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J Daniel Carpio Paniagua

Director Ejecutivo-Profesor Asociado

Universidad Austral de Chile

Valdivia, Chile

Estudio de modelos experimentales y en biopsias renales de distintas enfermedades renales. Estudios de modelos experimentales de neuropatía en animales con diversas enfermedades metabólicas.

Nefropatología, University of North Carolina at Chapel Hill. Estados Unidos, 2001
Anatomía Patológica, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1997
Médico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1989
Licenciatura en Medicina, UNIVERSIDAD DE CHILE. Chile, 1986

Profesor Instructor Part Time

UNIVERSIDAD DE CHILE

Facultad de Medicina Norte

Santiago, Chile

1992 - 1994
Profesor Colaborador Externo Part Time

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACION

Pedagogía

Santiago, Chile

1992 - 1993
Profesor Auxiliar Part Time

UNIVERSIDAD AUSTRAL DE CHILE

Facultad de Medicina

Valdivia, Chile

2002 - 2004
Profesor Asociado Part Time

UNIVERSIDAD AUSTRAL DE CHILE

Facultad de Medicina

Valdivia, Chile

2004 - At present
Profesor Invitado Other

UNIVERSIDAD DE LA FRONTERA

Facultad de Medicina

Temuco, Chile

2002 - 2007

Médico General de Atención Primaria Part Time

Consultorio Alejandro del Río

Puente Alto-Santiago, Chile

1989 - 1990
Médico Legista Tanatólogo Part Time

Instituto Médico Legal de Santiago

Saniago, Chile

1991 - 1994
Instructor de Anatomía Normal Part Time

Universidad de Chile

Santiago, Chile

1992 - 1994
Médico becario Anatomía Patológica Full Time

Hospital Base Valdivia-Universidad Austral de Chile

Valdivia, Chile

1994 - 1997
Anátomo Patólogo Full Time

Servicio Salud Valdivia-Hospital Base Valdivia

Valdivia, Chile

1997 - At present
Profesor Auxiliar Part Time

Universidad Austral de Chile

Valdivia, Chile

2002 - 2004
Profesor Asociado Part Time

Universidad Austral de Chile

Valdivia, Chile

2004 - At present


Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis. Droguett, Alejandra; Valderrama, Graciela; Burgos, María E; Carpio, Daniel; Saka, Constanza; Egido, Jesús; Ruiz-Ortega, Marta; Mezzano, Sergio Article Scientific reports (2019)
Hepatocellular damage, proteinuria and autoimmunity: multisystemic disorder or coexistence of diseases? Herrera, P; Ruiz, A; Carpio, D; Ardiles, L Article ISI REVISTA MEDICA DE CHILE (2018)
Hepatocellular damage, proteinuria and autoimmunity=> multisystemic disorder or coexistence of diseases? Herrera, P; Ruiz, A; Carpio, D; Ardiles, L Article REVISTA MEDICA DE CHILE (2018)
Kidney injury in systemic lupus erythematosus=> lack of correlation between clinical and histological data Fulgeri, C; Carpio, JD; Ardiles, L Article NEFROLOGIA (2018)
Lyso-Gb3 activates Notch1 in human podocytes Sanchez-Nino, MD; Carpio, D; Sanz, AB; Ruiz-Ortega, M; Mezzano S.; Ortiz A. Article ISI SCOPUS Human Molecular Genetics (2015)
Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus Ezquer, F; Giraud-Billoud, M; Carpio, D; Cabezas F.; Conget P.; Ezquer, M Article ISI SCOPUS BioMed Research International (2015)
Pre-stimulation of the kallikrein system in cisplatin-induced acute renal injury: An approach to renoprotection Aburto A, Barria A, Cárdenas A, Carpio D, Burgos ME, Figueroa CD, Ardiles LG Article Toxicology and Applied Pharmacology (2014)
Translational study of the Notch pathway in hypertensive nephropathy Lavoz C.; Droguett, A; Burgos, ME; Carpio, DJ; Ortiz A.; Egido J.; Mezzano S.; Ruiz-Ortega, M Article Nefrologia (2014)
Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice Droguett A.; Krall, P; BURGOS, ME; Valderrama, G; Carpio, D; Ardiles L.; Rodriguez-Diez, R; Kerr, B.; Walz, K; Ruiz-Ortega, M; Egido, J; Mezzano S. Article ISI SCOPUS PLOS ONE (2014)
Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney Gatica, R; Bertinat R.; Silva P.; Carpio, D; Ramirez, MJ; Slebe, JC; Martin, RS; Nualart, F.; Campistol, JM; Caelles, C; Yanez, AJ Article ISI SCOPUS Journal of Cellular Biochemistry (2013)
Antihypertensive and renoprotective effect of the kinin pathway activated by potassium in a model of salt sensitivity following overload proteinuria Ardiles L.; Cardenas, A; BURGOS, ME; Droguett A.; Ehrenfeld, P; Carpio, D; Mezzano S.; Figueroa, CD Article ISI SCOPUS American Journal of Physiology - Renal Physiology (2013)
Podocyte-Specific Overexpression of Wild Type or Mutant Trpc6 in Mice Is Sufficient to Cause Glomerular Disease Krall, P; Canales, CP; Kairath P., Carmona-Mora; P, Molina; J., Carpio; JD, Ruiz; P, Mezzano; SA, Li; J, Wei C.; Reiser, J; Young, JI; Walz, K Article PLoS ONE (2010)
[Bariatric surgery in patients with focal segmental glomerulosclerosis secondary to obesity]. Ramírez, J; Carpio, D; Mezzano, S; Mukdsi, J; Ardiles, L Article NefrologÃa : publicaciÃ³n oficial de la Sociedad EspaÃ±ola Nefrologia (2009)
Bariatric surgery in patients with focal segmental glomerulosclerosis secondary to obesity ramirez, j; Carpio, D; Mezzano S.; Mukdsi, J; Ardiles L. Article ISI NEFROLOGIA (2009)
Endovenous Administration of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells Prevents Renal Failure in Diabetic Mice Ezquer, F; Ezquer, M; Simon, V; Pardo F.; Yañez A.; Carpio, D; Conget P. Article ISI SCOPUS BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2009)
Vanishing prostate cancer. Clinical presentation and histological review Sepulveda, LE; Corti D; Foneron A.; Troncoso L.; Gil, G; Carpio, D; Canoles, R; Hornig, A; Valdevenito, G. Article ISI ACTAS UROLOGICAS ESPANOLAS (2009)
Gremlin: A novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy Carvajal, G; Droguett A.; BURGOS, ME; Aros, C.; Ardiles L.; Flores C.; Carpio, D; Ruiz-Ortega, M; Egido, J; Mezzano S. Article ISI SCOPUS TRANSPLANTATION PROCEEDINGS (2008)
Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type I diabetic mice Ezquer FE; Ezquer ME; Parrau DB; Carpio, D; Yanez, AJ; Conget PA Article ISI SCOPUS BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2008)
Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis Mezzano S.; Droguett A.; BURGOS, ME; Aros, C.; Ardiles L.; Flores C.; Carpio, D; Carvajal, G; Ruiz-Ortega, M; Egido, J Article ISI SCOPUS NEPHROLOGY DIALYSIS TRANSPLANTATION (2007)
Renal angiotensin II up-regulation and myofibroblast activation in human membranous nephropathy Mezzano, SA; Aros, CA; Droguett, A; Burgos, ME; Ardiles, LG; Flores, CA; Carpio, D; Vio, CP; Ruiz-Ortega, M; Egido, J Article KIDNEY INTERNATIONAL (2003)
Renal angiotensin II up-regulation and myofibroblast activation in human membranous nephropathy Mezzano, SA; Aros, CA; Droguett A.; BURGOS, ME; Ardiles, LG; Flores, CA; Carpio, D; Vio, CP; Ruiz-Ortega, M; Egido, J Article ISI KIDNEY INTERNATIONAL (2003)
Thyroid lymphoma. A case report. Perez, JA; Ramirez R.; Carpio, D; Carrasco C.; Pérez, A. Article ISI REVISTA MEDICA DE CHILE (2000)


Studies on the reversion of Kidney damage generated by diabetes Yañez A.; Bertinat R.; Jaramillo, K.; Perez M.; Carpio, D; Slebe, JC Abstract ISI FEBS JOURNAL (2015)
TUBULAR OVEREXPRESSION OF GREMLIN IN TRANSGENIC MICE AGGRAVATES RENAL DAMAGE IN DIABETIC NEPHROPATHY Droguett A.; Marchant, V.; Sánchez Y.; Valderrama, G; BURGOS, ME; Carpio, D; Kerr, B.; Ruiz-Ortega, M; Ejido, J; Mezzano S. Abstract ISI NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)
Sodium tungstate attenuates fibrosis through suppression of transforming growth factor-beta 1/Smad3 in diabetic nephropathy Jaramillo, K.; Mansilla, D.; Cumian, A; Perez M.; Carpio, D; Burgos, R; Yañez A. Abstract ISI FEBS JOURNAL (2013)
Sodium tungstate decreases the progression of renal damage through inhibition of fibrosis in diabetic rat kidney Silva P.; Jaramillo, K.; Carpio, D; Perez M.; Yañez A. Abstract ISI FEBS JOURNAL (2013)
Sodium tungstate modulates inflammation of diabetic nephropathy Jaramillo, K.; Cumian, A; Mansilla, D.; Silva P.; Perez M.; Carpio, D; Burgos, R; Yañez A. Abstract ISI FEBS JOURNAL (2012)
Expression of FPBase and PEPCK during the progression of tubular damage in diabetic nephropathy Yañez A.; Bertinat R.; Kairath P.; Jaramillo, K.; Soto M.; Carpio, D; Martin, RS; Slebe, JC Abstract ISI FEBS JOURNAL (2011)
Expression of glyconeogenic and gluconeogenic enzymes in kidney of long-term induced diabetic rats. Yanez, AJ; Westermeier, F; Salas, M; Gatica, R; Carpio, D; Concha, II; Guinovart, J; Slebe, JC Abstract ISI FEBS JOURNAL (2007)
Renal angiotensin II upregulation and myofibroblast activation in human membranous nephropathy. Mezzano, SA; Aros, C.; Droguett A.; Burgos, EM; Ardiles L.; Flores C.; Carpio, D; Vio, CP; Ruiz-Ortega, M; Egido, J Abstract ISI JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)


Sistema de Ultramicrotomía para Microscopia Electrónica de Transmisión, Barrido y Microanálisis para Cs Biológicas, de Materiales, Sociales y Antropológicas J. Daniel Carpio Proyecto (2017)
Gremlin: a profibrotic and proinflammatory mediator involved in diabetic nephropathy Mezzano, Sergio Agustin; Carpio, JD; Droguett, Maria Alejandra; Kerr, Bredford; Lavoz, Carolina; Krall O, Paola Proyecto (2016)
EVALUATION OF THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELL -ACELULAR DERIVATE- ON DRUG INDUCED STEATOSIS, IN A MODEL OF NORMAL AND IMPAIRED LIVER REGENERATION CAPACITY FONDECYT (1150589) Proyecto 2015-2018 Coinvestigador(a)
Desarrollo de un Kit de Diagnóstico temprano para la Nefropatía Diabética, no invasivo y que permita diferenciar la progresividad de esta enfermedad mediante la utilización de Exosomas Urinarios Yañez, Alejandro; Carpio J.D.; San Martin, Rody Proyecto (2013)
SODIUM TUNGSTATE A NEW TREATMENT FOR DIABETIC NEPHROPATHY=> EFFECT OF THIS DRUG IN INFLAMMATION, OXIDATIVE STRESS AND FIBROSIS DURING THE PROGRESSION OF THIS PATHOLOGY. FONDECYT (1131033) Proyecto 2013-2017 Coinvestigador(a)
GREMLIN=> A NOVEL RENAL PRO FIBROTIC BIOMARKER ? ITS ROLE IN HUMAN AND EXPERIMENTAL RENAL PATHOLOGY. FONDECYT (1120480) Proyecto 2012-2016 Coinvestigador(a)
THE ETIOLOGY OF DIABETES AND/OR THE STAGE OF DIABETIC NEPHROPATHY MODIFY THE RENOPROTECTIVE EFFECT OF DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS? FONDECYT (1120133) Proyecto 2012-2015 Coinvestigador(a)
REGULATION OF KIDNEY GLUCOSE AND GLYCOGEN METABOLISM BY INSULIN AND TUNGSTATE IN LONG TERM DIABETIC AND CONTROL RATS. FONDECYT (1090694) Proyecto 2009-2013 Coinvestigador(a)
FIBROSIS RENAL=> ESTUDIO DE NUEVOS MEDIADORES DE TRANSDIFERENCICION EPITELIO MESENQUIMAL (TEM) FONDECYT (1080083) Proyecto 2008-2012 Coinvestigador(a)
ROL DEL SISTEMA CALICREINA-CININAS EN LA PREVENCION DE LA FIBROSIS RENAL FONDECYT (1070245) Proyecto 2007-2010 Coinvestigador(a)
Renal Pathology center of Excellence Grant Carpio, Juan Daniel Proyecto (2006)
"RELACION DEL SINDROME DIABETICO CON LA EXPRESION Y LOCALIZACION CELULAR DE GLICOGENO SINTASA, FOSFOENOLPIRUVATO CARBOXIQUINASA Y FRUCTOSA-1, 6-BISFOSTASA, ENZIMAS CLAVES EN LA HOMEOSTASIS DE LA GLUCOSA" FONDECYT (1051057) Proyecto 2005-2008 Coinvestigador(a)
ESTUDIO DE LA TRANSDIFERENCIACION TUBULO-EPITELIAL EN ENFERMEDAD RENAL PROGRESIVA. ROL DE LA PROTEINURIA Y ANGIOTENSINA II FONDECYT (1040163) Proyecto 2004-2008 Coinvestigador(a)