Proteinopathies; Molecular and Celular Mechanism of Neurodegeneration processes; Splicing and RNA Biology; Chaperone Mediated Autophagy

2009-2014: Postdoctoral position at Molecular Pathology Laboratory. International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Co-direction of undergraduate thesis:

Name: Anna Daria
Tittle: “Sviluppo e Caratterizazzione di un Modello di Aggregazione di TDP-43” (Development and characterization of a TDP-43 aggregation model)
Finished

Name: Giulila Toniutti
Tittle: “Caratterizzazione molecolare dei meccanismi di aggregazione di TDP-43 ed implicazioni nelle malattie neurodegenerative” (Molecular characterization of TDP-43 aggregation mechanisms and its impact in neurodegenerative diseases).
Finished

Co-direction of PhD thesis:

Name: Valentina Romano "Doctor Philosophiae” (PhD) degree in the life sciences". PhD. Open University Program
Finished
Name: Zainuddin Quadri "Doctor Philosophiae” (PhD) degree in the life sciences". PhD. Open University Program
Finished

2014-up-to date:
Name: Sheila Vivanco
Undergraduate Thesis: Dentist. Dentistry Faculty, University of Chile
Co-direcction
Finished: 2016

Name: Francisca Lavin
Undergraduate Thesis: Dentist. Dentistry Faculty, University of Chile
Co-direcction
Finished: 2016

Name: Cecilia Hernando
Undergraduate Thesis: Biochemistry. Pharmaceutical and Chemical Sciences Faculty, University of Chile
Co-direcction
Finished 2016

Name: Sebastián Pino
Undergraduate Thesis: Biotechnology. Sciences Faculty, University of Chile
Co-direcction
Finished

Name: José Moreno
Undergraduate Thesis: Biochemistry. Pharmaceutical and Chemical Sciences Faculty, University of Chile
Director
On course

Name: Felipe Riquelme
Magister Thesis: Biotechnology, Andrés Bello University
Director
Finished

Name: Karina Cordero
Magister Thesis: Biotechnology, Andrés Bello University
Director
Finished

Congress and Meetings assistance

CHILEAN SOCIETY FOR CELL BIOLOGY XXXIII ANNUAL MEETING (2019). Characterization of Chaperon Mediated Autophagy (CMA) in POMC like neurons under fatty acids exposure. Javiera Rios, Fernando Ormeño, Sergio Hernández, Liliana Yantén, Iván E. Alfaro, Eugenia Morselli, Patricia Burgos, Alfredo Criollo, Mauricio Budini. November 25 to 29, 2019. Puerto Varas, Chile.

CHILEAN SOCIETY FOR CELL BIOLOGY XXXII ANNUAL MEETING (2018). Crosstalk between TDP-43 and Chaperone Mediated Autophagy (CMA): what do we know? Fernando Ormeño, Jose Moreno, Felipe Riquelme, Juan Hormazabal, Amelina Albornoz, Ivan Alfaro, Mauricio Budini. October, 22 26, 2018 Puerto Varas, Chile.

CHILEAN SOCIETY FOR CELL BIOLOGY XXXII ANNUAL MEETING (2018). Regulation of NF-H protein levels and cellular localization by Chaperone Mediated Autophagy in a Motor Neuron cell line model. Moreno J, Ormeño F. Ivan Alfaro, Budini M. October, 22 26, 2018 Puerto Varas, Chile.

Invited Speaker at the Dipartimento di Scienze Farmacologiche e Biomolecolari Universita' degli Studi di Milano. “Crosstalk between TDP-43 and Chaperone Mediated Autophagy (CMA): what do we know?”. Monday, 18 June 2018. Host: Angelo Poletti

Invited Speaker at the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste. “Crosstalk between TDP-43 and Chaperone Mediated
Autophagy (CMA): what do we know?”. Tuesday, 26 June 2018. Host: Emanuele Buratti

Invited Speaker at the Buenos Aires Research Conference on Autophagy 2017 “Molecular Mechanism in Biology and Diseases”. School of Pharmacy and Biochemistry, University of Buenos Aires. October 23-25, 2017.

XL ANNUAL MEETING CHILEAN BIOCHEMISTRY AND MOLECULAR BIOLOGY SOCIETY (2017). TDP-43 aggregation affects Chaperone Mediated Autophagy (CMA) pathway. Moreno J, Ormeño F, Riquelme F, Corvalan D, Budini M

XL ANNUAL MEETING CHILEAN BIOCHEMISTRY AND MOLECULAR BIOLOGY SOCIETY (2017). Transcriptomic analysis by RNA-Seq in a cellular model of aggregation of TDP-43 protein. Cordero K, Moya-Beltrán A, Ormeño F, Riquelme F, Covarrubias P, Quatrini R, Budini M

XXX ANNUAL MEETING CHILEAN SOCIETY FOR CELL BIOLOGY (2016). Haptoglobin, EIF4e and Annexin-A4 induce a mature phenotype and migration capacity in human dendritic cells: A potential new role as damage associated molecular patterns (DAMPs). Vivanco S., Lavín F., Reyes-Farias M., Budini M., Salazar-Onfray F., González F.E.

XXX ANNUAL MEETING CHILEAN SOCIETY FOR CELL BIOLOGY (2016). Relationship between TDP-43 aggregates and CMA. Riquelme F., Moreno J., Ormeño F., Pino S., Budini M.

XXXVIII ANNUAL MEETING OF BIOCHEMISTRY AND MOLECULAR BIOLOGY OF CHILE (2015). TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain. Budini, M., Romano V., Quadri, Z., Buratti, E., Baralle, EF.

4°AriSLA Convention. Milan (2013). TDP-43-ALTERED METABOLISM IN ALS. Mauricio Budini, Jeremias Herzog, Valentina Romano, Amit Bhardwaj, Zainuddin Quadri, Natasa Skoko, Laura De Conti, Cristiana Stuani, Maurizio Romano, Marco Baralle, Claudia Colombita, Elisa Onesto, Emanuele Buratti, Antonia Ratti and Francisco E. Baralle.

International Sypmposium in “Gene Expression and RNA Processing”. IGUAZU FALLS, MISIONES ARGENTINA, (2011). “Establishing a cellular model of TDP-43 protein aggregation”. Budini, M. F.; Stuani, C.; Guarnaccia, C.; Romano, V.; Buratti, E.; Baralle, F. E.

ICGEB Trieste, Annual Symposium – ICGEB (2011), Trieste, Italy. “TDP-43: determinants of aggregation” Budini, M.

International Symposium on Alternative Splicing in Neurodegenerative Diseases and Cancer. Tel Aviv (2010). “Characterization of peptide sequences that can modulate TDP-43 splicing properties and/or aggregation/localization in neuronal tissues” Budini M., Romano M., Stuani S., Baralle F.E., and Buratti E.

ICGEB Trieste, Annual Symposium – ICGEB (2009), Trieste, Italy. “Targeting the TDP-43/hnRNP Functional Interaction” Budini, M.

XLIX Annual Meeting of Chilean Biology Society. XXIX Annual Meeting of Chilean Biology and Molecular Biology Society. XVIII Annual Meeting of Chilean Botanic Society. XXXVIII Annual Meeting of Chilean Genetic Society (2006). “Caracterization of autophosphorylation of CK1a variants”. Budini, M., Jacob G., Whitesel, M., Allende, C. C., Allende, J. E.

X PABMB Congress. SAIB, XLI Annual Meeting, SAN, XX Annual Meeting (2005). “In vivo phosphorylation of Rotavirus`NSP5 protein by casein kinase 1 a (CK1a)”. Budini, Mauricio F.; Campagna, Michela; Burrone, Oscar and Allende, Jorge E.

XXVI ANNUAL MEETING OF BIOCHEMISTRY AND MOLECULAR BIOLOGY OF CHILE (2003). “Phosphorylation of insert L of the CK1aL (from Zebra Fish) by protein kinase dependent of cAMP, PKA”. Budini, M., Jacob, G., Burzio, V. Allende, C. C., Allende, J. E.

Congress and Meeting Organization

Workshop-Autophagy: Physiological and Pathological Roles. University of Chile. 23rd and 24th November 2016, Santiago, Chile.