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Patricia Winnie Siques Lee

Profesor titular

UNIVERSIDAD ARTURO PRAT, INSTITUTO DE ESTUDIOS DE LA SALUD

Iquique, Chile

Public Health; Cronic Intermitent Hypoxia; High Altitude; Biotechnology

Matrona, UNIVERSIDAD DE CHILE. Chile, 1982
Licenciada en Ciencias Biológicas y de la Salud, Universidad Arturo Prat. Chile, 1999
Doctora en Salud pública y medicina preventiva, Universidad Autónoma de Madrid. España, 2007
Bioetica , UNIVERSIDAD DE CHILE. Chile, 2008

Profesor Titular Full Time

UNIVERSIDAD ARTURO PRAT

Iquique, Chile

2008 - At present

Matrona, Unidad de Ginecología Other

Ministerio de Salud, Servicio de Salud

Iquique, Chile

1982 - 1984
matrona Full Time

Consultorio médico Instituto Profesional Iquique

Iquique, Chile

1984 - 1984
Matrona, encargada de policlínico embarazada adolescente Full Time

Corporación municipal de desarrollo social de Iquique

Iquique, Chile

1984 - 1988
Asistencia de pacientes de emergencia y electivos Other

Hospital dr. Ernesto Torres y Clínica ex Schweitzer

Iquique, Chile

1984 - 2004
encargada del área de epidemiología Part Time

Universidad Arturo Prat/Proyecto FONDEF

Iquique, Chile

1997 - 2000
Encargada del área de investigación en el Instituto de Estudios de la Salud Full Time

Universidad Arturo Prat

Iquique, Chile

1999 - At present

miembro benemerito

UNIVERSIDAD ARTURO PRAT

Chile, 2017

Profesor Benemerito


Involvement of overweight and lipid metabolism in the development of pulmonary hypertension under conditions of chronic intermittent hypoxia Article ISI PULMONARY CIRCULATION (2020)
Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension Article ISI PULMONARY CIRCULATION (2020)
Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation Article ISI FRONTIERS IN PHYSIOLOGY (2020)
Nox2 Upregulation and p38 alpha MAPK Activation in Right Ventricular Hypertrophy of Rats Exposed to Long-Term Chronic Intermittent Hypobaric Hypoxia Arribas, Silvia M.; Boeger, Rainer; Carmen Gonzalez, M.; Rosario Lopez, M.; Lopez de Pablo, Angel Luis Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Oxidative Stress, Kinase Activity and Inflammatory Implications in Right Ventricular Hypertrophy and Heart Failure under Hypobaric Hypoxia El Alam, Samia Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Pre-Analytical and Clinical Validation of a Dried Blood Spot Assay for Asymmetric Dimethylarginine and L-Arginine Article ISI JOURNAL OF CLINICAL MEDICINE (2020)
Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude Siques P.; Schwedhelm E.; LeÃ³n-Velarde F.; BÃ¶ger R.H. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats SIQUES, PATRICIA; BRITO, JULIO; Ordenes, Stefany; Arriaza, Karem; PENA, EDUARDO; López de Pablo, Ángel L.; Arribas, Silvia Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Long-Term Intermittent Work at High Altitude: Right Heart Functional and Morphological Status and Associated Cardiometabolic Factors BRITO, JULIO; SIQUES, PATRICIA; Lopez, Rosario; Romero, Raul; Flores, Karen; Lueneburg, Nicole; Hannemann, Juliane; Boeger, Rainer H. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults Hannemann, J Article ISI HIGH ALTITUDE MEDICINE BIOLOGY (2017)
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension? Article WOS-ESCI SCOPUS Pulmonary Medicine (2016)
Adventitial Alterations Are the Main Features in Pulmonary Artery Remodeling due to Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Brito, J; Siques P.; Arribas, SM; De Pablo, ALL; Gonzalez, MC; Naveas, N; Arriaza K; Flores, K.; Leon-Velarde, F; Pulido, R; et al. Article ISI SCOPUS BioMed Research International (2015)
Nitric Oxide and Superoxide Anion Balance in Rats Exposed to Chronic and Long Term Intermittent Hypoxia Siques P.; De Pablo, ALL; Brito, J; Arribas, SM; Flores, K.; Arriaza K; Naveas, N; Gonzalez, MC; Hoorntje, A; Leon-Velarde, F; et al. Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2014)
Plasma and Liver Lipid Profiles in Rats Exposed to Chronic Hypobaric Hypoxia: Changes in Metabolic Pathways Siques P.; Brito, J; Naveas, N; Pulido, R; De La Cruz, JJ; Mamani, M.; Leon-Velarde, F Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2014)
Relation of Breast Cancer and Malathion Aerial Spraying in Arica, Chile Cabello, Gertrudis; Valenzuela-Estrada, Mario; SIQUES, PATRICIA; BRITO, JULIO; Parra, Eduardo; Valdivia, Ursula; Lavin, Claudia; Manríquez, Alejandra; Ortega, Alejandro Article ISI SCIELO SCOPUS International Journal of Morphology (2013)
Blood Pressure Responses in Young Adults First Exposed to High Altitude for 12 Months at 3550 m Siques P.; Brito, J; Banegas, JR; Leon-Velarde, F; de la Cruz-Troca, JJ; López, V.; Naveas, N; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2009)
Upregulation of Arginase Expression and Activity in Hypertensive Rats Exposed to Chronic Intermittent Hypobaric Hypoxia López, V.; Siques P.; Brito, J; Vallejos C.; Naveas, N; Carvallo C.; Leon-Velarde, F; Carvajal N. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2009)
Varying exposure regimes to long term chronic intermittent hypoxia exert different outcomes and morphological effects on Wistar rats at 4600 m Brito, J; Siques P.; Barlaro, T; López, V.; Leon-Velarde, F; Herruzo R. Article SCOPUS TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY (2008)
Chronic intermittent hypoxia at high altitude exposure for over 12 years: Assessment of hematological, cardiovascular, and renal effects Brito, J; Siques P.; Leon-Velarde, F; De La Cruz, JJ; López, V.; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2007)
Hematological and lipid profile changes in sea-level natives after exposure to 3550-m altitude for 8 months Siques P.; Brito, J; Leon-Velarde, F; Barrios, L; De La Cruz, JJ; López, V.; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2007)
Prevalence and characteristics of smoking in primary healthcare workers in Iquique, Chile Siques P.; Brito, J; Munoz, C; Pasten, P; Zavala P.; Vergara, J. Article ISI SCOPUS PUBLIC HEALTH (2006)
Sustained acclimatization in Chilean mine workers subjected to chronic intermittent hypoxia Osorio, J; Soto G.; Brito, J; Siques P. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2006)
Time course of cardiovascular and hematological responses in rats exposed to chronic intermittent hypobaric hypoxia (4600 m) Siques P.; Brito, J; Leon-Velarde, F; Barrios, L; De La Cruz, JJ; López, V.; Herruzo R. Article ISI SCOPUS HIGH ALTITUDE MEDICINE BIOLOGY (2006)


Alterations in pulmonary artery NO and O2-center dot balance associates with remodeling in rats exposed to chronic and long term intermittent hypoxia Arribas, SM; Siques P.; De Pablo, ALL; Brito, J; Flores, K.; Arriaza K; Naveas, N; Gonzalez, MC; Leon-Velarde, F; Lopez, MR Abstract ISI CARDIOVASCULAR RESEARCH (2014)
Chronic Hypobaric Hypoxia and Chronic Intermittent Hypobaric Hypoxia in Rats Leads to a Mismatch in the ADMA-NO Pathway Lueneburg, N; Siques P.; Brito, J; Arriaza K; Peña, E; Klose H. Abstract ISI CIRCULATION (2013)
Increased Dimethylarginines in Rats and Humans Exposed to Chronic Intermittent Hypobaric Hypoxia Luneburg, N; López, V.; Schwedhelm E.; Brito, J; Boger, RH; Siques P. Abstract ISI CIRCULATION (2010)


Reactive Oxygen Species (ROS) at High Altitude (Hypobaric Hypoxia) on the Cardiovascular System BookSection (2018)


Vivir y Trabajar en Altura BookWhole (2015)
Trabajo a Gran Altura Intermitente: Nueva Situación Epidemiológica P. Siqués; J. Brito BookWhole


PROYECTO MEDICINA DE ALTURA: VALIDACION DE BIOMARCADORES Y DE MITIGADORES Siques Lee P. Proyecto (2020)
HABITAT: TARAPACA SE PROYECTA EN INVESTIGACIÓN DE AMBIENTES EXTREMOS Siques Lee P. Proyecto (2017)
INICIATIVA CHILENO-ALEMANA DE INVESTIGACIÓN DE LA HIPOXIA PULMONAR Y LAS ENFERMEDADES ASOCIADAS (DECIPHER). Siques Lee P. Proyecto (2017)
POYECTO DE GENERACION DE NUEVOS PRODUCTOS PARA POTENCIAR EL CAPITAL HUMANO Y TECNOLÓGICO EN EL DESARROLLO INNOVATIVO DE LA MEDICINA DE ALTURA EN LA REGIÓN DE TARAPACÁ Siques Lee P. Proyecto (2016)
PROYECTO DE MEDICINA Y BIOLOGIA DE ALTURA PARA LA REGION DE TARAPACA ETAPA II Siques Lee P. Proyecto (2015)
ALTMEDFIS Red Iberoamericana de Medicina y Fisiología de Altura Siques Lee P. Proyecto (2013)
DETERMINACIÓN DE CAMBIOS EN EL CIRCUITO DERECHO, REPERCUCIONES FUNCIONALES Y VALIDACION DE SCORE IQUIQUE DE ACLIMATACION, EN UNA COHORTE DE SUJETOS JOVENES EXPUESTOS A HIPOXIA CRONICA INTERMITENTE Siques Lee P. Proyecto (2012)
PROYECTO DE MEDICINA Y BIOLOGIA DE ALTURA PARA LA REGION DE TARAPACA Siques Lee P. Proyecto (2012)
DETERMINACION DE CRITERIOS DE ACLIMATACION EN UNA COHORTE DE SUJETOS JOVENES, EXPUESTOS A UN SISTEMA DE TURNOS EN HIPOXIA CRONICA INTERMITENTE A GRAN ALTURA Siques Lee P. Proyecto (2009)


Reactive Oxygen Species and Pulmonary Vasculature During Hypobaric Hypoxia Siques P.; Brito, J Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Obesity as a Conditioning Factor for High-Altitude Diseases Review ISI SCOPUS OBESITY FACTS (2017)