PDI - Resultado de Búsqueda

Cristian Antonio Hernández Rocha

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Inflammatory Bowel Disease Microbiome Transcriptome Therapeutic drug monitoring

Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 2003
Specialist in Internal Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
Specialist in Gastroenterology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
Advanced Inflammatory Bowel Disease Fellow, UNIVERSITY OF TORONTO. Canada, 2021

Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2014 - A la fecha

Gastroenterologist Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2012 - A la fecha
Advanced Inflammatory Bowel Disease Fellow Full Time

Mount Sinai Hospital

Toronto, Canada

2018 - 2021
Gastroenterology Fellow Full Time

Pontificia Universidad Catolica of Chile

Santiago, Chile

2010 - 2012
Internal Medicine Resident Full Time

Pontificia Universidad Catolica of Chile

Santiago, Chile

2007 - 2010
Community Physician, Law No 19,664. Rural Medical Doctor Full Time

Ministry of Health, Chile

Chile

2003 - A la fecha

- 2015-2016. Director of thesis to qualify for the professional title of Master of Biotechnology. Valentina Camilli Santiago. Universidad Andrés Bello. "Rol del receptor GPBAR-1 en la gravedad de la infección causada por Clostridium difficile". URL: http://repositorio.unab.cl/xmlui/handle/ria/4449
-2015-2016. Director of thesis to qualify for the professional title of Master of Biotechnology. Constanza Galilea Solar. Universidad Andrés Bello. "Evaluación de la correlación entre un polimorfismo en GPBAR1 y la gravedad clínica de la infección por clostridium difficile". URL: http://repositorio.unab.cl/xmlui/handle/ria/3992
- 2014-2015 Director of thesis to qualify for the professional title of gastroenterologist. Rodrigo Irarrazaval. Efecto de la vitamina D en un modelo murino de infección por Clostridium difficile
-2014-2015. Director of thesis to qualify for the professional title of Biotechnology. Edgar Montiel Muñoz. Universidad de Antofagasta. "Rol del receptor GPBAR-1 en la gravedad de la infección asociada a Clostridium difficile”.

Young Investigator. Dr. Jaime Chesta Award

SOCIEDAD CHILENA DE GASTROENTEROLOGIA

Chile, 2015

Young Investigator with Projection in Basic and Clinical Research (Gastoenterology)
Best Scientific Abstract from Gastroenterology Fellow. Dr. Iván Marinovic Award

SOCIEDAD CHILENA DE GASTROENTEROLOGIA

Chile, 2015

Best Scientific Abstract from Gastroenterology Fellow, XLII Annual meeting of Chilean Society of Gastroenterology. “Effect of vitamin D in a mouse model of Clostridium difficile infection”. Dr. Cristian Hernández was the supervisor of Dr. Rodrigo Irarrazaval
Best Scientific Abstract XLI Annual meeting of Chilean Society of Gastroenterology. Award Saval Laboratory

SOCIEDAD CHILENA DE GASTROENTEROLOGIA

Chile, 2014

Best Scientific Abstract XLI Annual meeting of Chilean Society of Gastroenterology, “High frequency of PNPLA3 rs738409 (I148M) polymorphism in the Chilean population: association with non-alcoholic fatty liver disease risk and histological severity”
CIHR/CAG Fellowship Award

Canadian Institutes of Health Research/Canadian Association of Gastroenterology

Chile, 2018

CIHR (Institute of Nutrition, Metabolism and Diabetes (INMD)) ’s Health Research Training Strategy aims to equip research trainees so that they emerge from their training as scientific, professional, or organizational leaders within and beyond the health research enterprise


Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort Perez-Jeldres, Tamara; Magne, Fabien; Ascui, Gabriel; Alvares, Danilo; Orellana, Matias; Alvarez-Lobos, Manuel; Hernandez-Rocha, Cristian; Azocar, Lorena; Aguilar, Nataly; Espino, Alberto; Estela, Ricardo; Escobar, Sergio; Zazueta, Alejandra; Baez, Pablo; Silva, Veronica; de la Vega, Andres; Arriagada, Elizabeth; Pavez-Ovalle, Carolina; Diaz-Asencio, Alejandro; Travisany, Dante; Miquel, Juan Francisco; Villablanca, Eduardo J.; Kronenberg, Mitchell; Bustamante, Maria Leonor Article ISI FRONTIERS IN MEDICINE (2023)
Clinical Predictors of Early and Late Endoscopic Recurrence Following Ileocolonic Resection in Crohn's Disease Hernandez-Rocha, Cristian; Walshe, Margaret; Birch, Sondra; Sabic, Ksenija; Korie, Ujunwa; Chasteau, Colleen; Miladinova, Vessela M.; Sabol, William B.; Mengesha, Emebet; Hanna, Mary; Pozdnyakova, Valeriya; Datta, Lisa; Kohen, Rita; Milgrom, Raquel; Stempak, Joanne M.; Bitton, Alain; Brant, Steven R.; Rioux, John D.; McGovern, Dermot P. B.; Duerr, Richard H.; Cho, Judy H.; Schumm, Phil L.; Silverberg, Mark S.; Lazarev, Mark Article ISI JOURNAL OF CROHNS & COLITIS (2023)
Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study Perez-Jeldres, Tamara; Bustamante, M. Leonor; Segovia-Melero, Roberto; Aguilar, Nataly; Magne, Fabien; Ascui, Gabriel; Uribe, Denisse; Azocar, Lorena; Hernandez-Rocha, Cristian; Estela, Ricardo; Silva, Veronica; De La Vega, Andres; Arriagada, Elizabeth; Gonzalez, Mauricio; Onetto, Gian-Franco; Escobar, Sergio; Baez, Pablo; Zazueta, Alejandra; Pavez-Ovalle, Carolina; Miquel, Juan Francisco; Alvarez-Lobos, Manuel Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
A Role for CXCR3 Ligands as Biomarkers of Post-Operative Crohn's Disease Recurrence Walshe, Margaret; Nayeri, Shadi; Ji, Jiayi; Hernandez-Rocha, Cristian; Sabic, Ksenija; Hu, Liangyuan; Giri, Mamta; Nayar, Shikha; Brant, Steven; McGovern, Dermot P. B.; Rioux, John D.; Duerr, Richard H.; Cho, Judy H.; Schumm, Phil L.; Lazarev, Mark; Silverberg, Mark S. Article ISI JOURNAL OF CROHNS & COLITIS (2022)
Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn's Disease Leibovitzh, Haim; Lee, Sun-Ho; Xue, Mingyue; Garay, Juan Antonio Raygoza; Hernandez-Rocha, Cristian; Madsen, Karen L.; Meddings, Jonathan B.; Guttman, David S.; Espin-Garcia, Osvaldo; Smith, Michelle, I; Goethel, Ashleigh; Griffiths, Anne M.; Moayyedi, Paul; Steinhart, A. Hillary; Panaccione, Remo; Huynh, Hien Q.; Jacobson, Kevan; Aumais, Guy; Mack, David R.; Abreu, Maria T.; Bernstein, Charles N.; Marshall, John K.; Turner, Dan; Xu, Wei; Turpin, Williams; Croitoru, Kenneth; CCC GEM Project Res Consortium Article ISI GASTROENTEROLOGY (2022)
Combined Histo-endoscopic Remission but not Endoscopic Healing Alone in Ulcerative Colitis is Associated with a Mucosal Transcriptional Profile Resembling Healthy Mucosa Hernandez-Rocha, Cristian; Nayeri, Shadi; Turpin, Williams; Steel, Mike; Borowski, Krzysztof; Stempak, Joanne M.; Conner, James; Silverberg, Mark S. Article ISI JOURNAL OF CROHNS & COLITIS (2022)
Ethnicity influences phenotype and clinical outcomes: Comparing a South American with a North American inflammatory bowel disease cohort Perez-Jeldres, Tamara; Pizarro, Benjamin; Ascui, Gabriel; Orellana, Matias; Cerda-Villablanca, Mauricio; Alvares, Danilo; de la Vega, Andres; Cannistra, Macarena; Cornejo, Barbara; Baez, Pablo; Silva, Veronica; Arriagada, Elizabeth; Rivera-Nieves, Jesus; Estela, Ricardo; Hernandez-Rocha, Cristian; alvarez-Lobos, Manuel; Tobar, Felipe Article ISI MEDICINE (2022)
Integrative Analysis of Colonic Biopsies from Inflammatory Bowel Disease Patients Identifies an Interaction Between Microbial Bile Acid-inducible Gene Abundance and Human Angiopoietin-like 4 Gene Expression Hernandez-Rocha, Cristian; Borowski, Krzysztof; Turpin, Williams; Filice, Melissa; Nayeri, Shadi; Garay, Juan Antonio Raygoza; Stempak, Joanne M.; Silverberg, Mark S. Article ISI JOURNAL OF CROHNS & COLITIS (2021)
Colonoscopy-guided therapy for the prevention of post-operative recurrence of Crohn’s disease Candia, Roberto; Bravo-Soto, Gonzalo A; Monrroy, Hugo; Hernandez, Cristian; Nguyen, Geoffrey C Article Cochrane Database of Systematic Reviews (2020)
JAK inhibitors: current position in treatment strategies for use in inflammatory bowel disease Hernandez-Rocha, Cristian; Vande Casteele, Niels Article ISI CURRENT OPINION IN PHARMACOLOGY (2020)
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease Salas, Azucena; Hernandez-Rocha, Cristian; Duijvestein, Marjolijn; Faubion, William; McGovern, Dermot; Vermeire, Severine; Vetrano, Stefania; Vande Casteele, Niels Article ISI NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)
Experiencia de educación continua en línea en gastroenterología para médicos no especialistas Lorena Isbej; Javier Uribe; Olga Carrasco; Isaac Villarroel; Margarita Pizarro; María Isabel Jirón; Edgar Sanhueza; Manuel Álvarez-Lobos; Cristián Hernández-Rocha; Antonio Rollán; Ximena Monsalve; Luis Antonio Díaz; María Alejandra Cerda; Tomás Kramer; Fernando Munizaga; Arnoldo Riquelme Article SCIELO SCOPUS Revista Medica de Chile (2019)
Claves prácticas para un trasplante de microbiota fecal por colonoscopía en infección por Clostridium difficile recurrente. Experiencia en un centro universitario Ricardo Cruz; Hugo, Monrroy; Jorge Flandez; Carlos M. Pérez; Manuel Álvarez-Lobos; Cristian Hernández-Rocha Article SCIELO SCOPUS REVISTA CHILENA DE INFECTOLOGIA (2018)
Management of severe ulcerative colitis An up-to-date Hernandez-Rocha, C; Ibanez, P; Molina, ME; Klaassen, J; Valenzuela, A; Candia, R; Bellolio, F; Zuniga, A; Miguieles, R; Miquel, JF; Chianale, J; Alvarez-Lobos, M Article ISI REVISTA MEDICA DE CHILE (2017)
Serum cytokeratin-18 fragment levels as noninvasive marker of nonalcoholic steatohepatitis in the chilean population Arab, Juan Pablo; Hern?ndez-Rocha, Cristi?n; Morales, Carolina; Vargas, Jos? Ignacio; Sol?s, Nancy; Pizarro, Margarita; Robles, Camila; Sandoval, Daniela; Ponthus, Simon; Ben?tez, Carlos; Barrera, Francisco; Soza, Alejandro; Riquelme, Arnoldo; Arrese, Marco Article ISI SCOPUS GASTROENTEROLOGIA Y HEPATOLOGIA (2017)
Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients Candia, Roberto; Norero, Blanca; Agu?ero, Carlos; Díaz, Luis; Ortega, Juan Pablo; Wolff, Rodrigo; Hernández-Rocha, Cristian; Duarte, Ignacio; Soza, Alejandro; Benítez, Carlos; Arrese, Marco Article ISI SCOPUS Annals of Hepatology (2017)
Consenso chileno de prevención, diagnóstico y tratamiento de la diarrea asociada a Clostridium difficile Cristian Hernández-Rocha; Paola Pidal; M. Cristina Ajenjo; Rodrigo Quera; Marcela Quintanilla; Jaime Lubascher; M. Irene Jemenao; Patricio Ibáñez; Manuel Álvarez-Lobos; Alexis Diomedi; Alejandra Marcotti; Mirta Acuña; Juan P Arab; Arnoldo Riquelme; Roberto Candía; Sergio Carvajal Article ISI SCIELO SCOPUS REVISTA CHILENA DE INFECTOLOGIA (2016)
Predominance of Clostridium difficile ribotypes 012, 027 and 046 in a university hospital in Chile, 2012 Plaza-Garrido, A; Barra-Carrasco, J; Macias, JH; Carman, R; Fawley, WN; Wilcox, MH; Hernandez-Rocha, C; Guzman-Duran, AM; Alvarez-Lobos, M; Paredes Sabja D Article ISI SCOPUS EPIDEMIOLOGY AND INFECTION (2016)
Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes Plaza-Garrido, A; Miranda-Cardenas, C; Castro-Cordova, P; Olguin-Araneda, V; Cofre-Araneda, G; Hernandez-Rocha, C; Carman, R; Ibáñez P.; Fawley, WN; Wilcox, MH; Gil, F; Calderon, IL; Fuentes, JA.; Guzman-Duran, AM; Alvarez-Lobos, M; Paredes Sabja D Article ISI SCOPUS Anaerobe (2015)
Esporas de Clostridium difficile y su relevancia en la persistencia y transmisión de la infección Jonathan Barra-Carrasco; Cristian Hernández-Rocha; Patricio Ibáñez; Ana M Guzmán-Durán; Manuel Álvarez-Lobos; Daniel Paredes-Sabja Article SCIELO REVISTA CHILENA DE INFECTOLOGIA (2014)
Rendimiento de índices pronósticos en infección asociada a Clostridium difficile grave: Análisis retrospectivo en un hospital universitario Cristian Hernández-Rocha; Rodrigo Tejos Sufan; Ángela Plaza-Garrido; Jonathan Barra-Carrasco; Carlos Agüero Luengo; Gonzalo Inostroza Levy; Patricio Ibáñez Lazo; Ana M Guzmán-Durán; Daniel Paredes-Sabja; M. Elena Molina Pezoa; Manuel Álvarez-Lobos Article SCIELO REVISTA CHILENA DE INFECTOLOGIA (2014)
Atypical presentation of pseudomembranous colitis localized in adenomatous polyps Cristian Hernández-Rocha, Jonathan Barra-Carrasco; Ana María Guzman, Paredes- Sabja Daniel; Lezcano Gabriel, Zoroquiaín Pablo Article World Journal Gastroenterology (2013)
Diagnostic accuracy of a multiplex real-time PCR to predict Clostridium difficile ribotype 027. Jonathan Barra-Carrasco, Cristian Hernández-Rocha; Camila Miranda-Cárdenas, Manuel Álvarez-Lobos; Ana María Duran-Guzmán, Daniel Paredes-Sabja Article Anaerobe (2013)
Prospective comparison of a commercial multiplex real-time polymerase chain reaction and an enzyme immunoassay with toxigenic culture in the diagnosis of Clostridium difficile-associated infections Cristian Hernández Rocha, Jonathan Barra- Carrasco; Manuel Álvarez-Lobos, Daniel Paredes-Sabja Article Diagnostic Microbilogy and Infectious Disease (2013)
Validation study of systems for noninvasive diagnosis of fibrosis in nonalcoholic fatty liver disease in Latin population Ome Pérez-Gutiérrez, Cristian Hernández-Rocha; Roberto Candia, Marco Arrese; Carlos Benítez, Diana Brizuela-Alcántara; Nahum Méndez-Sánchez, Misael Uribe Article Annals of Hepatology (2013)
Clostridium difficile associated infections=> an updated view Cristian Hernández-Rocha, Sebastian Naour; Manuel Álvarez-Lobos, Daniel Paredes-Sabja Article Revista Chilena de Infectología (2012)
Epidemic Clostridium difficile ribotype 027 in Chile Cristian Hernandez-Rocha, Jonathan Barra- Carrasco; Marjorie Pizarro- Guajardo, Patricio Ibañez; Susan Bueno, MR Sarker; Ana María Guzmán, Manuel Álvarez-Lobos Article Emerging Infectious Diseases Journal (2012)


Accesos para nutrición enteral en UCI Hernández-Rocha, Cristian; Riquelme, Arnoldo J.; Bugedo G.; Castillo L.; Romero C. BookSection (2015)


Mucosal microbial profiles at the neo-terminal ileum are associated with future development of postoperative endoscopic recurrence in Crohn’s disease patients Hernandez-Rocha Cristian, Turpin Williams, Nayeri Shadi, Borowski Krzysztof, Stempak Joanne, Schumm Philip, Brant Steven R, Lazarev Mark, Rioux John D, McGovern Dermot, Duerr Richard H, Cho Judy H, Silverberg Mark S ConferencePaper (2022)
BACTERIAL BILE SALT HYDROLASE GENE ABUNDANCE IS ASSOCIATED WITH RORC GENE EXPRESSION IN INTESTINAL MUCOSA OF INFLAMMATORY DISEASE PATIENTS Hernandez-Rocha, Cristian; Borowski, Krzysztof; Turpin, Williams; Smith, Michelle; Stempak, Joanne; Silverberg, Mark S. ConferencePaper (2020)
ASSOCIATION ANALYSIS BETWEEN BILE ACID-METABOLIZING MICROBIOTA ABUNDANCE AND ENDOSCOPIC INFLAMMATION IN INFLAMMATORY BOWEL DISEASE PATIENTS Hernandez Rocha Cristian A.; Borowski, Krzysztof; Turpin, Williams; Kabakchiev, Boyko; Boland, Karen; Bedrani, Larbi; Stempak, Joanne; Smith, Michelle; Nguyen, Geoffrey C.; Steinhart, Hillary; Croitoru, Ken; Silverberg, Mark S. ConferencePaper (2019)
Higher Abundance of Bile Acid-Metabolizing Microbiota is Associated with Type of Disease, Biopsy Location and Mucosal Inflammation in Inflammatory Bowel Disease Patients Hernández-Rocha, Cristian; Kabakchiev, boyko; Borowski, Krzysztof; Turpin, Williams; Boland, Karen; Milgrom, Raquel; Stempak, Joanne M.; Smith, Michelle I.; Silverberg, Mark S ConferencePaper (2019)


INCREASED ABUNDANCE OF BACTERIAL BILE SALT HYDROLASE GENES IS ASSOCIATED WITH MUCOSAL RORγT GENE EXPRESSION IN INFLAMMATORY BOWEL DISEASE PATIENTS. Hernandez-Rocha, Cristian; Borowski, Krzysztof; Filice, Melissa; Turpin, Williams; Milgrom, Raquel; Stempak, Joanne M.; Smith, Michelle I.; Silverberg, Mark S ConferencePoster (2020)
LOSS OF SATB2 EXPRESSION IN COLORECTAL CANCER IS ASSOCIATED WITH DURATION OF INFLAMMATORY BOWEL DISEASE Hernandez-Rocha, Cristian; Atin, Julia; Borowski, Krzysztof; Stempak, Joanne M.; Smith, Michelle I.; Conner, James; Silverberg, Mark S. ConferencePoster (2020)
RNA-SEQ GENE EXPRESSION PROFILE REVEALS THAT DUOXA2 AND CCL11 GENES ARE ASSOCIATED WITH PROGRESSIVE RISK OF COLORECTAL CANCER IN INFLAMMATORY BOWEL DISEASE PATIENTS Hernandez-Rocha, Cristian; Nayeri, Shadi; Borowski, Krzysztof; Smith, Michelle I; Stempak, Joanne M.; Conner, James; Silverberg, Mark S. ConferencePoster (2020)


Composition and Metabolic Activity of Gut Microbiota to Predict Early Inflammatory Bowel Disease Progression Hernandez-Rocha, Cristian; Garrido, Daniel Antonio; Manuel Álvarez-Lobos; Perez-Jeldres, Tamara Proyecto (2023)
Interplay of diet, bile acid-metabolizing bacteria and bile acid receptors as a gut microbiota-driven immunomodulatory pathway in inflammatory bowel disease Hernández-Rocha, Cristian Proyecto (2019)
Dysfunction Of Intestinal Epithelial Barrier Mediated By Bile Acid Receptor Gp-Bar1: A Modulator Of The Severity Of Clostridium Difficile Infection Hernández-Rocha, Cristian Proyecto (2013)
Adherence of Clostridium difficile spores to the intestinal mucosa FONDECYT (1110569) Proyecto 2011-2015 Investigador(a)
Prospective comparison of a commercial multiplex real-time polymerase chain reaction and an enzyme immunoassay with toxigenic culture in the diagnosis of Clostridium difficile-associated infections Concurso de investigación para becados residentes (PG 20/11) Proyecto 2011-2012 Inv. Principal