Man

Daniel Jordi Hachim Diaz

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


- Functional Biomaterials - Drug delivery - Tissue engineering - Organ-on-a-chip

Educación

  •  Tissue Engineering and Regenerative Medicine, UNIVERSITY OF PITTSBURGH. Estados Unidos, 2017
  •  Pharmaceutical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Experiencia Académica

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Química y de Farmacia

    Chile

    2023 - A la fecha

  •   Postdoctoral Research Associate Full Time

    IMPERIAL COLLEGE LONDON

    Engineering

    London, Reino Unido

    2018 - 2022

  •   PhD Student Full Time

    University of Pittsburgh

    Estados Unidos

    2012 - 2017

  •   Investigador Asistente Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Química y de Farmacia

    Chile

    2010 - 2012

  •   Profesor Instructor Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Química y de Farmacia

    Chile

    2010 - 2012

Experiencia Profesional

  •   Assistant Professor Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2023 - A la fecha

  •   Research Assistant Part Time

    Pontificia Universidad Catolica de Chile

    Chile

    2010 - 2012

  •   Instructor Professor Part Time

    Pontificia Universidad Catolica de Chile

    Chile

    2010 - 2011

Formación de Capital Humano


- Pontificia Universidad Católica de Chile: I am Director of three undergraduate thesis and co-director of three PhD. Students.
- Imperial College London: I have mentored and co-supervised the Theses of seven graduated Master Students and 2 PhD students (not graduated yet)
- McGowan Institute for Regenerative Medicine. I have mentored six students and one Visiting Scholar in laboratory skills and research study design. Two of my students have won awards (Best Poster in undergraduate category) for the research done under my supervision.


Difusión y Transferencia


Patents and Disclosures:
1. Hachim D, Brown BN. Layer by Layer Coated Mesh for Local Release of Bio-active Proteins. US20170266352A1. (2016).
2. Hachim D, Ebensperger R. Method for selective targeting of nanoencapsulated cells on target tissue or organs. WO2013106944 A3. (2013).
3. Hachim D, Ghurman H, Modo M, Brown BN. Labeling Methods of Extracellular Matrix- Derived Scaffolds for Research and Clinical Monitoring. Invention disclosure in progress. Pitt Ref 04308. (2017).

Conferences:
1. Hachim D*, Foote J, Herna?ndez O, Delahaye M, Ouyang L, Wang R, Harding SE, Stevens MM. Glycosaminoglycan-PEDOT conductive hydrogels for iPSC-derived cardiomyocyte implantation and electrical coupling. 7th International Bioelectronics Conference 2022. Tirol, Austria.
2. Hachim D*, Zhao J, Bhankaria J, Nun?ez-Toldra R, Brito L, Seong H, Becce M, Grigsby C, Terracciano C, Stevens MM. Polysaccharide-polyplex ultrathin coatings for nanoneedle-based gene delivery. Tissue Engineering and Regenerative Medicine International Society (TERMIS) - World Conference 2021 (Podium presentation). Maastricht, Netherlands.
3. Hachim D*, Mylonaki I, Dondi C, Stuckey D, Brito L, Harding SE, Stevens MM. Injectable memory-shape cryogels for minimally invasive delivery of cardiac progenitors into the heart. 11th World Biomaterials Congress (Podium presentation). December 2020. Glasgow, Scotland, United Kingdom.
4. Hachim D, Mylonaki I*, Dondi C, Stuckey D, Brito L, Harding SE, Stevens MM. An injectable shape-memory cell-laden hydrogel patch for cell delivery on the heart. Cardiovascular Biology and Vascular Tissue Engineering Conference. June 2019. Zurich, Switzerland.
5. Hachim D*, LoPresti ST, Brown BN. Unveiling macrophage populations and mechanisms driving the better remodeling outcomes associated with shifting phenotype in the host response against biomaterials (Podium and poster presentation). Regenerative Medicine Workshop, March 2017. Hilton Head Island, SC, United States.
6. Hachim D*, LoPresti ST, Brown BN. IL-4 Eluting Nano-layered Coating Promotes Better Implant Integration into the Host Tissue via Macrophage Modulation (Podium presentation). Tissue Engineering and Regenerative Medicine Society (TERMIS) 2016, December 2016. San Diego, CA, United States.
7. Hachim D*, LoPresti ST, Mani D, Brown BN. Improvements in the resolution of the foreign body reaction by the modulation of macrophage polarization towards an M2 phenotype at the tissue-implant interface by local release of IL-4 from layer by layer coated polypropylene meshes (Podium presentation). Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress, May 2016. Montreal, Canada.
8. Hachim D, Mani D, LoPresti ST, Brown BN*. Effects of Aging upon the Host Response to Polypropylene Mesh (Podium presentation). AUGS 36th Annual Meeting, October 2016. Seattle, WA, United States.
9. Hachim D, Mani D, LoPresti ST, Brown BN*. Promoting Tissue Integration via Release of IL-4 from the Surface of Polypropylene Mesh (Podium presentation). AUGS 36th Annual Meeting, October 2016. Seattle, WA, United States.
10.Hachim D*, LoPresti ST, Mani D, Brown BN. Modulation of Macrophage Polarization at the Tissue-Implant Interface by Local Release of IL-4 from a Nanometer Thickness Coating on Polypropylene Meshes. Biomedical Engineering Society (Podium presentation), October 2015. Tampa, FL, United States.
11.Hachim D*, LoPresti ST, Mani D, Brown BN. Modulation of Macrophage Polarization at the Tissue Implant Interface by Local Release of IL-4 from a Nanometer Thickness Coating on Polypropylene Meshes. Regenerative Medicine Workshop (Poster), May 2015. Hilton Head, NC, United States.
12.Hachim D*, LoPresti ST, Mani D, Brown BN. Pro-remodeling Macrophage Polarization at the Tissue-Implant Interface by Local Release of IL-4 from Coated Polypropylene Meshes. TERMIS Word Conference (Poster), September 2015. Boston, MA, United States.
13. Hachim D*, LoPresti ST, Brown BN. Development of a Cytokine-Loaded Layer by Layer Coating on Polypropylene Meshes to Modulate Macrophage Polarization at the Tissue-Implant Interface. Society for Biomaterials (Podium presentation), April 2015. Charlotte, NC, United States.
14. Hachim D*, Ebensperger R. Polycation influence on cell viability in nanoencapsulation of human adipose derived mesenchymal stem cells (Poster presentation). XXIV Annual congress of the Chilean Society of Cell Biology, November 2010. Puco?n, Chile.

Organization of Events at International Conferences:
- Exploring options after your degree. Panel discussion at the Society for Biomaterials Conference, April 2018, Atlanta. Role: Session organizer.

Leadership and Outreach:
- 2022. Stevens Group exhibition committee. Great Exhibition Road Festival, London, United Kingdom.
- 2018, 2019. Volunteer exhibitor. London International Young Science Forum (LIYSF).
- 2017 - 2018. President, Society for Biomaterials (SFB) United States National Student Council.
- 2016 - 2017. President-elect, Society for Biomaterials (SFB) United States National Student Council.
- 2015 - 2018. Student Representative and Webmaster, Society for Biomaterials, Drug Delivery SIG.
- 2015 - 2017. Newsletter Chair, Biomedical Engineering Society Chapter (BMES), University of Pittsburgh.


Premios y Distinciones

  •   3rd Place for Best Poster Presentation

    Congreso Ingeniería en Tejidos y Medicina Regenerativa 2024

    Chile, 2024

    3rd Place for Best Poster Presentation

  •   1st Prize Award for Best Poster Presentation

    IMPERIAL COLLEGE LONDON

    Reino Unido, 2018

    1st Prize Award for Best Poster Presentation at the 8th Annual Department of Materials Postdoc Symposium 2018, Imperial College, London, UK.

  •   Seal of Excellence

    EUROPEAN UNION

    Chile, 2018

    Horizon 2020’s Marie Sklodowska - Curie Actions. Seal of Excellence for proposal “Conformally coated nanoneedles (CoNad) for sustained and sequential drug delivery for cardiac ischaemia-reperfusion injury”.

  •   2nd place in 2016 TERMIS-AM Business Competition

    TERMIS

    Estados Unidos, 2017

    2nd place in 2016 TERMIS-AM Business Competition, December 11th - 14th, San Diego, CA.

  •   2nd place in the Wells Healthcare Business Competition

    UNIVERSITY OF PITTSBURGH

    Chile, 2016

    2nd place in the Wells Healthcare Business Competition (US$ 10,000), Pittsburgh, PA.

  •   NSF I-Corps Program Award

    UNIVERSITY OF PITTSBURGH

    Chile, 2016

    NSF I-Corps Program Award (US$3,000) for “Layer-Up”. University of Pittsburgh, PA.

  •   Finalist. Round-1 Pilot Funding Program

    UNIVERSITY OF PITTSBURGH

    Chile, 2016

    Finalist. Round-1 Pilot Funding Program, Pittsburgh's Center for Medical Innovation (CMI).

  •   Fulbright Fellowship

    COMISION FULBRIGHT-CHILE

    Chile, 2012

    Fulbright Fellowship for Doctoral Studies


 

Article (12)

Self-Doped and Biodegradable Glycosaminoglycan-PEDOT Conductive Hydrogels Facilitate Electrical Pacing of iPSC-Derived Cardiomyocytes
Functional microvascularization of human myocardium <i>in vitro</i>
Polysaccharide-Polyplex Nanofilm Coatings Enhance Nanoneedle-Based Gene Delivery and Transfection Efficiency
Assessing the impact of silicon nanowires on bacterial transformation and viability of <i>Escherichia coli</i>
Nanoceria provides antioxidant and osteogenic properties to mesoporous silica nanoparticles for osteoporosis treatment
Distinct macrophage populations and phenotypes associated with IL-4 mediated immunomodulation at the host implant interface
Expanding and optimizing 3D bioprinting capabilities using complementary network bioinks
Distinct release strategies are required to modulate macrophage phenotype in young versus aged animals
Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices
Surface modification of polypropylene for enhanced layer-by-layer deposition of polyelectrolytes
Effects of aging upon the host response to implants
Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration
12
Daniel Hachim

Assistant Professor

Química y de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile