Man

Paulina Schmitt Rivera

Assistant Professor

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

Líneas de Investigación


Microbiology and Immunology - Cellular Biology - Innate Immunity - Host-pathogen interactions

Educación

  •  Microbiologie et Parasitologie, University of Montpellier. Francia, 2010
  •  Marine Biology, UNIVERSIDAD DE VALPARAISO. Chile, 2002

Experiencia Académica

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Faculty of Sciences

    Valparaiso, Chile

    2014 - A la fecha

  •   Postdoctoral Research Associate Full Time

    UNIVERSITY OF SOUTHERN CALIFORNIA

    OF MEDICINE

    Los Angeles, Estados Unidos

    2010 - 2012

  •   Postdoctoral Research Associate Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Faculty of Sciences

    Valparaiso, Chile

    2012 - 2014

Experiencia Profesional

  •   ASSISTANT PROFESSOR Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    VALPARAISO, Chile

    2014 - A la fecha

Formación de Capital Humano


Teaching experience at Pontificia Universidad Católica de Valparaíso:

Undergraduate Courses
BIO 122 Cell Biology for the Biochemical Engineering program
BIO 1224 Research Unit 1 for the Bachelor's degree in Biology program
BIO 208 Immunology for the Biology and Natural Sciences program
BIO 505 Immunology for the Biochemistry program
BIO 1133 Molecular Biology for the Bachelor of Science program
BIO 336 Cellular Physiology for the Biochemistry program
BIO 131 Cell Biology for the Kinesiology program
BIO 328 Cell Biology for the Medical Technology program
BIO 1113 Cellular and Molecular Biology for the Medical Technology program

Graduate Courses
Participation in courses taught at the Master's Program in Microbiological Sciences, Institute of Biology:
BIO 700 Molecular Bases of Immune Response in Marine Invertebrates
BIO 760 Advanced Microbiological Sciences
BIO 761 Methods in Microbiological Sciences
BIO 703 Immunology in Pathogen-Host Interaction
BIO 1005 Antimicrobial Peptides

Participation in courses taught at the Doctorate Program in Aquaculture, cooperative program UCh/UCN/PUCV:
DAC 903 Molecular Biology of Pathogens and Immunity in Aquaculture
DAC 932 Computational Tools for Molecular Biology

Supervision of Thesis Projects and Seminars

Undergraduate

2022 -2023: “Lipopolysaccharide-binding protein (LBP) as a biomarker for resistance to Vibrio bivalvicida in larvae of the oyster Argopecten purpuratus”. Student: Camila Montesinos. Biochemistry Program. Pontificia Universidad Católica de Valparaíso.
2022 - 2023: “Potential for genetic manipulation of Vibrio-type bacteria”. Student: Ambar Perez. Biochemistry Program. Pontificia Universidad Católica de Valparaíso.
2021: “Production and purification of the bactericidal protein of bacterial permeability increasing ApLBP/BPI1 from the oyster Argopecten purpuratus in Pichia pastoris”. Student: Camila Muñoz. Biochemistry Program. Pontificia Universidad Católica de Valparaíso.
2020 -2022: “Functional characterization of the C-type lectin receptor (ApCLR) expressed in hemocytes of the oyster Argopecten purpuratus”. Student: Valentina Muñoz. Biochemistry Program. Pontificia Universidad Católica de Valparaíso.
2020 -2022: “Cloning and molecular characterization of two isoforms of interleukin-17 from the oyster Argopecten purpuratus”. Student: Yurubi Borregales. Biochemistry Program. Pontificia Universidad Católica de Valparaíso.
2018-2019: “Establishment of molecular surface markers of hemocytes of the oyster Argopecten purpuratus: Toll-like and Mannose receptors”. Student: Varinia Morales. Marine Biology Program. Universidad de Valparaíso.
2016-2017: “Immunity-microbiota interaction in the oyster Argopecten purpuratus: identification of immune response biomarkers”. Student: Katherine Muñoz. Biochemistry Program. Pontificia Universidad Católica de Valparaíso.
2016-2017 "Identification and molecular characterization of a G-type lysozyme in the Chilean scallop Argopecten purpuratus (Lamark, 1819) and its potential role as a biomarker of immune response". Student: Daniel González. Marine Biology Degree. University of Valparaíso.
2015 "Standardization of a primary culture method of hemocytes from the Northern scallop Argopecten purpuratus for the evaluation of in vitro immune response". Student: Bárbara González. Biology Education Degree. Pontifical Catholic University of Valparaíso.
2015 "Expression and purification of recombinant Interleukin-1? protein from rainbow trout Oncorhynchus mykiss produced in Escherichia coli". Student: Roberto Cisternas. Biology Education Degree. Pontifical Catholic University of Valparaíso.

Graduate:

2020 to present: "Characterization of bioactive peptides with antimicrobial activity derived from microalgae with potential for aquaculture". Student: Pabla Ugalde. PhD program in Aquaculture, cooperative program UCh/UCN/PUCV (co-direction).
2020 -2022: "Analysis of the de novo transcriptome of hemocytes from the Chilean scallop Argopecten purpuratus and identification of new antimicrobial peptides". Student: Felipe Stambuk. Master's in Microbiological Sciences. Pontifical Catholic University of Valparaíso.
2019 -2022: "Identification of genes associated with immune response throughout the larval and post-larval development of the Chilean scallop Argopecten purpuratus and the effect of a diet rich in polyunsaturated fatty acids on their expression against the pathogenic bacteria Vibrio splendidus". Student: Isis Rojas. PhD program in Aquaculture, cooperative program UCh/UCN/PUCV (co-direction).
2018 -2021: "Immune response effectors and their impact on the bacterial microbiota composition in Argopecten purpuratus". Student: Roxana González. PhD program in Aquaculture, cooperative program UCh/UCN/PUCV.
2017 "Detection of pathogens responsible for human infectious ocular keratitis by multiple qPCR with fluorescent probes". Student: Helen Gutiérrez. Master's in Microbiological Sciences. Pontifical Catholic University of Valparaíso. (co-direction).
2016 "Respiratory burst and its modulating function on the expression of antimicrobial effectors in hemocytes of Argopecten purpuratus induced with molecular patterns associated with pathogens". Student: Daniel Oyanedel. Master's in Microbiological Sciences. Pontifical Catholic University of Valparaíso.
2016 "Evaluation of the biological activity of synthetic peptides obtained from the microalga Tetraselmis suecica". Student: Genezareth Wong. Master's in Microbiological Sciences. Pontifical Catholic University of Valparaíso. (co-direction).


Premios y Distinciones

  •   Beca Presidente de La Republica/BECAS CHILE

    UNIVERSITE MONTPELLIER II

    Chile, 2006

    Scholarship to perform PhD studies at the Laboratory of Ecology of Coastal Marine Systems, CNRSUMR5119, University of Montpellier 2, Ifremer, University of Montpellier 1, and IRD, Place Eugène Bataillon, F-34095 Montpellier, France from 2006 to 2010.

  •   EGIDE- French Government postdoctoral mobility grant.

    EMBAJADA DE FRANCIA EN CHILE

    Francia, 2013

    Internship at Immune Response, Aquaculture, Environment Laboratory. Lagoon Ecosystem Research Unit. University of Montpellier 2, France.

  •   Carl Storm International Diversity (CSID) Fellowship

    Gordon Research Association

    Estados Unidos, 2013

    Fellowship for the 2013 Antimicrobial Peptides Gordon Research Conference.

  •   SIBAGHE-University of Montpellier 2 Fellowship grant.

    UNIVERSITE DES SCIENCES ET TECHNIQUES DU LANGUEDOC, MONTPELLIER II

    Francia, 2010

    Internship at Institute of Medical Microbiology, Immunology, and Parasitology, University of Bonn, Germany.

  •   Premio a la Docencia Distinguida

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Chile, 2016

    Premio a la docencia distinguida en pregrado de la PUCV

  •   Premio a la docencia distinguida

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Chile, 2021

    -


 

Article (41)

Scallop larvae resistant to a pathogenic<i> Vibrio</i> harbor host-associated bacteria with probiotic potential
Antimicrobial Spectrum of Activity and Mechanism of Action of Linear Alpha-Helical Peptides Inspired by Shrimp Anti-Lipopolysaccharide Factors
Crassostrea gigas oysters from a non-intensive farming area naturally harbor potentially pathogenic Vibrio strains
Evidence of the Autophagic Process during the Fish Immune Response of Skeletal Muscle Cells against Piscirickettsia salmonis
Resistance of Argopecten purpuratus scallop larvae to vibriosis is associated with the front-loading of immune genes and enhanced antimicrobial response
RNA interference-mediated silencing of retinoid X receptor causes reproductive failure in the sea lice Caligus rogercresseyi
Silencing of the <i>Vasa</i> gene by RNA Interference Affects Embryonic Development and Reproductive Output in the Sea Louse <i>Caligus rogercresseyi</i>
A g-type lysozyme from the scallop Argopecten purpuratus participates in the immune response and in the stability of the hemolymph microbiota
Analysis and gonadal localization of Speedy A mRNA transcript, a novel gene associated with early germline cells in the scallop, Argopecten purpuratus
Molecular characterization and cellular localization of a transmembrane C-type lectin receptor in hemocytes from the scallop Argopecten purpuratus
The gill microbiota of Argopecten purpuratus scallop is dominated by symbiotic Campylobacterota and upwelling intensification differentially affects their abundance
Big defensin from the scallop Argopecten purpuratus ApBD1 is an antimicrobial peptide which entraps bacteria through nanonets formation
Expression of immune-related genes during early development of the scallop Argopecten purpuratus after Vibrio splendidus challenge
Induction of foxp3 during the Crosstalk between Antigen Presenting Like-Cells MHCII(+)CD83(+) and Splenocytes CD4(+)IgM(-) in Rainbow Trout
Interferon Gamma Induces the Increase of Cell-Surface Markers (CD80/86, CD83 and MHC-II) in Splenocytes From Atlantic Salmon
Metabolic Cost of the Immune Response During Early Ontogeny of the Scallop Argopecten purpuratus
Functional Insights From the Evolutionary Diversification of Big Defensins
Host Defense Effectors Expressed by Hemocytes Shape the Bacterial Microbiota From the Scallop Hemolymph
Molecular characterization and expression patterns of two LPS binding /bactericidal permeability-increasing proteins (LBP/BPIs) from the scallop Argopecten purpuratus
De novo assembly, characterization of tissue-specific transcriptomes and identification of immune related genes from the scallop Argopecten purpuratus
Identification of Antimicrobial Peptides from the Microalgae Tetraselmis suecica (Kylin) Butcher and Bactericidal Activity Improvement
Litopenaeus vannamei stylicins are constitutively produced by hemocytes and intestinal cells and are differentially modulated upon infections
Reproduction Immunity Trade-Off in a Mollusk: Hemocyte Energy Metabolism Underlies Cellular and Molecular Immune Responses
The immune response of the scallop Argopecten purpuratus is associated with changes in the host microbiota structure and diversity
Massive Gene Expansion and Sequence Diversification Is Associated with Diverse Tissue Distribution, Regulation and Antimicrobial Properties of Anti-Lipopolysaccharide Factors in Shrimp
Insights into the diversity of NOD-like receptors: Identification and expression analysis of NLRC3, NLRC5 and NLRX1 in rainbow trout
Molecular characterization and protein localization of the antimicrobial peptide big defensin from the scallop Argopecten purpuratus after Vibrio splendidus challenge
An intimate link between antimicrobial peptide sequence diversity and binding to essential components of bacterial membranes
Antimicrobial peptides in marine invertebrate health and disease
Insight into the messenger role of reactive oxygen intermediates in immunostimulated hemocytes from the scallop Argopecten purpuratus
Molecular characterization of an inhibitor of NF-kappa B in the scallop Argopecten purpuratus: First insights into its role on antimicrobial peptide regulation in a mollusk
Immunomodulatory effect of cathelicidins in response to a beta-glucan in intestinal epithelial cells from rainbow trout
Phenotypical parameters as a tool to evaluate the immunostimulatory effects of laminarin in Oncorhynchus mykiss
The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view
Antimicrobial Histones and DNA Traps in Invertebrate Immunity EVIDENCES IN CRASSOSTREA GIGAS
Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas
Insight into Invertebrate Defensin Mechanism of Action: OYSTER DEFENSINS INHIBIT PEPTIDOGLYCAN BIOSYNTHESIS BY BINDING TO LIPID II
Molecular diversity of antimicrobial effectors in the oyster Crassostrea gigas
Oyster hemocytes express a proline-rich peptide displaying synergistic antimicrobial activity with a defensin
Characterization and functional recovery of a novel antimicrobial peptide (CECdir-CECret) from inclusion bodies after expression in Escherichia coli
Gill tissues of the mussel Mytilus edulis chilensis: A new source for antimicrobial peptides

Abstract (1)

Immunostimulatory effect of beta-glucans in rainbow trout (Oncorhynchus mykiss)

BookSection (1)

Scallop Immunology

Proyecto (9)

Unraveling scallop immunity - pathogen interplay by dual transcriptomics: Identification of molecular markers associated with resistance in larvae and virulence in a pathogenic Vibrio
Understanding the crosstalk between differentially activated M1 macrophages and NK cells to improve specific innate immune responses against bacterial or viral pathogens in aquacultured salmonids
Desarrollo de una quimera multiantigénica y multiepitópica para su uso potencial como vacuna en el control de Piscirickettsia salmonis
Estudio del estatus inmune de Salmo salar en condiciones de campo y su relación con la infección por Piscirickettsia salmonis y bases para la incorporación de péptidos inmunomoduladores en dieta como nuevos medicamentos contra el patógeno
Unveiling immunity trade-offs at critical developmental stages in scallops=> role of dietary PUFAs and its potential use in aquaculture.
EARLY WARNING BIOMARKERS TO ASSESS SCALLOP IMMUNE STATUS=> EXPANDING THE HOLOBIONT CONCEPT IN MARINE BIVALVES
IMMUNOMODULATION OF INTESTINAL INNATE IMMUNE PARAMETERS BY HOST DEFENSE PEPTIDES IN THE RAINBOW TROUT, ONCORHYNCHUS MYKISS, FOLLOWING B-GLUCAN ORAL ADMINISTRATION.
Peptide effectors of enteric host defense
Studies of alpha-defensins in primate innate immunity

Review (1)

Resistance to antimicrobial peptides in vibrios
46
Paulina Schmitt

Assistant Professor

Biology

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

13
LUIS MERCADO

Profesor Titular

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

9
Katherina Brokordt

Académico/Profesor Asociado

Acuicultura

Universidad Católica del Norte

Coquimbo, Chile

7
Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

7
Roxana González

Investigadora Postdoctoral

Acuicultura

Universidad Católica del Norte

Coquimbo, Chile

6
Rodolfo Farlora

Full time professor

Instituto de Biología

Universidad de Valparaíso

Valparaiso, Chile

4
rodrigo rojas

Académico

Acuicultura

Universidad Católica del Norte

COQUIMBO, Chile

3
Claudio Alvarez

Profesor Asistente

Acuicultura

Universidad Católica del Norte

Coquimbo, Chile

2
Sergio Marshall

PROFESSOR

BIOLOGY INSTITUTE

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

2
DONALD BROWN

PROFESOR TITULAR

FACULTAD DE CIENCIAS

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

2
María Rojas

Profesor adjunto

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

2
Erwin de la Fuente

PROFESOR ASOCIADO

CIENCIAS BIOMÉDICAS

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

2
Claudia Cárcamo

Investigador

Centro Tecnologico de innovacion acuicola

Coquimbo, Chile

2
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Fabian Cuadros

Profesor

Facultad de Ciencias

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Teodoro Coba

Investigador Titular indefinido

BIOTEC

CORPORACION CENTRO DE ESTUDIOS AVANZADOS EN ZONAS ARIDAS

La Serena, Chile

1
Jorn Bethke

CTO

AQUIT

Viña del mar, Chile

1
Claudio Alvarez

Investigador Titular

Laboratorio FIGEMA

Centro de Estudios Avanzados en Zonas Aridas

Coquimbo, Chile

1
LINA CORTES

Investigadora Postdoctoral

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

1
Paula Santana

Profesora Asistente e Investigadora

Facultad de Ingeniería

Universidad Autónoma de Chile

Santiago, Chile

1
Jurij Wacyk

Profesor Asistente

Producción Animal

Universidad de Chile

Santiago , Chile

1
Carolina Yáñez

Profesor Adjunto

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso , Chile

1
Constanza Cárdenas

Associate Researcher

Nucleo Biotecnologia Curauma

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Jurij Wacyk

Profesor Asociado

Produccion Animal

UNIVERSIDAD DE CHILE, FAC. CS AGRONÓMICAS

Stgo, Chile

1
Derie Fuentes

Director

Center For Systems Biotechnology

Universidad Andrés Bello

Santiago, Chile

1
Tanya Román

Estudiante de Postgrado

Nucleo de Biotecnología de Curauma

PUCV

Valparaíso, Chile

1
Mauricio Diaz

Investigador

empresa Neobiotec S.A.

Viña del Mar, Chile