PDI - Resultado de Búsqueda

Gerson Dierley Keppeke

Professor

Universidad Católica del Norte

Coquimbo, Chile

Depleção de autoanticorpos por edição gênica com o sistema CRISPR/Cas9.

Ciencias Biologicas, Centro Universitário Adventista de São Paulo. Brasil, 2008
Ciencias de la Salud, UNIVERSIDADE FEDERAL DE SAO PAULO. Brasil, 2011
Ciencias de la Salud, UNIVERSIDADE FEDERAL DE SAO PAULO. Chile, 2015

Professor Visitante Full Time

Universidade Federal de São Paulo

Disciplina de Reumatologia

São Paulo, Brasil

2018 - 2019
Post-Doctorate Full Time

UNIVERSITY OF OXFORD

Oxford, Reino Unido

2015 - 2017
Visiting Scholar Full Time

ShanghaiTech University

Shanghai, China

2019 - 2020
Jovem Pesquisador/Professor Full Time

Universidade Federal de São Paulo

Disciplina de Reumatologia

São Paulo, Brasil

2019 - 2023
Professor Full Time

UNIVERSIDAD CATOLICA DEL NORTE

Facultad de Medicina

Coquimbo, Chile

2023 - A la fecha
Profesor Afiliado Other

UNIVERSIDADE FEDERAL DE SAO PAULO

Disciplina de Reumatologia

São Paulo, Brasil

2024 - A la fecha

Profesor Full Time

Universidad Católica del Norte

Coquimbo, Chile

2023 - A la fecha

Prêmio Prof. Dr. Wiliam Habib Chahade - 1º lugar PÔSTER

Sociedade Paulista de Reumatologia

Brasil, 2020

Prêmio Prof. Dr. Wiliam Habib Chahade - 1º lugar categ PÔSTER, no 26º Encontro de Reumatologia Avançada 2020, Sociedade Paulista de Reumatologia
IWAA PRIZE -3rd Place-

International Workshop on Autoantibodies and Autoimmunity

Chile, 2014

IWAA PRIZE -3rd Place-, 12th International Workshop on autoimmunity and autoantibodies, São Paulo, Brazil.
Dresden Prize for the Study on Autoantibodies

The Association for the Advancement of Immune Diagnostics

Alemania, 2013

Dresden Prize for the Study on Autoantibodies 2013, The Association for the Advancement of Immune Diagnostics. Dresden, Alemania.
1° lugar no Prêmio Melhores Pôsteres

XXIX Congresso Brasileiro de Reumatologia

Brasil, 2012

1° lugar no Prêmio Melhores Pôsteres do XXIX Congresso Brasileiro de Reumatologia, Sociedade Brasileira de Reumatologia. Vitória - ES, Brasil.
IV Fórum Integrador de Pesquisadores, UNIFESP

Universidade Federal de São Paulo

Chile, 2012

Menção honrosa como um dos melhores Posters apresentado no IV Fórum Integrador de Pesquisadores, UNIFESP, São Paulo, Brasil.


Design of an all-in-one drug-inducible CRISPR-based genome editing system and evaluation of its efficacy against a recombinant anti-AChR autoantibody Article ISI MINERVA BIOTECHNOLOGY AND BIOMOLECULAR RESEARCH (2025)
Hyperhomocysteinemia in Takayasu arteritis-genetically defined or burden of the proinflammatory state? Zarur, Eduarda Bonelli; Peron Filho, Faustino; de Oliveira, Allan Chiaratti; Keppeke, Gerson Dierley; D'Almeida, Vania; de Souza, Alexandre Wagner Silva Article ISI FRONTIERS IN IMMUNOLOGY (2025)
Precision medicine for Autoimmunity: From CAAR-T Cells to AI-Driven CRISPR-based therapies, challenges and perspectives. Keppeke, Gerson D. Article GenoMed Connect (2025)
Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism Chang, Chia-Chun; Peng, Min; Keppeke, Gerson Dierley; Tsai, Li-Kuang; Zhang, Ziheng; Pai, Li-Mei; Sung, Li-Ying; Liu, Ji-Long Article ISI FEBS JOURNAL (2025)
A new therapeutic pathway in autoimmune diseases: chimeric antigen receptor T cells (CAR-T) targeting specific cell subtypes or antigen-specific B lymphocytes—a brief review Segovia, Maria F.; Landoni, Diana; Defranchi, Yohana; Calderón-Jofré, Rodrigo; Olivares, Carlos F.; Keppeke, Gerson D. Article Scopus Exploration of Immunology (2024)
Autoanticorpos específicos e associados na esclerose sistêmica: investigação e diagnóstico Matos, P.; Keppeke, Gerson D.; Kayser, C Article Rev Paul Reumatol (2024)
Detection of Autoantibodies Against the Acetylcholine Receptor, Evaluation of Commercially Available Methodologies: Fixed Cell-Based Assay, Radioimmunoprecipitation Assay and Enzyme-Linked Immunosorbent Assay Dellavance, Alessandra; Baldo, Danielle Cristiane; Gozzi-Silva, Sarah Cristina; Dierley Keppeke, Gerson Article ISI JOURNAL OF NEUROMUSCULAR DISEASES (2024)
The IMPDH cytoophidium couples metabolism and fetal development in mice Tsai, Li-Kuang Article ISI CELLULAR AND MOLECULAR LIFE SCIENCES (2024)
"Untargeting" autoantibodies using genome editing, a proof-of-concept study Gomes, Kethellen Article ISI CLINICAL IMMUNOLOGY (2023)
Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn Article ISI Frontiers in Cell and Developmental Biology (2023)
Evaluation of commercially available chemical reagents and electroporation for insertion of nucleic acids into hard-to-transfect cells Gomes, K.; Aires, P. P.; Keppeke, G. D. Article ISI GENETICS AND MOLECULAR RESEARCH (2023)
A cell-based assay for detection of anti-fibrillarin autoantibodies with performance equivalent to immunoprecipitation Kayser, Cristiane; Hasegawa, Tomoko; Tanaka, Shin; Diogenes, Larissa; Amaral, Rogerio Quintiliano Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation Zhong, Jiale; Zhang, Ziheng Article ISI CELLULAR AND MOLECULAR LIFE SCIENCES (2022)
Serum Myostatin and Follistatin Levels in Patients With Dermatomyositis and Polymyositis de Sordi, Cintia M.; dos Reis-Neto, Edgard T.; Shinjo, Samuel K.; Sato, Emilia Inoue Article ISI JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2022)
CTPS forms the cytoophidium in zebrafish Antos, Christopher L. Article ISI EXPERIMENTAL CELL RESEARCH (2021)
IMPDH forms the cytoophidium in zebrafish Article ISI DEVELOPMENTAL BIOLOGY (2021)
Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study Moreira, Thais G.; Matos, Kimble T. F.; De Paula, Giovana S.; Santana, Thais M. M.; Da Mata, Raquel G.; Pansera, Fernando C.; Cortina, Andre S.; Spinola, Marcelle G.; Jacob, Jules; Palejwala, Vaseem; et al. Article ISI FRONTIERS IN IMMUNOLOGY (2021)
IMP dehydrogenase rod/ring structures in acral melanomas Barcelos, Denise; Fernandes, Mariana; Comodo, Andreia N.; Guimaraes, Daiane P.; Cardili, Leonardo; Carapeto, Fernando C. L.; Landman, Gilles Article ISI PIGMENT CELL & MELANOMA RESEARCH (2020)
IMPDH-Based Cytoophidium Structures as Potential Theranostics in Cancer Article ISI MOLECULAR THERAPY (2020)
Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs Article ISI ANTIVIRAL RESEARCH (2019)
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity Chang, Chia Chun; Chen, Li-Yu; Lin, Wei-Cheng; Pai, Li-Mei; Andrade, Luis Eduardo Coelho Article ISI CELL DIVISION (2018)
Interfilament interaction between IMPDH and CTPS cytoophidia Article ISI FEBS JOURNAL (2018)
Psychological characteristics of caregivers of pediatric patients with chronic rheumatic disease in relation to treatment adherence Keppeke, Livia de Freitas; Molina, Juliana; Miotto e Silva, Vanessa Bugni; Ramos Ascensao Terreri, Maria Teresa de Sande e Lemos; Schoen, Teresa Helena; Len, Claudio Arnaldo Article ISI PEDIATRIC RHEUMATOLOGY (2018)
CTP synthase forms the cytoophidium in human hepatocellular carcinoma Chang, Chia-Chun; Jeng, Yung-Ming; Peng, Min; Sung, Li-Ying; Liu, Ji-Long Article ISI EXPERIMENTAL CELL RESEARCH (2017)
Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-alpha/ribavirin therapy Article ISI WORLD JOURNAL OF GASTROENTEROLOGY (2016)
Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings autoantibodies Prado, Monica Simon; Perazzio, Sandro Felix; Rodrigues, Silvia Helena; Coelho Andrade, Luis Eduardo Article ISI CLINICAL IMMUNOLOGY (2016)
Anti-rods/rings: a human model of drug-induced autoantibody generation Calise, S. John; Keppeke, Gerson D.; Andrade, Luis E. C. Article ISI FRONTIERS IN IMMUNOLOGY (2015)
Assembly of IMPDH2-Based, CTPS-Based, and Mixed Rod/Ring Structures Is Dependent on Cell Type and Conditions of Induction John Calise, S. Article ISI JOURNAL OF GENETICS AND GENOMICS (2015)
Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures Grieshaber, Scott S. Article ISI CELL AND BIOSCIENCE (2015)
Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-alpha Article ISI IMMUNOLOGIC RESEARCH (2014)
Longitudinal Study of a Human Drug-Induced Model of Autoantibody to Cytoplasmic Rods/Rings following HCV Therapy with Ribavirin and Interferon-alpha Keppeke, Gerson Dierley; Nunes, Eunice; Gomes Ferraz, Maria Lucia; Benedito Silva, Eduardo Antonio; Granato, Celso; Chan, Edward K. L.; Andrade, Luis Eduardo C. Article ISI PLOS ONE (2012)


Chapter 88 - Future Direction of Laboratory Testing for Autoimmune Diseases Keppeke, Gerson D.; Agustinelli, Renan A.; Landoni, D.; Cruvinel, Wilson M.; Chan, Edward K.; Andrade, Luis E. C.; Schmitz, John L.; Detrick, Barbara; O'Gorman, Maurice R. G. BookSection (2024)

Gerson Keppeke

Professor

Depto. de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Gerson Dierley Keppeke

Líneas de Investigación

Educación

Ciencias Biologicas, Centro Universitário Adventista de São Paulo. Brasil, 2008

Ciencias de la Salud, UNIVERSIDADE FEDERAL DE SAO PAULO. Brasil, 2011

Ciencias de la Salud, UNIVERSIDADE FEDERAL DE SAO PAULO. Chile, 2015

Experiencia Académica

Professor Visitante Full Time

Post-Doctorate Full Time

Visiting Scholar Full Time

Jovem Pesquisador/Professor Full Time

Professor Full Time

Profesor Afiliado Other

Experiencia Profesional

Profesor Full Time

Premios y Distinciones

Prêmio Prof. Dr. Wiliam Habib Chahade - 1º lugar PÔSTER

IWAA PRIZE -3rd Place-

Dresden Prize for the Study on Autoantibodies

1° lugar no Prêmio Melhores Pôsteres

IV Fórum Integrador de Pesquisadores, UNIFESP

Article (31)

BookSection (1)