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Mauricio Bedoya Tabares

Profesor Auxiliar

Universidad Católica del Maule

Talca, Chile

Química computacional aplicada al estudio de canales iónicos y al diseño racional de fármacos.

Pharmaceutical Chemistry, UNIVERSIDAD DE ANTIOQUIA. Colombia, 2015
PhD in Applied Sciences, UNIVERSIDAD DE TALCA. Chile, 2020

Profesor Auxiliar Full Time

UNIVERSIDAD CATOLICA DEL MAULE

CIEAM

Talca, Chile

2022 - At present

Químico Farmacéutico Full Time

Proinsalud S.A

Pasto, Colombia

2015 - 2016

Cotutor de tesis de Doctorado:

1. Estudio de la selectividad del sustrato en simportadores azúcar/protón pertenecientes a árboles frutales de peral Pyrus communis (PcSTP13) y manzano Malus domestica (MdSTP13). Universidad de Talca. 2026
2. Electrophysiological and computational study of TREK channel modulation and activation by charged molecules. Universidad de Talca. 2026
3. Rutas de acceso extracelular en el canal OsHKT2;2: identificación y caracterización de rutas clave para la entrada de Na+ y K+ hacia el filtro de selectividad. Universidad de Talca. 2026

Tutor de tesis de Pregrado:

1. Estudio de la interacción entre proteínas asociadas a la respuesta inflamatoria de la psoriasis y compuestos de Aloe vera L. Universidad Católica del Maule. 2025
2. Modelado molecular y simulación computacional de biopolímeros para la adsorción de contaminantes farmacéuticos en el agua. Universidad Católica del Maule. 2026

Co-tutor de tesis de Pregrado:

1. Análisis computacional de la interacción entre estatinas y la isoenzima I de la adenilato quinasa humana (hAK1): evaluación de los sitios alostéricos y estimación de la afinidad hAK1-estatina. Universidad de Talca. 2023
2. Estudio computacional de las estatinas que interactúan con la enzima reductasa HMG-CoA humana: comprensión de las interacciones estructurales para su diseño racional de fármacos. Universidad de Talca. 2023
3. Perfil fitoquímico y análisis de acoplamiento in silico de extractos de alperujo de oliva como inhibidores de la acetilcolinesterasa y la butirilcolinesterasa en la enfermedad de Alzheimer. Universidad Católica del Maule. 2025


A pathogenic mutation in α-SNAP impairs membrane lipid binding by concealing a critical hydrophobic loop Mendez-Ruette, Maxs; Bedoya, Mauricio; Hinrichsen, Bryan; Henzi, Roberto; Munoz-Gutierrez, Camila; Parga, Cristian; Munoz, Camilo; Marquez, Guillermo; Munoz, Rosa Iris; Sandoval, Soledad; et al. Article ISI COMMUNICATIONS BIOLOGY (2026)
Computational Estimation of Residence Time on Roniciclib and Its Derivatives against CDK2: Extending the Use of Classical and Enhanced Molecular Dynamics Simulations Bravo-Moraga, Felipe; Bedoya, Mauricio; Zinovjev, Kirill; Tunon, Inaki; Alzate-Morales, Jans Article ISI ACS Omega (2025)
From Infinite Helices to β Sheets: Structural Insights from Electronic Structure Calculations Adasme-Carreno, F; Munoz-Gutierrez, C; Bedoya M.; Ireta J. Article ISI Journal of Chemical Theory and Computation (2025)
Main methods and tools for peptide development based on protein-protein interactions (PPIs) Baeza, Javiera; Bedoya, Mauricio; Cruz, Pablo; Ojeda, Paola; Adasme-Carreño, Francisco; Cerda, Oscar; Gonzalez, Wendy Article ISI Biochemical and Biophysical Research Communications (2025)
Moltiverse: Molecular Conformer Generation Using Enhanced Sampling Methods Bedoya M.; Adasme-Carreno, F; Peña-Martínez, PA; Munoz-Gutierrez, C; Peña-Tejo, L; Montesinos, JCEM; Hernandez-Rodriguez E.W.; González, W; Martínez, L; Alzate-Morales J. Article ISI Journal of Chemical Information and Modeling (2025)
Rational design, synthesis, and evaluation of novel polypharmacological compounds targeting NaV1.5, KV1.5, and K2P channels for atrial fibrillation Camargo-Ayala, Lorena; Bedoya, Mauricio; Dasi, Albert; Prueser, Merten; Schuette, Sven; Prent-Penaloza, Luis; Adasme-Carreño, Francisco; Kiper, Aytug K.; Rinne, Susanne; Camargo-Ayala, Paola Andrea; et al. Article ISI Journal of Biological Chemistry (2025)
Crystal structure, quantum chemical insights, and molecular docking studies of Naryl-2-(N-disubstituted) acetamide compounds: potential inhibitors for neurodegenerative enzymes Osorio, Edison Article ISI (2024)
Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2 Neelsen, Lea C.; Riel, Elena B.; Rinne, Susanne; Schmid, Freya-Rebecca; Juers, Bjoern C.; Bedoya, Mauricio; Langer, Jan P.; Eymsh, Bisher; Kiper, Aytug K.; Cordeiro, Soenke; et al. Article ISI (2024)
Understanding the Differences of Danusertib's Residence Time in Aurora Kinases A/B: Dissociation Paths and Key Residues Identified using Conventional and Enhanced Molecular Dynamics Simulations Bravo-Moraga, Felipe; Bedoya, Mauricio; Vergara-Jaque, Ariela; Alzate-Morales, Jans Article ISI (2024)
Iridoid esters from Valeriana pavonii Poepp. & Endl. as GABAA modulators: Structural insights in their binding mode and structure-activity relationship Giraldo, Sara E.; Bazzocchi, Isabel L.; Marder, Mariel; Vergel, Nadezdha E.; Guerrero, Mario F. Article ISI SCOPUS Journal of Pharmacy and Pharmacognosy Research (2023)
Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability Vergara, Fernando; Mazola, Yuliet; Bustos, Daniel; Cikutovic, Rocio; Teresa Ramirez-Apan, M.; Cerda, Oscar; Lopez-Collazo, Eduardo Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2022)
Identification of a critical binding site for local anaesthetics in the side pockets of K(v)1 channels Stalke, Sarah; Marzian, Stefanie; de la Cruz, Alicia; Peraza, Diego A.; Vera-Zambrano, Alba; Marquez Montesinos, Jose C. E.; Arevalo Ramos, Barbara A. Article ISI SCOPUS British Journal of Pharmacology (2021)
Molecular Pharmacology of K2P Potassium Channels Article CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2021)
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels Bustos, Daniel Article ISI SCOPUS International journal of molecular sciences (2020)
Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-PoreDomain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site Wiedmann F, Kiper AK, Bedoya M, Ratte A, Rinné S, Kraft M, Waibel M, Anad P, Wenzel W, González W, Katus HA, Decher N, Schmidt C Article SCOPUS Cellular Physiology and Biochemistry (2019)
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
TASK Channels Pharmacology: New Challenges in Drug Design Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2019)
The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels Rinné, S; Kiper A.K.; Bedoya M.; Aser, D; Gensler, I; Netter, MF; Stansfeld, PJ; Decher N Article ISI SCOPUS ELIFE (2019)
A NEW ENHANCED SORBITOL: CALCIUM DIPHOSPHATE COMPOSITE AS A DIRECT COMPRESSION EXCIPIENT: A COMPARATIVE STUDY Echeverri, Edward; Rojas, Jhon Article INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2016)


Current Trends in the Production of Cellulose Nanoparticles and Nanocomposites for Biomedical Applications Rojas, John; Ciro, Yhors; Ornaghi Jr., Heitor Luiz BookSection (2015)