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César Aliro González Higuera

Profesor Asistente

Universidad San Sebastián

Puerto Montt, Chile

Básicamente mi interés científico ha estado centrado en el modelado de enfermedades neurodegenerativas mediante sistemas in vitro (cultivos bidimensionales y organoides cerebrales) utilizando células madres pluripotentes inducidas.

Biologia celular y molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Profesor de Histologia general e Histologia Bucodentaria Part Time

Universidad San Sebastian

Facultad de Ciencias de la Salud, Facultad de Odontologia

Valdivia, Chile

2004 - 2009
Profesor de Histologia general y Biologia Celular Part Time

Universidad San Sebastian

Medicina y Ciencias

Puerto Montt, Chile

2017 - 2018
Profesor de Biologia Celular Part Time

UNIVERSIDAD AUSTRAL DE CHILE

Medicina

Puerto Montt, Chile

2017 - 2017
Profesor de Histologia y Fisiologia Full Time

Universidad San Sebastian

Medicina y Ciencias

Puerto Montt, Chile

2018 - At present

Postdoctoral Fellow Full Time

University of Texas Health Science Center at Houston

Houston, Estados Unidos

2010 - 2017


Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer's Disease Armijo, Enrique; Edwards, George; Flores, Andrea; Vera, Jorge; Shahnawaz, Mohammad; Moda, Fabio; Gonzalez, Cesar; Sanhueza, Magdalena; Soto, Claudio Article ISI CELLS (2021)
Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic And Pathological Abnormalities In A Mouse Model Of Alzheimer’s Disease Gonzalez, Cesar A. Article CELLS (2021)
Modeling amyloid beta and tau pathology in human cerebral organoids Gonzalez C.; Armijo, E; Bravo-Alegria J.; Becerra-Calixto A.; Mays C.E.; Soto C. Article ISI SCOPUS MOLECULAR PSYCHIATRY (2018)
Neurospheres from neural stem/neural progenitor cells (NSPCs) of non-hydrocephalic HTx rats produce neurons, astrocytes and multiciliated ependyma: the cerebrospinal fluid of normal and hydrocephalic rats supports such a differentiation Henzi, R; Guerra, M; Vio, K; Gonzalez, C; Herrera, C; McAllister, P; Johanson C; Rodriguez, EM Article ISI SCOPUS CELL AND TISSUE RESEARCH (2018)
Increased susceptibility to A beta toxicity in neuronal cultures derived from familial Alzheimer's disease (PSEN1-A246E) induced pluripotent stem cells Armijo E.; Gonzalez C.; Shahnawaz M.; Flores A.; Davis B.; Soto C. Article ISI SCOPUS NEUROSCIENCE LETTERS (2017)
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism Mukherjee A.; Morales-Scheihing D.; Salvadores N.; Moreno-Gonzalez I.; Gonzalez C.; Taylor-Presse K.; Mendez N.; Shahnawaz M.; Gaber A.O.; Sabek O.M.; Fraga D.W.; Soto C. Article ISI SCOPUS JOURNAL OF EXPERIMENTAL MEDICINE (2017)
Cell Junction Pathology of Neural Stem Cells Is Associated With Ventricular Zone Disruption, Hydrocephalus, and Abnormal Neurogenesis Guerra MM; Henzi, R; Ortloff A.; Lichtin, N; Vio, K; Jimenez, AJ; Dominguez-Pinos, MD; González C; Jara, MC; Hinostroza, F; Rodríguez, S.; Jara M.; Ortega, E.; Guerra, F; Sival, DA; den Dunnen, WFA; Perez-Figares, JM; McAllister, JP; Johanson, CE; Rodriguez, EM Article ISI SCOPUS Journal of Neuropathology and Experimental Neurology (2015)
Understanding How the Subcommissural Organ and Other Periventricular Secretory Structures Contribute via the Cerebrospinal Fluid to Neurogenesis Guerra MM; González C; Caprile T.; Jara M.; Vio, K; Munoz, RI; Rodríguez, S.; Rodriguez, EM Article ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Disruption of CDH2/N-cadherin-based adherens junctions leads to apoptosis of ependymal cells and denudation of brain ventricular walls Oliver C.; GonzÃ¡lez C.A.; Alvial G.; Flores C.A.; RodrÃguez E.M.; BÃ¡tiz L.F. Article ISI SCOPUS Journal of Neuropathology and Experimental Neurology (2013)
A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus Rodriguez, Esteban M.; Guerra, María M; Vio, Karin.; González, César; Ortloff, Alexander; Bátiz, Luis F.; Rodriguez, Sara; Jara, María C; Muñoz, Rosa I; Ortega, Eduardo; Jaque, Jaime; Guerra, Francisco; Sival, Deborah A; Dunnen, Wilfred F. A. den; Jiménez, Antonio J; Domínguez-Pinos, María D; Pérez-Fígares, José M; McAllister, James P; Johanson, Conrad Article SCIELO SCOPUS BIOLOGICAL RESEARCH (2012)
A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus Rodriguez, EM; Guerra, MM; Vio, K; González C, Ortloff A.; Batiz LF, Rodríguez; S., Jara; MC, Munoz; RI, Ortega; E., Jaque; J., Guerra; F, Sival; DA, den Dunnen; WFA, Jimenez; AJ, Dominguez-Pinos; MD, Perez-Figares; JM, McAllister; JP, Johanson Article Biological Research (2012)
Disruption of the Neurogenic Niche in the Subventricular Zone of Postnatal Hydrocephalic hyh Mice Jesus Jimenez, Antonio; Manuel Garcia-Verdugo, Jose; Gonzalez, Cesar Aliro; Federico Batiz, Luis; Manuel Rodriguez-Perez, Luis; Paez, Patricia; Soriano-Navarro, Mario; Roales-Bujan, Ruth; Rivera, Patricia; Rodriguez, Sara; Martin Rodriguez, Esteban; Manuel Perez-Figares, Jose Article ISI JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)
Organ Culture of the Bovine Subcommissural Organ: Evidence for Synthesis and Release of the Secretory Material K Schöbitz 1, C Gonzalez, B Peruzzo, C R Yulis, E M Rodríguez Article MICROSCOPY RESEARCH AND TECHNIQUE (2001)
Organ culture of the bovine subcommissural organ=> Evidence for synthesis and release of the secretory material Schobitz, K; González C, Peruzzo; B, Yulis; CR, Rodriguez Article MICROSCOPY RESEARCH AND TECHNIQUE (2001)
The dispersed cell culture as model for functional studies of the subcommissural organ: preparation and characterization of the culture system Schoniger, S; Wehming, S; Gonzalez, C; Schobitz, K; Rodriguez, E; Oksche, A; Yulis, CR; Nurnberger, F Article ISI JOURNAL OF NEUROSCIENCE METHODS (2001)
Isograft and xenograft of the subcommissural organ into the lateral ventricle of the rat and the formation of Reissner's fiber Rodriguez, S; Navarrete, EH; Vio, K; Gonzalez, C; Schobitz, K; Rodriguez, EM Article ISI CELL AND TISSUE RESEARCH (1999)
The ependymocytes of the bovine subcommissural organ are functionally coupled through gap junctions Gonzalez, CA; Garces, G; Saez, JC; Schobitz, K; Rodriguez, EM Article ISI NEUROSCIENCE LETTERS (1999)


Production of a human cerebral organoid model of Alzheimer’s disease. The University of Texas Health Science Center at Houston (NNN) Proyecto 2015-2016 Postdoctorado