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Carolina Marcela Manosalva Altamirano

Académico Asociado categoría 02

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Farmacología Molecular; Bilogía Celular

Doctorado en Ciencias Mención Biología Celular y Molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2015

Académico Auxiliar categoría 03 Full Time

UNIVERSIDAD AUSTRAL DE CHILE

2005 - A la fecha
Académico Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia , Chile

2008 - A la fecha

Químico Farmacéutico

Farmacias Cruz Verde

Chile

2005 - 2009
Profesor Adjunto

Universidad Austral de Chile

Chile

2005 - 2006
Profesor adjunto

Universidad Austral de Chile

Chile

2006 - 2006
Profesor adjunto

Universidad Austral de Chile

Chile

2007 - 2007
Académico categoría 04

Universidad Austral de Chile

Chile

2008 - A la fecha
Estudiante de Doctorado

Justus-Liebig-Universität Gießen

Alemania

2012 - 2012
Estudiante de Doctorado

University of Illinois at Chicago - UIC

Estados Unidos

2013 - 2014
Académico Asociado categoría 02 Full Time

Universidad Austral de Chile

Valdivia , Chile

2022 - A la fecha


Linoleic Acid Induces Metabolic Reprogramming and Inhibits Oxidative and Inflammatory Effects in Keratinocytes Exposed to UVB Radiation Manosalva, Carolina; Bahamonde, Claudio; Soto, Franco; Leal, Vicente; Ojeda, Cesar; Cortes, Carmen; Alarcon, Pablo; Burgos, Rafael A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogramming Manosalva, Carolina; Carretta, Maria D.; Bustamante, Hedie Article ISI SCIENTIFIC REPORTS (2023)
D-lactate-induced ETosis in cattle polymorphonuclear leucocytes is dependent on the release of mitochondrial reactive oxygen species and the PI3K/Akt/HIF-1 and GSK-38 pathways Ramirez, Maria Fernanda; Manosalva, Carolina Article ISI DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2023)
D-lactate-triggered extracellular trap formation in cattle polymorphonuclear leucocytes is glucose metabolism dependent Manosalva, Carolina Article ISI DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2022)
Role of Lactate in Inflammatory Processes: Friend or Foe Manosalva, Carolina; Anseoleaga, Nicolas Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Hydrocortisone decreases metacognitive efficiency independent of perceived stress Vivanco-Carlevari, Anastassia; Medina, Franco; Manosalva, Carolina; de Gardelle, Vincent; Sackur, Jerome Article ISI SCIENTIFIC REPORTS (2020)
Functional expression of the free fatty acids receptor-1 and-4 (FFA1/GPR40 and FFA4/GPR120) in bovine endometrial cells Valenzuela, Pamela; Manosalva, Carolina; Figueroa, Carlos D.; Ratto, Marcelo Article ISI SCOPUS VETERINARY RESEARCH COMMUNICATIONS (2019)
Metabolic disturbances in synovial fluid are involved in the onset of synovitis in heifers with acute ruminal acidosis Hidalgo, Alejandra, I; Manosalva, Carolina; Cristi, Raul; Burgos, Rafael A. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Transcriptional analysis of flagellar and putative virulence genes of Arcobacter butzleri as an endocytobiont of Acanthamoeba castellanii Neves, Patricia; Flores-Martin, Sandra; Manosalva, Carolina; Andaur, Marcela; Otth, Carola. Article ISI SCOPUS ARCHIVES OF MICROBIOLOGY (2019)
Fatty and hydroxycarboxylic acid receptors=> the missing link of immune response and metabolism in cattle Alarcon P, Manosalva C; Carretta MD, Hidalgo AI; Figueroa CD, Taubert A; Hermosilla C, Hidalgo MA Article VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2018)
D(?) lactic acid-induced adhesion of bovine neutrophils onto endothelial cells is dependent on neutrophils extracellular traps formation and CD11b expression Alarcón P., Manosalva C.; Conejeros I., Carretta M.D.; Muñoz-Caro T., Silva L.M.R.; Taubert A., Hermosilla C.; Hidalgo M.A., Burgos R.A. Article Frontiers in Immunology (2017)
Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils. Mena, Sandra J; Manosalva, Carolina; Carretta, Maria D; Teuber, Stefanie; Olmo, Iván; Burgos, Rafael A; Hidalgo, Maria A Article Innate immunity (2016)
Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils Manosalva C; Mena J; Velasquez Z; Colenso CK; Brauchi S; Burgos RA; Hidalgo MA Article PLoS One (2015)
Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils Manosalva C; Mena, J.; Velasquez, Z; Brauchi, S.; Hidalgo, MA Article ISI SCOPUS PLOS ONE (2015)
Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils Mena, J.; Manosalva C; Ramirez R.; Chandia, L; Carroza, D.; Loaiza A.; Hidalgo, MA Article ISI SCOPUS Veterinary Immunology and Immunopathology (2013)
Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils Mena J., Manosalva; C, Ramirez R.; Chandia, L; Carroza, D.; Loaiza A, Burgos; RA, Hidalgo Article Veterinary Immunology and Immunopathology (2013)
Oleic acid induces intracellular calcium mobilization, MAPK phosphorylation, superoxide production and granule release in bovine neutrophils Hidalgo, MA; Nahuelpan, C; Manosalva C; Jara, E; Carretta, MD; Conejeros I.; Loaiza A.; Chihuailaf, R Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Oleic acid induces intracellular calcium mobilization, MAPK phosphorylation,superoxide production and granule release in bovine neutrophils Maria A. Hidalgo; Carla Nahuelpan; Carolina Manosalva; Evelyn Jara; Maria D. Carretta; Ivan Conejeros; Anitsi Loaiza; Ricardo Chihuailaf; Rafael A. Burgos Article Biochemical and Biophysical Research Communications (2011)


Role of FFA1 receptor agonists on wound healing in aging Manosalva Altamirano Carolina Proyecto (2022)
D (-) lactic acid triggers Fibroblast-Like Synoviocytes activity, a hallmark in the pathophysiology of neutrophilic polysynovitis in cattle with acute ruminal acidosis FONDECYT (283860) Proyecto 2018-2021 Coinvestigador(a)
MetaStress=> Mecanismo Hormonal regulador de la capacidad Metacognitiva FONDECYT (252673) Proyecto 2017-2021 Coinvestigador(a)
Rol de ácido linoleico sobre la producción de quimiocinas en queratinocitos humanos y su impacto en la fase inflamatoria durante la cicatrización de heridas Universidad Austral de Chile, Dirección de Investigación y Desarrollo (DID) (S-2016-07) Proyecto 2016-2018 Inv. Responsable
"Rol del receptor de ácidos grasos GPR40 en la liberación de MMP-9, migración y proliferación de queratinocitos estimulados con ácido oleico y ácido linoleico" Universidad Austral de Chile, Dirección de Investigación y Desarrollo (DID) (DID N°S-2014-13) Proyecto 2014-2016 Inv. Principal
DIFFERENTIAL EFFECT OF NONESTERIFIED FATTY ACIDS SPECIES ON THEPOLYMORPHONUCLEAR LEUKOCYTE FUNCTION IN DAIRY HEIFERS FONDECYT (11100413) Proyecto 2010-2013 Tesista


The D-lactate enigma: exploring the inflammatory influence of D-lactate in cattle Burgos, Rafael Agustin; Manosalva, Carolina; Alarcon, Pablo; Navarro, Max; Quiroga, John; Moran, Gabriel; Gallastegui, Jan; Brauchi, Sebastian; Carretta, Maria Daniella Review ISI FRONTIERS IN VETERINARY SCIENCE (2024)
Fatty and hydroxycarboxylic acid receptors: The missing link of immune response and metabolism in cattle Manosalva C; Carretta, MD; Hidalgo, AI; Taubert, A; Herrnosilla, C; Hidalgo, MA Review ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2018)