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Daniel Alonso González Mañán

Académico regular

Universidad Mayor de Chile

Santiago, Chile

Enfermedad por hígado graso no alcohólico; Síndrome metabólico; Compuestos bioactivos.

Doctor en Nutrición y Alimentos, UNIVERSIDAD DE CHILE. Chile, 2017
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2012
Licenciado en Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2010

Profesor asociado Full Time

Universidad Mayor

Facultad de Ciencias, Ingeniería y Tecnología

SANTIAGO, Chile

2018 - At present
Profesor ayudante Part Time

Universidad de O'Higgins

Rancagua, Chile

2017 - 2017


Dietary alpha- and gamma-tocopherol (1:5 ratio) supplementation attenuates adipose tissue expansion, hepatic steatosis, and expression of inflammatory markers in a high-fat-diet-fed murine model Juretic, Nevenka; Sepulveda, Ruth; D'Espessailles, Amanda; Vera, Daniela B.; Cadagan, Cynthia; de Miguel, Manuel; Gonzalez-Manan, Daniel; Tapia, Gladys Article ISI NUTRITION (2021)
Iron-induced derangement in hepatic ?-5 and ?-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil Barrera C.; Valenzuela R.; RincÃ³n M.A.; Espinosa A.; LÃ³pez-Arana S.; GonzÃ¡lez-MaÃ±an D.; Romero N.; Vargas R.; Videla, L.A. Article ISI SCOPUS (2020)
Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation=> involvement of resolvins RvE1/2 and RvD1/2. Echeverría, F; Valenzuela, R; Espinosa, A; Bustamante, A; Álvarez, D; Gonzalez-Mañan, D; Ortiz, M; Soto-Alarcon, S A; Videla, L A Article The Journal of nutritional biochemistry (2019)
Anti-oxidative and anti-inflammatory effects of Rosa Mosqueta oil supplementation in rat liver ischemia-reperfusion. Dossi, Camila G; González-Mañán, Daniel; Romero, Nalda; Silva, David; Videla, Luis A; Tapia, Gladys S Article Food & function (2018)
Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration Barrera, C; Valenzuela, R; Rincon, MA; Espinosa, A; Echeverria, F; Romero, N; Gonzalez-Manan, D; Videla, LA Article FREE RADICAL BIOLOGY AND MEDICINE (2018)
Role of dietary Î±- and Î³-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model. Tapia, Gladys; Silva, David; Romero, Nalda; Pettinelli, Paulina; Dossi, Camila G; de Miguel, Manuel; González-Mañán, Daniel Article Nutrition (Burbank, Los Angeles County, Calif.) (2018)
Effects of rosa mosqueta oil supplementation in lipogenic markers associated with prevention of liver steatosis Dossi C.G., Cadagan C.; San Martín M., Espinosa A.; González-Mañán D., Silva D.; Mancilla R.A., Tapia G.S. Article Food and Function (2017)
Rosa mosqueta oil prevents oxidative stress and inflammation through the upregulation of PPAR-? and NRF2 in C57BL/6J mice fed a high-fat diet González-Mañán D., Espessailles A.D.; Dossi C.G., Martín M.S.; Mancilla R.A., Tapia G.S. Article Journal of Nutrition (2017)
Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-? and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation Hernández-Rodas, María C.; Valenzuela, Rodrigo; Echeverría, Francisca; Rincón-Cervera, Miguel Ángel; Espinosa, Alejandra; Illesca, Paola; Muñoz, Patricio; Corbari, Alicia; Romero, Nalda; Gonzalez-Mañan, Daniel; Videla, Luis A. Article Molecular Nutrition & Food Research (2017)
Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood Valery Ambrosetti, Marcelo Guerra; Luisa A. Ramírez, Aldo Reyes; Daniela Álvarez, Sofía Olguín; Daniel González-Mañan , Daniela Fernandois Article Endocrine (2016)
n-3 LCPUFA in the reversal of hepatic steatosis=> the role of ACOX and CAT-1 Gladys Tapia, Daniel González-Mañán Article Grasas y aceites (2016)
Dietary Rosa mosqueta (Rosa rubiginosa) oil prevents high diet-induced hepatic steatosis in mice D'Espessailles A., Dossi; CG, Espinosa A; Gonzalez-Manan, D; Tapia, GS Article Food and Function (2015)
N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-alpha upregulation and NF-kappa B DNA binding abrogation Tapia G., Valenzuela R; Espinosa A, Romanque; P, Dossi; C, Gonzalez-Manan; D, Videla; LA, D'Espessailles A. Article Molecular Nutrition & Food Research (2014)
Prevention of liver steatosis through fish oil supplementation=> correlation of oxidative stress with insulin resistance and liver fatty acid content Alejandra Espinosa, Rodrigo Valenzuela; Daniel González-Mañán, Amanda D’Espessailles; Juan Guillermo Gormaz, Cynthia Barrera Article ARCHIVOS LATINOAMERICANOS DE NUTRICIÓN (2013)
Bioconversion of alpha-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with alpha-linolenic acid-rich oils Gonzalez-Manan, D; Tapia G., Gormaz J.G.; D'Espessailles A., Espinosa A; Masson L., Varela P.; Valenzuela A., Valenzuela R Article Food and Function (2012)
N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis Valenzuela R, Espinosa A; Gonzalez-Manan, D; D'Espessailles A., Fernández V.; Videla L.A., Tapia G. Article PLOS ONE (2012)
Nuevas fuentes dietarias de acido alfa-linolénico=> una visión crítica Jessica Morales, Rodrigo Valenzuela; Daniel González-Mañán , Marcela González; Gladys Tapia , Julio Sanhueza Article Revista chilena de nutrición (2012)


"Hepatoprotective mechanisms of Rosa rubiginosa oil (Rosa mosqueta) in preconditioning against ischemia reperfusion injury in healthy and steatotic liver and prevention of liver steatosis=> role of Nrf2, PPAR-alpha, NF-kB and expression of FONDECYT (1140547) Proyecto 2014-2018 Tesista
Promoción del uso de aceite de rosa mosqueta para el tratamiento de la resistencia a la insulina y esteatosis VIU-FONDEF (VIU120040) Proyecto 2012-2013 Inv. Responsable
“Protection with oral n-3 PUFA (EPA + DHA) supplementation against liver injury, inflammation, oxidative stress and insuline resistance induced by a high-fat diet=> activation of PPAR-alpha and NF-kB inactivation” FONDECYT (1110043) Proyecto 2011-2014 Tesista

Daniel González

Académico regular

Núcleo de química y bioquímica

Universidad Mayor de Chile

Santiago, Chile

Berta Espinosa

Full Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

Amanda D'Espessailles

Investigadora Postdoctoral

Instituto de Ciencias de a Salud

Universidad de O'Higgins

Rancagua, Chile

Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

SANDRA LOPEZ

Profesora Asistente

Nutrición

Universidad de Chile

Santiago, Chile

Nalda Romero

Profesora Asociada

Ciencia de los Alimentos

UNIVERSIDAD DE CHILE

Santiago, Chile

Miguel Ángel Rincón

Académico profesor asociado

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

Santiago, Chile

Daniel Alonso González Mañán

Líneas de Investigación

Educación

Doctor en Nutrición y Alimentos, UNIVERSIDAD DE CHILE. Chile, 2017

Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2012

Licenciado en Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

Profesor asociado Full Time

Profesor ayudante Part Time

Article (17)

Dietary alpha- and gamma-tocopherol (1:5 ratio) supplementation attenuates adipose tissue expansion, hepatic steatosis, and expression of inflammatory markers in a high-fat-diet-fed murine model

Iron-induced derangement in hepatic ?-5 and ?-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil

Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation=> involvement of resolvins RvE1/2 and RvD1/2.

Anti-oxidative and anti-inflammatory effects of Rosa Mosqueta oil supplementation in rat liver ischemia-reperfusion.

Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration

Role of dietary Î±- and Î³-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model.

Effects of rosa mosqueta oil supplementation in lipogenic markers associated with prevention of liver steatosis

Rosa mosqueta oil prevents oxidative stress and inflammation through the upregulation of PPAR-? and NRF2 in C57BL/6J mice fed a high-fat diet

Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-? and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation

Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood

n-3 LCPUFA in the reversal of hepatic steatosis=> the role of ACOX and CAT-1

Dietary Rosa mosqueta (Rosa rubiginosa) oil prevents high diet-induced hepatic steatosis in mice

N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-alpha upregulation and NF-kappa B DNA binding abrogation

Prevention of liver steatosis through fish oil supplementation=> correlation of oxidative stress with insulin resistance and liver fatty acid content

Bioconversion of alpha-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with alpha-linolenic acid-rich oils

N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis

Nuevas fuentes dietarias de acido alfa-linolénico=> una visión crítica

Proyecto (3)

"Hepatoprotective mechanisms of Rosa rubiginosa oil (Rosa mosqueta) in preconditioning against ischemia reperfusion injury in healthy and steatotic liver and prevention of liver steatosis=> role of Nrf2, PPAR-alpha, NF-kB and expression of

Promoción del uso de aceite de rosa mosqueta para el tratamiento de la resistencia a la insulina y esteatosis

“Protection with oral n-3 PUFA (EPA + DHA) supplementation against liver injury, inflammation, oxidative stress and insuline resistance induced by a high-fat diet=> activation of PPAR-alpha and NF-kB inactivation”

Daniel González

Berta Espinosa

Amanda D'Espessailles

Gladys Tapia

SANDRA LOPEZ

Nalda Romero

Miguel Ángel Rincón