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Julio Enrique Brito Richards

DIRECTOR

UNIVERSIDAD ARTURO PRAT- INSTITUTO DE ESTUDIOS DE LA SALUD

IQUIQUE, Chile

BIOTECHNOLOGY; BIOMEDICINE; MOLECULAR AND CELL BIOLOGY; PUBLIC HEALTH; CHRONIC INTERMITENT HYPOXIA; HIGH ALTITUDE

MÉDICO CIRUJANO, UNIVERSIDAD DE CHILE. Chile, 1975
SALUD PÚBLICA, UNIVERSIDAD AUTÓNOMA DE MADRID. España, 2003
ESPECIALISTA EN CIRUJÍA TORÁCICA, UNIVERSIDAD DE TORONTO. Canada, 1986
Bioetica , UNIVERSIDAD DE CHILE. Chile, 2008

DIRECTOR Other

UNIVERSIDAD ARTURO PRAT

INSTITUTO DE ESTUDIOS DE LA SALUD

IQUIQUE, Chile

1996 - At present
PROFESOR TITULAR Other

UNIVERSIDAD ARTURO PRAT

INSTITUTO DE ESTUDIOS DE LA SALUD

IQUIQUE, Chile

1997 - At present

DIRECTOR Other

INSTITUTO DE ESTUDIOS DE LA SALUD

IQUIQUE, Chile

1996 - At present
Jefe del Servicio de Cirugía Other

Hospital “Dr. E. Torres G

IQUIQUE, Chile

2001 - 2009
Jefe de Área Biológica del Proyecto CONICYT Other

Gobierno Regional “Centro de Investigación del Hombre en el Desierto”

IQUIQUE, Chile

2001 - At present
Medico - Interno Part Time

Hospital FACH

IQUIQUE, Chile

1973 - 1975
Medico General Diferenciado en Cirugía Other

Hospital Iquique

IQUIQUE, Chile

1975 - 1980
Oficial de Sanidad Part Time

Fuerza Aérea de Chile

IQUIQUE, Chile

1976 - 1998
DIRECTOR Full Time

Hospital Iquique

IQUIQUE, Chile

1994 - 2000


Involvement of overweight and lipid metabolism in the development of pulmonary hypertension under conditions of chronic intermittent hypoxia Siques, Patricia; Brito, Julio; Ordenes, Stefany; Pena, Eduardo Article ISI PULMONARY CIRCULATION (2020)
Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension Brito, Julio; Siques, Patricia; Pena, Eduardo Article ISI PULMONARY CIRCULATION (2020)
Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation Flores, Karen; Siques, Patricia; Brito, Julio; Ordenes, Stefany; Arriaza, Karem; Pena, E.; Leon-Velarde, Fabiola; Lopez, Rosario; Lopez de Pablo, Angel L.; Arribas, Silvia Article ISI FRONTIERS IN PHYSIOLOGY (2020)
Nox2 Upregulation and p38 alpha MAPK Activation in Right Ventricular Hypertrophy of Rats Exposed to Long-Term Chronic Intermittent Hypobaric Hypoxia Pena, Eduardo; Siques, Patricia; Brito, Julio; Arribas, Silvia M.; Boeger, Rainer; Hannemann, Juliane; Leon-Velarde, Fabiola; Carmen Gonzalez, M.; Rosario Lopez, M.; Lopez de Pablo, Angel Luis Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Oxidative Stress, Kinase Activity and Inflammatory Implications in Right Ventricular Hypertrophy and Heart Failure under Hypobaric Hypoxia Pena, Eduardo; Brito, Julio; El Alam, Samia; Siques, Patricia Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Pre-Analytical and Clinical Validation of a Dried Blood Spot Assay for Asymmetric Dimethylarginine and L-Arginine Hannemann, Juliane; Roskam, Thore I.; Eilermann, Ina; Siques, Patricia; Brito, Julio; Boeger, Rainer Article ISI Journal of Clinical Medicine (2020)
Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude Siques P.; Brito J.; Schwedhelm E.; Pena E.; LeÃ³n-Velarde F.; De La Cruz J.J.; BÃ¶ger R.H.; Hannemann J. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats SIQUES, PATRICIA; BRITO, JULIO; Flores, Karen; Ordenes, Stefany; Arriaza, Karem; PENA, EDUARDO; León-Velarde, Fabiola; López de Pablo, Ángel L.; Gonzalez, M. C.; Arribas, Silvia Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Long-Term Intermittent Work at High Altitude: Right Heart Functional and Morphological Status and Associated Cardiometabolic Factors BRITO, JULIO; SIQUES, PATRICIA; Lopez, Rosario; Romero, Raul; Leon-Velarde, Fabiola; Flores, Karen; Lueneburg, Nicole; Hannemann, Juliane; Boeger, Rainer H. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults Luneburg, N; Siques, P; Brito, J; De La Cruz, JJ; Leon-Velarde, F; Hannemann, J; Ibanez, C; Boger, RH Article ISI HIGH ALTITUDE MEDICINE BIOLOGY (2017)
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension? Lüneburg N.; Siques P.; Brito J.; Arriaza K.; Pena E.; Klose H.; Leon-Velarde F.; Böger R.H. Article WOS-ESCI SCOPUS Pulmonary Medicine (2016)
Adventitial Alterations Are the Main Features in Pulmonary Artery Remodeling due to Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Brito, J; Siques P.; Arribas, SM; De Pablo, ALL; Gonzalez, MC; Naveas, N; Arriaza, K; Flores, K.; Leon-Velarde, F; Pulido, R; Ordenes, S; Lopez, MR Article ISI SCOPUS BioMed Research International (2015)
Nitric Oxide and Superoxide Anion Balance in Rats Exposed to Chronic and Long Term Intermittent Hypoxia Siques P.; De Pablo, ALL; Brito, J; Arribas, SM; Flores, K.; Arriaza, K; Naveas, N; Gonzalez, MC; Hoorntje, A; Leon-Velarde, F; Lopez, MR Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2014)
Plasma and Liver Lipid Profiles in Rats Exposed to Chronic Hypobaric Hypoxia: Changes in Metabolic Pathways Siques P.; Brito, J; Naveas, N; Pulido, R; De La Cruz, JJ; Mamani, M.; Leon-Velarde, F Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2014)
Relation of Breast Cancer and Malathion Aerial Spraying in Arica, Chile Cabello, Gertrudis; Valenzuela-Estrada, Mario; SIQUES, PATRICIA; BRITO, JULIO; Parra, Eduardo; Valdivia, Ursula; Lavin, Claudia; Manríquez, Alejandra; Ortega, Alejandro Article ISI SCIELO SCOPUS International Journal of Morphology (2013)
Blood Pressure Responses in Young Adults First Exposed to High Altitude for 12 Months at 3550 m Siques P.; Brito, J; Banegas, JR; Leon-Velarde, F; de la Cruz-Troca, JJ; López, V.; Naveas, N; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2009)
Upregulation of Arginase Expression and Activity in Hypertensive Rats Exposed to Chronic Intermittent Hypobaric Hypoxia López, V.; Siques P.; Brito, J; Vallejos C.; Naveas, N; Carvallo C.; Leon-Velarde, F; Carvajal N. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2009)
Varying exposure regimes to long term chronic intermittent hypoxia exert different outcomes and morphological effects on Wistar rats at 4600 m Brito, J; Siques P.; Barlaro, T; López, V.; Leon-Velarde, F; De La Cruz J.J.; Herruzo R. Article SCOPUS TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY (2008)
Chronic intermittent hypoxia at high altitude exposure for over 12 years: Assessment of hematological, cardiovascular, and renal effects Brito, J; Siques P.; Leon-Velarde, F; De La Cruz, JJ; López, V.; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2007)
Hematological and lipid profile changes in sea-level natives after exposure to 3550-m altitude for 8 months Siques P.; Brito, J; Leon-Velarde, F; Barrios, L; De La Cruz, JJ; López, V.; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2007)
Prevalence and characteristics of smoking in primary healthcare workers in Iquique, Chile Siques P.; Brito, J; Munoz, C; Pasten, P; Zavala P.; Vergara, J Article ISI SCOPUS Public Health (2006)
Sustained acclimatization in Chilean mine workers subjected to chronic intermittent hypoxia Farias, JG; Osorio J.; Soto G.; Brito, J; Siques P.; Reyes JG. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2006)
Time course of cardiovascular and hematological responses in rats exposed to chronic intermittent hypobaric hypoxia (4600 m) Siques P.; Brito, J; Leon-Velarde, F; Barrios, L; De La Cruz, JJ; López, V.; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2006)
Hydroformylation and Isomerization of Alkenes Catalyzed by [Rh(COD)(Amine)2]PF6 Complexes Immobilized on poly(4-vinylpyridine) Under CO/H2O Conditions Pardey, AJ; Brito, J; Rivas, AB; Ortega, MC; Longo C.; Baricelli, P; Lujano, E; Yañez M.; Zúñiga C.; Lopez R.; Moya, SA Article ISI SCIELO Journal of the Chilean Chemical Society (2003)


Alterations in pulmonary artery NO and O2-center dot balance associates with remodeling in rats exposed to chronic and long term intermittent hypoxia Arribas, SM; Siques P.; De Pablo, ALL; Brito, J; Flores, K.; Arriaza, K; Naveas, N; Gonzalez, MC; Leon-Velarde, F; Lopez, MR Abstract ISI CARDIOVASCULAR RESEARCH (2014)
Chronic Hypobaric Hypoxia and Chronic Intermittent Hypobaric Hypoxia in Rats Leads to a Mismatch in the ADMA-NO Pathway Lueneburg, N; Siques P.; Brito, J; Arriaza, K; Peña E; Klose H. Abstract ISI CIRCULATION (2013)
Increased Dimethylarginines in Rats and Humans Exposed to Chronic Intermittent Hypobaric Hypoxia Luneburg, N; López, V.; Schwedhelm E.; Brito, J; Boger, RH; Siques P. Abstract ISI CIRCULATION (2010)
Endocrine changes in the hypophysis-gonad axis induced by hypobaric hypoxia in male rats Farias, JG; Bustos-Obregon, E; Soto G.; Brito, J; Reyes JG. Abstract ISI PLACENTA (2006)


Reactive Oxygen Species (ROS) at High Altitude (Hypobaric Hypoxia) on the Cardiovascular System SIQUES, PATRICIA; BRITO, JULIO; PENA, EDUARDO; FILIP, CRISTINA; ALBU, ELENA BookSection (2018)


VIVIR Y TRABAJAR EN ALTURA Osorio, Jorge; SIQUÉS, PATRICIA; BRITO, JULIO; OSORIO, JORGE; SIQUÉS, PATRICIA; BRITO, JULIO BookWhole (2014)


Reactive Oxygen Species and Pulmonary Vasculature During Hypobaric Hypoxia SIQUES, PATRICIA; BRITO, JULIO; PENA, EDUARDO; SENA, CRISTINA JournalWhole (2018)


Quality of life in the Aymara population of Chile Siques, R; Brito, J; Lopez R. Letter ISI SCOPUS Revista Clinica Espanola (2011)


PROYECTO MEDICINA DE ALTURA: VALIDACION DE BIOMARCADORES Y DE MITIGADORES Siques Lee P.; Brito, Julio E Proyecto (2020)
HABITAT: TARAPACA SE PROYECTA EN INVESTIGACIÓN DE AMBIENTES EXTREMOS Arriaza, Karem; Brito, Julio E Proyecto (2017)
INICIATIVA CHILENO-ALEMANA DE INVESTIGACIÓN DE LA HIPOXIA PULMONAR Y LAS ENFERMEDADES ASOCIADAS (DECIPHER) Siques Lee P.; Brito, Julio E Proyecto (2017)
POYECTO DE GENERACION DE NUEVOS PRODUCTOS PARA POTENCIAR EL CAPITAL HUMANO Y TECNOLÓGICO EN EL DESARROLLO INNOVATIVO DE LA MEDICINA DE ALTURA EN LA REGIÓN DE TARAPACÁ Brito, Julio E; Siques Lee P. Proyecto (2016)
PROYECTO DE MEDICINA Y BIOLOGIA DE ALTURA PARA LA REGION DE TARAPACA ETAPA II Siques Lee P.; Brito, Julio E Proyecto (2015)
Determinación de criterios de aclimatación en una corte de sujetos jóvenes, expuestos a un sistema de turnos en hipoxia crónica intermitente a gran altura Patricia Siques; brito, julio Proyecto (2010)
Estudio comparativo de los indicadores epidemiológicos y de los mecanismos implicados mediante un modelo experimental, en la hipertensión pulmonar de altura en la población chilena de etnia aymara y mineros Brito, Julio; Brito, Julio Proyecto (2010)
Equipamiento en una línea de Investigación en Hipoxia Hipobárica” BRITO, JULIO Proyecto (2009)
ALTMEDFIS Red Iberoamericana de Medicina y Fisiología de Altura Brito, Julio E; Siques Lee P. Proyecto (2003)
Centro Regional de Investigación del Hombre en el Desierto, Calogero Santoro; BRITO, JULIO Proyecto (2002)
Tolerancia Aclimatación del Trabajo Minero y Otros a la Exposición Intermitente a la Altura”, código D-97I1068 Director; Patricia Siques Proyecto (1997)


Obesity as a Conditioning Factor for High-Altitude Diseases San Martin R.; Brito J.; Siques P.; León-Velarde F. Review ISI SCOPUS OBESITY FACTS (2017)