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Haribabu Jebiti

Fondecyt-Postdoctoral Research Fellow

Universidad de Atacama

Copiapo, Chile

Líneas de Investigación


Dr. J. Haribabu is experienced in the field of Bioinorganic and Coordination Chemistry which includes the design, synthesis and characterization of bioactive compounds intending to develop potential anticancer drugs.

Educación

  •  Bioinorganic Chemistry and Development of Anticancer Drugs, National Institute of Technology (NIT), Trichy. India, 2018
  •  Organic Chemistry, Vellore Institute of Technology (VIT), Vellore. India, 2012
  •  Chemistry and Biotechnology, Sri Venkateswara University, Tirupati. Chile, 2010

Experiencia Académica

  •   Project Assistant Full Time

    CSIR-Central Leather Research Institute (CLRI), Chennai

    Scientist Dr. T. Narasimhaswamy

    Chennai, India

    2012 - 2013

  •   Visiting Researcher Full Time

    Kaohsiung Medical University, Kaohsiung

    Dr. Sodio C. N. Hsu

    Kaohsiung, Taiwán

    2017 - 2018

  •   JSPS-Postdoctoral Research Fellow Full Time

    Tokyo University of Science, Japan

    Dr. Shin Aoki

    Noda, Japón

    2018 - 2020

  •   Fondecyt-Postdoctoral Research Fellow Full Time

    UNIVERSIDAD DE ATACAMA

    Dr. Cesar Echeverría

    Atacama, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Project Assistant Full Time

    CSIR-Central Leather Research Institute (CLRI)

    Chennai, India

    2012 - 2013

  •   Visiting Researcher Full Time

    Kaohsiung Medical University

    Kaohsiung, Taiwán

    2017 - 2018

  •   JSPS-Postdoctoral Research Fellow Full Time

    Tokyo University of Science

    Noda, Japón

    2018 - 2020

  •   Fondecyt-Postdoctoral Research Fellow Full Time

    University of Atacama

    Copiapo, Chile

    2020 - A la fecha

Formación de Capital Humano


REVIEWERS FOR INTERNATIONAL JOURNALS
? Journal of Organometallic Chemistry (Elsevier Publications, from 2020)
? Polyhedron (Elsevier Publications, from 2021)
? Applied Organometallic Chemistry (Wiley Publications, from 2021)
? Advanced Materials Letter (International Association of Advanced Materials, from 2021)
? Inorganic Chemistry Communications (Elsevier Publications, from 2022)
? Journal of Biomaterials Science: Polymer Edition (Taylor and Francis Publications, from 2021)
? Results in Chemistry (Elsevier Publications, from 2022)
? International Journal of Polymeric Materials and Polymeric Biomaterials (Taylor and Francis Publications, from 2022)
? Heliyon (Elsevier Publications, from 2022)
? Process Biochemistry (Elsevier Publications, from 2022)

INVITED LECTURES
1. Innovative Strategies in Chemical Science and Technology (ISCST-2020), Bhaktavatsalam Memorial College for Women, India, 28/06/2020 ? “Design and Development of Novel Metal Complexes for Cancer Therapy” (Online).
2. International Webinar for Engineering and Science, National Engineering College, Kovilpatti, India, 11/06/2020 ? “Role of Engineers in Drug Design: Molecular Docking Studies” (Online).
3. Novel Materials for Energy and Biological (COVID-19) Health Applications, M.Kumarasamy College of Engineering, Karur, India, 16/05/2020 ? “Synthesis of Palladium(II) Complexes and Docking with SARS COV-2” (Online).
4. Science Dialogue Program, Utsunomiya Girls’ High School, Utsunomiya, Tochigi, Japan, 26/10/2019 ? “Idea of Cancer and Anticancer Drugs, and Motivation of Students Towards to Research”.
5. Six Days International Faculty Development Program titled Innovative Trends in Science & Technology, M.Kumarasamy College of Engineering, Karur, India, 26-31/07/2021 “Organometallic (Ir and Ru) Compounds: Next-Generation Anticancer and Antiviral Metallodrugs?” (Online).

ORAL AND INVITED PRESENTATIONS IN CONFERENCES
1. 64th Annual Meeting of the Pharmaceutical Society of Japan, Kanto Region, Japan, 19/09/2020 ? “Design, Synthesis and Anticancer Properties of Bis-, and Mono(Cationic Peptide) Hybrids of Ir(III) Complexes: Effect of the Number of Peptide Units on Anticancer Activity”.
2. 7th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2020), Tokyo University of Science, Japan, 28/02/2020 ? “Design, Synthesis, Bioimaging and Anticancer Properties of Mono-, and Disubstituted Cyclometalted Ir(III) Complex-Peptide Hybrids”.
3. 3rd Acian Conference on Chemosensors and Imaging Probes (Asian ChIP-2019), Guru Nanak Dev University, Amritsar, India, 06-09/11/2019 ? “Design and Synthesis of Cyclometalated Iridium(III) Complexes Based on Post Complexation Functionalization”.
4. The 27th International Society of Heterocyclic Chemistry" Congress (ISHC2019), ROHM Theatre Kyoto, Japan, 01-06/9/2019 ? “Selective Substitution and Decomposition Reactions of Cyclometalated Iridium Complexes and Their Applications to Biomedical and Material Sciences”.
5. International Conference on Synthetic Materials for Science and Engineering Applications (SMSEA-2018), M.Kumarasamy College of Engineering, Karur, India, 11/04/2018 “Formation of Pd(II)-pyrazole based thiourea from chromone thiosemicarbazone – Apoptosis by the complexes”.
6. Research Awards, Dr. K. V. Rao Scientific Society, Hyderabad, India, 27/05/2017 ? “Unprecedented formation of Pd(II)-pyrazole based thiourea from chromone thiosemicarbazone and [PdCl2(PPh3)2]: Complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in HepG2 cells”.
7. 3rd International Conference on Science, Engineering and Technology (SET), Vellore Institute of Technology (VIT), Vellore, India, 17-18/02/2012 ? “Synthesis of novel spiro heterocyclic compounds from 1,3 dipolar cyclo-addition and biological studies”.
8. 2nd International Conference on Science, Engineering and Technology (SET), Vellore Institute of Technology (VIT), Vellore, India, 20-21/04/2011 ? “Studies on synthesis of bis indoles and biological applications”.
9. 25th National Science Day (NSD), Vellore Institute of Technology (VIT), Vellore, India, 28/02/2011 ? “Solvent free synthesis of 1,3,5-trisubstituted pyrozolines using imidazolium based ionic liquid as solvent & catalyst: A green route approach”.


Premios y Distinciones

  •   Young Scientist Award

    National Institute of Technology, Trichy

    India, 2017

    Young Scientist Award from Dr. K. V. Rao Scientific Society, Hyderabad, India, 2016-2017.

  •   Fondecyt-Postdoctoral Research Fellow

    UNIVERSIDAD DE ATACAMA

    Chile, 2020

    Selected for – 2020 funding by Chile Government (Project No: 3200391).

  •   Japan Society for the Promotion of Science (JSPS)-Postdoc

    TOKYO UNIVERSITY OF SCIENCE (TUS)

    Japón, 2018

    Selected for prestigious Japan Society for the Promotion of Science (JSPS) – 2018 funding by the Japan Government (ID: P18412).

  •   National Postdoctoral Fellowship

    Indian Institute of Science Education and Research

    India, 2019

    Selected for National Postdoctoral Fellowship (PDF/2018/001115) from Science and Engineering Research Board (SERB), Govt. of India, 2019.

  •   Junior and Senior Research fellow

    National Institute of Technology, Trichy

    Chile, 2013

    Selected for Junior and Senior Research fellow awarded from University Grants Commission, Govt. of India, July 2013-July 2018.


 

Article (76)

A new subtle and integrated detector to sense Hg2+ ions: A vision towards its applicabilityon water samples and live cells
Bidentate acylthiourea ligand-anchored Pd-PPh3 complexes with biomolecular binding, cytotoxic, antioxidant and anti-hemolytic properties
Coordination behaviour of acylthiourea ligands in their Ru(II)-benzene complexes – Structures and anticancer activity
Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi-target inhibitors of SARS-CoV-2 and cytotoxicity
Design of a dual responsive receptor with oxochromane hydrazide moiety to monitor toxic Hg2+ and Cd2+ ions: Usage on real samples and live cells
Development of thiosemicarbazone-based transition metal complexes as homogeneous catalysts for various organic transformations
Dinitro dinitrobenzene ether reactive turn-on fluorescence probes for the selective detection of H2S
Effect of N-benzyl group in indole scaffold of thiosemicarbazones on the biological activity of their Pd(II) complexes: DFT, biomolecular interactions, in silico docking, ADME and cytotoxicity studies
Impact of denticity of chromone / chromene thiosemicarbazones in the ruthenium(II)-DMSO complexes on their cytotoxicity against breast cancer cells
Pd(II)-PPh3 complexes of halogen substituted acylthiourea ligands: Biomolecular interactions and anticancer activity
Piano stool Ru(II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade
Synthesis, structural, DNA/protein binding and cytotoxic studies of copper (I) proportional to-diimine hydrazone complexes
2'-Thiophenecarboxaldehyde derived thiosemicarbazones metal complexes of copper(II), palladium(II) and zinc(II) ions: Synthesis, spectroscopic characterization, anticancer activity and DNA binding studies
Binding mode transformation and biological activity on the Ru(II)-DMSO complexes bearing heterocyclic pyrazolyl ligands
Cyclometalated iridium(III)-cationic peptide hybrids trigger paraptosis in cancer cells via an intracellular Ca2+ overload from the endoplasmic reticulum and a decrease in mitochondrial membrane potential
Effect of morphology and (Sn, Cr) doping on in vitro antiproliferation properties of hydrothermally synthesized 1D GaOOH nanostructures
Effect of new Pd(II)-aroylthiourea complex on pancreatic cancer cells
Effective inhibition of insulin amyloid fibril aggregation by nickel(II) complexes containing heterocyclic thiosemicarbazones
Impact of aliphatic acyl and aromatic thioamide substituents on the anticancer activity of Ru(II)-p-cymene complexes with acylthiourea ligands-in vitro and in vivo studies
N-Substitution in isatin thiosemicarbazones decides nuclearity of Cu(II) complexes – Spectroscopic, molecular docking and cytotoxic studies
Near-infrared fluorogenic receptor for selective detection of cysteine in blood serum and living cells
Spectroscopic, anticancer and antioxidant studies of fluxional trans-[PdCl2(S-acylthiourea)2] complexes
Synthesis and anticancer properties of bis- and mono(cationic peptide) hybrids of cyclometalated iridium(III) complexes: Effect of the number of peptide units on anticancer activity
Synthesis, cytotoxicity and docking studies (with SARS-CoV-2) of water-soluble binuclear Ru-p-cymene complex holding indole thiosemicarbazone ligand
Synthesis, cytotoxicity, and docking studies (with SARS-CoV-2) of water-soluble binuclear Ru-p-cymene complex holding indole thiosemicarbazone ligand
Tunable anticancer activity of furoylthiourea-based Ru(II)-arene complexes and their mechanism of action
Enhanced anticancer activity of half-sandwich Ru(II)-p-cymene complex bearing heterocyclic hydrazone ligand
Pd(II)-NNN pincer complexes for catalyzing transfer hydrogenation of ketones
Synthesis and molecular structure of zinc(II) complex bearing N, S donor ligand
Synthesis of palladium(II) complexes via michael addition: Antiproliferative effects through ROS-mediated mitochondrial apoptosis, and docking with SARS-COV-2
Thiosemicarbazone(s)-anchored water soluble mono- and bimetallic Cu(II) complexes: Enzymes-like activities, biomolecular interactions, anticancer property and real-time live apoptosis study
Unprecedented formation of palladium(II)-pyrazole based thiourea from chromone thiosemicarbazone and [PdCl2(PPh3)2]: Interaction with biomolecules and apoptosis by the complexes through mitochondrial signaling pathway 2020, 205,
Chemosensing, molecular docking and antioxidant studies of 8-amino quinoline appended acylthiourea derivatives
Coordination behavior of N,N′,N″‑trisubstituted guanidine ligands in their Ru-arene complexes: Synthetic, DNA/protein binding, and cytotoxic studies
Design, synthesis, DNA/HSA binding and cytotoxic activity of half-sandwich Ru(II)-arene complexes containing triarylamines-thiosemicarbazone hybrids
Effect of 2-bromopyridine ancillary ligand in the catalysis of Pd(II)-NNN pincer complexes towards Suzuki-Miyaura cross-coupling reaction
Half-sandwich Ru-(η6-p-cymene) complexes featuring pyrazol appended ligands: Synthesis, DNA binding and in vitro cytotoxicity
Highly active copper(I) complexes of aroylthiourea ligands against cancer cells – Synthetic and biological studies
Molecular structures, Hirshfeld analysis and biological investigations of isatin based thiosemicarbazones
NHC catalyzed green synthesis of functionalized chromones: DFT mechanistic insights and in vitro activities in cancer cells
Synthesis and anticancer activity of [RuCl2(η6-arene)(aroylthiourea)] complexes – High activity against human neuroblastoma (IMR-32) cancer cells
Vibrational spectroscopic (FT-IR, FT-Raman), anti-inflammatory, docking and molecular characteristic studies of Ni(II) complex of 2-aminonicotinaldehyde using theoretical and experimental methods
Zinc(II) complexes of indole thiosemicarbazones: DNA/protein binding, molecular docking and in vitro cytotoxicity studies
Half-sandwich Ru(II)(η6-p-cymene) complexes bearing N-dibenzosuberenyl appended thiourea for catalytic transfer hydrogenation and in vitro anticancer activity
Nickel(II) bis(isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells
Ru(II)-η6-arene complexes of dibenzosuberenyl appended aroyl/acylthiourea ligands: In vitro biomolecular interaction studies and catalytic transfer hydrogenation
Synthesis, crystal structure, DNA binding and antitumor studies of β-diketonate complexes of divalent copper, zinc and palladium
Synthesis, structural, biological evaluation, molecular docking and DFT studies of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes bearing heterocyclic thiosemicarbazone ligand
Synthesis, structures and mechanistic pathways of anticancer activity of palladium(II)complexes with indole-3-carbaldehyde thiosemicarbazones
Water-soluble mono- and binuclear Ru(η6-p-cymene) complexes containing indole thiosemicarbazones: Synthesis, DFT modeling, biomolecular interactions and in vitro anticancer activity through apoptosis
An investigation on the DNA/protein binding, DNA cleavage and in vitro anticancer properties of SNO pincer type palladium(II) complexes with N-substituted isatin thiosemicarbazone ligands
Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone: Synthesis, characterization and in vitro evaluation of cytotoxicity and DNA/protein binding properties
Crystal structures of the Schiff base derivatives (E)-N'-[(1H-indol-3-yl)methylidene]isonicotinohydr- azide ethanol monosolvate and (E)-N-methyl-2-[1-(2-oxo-2H-chromen-3-yl)ethylidene]hydrazinecarbo- thioamide
In vitro antioxidant, anti-inflammatory and in silico molecular docking studies of thiosemicarbazones
Naphthalenyl appended semicarbazone as “turn on” fluorescent chemosensor for selective recognition of fluoride ion
Ru(II)-p-cymene thiosemicarbazone complexes as inhibitors of Amyloid β (Aβ) peptide aggregation and Aβ-induced cytotoxicity
Synthesis of Ni(II) complexes bearing indole-based thiosemicarbazone ligands for interaction with biomolecules and some biological applications
Synthesis of Ru(II)-benzene complexes containing aroylthiourea ligand, and their binding with biomolecules and in vitro cytotoxicity through apoptosis
Half-sandwich RuCl2(η6-p-cymene) core complexes containing sulfur donor aroylthiourea ligand: DNA and protein binding, DNA cleavage and cytotoxic studies
Isatin based thiosemicarbazone derivatives as potential bioactive agents: Anti-oxidant and molecular docking studies
Synthesis, X-ray crystal structure, DNA/protein binding, DNA cleavage and cytotoxicity studies of N(4) substituted thiosemicarbazone based copper(II)/nickel(II) complexes
A facile and diastereoselective synthesis of functionalized spirooxindoles via 3+2 cycloaddition reaction
Crystal structure of (Z)-2-(1-benzyl-2-oxoindolin-3-ylidene)-N-phenylhydrazine-1-carbo thioamide
Crystal structure of N-[(4-ethoxyphenyl)carbamothioyl]cyclohexanecarboxamide
Crystal structure of N-[(naphthalen-1-yl)carbamothioyl]cyclohexanecarboxamide
Crystal structures of two hydrazinecarbothioamide derivatives: (E)-N-ethyl-2-((4-oxo-4H-chromen-3-yl) methylene) hydrazinecarbothioamidehemihydrate and (E)-2-((4-chloro-2H-chromen-3-yl)methylidene)-N-phenyl hydrazinecarbothioamide
Facile and diastereo selective synthesis of 3,2'-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities
Synthesis, crystal structure, and in vitro and in silico molecular docking of novel acyl thiourea derivatives
Synthesis, DNA/protein binding, molecular docking, DNA cleavage and in vitro anticancer activity of nickel(II) bis(thiosemicarbazone) complexes
Crystal structure of (2E)-N-methyl-2-(2-oxo-1,2-di-hydroacenaphthylen-1-ylidene) hydrazine carbothio amide
Crystal structure of (2E)-N-methyl-2-[(4-oxo-4H-chromen-3-yl)methylidene]hydrazine- carbothioamide
Crystal structure of (E)-2-[(4-chloro-2H-chromen-3-yl)methylidene]-N-cyclohexylhydrazine carbothioamide
1'-(1,3-Diphenyl-1H-pyrazol-4-yl)-1''-(prop-2-en-1-yl)-2',3',5',6',7',7a'-hexahydro-1'Hdispiro [1-benzopyran-3,2'-pyrrolizine-3',3''-indoline]-2'',4-dione 0.75-hydrate
1'-(1,3-Diphenyl-1H-pyrazol-4-yl)-1''-methyl2',3',5',6',7',7a'octahydro1'H-dispiro[1-benzopyran -3,2'-pyrrolizine-3',3''-indoline]-2'',4 dione
1'-(1,3-Diphenyl-1H-pyrazol-4-yl)-2',3',5',6',7',7a'-hexa­hydro-1'H-di­spiro­[ace­naphthyl­ene-1,3'-pyrrolizine-2',3''-chromane]-2,4''(1H)-dione
6'R*,7'R*)-7'-(1,3,-Diphenyl-1H-pyrazol-4-yl)-1,2,5',6',7',7a',3'',4'octahydro1'H,2''Hdispiro [acenaphthylene-1,5'-pyrrolo[1,2-c][1,3]thiazole-6',3''-[1]benzopyran]-2,4''-dione

BookSection (1)

Potential of polymer-ceramic based solid composites as potential electrolytes for Lithium-ion batteries

BookWhole (1)

Biomolecular interactions, and anticancer activity of Ni, Pd and Ru complexes bearing heterocyclic thiosemicarbazone ligands
78
Haribabu Jebiti

Fondecyt-Postdoctoral Research Fellow

Faculty of Medicine

Universidad de Atacama

Copiapo, Chile

7
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile