-date
Serum cytokeratin-18 fragment levels as noninvasive marker of nonalcoholic steatohepatitis in the chilean population
Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients
Consenso chileno de prevención, diagnóstico y tratamiento de la diarrea asociada a Clostridium difficile
Predominance of Clostridium difficile ribotypes 012, 027 and 046 in a university hospital in Chile, 2012
Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes
Esporas de Clostridium difficile y su relevancia en la persistencia y transmisión de la infección
Rendimiento de índices pronósticos en infección asociada a Clostridium difficile grave: Análisis retrospectivo en un hospital universitario
Atypical presentation of pseudomembranous colitis localized in adenomatous polyps
Diagnostic accuracy of a multiplex real-time PCR to predict Clostridium difficile ribotype 027.
Prospective comparison of a commercial multiplex real-time polymerase chain reaction and an enzyme immunoassay with toxigenic culture in the diagnosis of Clostridium difficile-associated infections
Validation study of systems for noninvasive diagnosis of fibrosis in nonalcoholic fatty liver disease in Latin population
Clostridium difficile associated infections=> an updated view
Epidemic Clostridium difficile ribotype 027 in Chile
Diferenciación genética de Merluccius gayi gayi y Merluccius gayi peruanus (Pisces, Merlucciidae) y antecedentes paleogeográficos de su área de distribución

BookSection (1)

Accesos para nutrición enteral en UCI

ConferencePaper (3)

BACTERIAL BILE SALT HYDROLASE GENE ABUNDANCE IS ASSOCIATED WITH RORC GENE EXPRESSION IN INTESTINAL MUCOSA OF INFLAMMATORY DISEASE PATIENTS
ASSOCIATION ANALYSIS BETWEEN BILE ACID-­METABOLIZING MICROBIOTA ABUNDANCE AND ENDOSCOPIC INFLAMMATION IN INFLAMMATORY BOWEL DISEASE PATIENTS
Higher Abundance of Bile Acid-Metabolizing Microbiota is Associated with Type of Disease, Biopsy Location and Mucosal Inflammation in Inflammatory Bowel Disease Patients

ConferencePoster (3)

INCREASED ABUNDANCE OF BACTERIAL BILE SALT HYDROLASE GENES IS ASSOCIATED WITH MUCOSAL RORγT GENE EXPRESSION IN INFLAMMATORY BOWEL DISEASE PATIENTS.
LOSS OF SATB2 EXPRESSION IN COLORECTAL CANCER IS ASSOCIATED WITH DURATION OF INFLAMMATORY BOWEL DISEASE
RNA-SEQ GENE EXPRESSION PROFILE REVEALS THAT DUOXA2 AND CCL11 GENES ARE ASSOCIATED WITH PROGRESSIVE RISK OF COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE PATIENTS

Proyecto (4)

Interplay of diet, bile acid-metabolizing bacteria and bile acid receptors as a gut microbiota-driven immunomodulatory pathway in inflammatory bowel disease
Dysfunction Of Intestinal Epithelial Barrier Mediated By Bile Acid Receptor Gp-Bar1: A Modulator Of The Severity Of Clostridium Difficile Infection
Adherence of Clostridium difficile spores to the intestinal mucosa
Prospective comparison of a commercial multiplex real-time polymerase chain reaction and an enzyme immunoassay with toxigenic culture in the diagnosis of Clostridium difficile-associated infections
26
Cristian Hernández

Assistant Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Angela Plaza

Postodoctorado

Ingeniería Civile en Obras Civil

Universidad de Santiago de Chile

Estación Central, Chile

3
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Daniel Paredes

Associate Professor

Department of Biological Sciences

Universidad Andrés Bello

Santiago, Chile

2
Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Hugo Monrroy

Instructor Adjunto

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Perez

decano

Universidad San Sebastián

santiago, Chile

1
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Felipe Bellolio

Cirujano coloproctólogo, Profesor Asistente

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
IVAN CALDERON

Associate Professor / Academic Coordinator / Principal Investigator

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Juan Fuentes

Académico

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Fernando Gil

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Valeria Olguín

Lab Manager

Universidad del Desarrollo

Santiago, Chile

1
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ciro Oyarzún

Docente DN

Departamento de Oceanografía

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Ricardo Galleguillos

Profesor Asociado

Oceanografía

UNIVERSIDAD DE CONCEPCIÓN. FACULTAD DE CIENCIAS NATURALES Y OCEANOGRÁFICAS.DEPTO DE OCEANOGRAFÍA

Concepción, Chile