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Milena Villarroel Cickovic

JEFE CENTRO DE RESPONSABILIDAD

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

Infecciones respiratorias virales; Infecciones respiratorias bacterianas; BiologÃa molecular en el diagnÃ³stico de infecciones; Infecciones intrahospitalarias; Infecciones por hongos; Consumo de antibiÃ³ticos; Neutropenia febril en niÃ±os con cÃ¡ncer; Reactantes de fase aguda; Infecciones fÃºngicas invasoras; Sarcoma de Ewing; Sarcomas Ã³seos y de partes blandas; Neutropenia Febril / infecciones FÃºngicas Invasoras; Mecanismo de patogenocidad humana; InterecciÃ³n Bacteria-Hospedero; DiagnÃ³stico molecular; INFECCIONES EN NIÃƒâ€˜OS INMUNOCOMPROMETIDOS

Médico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1983
Médico Pediatra, UNIVERSIDAD DE CHILE. Chile, 1988
Médico Hemato Oncólogo Infantil, CONACEM. Chile, 1996
Diploma en Gestión de Instituciones de Salud., UNIVERSIDAD DE CHILE. Chile, 2009
Diplomado en Formación de Líderes., UNIVERSIDAD ADOLFO IBÁÑEZ. Chile, 2011

Jefa de Oncología Full Time

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

1993 - At present

Médico Unidad Oncología Part Time

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

1993 - 2003
JEFE UNIDAD DE ONCOLOGÍA Part Time

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

2003 - 2016
JEFE CENTRO DE RESPONSABILIDAD ONCOLOGÍA Full Time

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

2016 - At present
PEDIATRA ONCÓLOGO Part Time

CLINICA LAS CONDES

Santiago, Chile

1997 - 2018


Highlights from the 1st Latin American meeting on metronomic chemotherapy and drug repositioning in oncology, 27-28 May, 2016, Rosario, Argentina Graciela Scharovsky, O.; Gregianin, Lauro; Rose, Adriana; Mora Graupera, Jaume; Rozados, Viviana R.; Gomez Garcia, Wendy; Menacho Marquez, Mauricio; Epelman, Sidnei; Schaiquevich, Paula; Alasino, Carlos; Andre, Nicolas; Alonso, Daniel; Jose Rico, Maria; Chantada, Guillermo; Mainetti, Leandro E.; Villarroel, Milena Article WOS-ESCI ECANCERMEDICALSCIENCE (2016)
Successful treatment of a persistent rhino-cerebral mucormycosis in a pediatric patient with a debut of acute lymphoblastic leukemia Cofré F.; Villarroel M.; Castellon, L; Santolaya, ME Article ISI REVISTA CHILENA DE INFECTOLOGIA (2015)
TUMORES RAROS EN NIÑOS Y ADOLESCENTES Villarroel, Milena Article Revista Médica Clínica Las Condes (2015)
Characterization of episodes of febrile neutropenia in children with acute myeloid leukemia and acute lymphoblastic leukemia [Caracterización de los episodios de neutropenia febril en niños con leucemia mieloide aguda y leucemia linfoblástica aguda] Ducasse, K; Fernandez J.P.; Salgado, C.; Álvarez A.M.; Avilés C.L.; Becker, A; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M; Santolaya M.E. Article SCOPUS Revista Chilena de Infectologia (2014)
Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia Farfán M, Salas C, Canales C, Silva F, Villarroel M, Kopp K, Torres JP, Santolaya ME, Morales J Article BMC Cancer (2014)
Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia Farfan MJ; Salas C.; Canales, C; Silva, F; Villarroel M.; Kopp, K; Torres, JP; Santolaya, ME; Morales J. Article ISI SCOPUS BMC CANCER (2014)
Prospective Validation of a Risk Prediction Model for Severe Sepsis in Children With Cancer and High-risk Febrile Neutropenia Santolaya, ME; Alvarez, AM; Aviles, CL; Becker, A; Venegas, M; O´Ryan, M; Salgado, C.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M; De La Maza, V; Vergara A.; Farfan MJ; Torres, JP Article ISI SCOPUS Pediatric Infectious Disease Journal (2013)
Agentes causantes de bacteriemia en niños con cáncer y neutropenia febril de alto riesgo en seis hospitales de Santiago, Chile, período 2004-2009 Solis, Y; Álvarez A.M.; Fuentes, D; de la Barra D.; Avilés C.L.; Becker, A; Salgado, C.; Silva P.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M; Aedo S.; Santolaya M.E. Article SCIELO SCOPUS REVISTA CHILENA DE INFECTOLOGIA (2012)
Bloodstream infections in children with cancer and high risk fever and neutropenia episodes in six hospitals of Santiago, Chile between 2004 and 2009 Solis, Y; Alvarez, AM; Fuentes, D; de la Barra D.; Aviles, CL; Becker, A; Salgado, C.; Silva P.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M; Aedo S.; Santolaya, ME Article ISI REVISTA CHILENA DE INFECTOLOGIA (2012)
Cancer, febrile neutropenia and pulmonary images: Findings in bronchoalveolar lavage in children Aviles, CL; Silva P.; Zubieta, M; Alvarez, AM; Becker, A; Salgado, C.; Santolaya, ME; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T Article ISI REVISTA CHILENA DE INFECTOLOGIA (2012)
Cáncer, neutropenia febril e imágenes pulmonares: Hallazgos en el lavado broncoalveolar en niños Avilés CL, Silva P, Zubieta M, Álvarez AM, Becker A, Salgado C, Santolaya ME, Topelberg S, Tordecilla J, Varas M, Villarroel M, Viviani T Article Revista Chilena de Infectología (2012)
Dynamic contrast-enhanced magnetic resonance imaging as a prognostic factor in predicting event-free and overall survival in pediatric patients with osteosarcoma Guo J.; Reddick W.E.; Glass J.O.; Ji Q.; Billups C.A.; Wu J.; Hoffer F.A.; Kaste S.C.; Jenkins J.J.; Ortega Flores X.C.; Quintana, J; Villarroel M.; Daw N.C. Article ISI SCOPUS Cancer (2012)
Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia Torres, J.P.; Labraña Y.; Ibáñez C; Kasaneva P.; Farfan M.J.; De La Maza, V; Villarroel M.; Vergara, I; Piemonte, P; Zubieta, M; Salgado, C.; Tordecilla, J; Topelberg S.; O'Rryan M.; Santolaya M.E. Article ISI SCOPUS PEDIATRIC INFECTIOUS DISEASE JOURNAL (2012)
Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation. International Pediatric Fever and Neutropenia Guideline Panel Lehrnbecher T, Phillips R, Alexander S, Alvaro F, Carlesse F, Fisher B, Hakim H, Santolaya ME, Castagnola E, Davis BL, Dupuis LL, Gibson F, Groll AH, Gaur A, Gupta A, Kebudi R, Petrilli S, Steinback WJ, Villarroel M, Zaoutis T, Sung L Article Journal Clinical Oncology (2012)
Seroprevalence of varicella-zoster virus in children with cancer in six hospitals in Santiago, Chile Izquierdo, G; Zubieta, M; Martinez, MJ; Alvarez, AM; Aviles, CL; Becker, A; Pena M.; Salgado, C.; Silva P.; Topeberg, S; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Santolaya, ME Article ISI REVISTA CHILENA DE INFECTOLOGIA (2012)
Seroprevalencia de virus varicela-zoster en niños con cáncer en 6 hospitales de Santiago, Chile Izquierdo G, Zubieta M, Martínez G, Álvarez AM, Avilés CL, Becker A, Peña M, Salgado C, Silva P, Topelberg S, Tordecilla J, Varas M, Villarroel M, Viviani T, Santolaya ME Article Revista Chilena de Infectología (2012)
Diagnosis of Bacteremia in Febrile Neutropenic Episodes in Children With Cancer Microbiologic and Molecular Approach Santolaya, ME; Farfan MJ; De La Maza, V; Cociña M; santelices F; Alvarez, AM; Aviles, CL; Becker, A; O´Ryan, M; Roman, P.; Salgado, C.; Silva P.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M; Torres, JP Article ISI SCOPUS Pediatric Infectious Disease Journal (2011)
Diagnosis of Bacteremia in febrile neutropenic episodes in children with cancer: Microbiologic and molecular approach Santolaya ME, Farfán M, De la Maza V, Cociña M, Santelices F, Álvarez AM, Avilés CL, Becker A, O´Ryan M, Román P, Salgado C, Silva P, Topelberg S, Tordecilla J, Varas M, Villarroel M, Viviani T, Zubieta M, Torres JP Article Pediatric Infectious Diseases Journal (2011)
Frontline Treatment of Localized Osteosarcoma Without Methotrexate Results of the St. Jude Children's Research Hospital OS99 Trial Daw, NC; Neel, MD; Rao, BN; Billups, CA; Wu, JR; Jenkins, JJ; Quintana, J; Luchtman-Jones, L; Villarroel M.; Santana, VM Article ISI SCOPUS Cancer (2011)
Preliminary Efficacy of the Anti-Insulin-Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma Juergens, H; Daw, NC; Geoerger B.; Ferrari, S; Villarroel M.; Aerts I.; Whelan, J.; Dirksen U.; Hixon, ML; Yin, DH; Wang, T; Green, S.; Paccagnella, L; Gualberto A. Article ISI SCOPUS Journal of Clinical Oncology (2011)
Risk Factors Associated With Invasive Fungal Disease in Children With Cancer and Febrile Neutropenia A Prospective Multicenter Evaluation Villarroel M.; Aviles, CL; Silva P.; guzman AM; Poggi, H; Alvarez, AM; Becker, A; O´Ryan, M; Salgado, C.; Topelberg S.; Tordecilla, J; Varas, M; Viviani T; Zubieta, M; Santolaya, ME Article ISI SCOPUS Pediatric Infectious Disease Journal (2010)
Aggressive treatment of non-metastatic osteosarcoma improves health-related quality of life in children and adolescents Hinds, PS; Gattuso, JS; Billups, CA; West, NK; Wu, JR; Rivera, C.; Quintana, J; Villarroel M.; Daw, NC Article ISI SCOPUS EUROPEAN JOURNAL OF CANCER (2009)
Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile Zubieta, Marcela; Santolaya, María E; Hurtado, Carmen; Álvarez, Ana M; Avilés, Carmen L; Becker, Ana; Brahm, Javier; Salgado, Carmen; Silva, Pamela; Topelberg, Santiago; Tordecilla, Juan; Varas, Monica; Villarroel, Milena; Viviani, Tamara Article SCIELO REVISTA MEDICA DE CHILE (2009)
Predictors of severe sepsis not clinically apparent during the first twenty-four hours of hospitalization in children with cancer, neutropenia, and fever - A prospective, multicenter trial Santolaya, ME; Alvarez, AM; Aviles, CL; Becker, A; King, A; Mosso, C; O´Ryan, M; Paya, E; Salgado, C.; Silva P.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M Article ISI SCOPUS PEDIATRIC INFECTIOUS DISEASE JOURNAL (2008)
Transfer of complex frontline anticancer therapy to a developing country: The St. Jude osteosarcoma experience in Chile Rivera, GK; Quintana, J; Villarroel M.; Santana, VM; Rodriguez-Galindo, C; Neel, MD; Velez, G; Ribeiro, RC; Daw, NC Article ISI SCOPUS PEDIATRIC BLOOD & CANCER (2008)
Tratamiento antimicrobiano en niños con neutropenia febril de alto riesgo Muñoz E, Ossa JC, Villarroel M, Santolaya ME Article Revista Chilena de Pediatría (2008)
Admission clinical and laboratory factors associated with death in children with cancer during a febrile neutropenic episode Santolaya, ME; Alvarez, AM; Aviles, CL; Becker, A; Mosso, C; O´Ryan, M; Paya, E; Salgado, C.; Silva P.; Topelberg S.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M Article ISI SCOPUS PEDIATRIC INFECTIOUS DISEASE JOURNAL (2007)
Diagnóstico precoz del cáncer infantil. Villarroel, Milena Article Revista Médica Clínica Las Condes (2006)
Early hospital discharge followed by outpatient management versus continued hospitalization of children with cancer, fever and neutropenia al low risk for invasive bacterial infection Santolaya ME, Álvarez AM, Avilés CL, Becker A, Cofré J, Cumsille MA, O´Ryan ML, Payá E, Salgado C, Silva P, Tordecilla J, Varas M, Villarroel M, Viviani T, Zubieta M Article Journal of Clinical Oncology (2004)
Early hospital discharge followed by outpatient management versus continued hospitalization of children with cancer, fever, and neutropenia at low risk for invasive bacterial infection Santolaya, ME; Alvarez, AM; Aviles, CL; Becker, A; Cofre J.; Cumsille, MA; O'Ryan, ML; Paya, E; Salgado, C.; Silva P.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M Article ISI SCOPUS JOURNAL OF CLINICAL ONCOLOGY (2004)
Prospective evaluation of a model of prediction of invasive bacterial infection risk among children with cancer, fever, and neutropenia Santolaya, ME; Alvarez, AM; Aviles, CL; Becker, A; Cofre J.; Enriquez, N; O´Ryan, M; Paya, E; Salgado, C.; Silva P.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M Article ISI SCOPUS CLINICAL INFECTIOUS DISEASES (2002)
Causative agents of bloodstream infections in Chilean pediatric patients with cancer Paya, E; Alvarez, AM; Aviles C.; Cofre J.; Enriquez, N; Salgado, C.; Santolaya, ME; Silva P.; Tordecilla, J; Varas, M; Villarroel M.; Zubieta, M Article ISI REVISTA MEDICA DE CHILE (2001)
Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever Santolaya, ME; Alvarez, AM; Becker, A; Cofre J.; Enriquez, N; O´Ryan, M; Paya, E; Pilorget, J; Salgado, C.; Tordecilla, J; Varas, M; Villarroel M.; Viviani T; Zubieta, M Article ISI SCOPUS JOURNAL OF CLINICAL ONCOLOGY (2001)
Impacto de un programa educativo a los padres de niños con cáncer en el aumento del conocimiento de la enfermedad de sus hijos y la disminución de la ansiedad De la Maza V, Fernández M, Concha L, Santolaya ME, Villarroel M, Castro M, Torres JP Article Revista Chilena de Pediatría (0)


A multicentric study of interval compressed multiagent chemotherapy and metronomic chemotherapy for patients with Ewing sarcoma family of tumors: The Latin American Pediatric Oncology Group trial. Gregianin, LJ; Scopinaro, M; Rose, A; Boldrini, E; Ferman, S; Petrilli, AS; Costa, CMJ; Kirst, D; Dufort, G; Villarroel M.; Salgado, C.; Almeida, MTA; Valero, M; Rizzatti, M; Castillo, LA; Siqueira, L; Lustosa, D; Pizza, M; Rey G.; Brunetto, A Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2015)
Evaluation of the pharmacokinetics of high doses of methotrexate administration (HD-MTX) in pediatric patients with osteosarcoma Morales J.; Villarroel M.; Inostroza V.; Concha E. Abstract ISI PHARMACY WORLD SCIENCE (2010)
SAFETY AND EFFICACY RESULTS FROM A PHASE 1/2 STUDY OF THE ANTI-IGF-IR ANTIBODY FIGITUMUMAB IN PATIENTS WITH REFRACTORY EWING'S AND OTHER SARCOMAS Juergens, H; Daw, NC; Oberlin, O; Ferrari, S; Villarroel M.; Doz, F; Whelan JS; Wang, T; Paccagnella, L Abstract ISI ANNALS OF ONCOLOGY (2010)
CHILEAN NATIONAL PEDIATRIC CANCER PROGRAM (PINDA): 20 YEARS Campbell, M; Salgado, C.; Villarroel M.; Becker, A; Varas, M; Silva P.; Neira L.; Moline, N; Fernandez, E; Gajardo, C; Arriagada M.; Cea, G; Rayo, Y Abstract ISI PEDIATRIC BLOOD & CANCER (2009)
Frontline treatment of localized osteosarcoma without methotrexate: Results of the St. Jude Children's Research Hospital OS99 trial Daw, NC; Neel, MD; Rao, BN; Billups, CA; Wu J.; Jenkins, JJ; Villarroel M.; Luchtman-Jones, L; Quintana, J; Santana, VM Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2009)
THE NURSE'S ROLE IN CLINICAL RESEARCH IN A DEVELOPING COUNTRY Fernandez, MS; Fuenzalida, M; Villarroel M. Abstract ISI PEDIATRIC BLOOD & CANCER (2009)


Diagnóstico temprano del cáncer infantil Villarroel, Milena BookSection (2015)
Neurooncología pediátrica: una visión global Villarroel, Milena BookSection (2012)


Cáncer, neutropenia febril e imágenes pulmonares: Hallazgos en el lavado broncoalveolar en niños Avilés C.L.; Silva P.; Zubieta, M; Salgado, C.; Álvarez A.M.; Varas, M; Becker, A; Viviani T; Elena Santolaya M.; Villarroel M.; Topelberg S.; Tordecilla, J CaseReport SCIELO SCOPUS REVISTA CHILENA DE INFECTOLOGIA (2012)


The challenge of very rare childhood cancers in developed and developing countries Ferrari A.; Schneider D.T.; Bisogno G.; Orbach D.; Villarroel M.; Giron V.; Rodriguez-Galindo C.; Sorbara S.; Magni C.; Chiaravalli S.; Casanova M.; Cecchetto G.; Godzinski J.; Bien E.; Stachowicz-Stencel T.; Brennan B.; Reguerre Y.; Sultan I.; Brecht I.B. Review ISI SCOPUS EXPERT OPINION ON ORPHAN DRUGS (2017)