Man

Valentina Echeverria Moran

Profesora

Universidad San Sebastian

Concepcion, Chile

Líneas de Investigación


Molecular Mechanisms, Drug discovery, Clinical research, Epidemiology, PTSD, schizophrenia, MDD, E Alzheimer disease, Stroke, Aging, Cotinine, Caffeine, antioxidants, Nicotinic acetylcholine receptors, Astrocytes, Ethnopharmacology.

Educación

  •  Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 1999
  •  Bioquímica, UNIVERSIDAD DE CONCEPCION. Chile, 1994
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1991
  •  Clinical research, HARVARD UNIVERSITY. Estados Unidos, 2023

Experiencia Académica

  •   Adjunct Assistant Professor Other

    UNIVERSITY OF SOUTH FLORIDA

    Medicine

    Tampa, Estados Unidos

    2007 - 2014

  •   Professor Full Time

    Universidad San Sebastian

    Ciencias de la Salud

    Concepcion, Chile

    2015 - 2023

  •   Professor Full Time

    Universidad San Sebastian

    Medicine

    Concepcion, Chile

    2023 - A la fecha

Experiencia Profesional

  •   Principal Scientist Other

    Bay Pines VAHCS

    Bay Pines, Estados Unidos

    2007 - A la fecha

  •   Research Scientist Full Time

    Columbia University

    New York, Estados Unidos

    2005 - 2006

  •   Postdoctoral fellow Full Time

    Johns Hopkins University

    Baltimore, Estados Unidos

    2003 - 2005

  •   Postdoctoral fellow Full Time

    McGill University

    Montreal, Canada

    2001 - 2003

  •   Cientifico Postdoctoral Full Time

    Centro Nacional de Biotecnologia (CNB-CSIC)

    España

    1999 - 2001

Formación de Capital Humano


2006-2023
- PhD Thesis
1. Cristhian Mendoza)(2018). Docente Investigador. USS
2. Alex Grizzell) Co-tutor (University of South Florida), Prof. Assistant Professor
3. Rafael Vides, MD, Psychiatrist. 2023. (Universidad de San Carlos de Guatemala
Facultad de Ciencias Médicas. Escuela de Estudios de Postgrado

Master Thesis
- Magister BMENT
1. Ms. Nathalie Alvarez Ricartes TM, MS.(2023). (Lecturer de TM.USS)
2. Ms. Patricia Olivares Matus, TM. Pending. (TM Clinical Laboratory, Pto. Montt)
3. Mr. Nelson Perez Urrutia.TM. Pending. ( Lecturer. USSs)

Master in Biomedicine (University of South Florida) (9 graduates)
4. Sagar Patel. (2014). MD Emergency.
5. Rosalyn Solomon NP(2014). Nurse Practitioner.
6. John Tran J. NP (2014). Nurse
7. Rosaly Holmes (2014).
8. Michelle Mullins M .(2014). (Scientist Florida Department of Law Enforcement-Biology/DNA)
9. Rohani A .(2014). MD.
10. Leila Charry .(2014). MD.

Undergraduate Thesis
- Students of Medical Technology (TM),
1. Carlos Silva Lavin (2016-1)(EB)
2. Nelson Perez Urrutia (2016-2)
3. Patricia Oliveros Matus (2016-2)
4. Francisco Susperreguy Montoya (2018-1)
5. John Hernandez Escanilla (2018-1)
6. Luis Hidalgo (2018-2)
7. Genesis (2018-2)
8. Gloria Cárdenas Véliz (2018-2)
9. Nathalie Diaz Sanhueza (2019-2)
10. Nicolás Ignacio Maldonado Pino (2021-2)
11. Danitza Guzman Fernandez (2021-2)
12. Pablo Toro (2021-2)
13. Miriam Cornejo (2021-2)
14. Nataly Arriasa Leiva (2021-2)
15. Javiera Alvarez (2022-1)
16. Thiare Rosales (2022-1)
17. Alberto Lopez (2023-1)
-Florida State University, 2007
Undergraduate BS-Biology Thesis
18. Sarah Burgess, (). BS. NP. Veterans Affairs Administration.


Difusión y Transferencia


EDITORIAL BOARDS

American Journal of Alzheimer's Disease and Other Dementias; Journal of Alzheimer's Disease Associate Editor); Frontiers in ethnopharmacology; Neural Regeneration Research; World Journal of Pharmacology, Behavioral sciences; Frontiers in Pharmacology;American Journal of Neurodegenerative Disease; International Neuropsychiatric Disease Journal; Chronic Diseases – International; SM Journal of Depression Research and Treatment; Encyclopedia (Oxford).
Editor (>15 peer-reviewed journals); Ad Hoc Reviewer (33 journals).

Associate Editor Frontiers in Ethnopharmacology; Clinical Neurosciences; Guest Associate Editor: Front in Aging Neuroscience Archive, Neurodegeneration; Molecular Signalling and Pathways; Cellular and Molecular Mechanisms of Brain-aging; Alzheimer's Disease and Related Dementias; Review Editor Front in Aging Neuroscience Archive; Neurotrauma; Cellular and Molecular Mechanisms of Brain-aging; Psychiatry.

Patents

1. US 9,801,865 B2 Materials and methods for diagnosing, preventing, and treating stress disorders and conditions associated with Abeta peptide aggregation. The subject of the invention concerns treating posttraumatic stress disorder. Inventor: Valentina Echeverria Moran (United States of America (USA) Department of Veterans Affairs (VA), University of South Florida (USF), filed Sep. 24, 2009. Approved: October 31, 2017.
2. US 10238641 B2. The subject invention concerns using Cotinine to detect the accumulation of Amyloid beta peptide in neural tissue and diagnose conditions such as AD. The method comprises administering Cotinine labeled with a radioisotope to a person or animal to be detected by Positron Emission Tomography (PET). Filed: October 4, 2017. Date of Patent: March 26, 2019. Assignees: USF, and the USA represented by the VA. Inventor: Valentina Echeverria Moran.
3. US 10, 307,411 B2 The Use of Cotinine in Treating or Preventing Neurogenesis Deficits and Enhancing Neurogenesis. The subject invention concerns methods for preventing neurogenesis deficits in neural tissue in a human or Animal. Inventor:Valentina Echeverria Moran & Doreen Appunn (VA Filed 1/5/2017. Approved; June 4, 2019.
4. US 2020/0000790 A1 The combination of Cotinine plus antioxidants for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other brain Conditions. Appl. No: 16/486,498 (22). PCT Filed: February 16, 2018 (86) PCT No .: PCT/IB18 / 00306 § 371 (c) (1)(2 Aug. 15, 2019. 16-02-2018. Expiration date:16-02-2038.
5. Chile. 2019-2313, registration: 64.986. Submitted 14-08-2019, Granted 20-05-2022. Date of registration in Chile. 01-08-2022.Uso de cotinina y Aceite de krill para tratar o prevenir un trastorno inducido por estrés crónico, (depresión o ansiedad) y composición farmacéutica que los comprende, Universidad San Sebastián, The USA as represented by the VA. Chile, by the Instituto Nacional de Propiedad Industrial. Santiago, 22 de Agosto de 2022. 9:41:06. Expiration date:16-02-2038.
6. USA-Chile. US Patent No. 63/551,952 titled “Use of Cotinine to Reduce the Ill Effects of Stress in Farmed Sea Animals”. filed February 9, 2024 (VA ID No. 2017-449-06)


Premios y Distinciones

  •   Oversea Member

    Royal Society of Medicine, UK

    Reino Unido, 2018

    Elegida como miembro extranjero. Este honor requiere de la postulación por dos miembros secretos de la RSM y la aprobación por un comité de selección.

  •   Doctoral fellowship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 1995

    Four years competitive fellowship to perform the Biological sciences Ph.D. Program at the University of Concepcion, Chile. 1995-1999

  •   Fellowship to participate in the In Vitro Cell Biology and Biotechnology Program

    UNIVERSITY OF NEW YORK

    Estados Unidos, 1993

    Program in cell biology and Biotechnology 700hs,. Graduated with 4.0+/4.0

  •   Teaching Assistant Graduate Fellowship

    UNIVERSIDAD DE CONCEPCION

    Chile, 1991

    Four years Fellowship from the graduate school to perform the Master of Science Program.

  •   International contract

    MINISTERIO DE CIENCIA Y TECNOLOGIA

    España, 2000

    Two years Contract to work in the National Center of Biotechnology, CNB en el laboratorio del Dr. Jose Ramon Naranjo, in Neurobiology. Gene expression regulation by the transcription factor DREAM.

  •   Teaching Assistant Doctoral Fellowship

    UNIVERSIDAD DE CONCEPCION

    Chile, 1999

    One-year fellowship to finish the Ph.D. Program.

  •   Member

    American Psychological Association (APA)

    Estados Unidos, 2024

    Invited to join the American Psychological Association


 

Article (25)

Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases
Editorial: Improving memory deficits in Alzheimer’s disease
Electronic cigarette use and the risk of cardiovascular diseases
Insights in Ethnopharmacology 2021
Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease
Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
In silico interactions of statins with cell death-inducing DNA. fragmentation factor-like effector A (CIDEA)
Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling. Frontiers in pharmacology
Editorial: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside
Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury
Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells
Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation
Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta.
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress.
Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder
Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress.
Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice
Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury
Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder
Cotinine Reduces Depressive-Like Behavior and Hippocampal Vascular Endothelial Growth Factor Downregulation After Forced Swim Stress in Mice
Mutagenesis in the switch IV of the helical domain of the human Gs alpha reduces its GDP/GTP exchange rate
Mutagenesis in the switch IV of the helical domain of the human Gs? reduces its GDP/GTP exchange rate

Patent (4)

Combination of cotinine plus antioxidant for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other neuropathological
Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with a-beta peptide aggregation
Use of cotinine in treating or preventing neurogenesis deficits and enhancing neurogenesis
Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation

Review (6)

Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds
Strategies for the Treatment of Parkinson's Disease: Beyond Dopamine
Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Sex differences in Parkinsons disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics
Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system
2
José Martínez

Associate professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Marcela Torrejon

Associate Professor

Biochemistry and Molecular Biology

Biological Sciences Faculty

Concepcion, Chile

1
George Sampaio

Presidente

Colégio Colombiano de Neurociencias

5
CRISTHIAN MENDOZA

Docente Investigador

Facultad de Medicina y Ciencia

Universidad San Sebastián

Concepción, Chile

36
Valentina Echeverria

Profesora

Universidad San Sebastian

Concepcion, Chile

3
Alexandre Iarkov

Assistant professor

Ciencias de la Salud

Universidad San Sebastián

Concepcion, Chile

15
George Sampaio

Investigador

Universidad Autónoma de Chile

Santiafo, Chile