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Mauricio Andrés García Alcalde

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


My interest is the drug absorption process, involing dissolution and permeation at the absorption site, which results in drug product pharmacokinetics. For this, our laboratory combines in vitro methods with computational simulations.

Educación

  •  Químico Farmacéutico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2015
  •  Pharmacy, JOHANNES GUTENBERG UNIVERSITAT MAINZ. Alemania, 2022

Experiencia Académica

  •   Research Fellow Full Time

    JOHANNES GUTENBERG UNIVERSITAT MAINZ

    Chemie, Pharmazie, Geographie und Geowissenschaften

    Mainz, Alemania

    2018 - 2022

  •   Teaching: Practical training, 7th semester, Biopharamceutics and Pharmacokinetics Other

    JOHANNES GUTENBERG UNIVERSITAT MAINZ

    Chemie, Pharmazie, Geographie und Geowissenschaften

    Mainz, Alemania

    2019 - At present

  •   Asistente de investigación Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Química y de Farmacia

    Santiago, Chile

    2014 - 2014

  •   External lecturer Other

    Universidad Católica del Maule

    Medicina

    Talca, Chile

    2021 - 2021

  •   Profesor Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Química y de Farmacia

    Santiago, Macul, Chile

    2022 - At present

Experiencia Profesional

  •   Químico Farmacéutico Full Time

    Corporación Municipal de Desarrollo Social Ñuñoa

    Santiago, Chile

    2016 - 2017

  •   Research Assistant for Collaboration Project with F. Hoffmann-La Roche AG Part Time

    Johannes Gutenberg Universität Mainz

    Mainz, Alemania

    2021 - 2022

  •   Assistant Professor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2022 - At present


 

Article (8)

Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Garcia, Mauricio A.; Hensler, Gonul; Al-Gousous, Jozef; Pielenhofer, Jonas; Wagner, Manfred; Lennernas, Hans; Langguth, Peter

Article ISI
DRUG METABOLISM AND PHARMACOKINETICS  (2023)

In Vitro Methodologies for Evaluating Colon-Targeted Pharmaceutical Products and Industry Perspectives for Their Applications

Garcia, Mauricio A.; Varum, Felipe; Al-Gousous, Jozef; Hofmann, Michael; Page, Susanne; Langguth, Peter

Article ISI
PHARMACEUTICS  (2022)

Predicting Pharmacokinetics of Multisource Acyclovir Oral Products Through Physiologically Based Biopharmaceutics Modeling

Garcia, Mauricio A.; Bolger, Michael B.; Suarez-Sharp, Sandra; Langguth, Peter

Article ISI
JOURNAL OF PHARMACEUTICAL SCIENCES  (2022)

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Carbamazepine

Garcia, Mauricio A.; Cristofoletti, Rodrigo; Abrahamsson, Bertil; Groot, Dirk W.; Parr, Alan; Polli, James E.; Mehta, Mehul; Shah, Vinod P.; Tomakazu, Tajiri; Dressman, Jennifer B.; Langguth, Peter

Article ISI
JOURNAL OF PHARMACEUTICAL SCIENCES  (2021)

Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia

Catalan-Figueroa, Johanna; Garcia, Mauricio A.; Contreras, Pilar; Boisset, Constanza B.; Gonzalez, Pablo M.; Fiedler, Jenny L.; Perez, Mariela F.; Morales, Javier O.

Article ISI
MOLECULAR PHARMACEUTICS  (2021)

In vitro prediction of in vivo absorption of ibuprofen from suspensions through rational choice of dissolution conditions

Hofmann, Michael; Garcia, Mauricio A.; Al-Gousous, Jozef; Ruiz-Picazo, Alejandro; Thieringer, Florian; Nguyen, Mai A.; Mansson, Wiking; Galle, Peter R.; Langguth, Peter

Article ISI
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS  (2020)

Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability

Garcia, Mauricio A.; Contreras, Danae; Gonzalez, Pablo M.

Article ISI
PHARMACEUTICAL RESEARCH  (2020)

The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir

Kubbinga, Marlies; Augustijns, Patrick; Garcia, Mauricio A.; Heinen, Christian; Wortelboer, Heleen M.; Verwei, Miriam; Langguth, Peter

Article ISI
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS  (2019)

Proyecto (1)

"Angiotensina-(1-9), un nuevo principio activo para el tratamiento de la hipertensión y del daño cardiovascular y renal secundarios=> estudio y desarrollo preclínicos."

FONDEF (D11I1122)

Proyecto
2012-2015
Personal técnico y/o de apoyo

8
Mauricio García

Assistant Professor

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Pablo González

Gerente General

Innovation and Biopharmaceutical Evaluation Center

Santiago, Chile

1
Javier Morales

Profesor Asociado

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile