Man

Valentina Echeverria Moran

Profesora

Universidad San Sebastian

Concepcion, Chile

Líneas de Investigación


Molecular Mechanisms, Drug discovery, Clinical research, Epidemiology, PTSD, schizophrenia, MDD, E Alzheimer disease, Stroke, Aging, Cotinine, Caffeine, antioxidants, Nicotinic acetylcholine receptors, Astrocytes, Ethnopharmacology.

Educación

  •  Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 1999
  •  Bioquímica, UNIVERSIDAD DE CONCEPCION. Chile, 1994
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1991
  •  Clinical research, HARVARD UNIVERSITY. Estados Unidos, 2023

Experiencia Académica

  •   Adjunct Assistant Professor Other

    UNIVERSITY OF SOUTH FLORIDA

    Medicine

    Tampa, Estados Unidos

    2007 - 2014

  •   Professor Full Time

    Universidad San Sebastian

    Ciencias de la Salud

    Concepcion, Chile

    2015 - 2023

  •   Professor Full Time

    Universidad San Sebastian

    Medicine

    Concepcion, Chile

    2023 - A la fecha

Experiencia Profesional

  •   Principal Scientist Other

    Bay Pines VAHCS

    Bay Pines, Estados Unidos

    2007 - A la fecha

  •   Research Scientist Full Time

    Columbia University

    New York, Estados Unidos

    2005 - 2006

  •   Postdoctoral fellow Full Time

    Johns Hopkins University

    Baltimore, Estados Unidos

    2003 - 2005

  •   Postdoctoral fellow Full Time

    McGill University

    Montreal, Canada

    2001 - A la fecha

  •   Cientifico Postdoctoral Full Time

    Centro Nacional de Biotecnologia (CNB-CSIC)

    España

    1999 - 2001

Formación de Capital Humano


2006-2023
- PhD Thesis
1. Cristhian Mendoza)(2018). Docente Investigador. USS
2. Alex Grizzell) Co-tutor (University of South Florida), Prof. Assistant Professor
3. Rafael Vides, MD, Psychiatrist. 2023. (Universidad de San Carlos de Guatemala
Facultad de Ciencias Médicas. Escuela de Estudios de Postgrado

Master Thesis
- Magister BMENT
1. Ms. Nathalie Alvarez Ricartes TM, MS.(2023). (Lecturer de TM.USS)
2. Ms. Patricia Olivares Matus, TM. Pending. (TM Clinical Laboratory, Pto. Montt)
3. Mr. Nelson Perez Urrutia.TM. Pending. ( Lecturer. USSs)

Master in Biomedicine (University of South Florida) (9 graduates)
4. Sagar Patel. (2014). MD Emergency.
5. Rosalyn Solomon NP(2014). Nurse Practitioner.
6. John Tran J. NP (2014). Nurse
7. Rosaly Holmes (2014).
8. Michelle Mullins M .(2014). (Scientist Florida Department of Law Enforcement-Biology/DNA)
9. Rohani A .(2014). MD.
10. Leila Charry .(2014). MD.

Undergraduate Thesis
- Students of Medical Technology (TM),
1. Carlos Silva Lavin (2016-1)(EB)
2. Nelson Perez Urrutia (2016-2)
3. Patricia Oliveros Matus (2016-2)
4. Francisco Susperreguy Montoya (2018-1)
5. John Hernandez Escanilla (2018-1)
6. Luis Hidalgo (2018-2)
7. Genesis (2018-2)
8. Gloria Cárdenas Véliz (2018-2)
9. Nathalie Diaz Sanhueza (2019-2)
10. Nicolás Ignacio Maldonado Pino (2021-2)
11. Danitza Guzman Fernandez (2021-2)
12. Pablo Toro (2021-2)
13. Miriam Cornejo (2021-2)
14. Nataly Arriasa Leiva (2021-2)
15. Javiera Alvarez (2022-1)
16. Thiare Rosales (2022-1)
17. Alberto Lopez (2023-1)
-Florida State University, 2007
Undergraduate BS-Biology Thesis
18. Sarah Burgess, (). BS. NP. Veterans Affairs Administration.


Premios y Distinciones

  •   Oversea Member

    Royal Society of Medicine, UK

    Reino Unido, 2018

    Elegida como miembro extranjero. Este honor requiere de la postulación por dos miembros secretos de la RSM y la aprobación por un comité de selección.

  •   Doctoral fellowship

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 1995

    Four years competitive fellowship to perform the Biological sciences Ph.D. Program at the University of Concepcion, Chile. 1995-1999

  •   Fellowship to participate in the In Vitro Cell Biology and Biotechnology Program

    UNIVERSITY OF NEW YORK

    Estados Unidos, 1993

    Program in cell biology and Biotechnology 700hs,. Graduated with 4.0+/4.0

  •   Teaching Assistant Graduate Fellowship

    UNIVERSIDAD DE CONCEPCION

    Chile, 1991

    Four years Fellowship from the graduate school to perform the Master of Science Program.

  •   International contract

    MINISTERIO DE CIENCIA Y TECNOLOGIA

    España, 2000

    Two years Contract to work in the National Center of Biotechnology, CNB en el laboratorio del Dr. Jose Ramon Naranjo, in Neurobiology. Gene expression regulation by the transcription factor DREAM.

  •   Teaching Assistant Doctoral Fellowship

    UNIVERSIDAD DE CONCEPCION

    Chile, 1999

    One-year fellowship to finish the Ph.D. Program.


 

Article (106)

Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases
Editorial: Improving memory deficits in Alzheimer’s disease
Electronic cigarette use and the risk of cardiovascular diseases
Insights in Ethnopharmacology 2021
Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease
Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
In silico interactions of statins with cell death-inducing DNA. fragmentation factor-like effector A (CIDEA)
Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling. Frontiers in pharmacology
Editorial: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside
(E)-Nicotinaldehyde O-Cinnamyloxime, a Nicotine Analog, Attenuates Neuronal Cells Death Against Rotenone-Induced Neurotoxicity
Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury
Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells
Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation
Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta
Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta.
Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay.
Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro
Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro.
Correction to=> Cotinine=> A Therapy for Memory Extinction in Post-traumatic Stress Disorder.
Correction to=> Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress.
Correction to=> Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice.
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress.
Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder
Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress.
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress.
Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice
Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult
Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid
Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid.
Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta
Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta.
4'-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation.
4?-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation
Advances in Medicinal Plants with Effects on Anxiety Behavior Associated to Mental and Health Conditions
Advances in Medicinal Plants with Effects on Anxiety Behavior Associated to Mental and Health Conditions.
Approaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets.
Approaches of the transcriptomic analysis in astrocytes=> Potential pharmacological targets.
Astrocytes and endoplasmic reticulum stress=> A bridge between obesity and neurodegenerative diseases.
Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay.
Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice.
Ginkgo biloba as an Alternative Medicine in the Treatment of Anxiety in Dementia and other Psychiatric Disorders.
Gliomas=> New Perspectives in Diagnosis, Treatment and Prognosis.
Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice.
Is VEGF a key target of cotinine and other potential therapies against Alzheimer disease?
Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease?
Medicinal plants as protective strategies against Parkinson's Disease.
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult.
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration.
Ginkgo biloba as an alternative medicine in the treatment of anxiety in dementia and other psychiatric disorders
Growth Factors and Astrocytic Metabolism: Possible Roles for Platelet Derived Growth Factor.
Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease
Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease.
Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease.
L-Type Calcium Channels Modulation by Estradiol.
Microglial Dependent Protective Effects of Neuroactive Steroids.
Neuroinflammation: a therapeutic target of cotinine for the treatment of psychiatric disorders.
Neuroprotective effects of the catalytic subunit of telomerase=> A potential therapeutic target in the central nervous system.
Novel Approaches in Astrocyte Protection: from Experimental Methods to Computational Approaches
Positive modulators of the α7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease
Positive modulators of the alpha7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer’s disease
Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats
Protection by Neuroglobin Expression in Brain Pathologies.
Relationship Between Obesity, Alzheimer's Disease, and Parkinson's Disease=> an Astrocentric View.
Role of neuroinflammation and sex hormones in war-related PTSD.
Role of neuroinflammation and sex hormones in war-related PTSD.
Targeting the nicotinic acetylcholine receptors (nAChRs) in astrocytes as a potential therapeutic target in Parkinson’s disease
Testosterone Protects Mitochondrial Function and Regulates Neuroglobin Expression in Astrocytic Cells Exposed to Glucose Deprivation.
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease.
Nanoparticles as Alternative Strategies for Drug Delivery to the Alzheimer Brain=> Electron Microscopy Ultrastructural Analysis
New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine.
Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder
Cotinine halts the advance of Alzheimer’s disease-like pathology and associated depressive-like behavior in Tg6799 mice
Cotinine Reduces Depressive-Like Behavior and Hippocampal Vascular Endothelial Growth Factor Downregulation After Forced Swim Stress in Mice
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice
Brain effects of Nicotine and Derived Compounds
Cotinine Enhances the Extinction of Contextual Fear Memory and Reduces Anxiety after fear conditioning.
Cotinine: a potential new therapeutic agent against Alzheimer's disease.
Cotinine: Beyond that Expected, More than a Biomarker of Tobacco Consumption.
Caffeine Induces Beneficial Changes in PKA Signaling and JNK and ERK Activities in the Striatum and Cortex of Alzheimer’s Transgenic Mice
Raf Inhibitors as Therapeutic Agents against Neurodegenerative Diseases
Caffeine reverses cognitive impairment and decreases brain Abeta levels in aged Alzheimer’s mice.
Sorafenib inhibited cRaf-1/NF-kappaB pathway and restored working memory in aged APPswe mice.
Raf inhibition is Neuroprotective against Amyloid beta toxicity.
Transcription factor Sp1 dysregulation in Alzheimer’s disease.
Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons.
1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia.
Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity.
Endogenous beta-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells.
Expression of prostaglandin E2 synthases in mouse postnatal cortical neurons.
Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure.
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex.
Intracellular A-beta amyloid, a sign for worse things to come?
Mutagenesis in the switch IV of the helical domain of the human Gs alpha reduces its GDP/GTP exchange rate
Mutagenesis in the switch IV of the helical domain of the human Gs? reduces its GDP/GTP exchange rate
The DREAM-DRE interaction: key nucleotides and dominant negative mutants.
The C2 cytosolic loop of adenylyl cyclase interacts with the activated form of G alpha s.
Molecular cloning and expression of an adenylyl cyclase from Xenopus laevis oocytes.
Partial DNA sequence of a beta-lactamase produced by a Shigella flexneri strain.
Characterization of a plasmid codifying the synthesis of a beta-lactamase produced by Shigella flexneri.

Patent (4)

Combination of cotinine plus antioxidant for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other neuropathological
Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with a-beta peptide aggregation
Use of cotinine in treating or preventing neurogenesis deficits and enhancing neurogenesis
Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation

Proyecto (9)

Role of bone-morphometric proteins in the enhancement of fear extinction and astrocyte protection induced by cotinine in fear-conditioned mice
INVESTIGATING COTININE AS A THERAPY FOR POST-TRAUMATIC STRESS DISORDER
Memory enhancing effects of high-energy compounds plus cotinine in aged mice
Cotinine to reduce Chemotherapy-induced Cognitive Impairment
Investigating Cotinine to Improve Memory and Prevent Tobacco Abuse in Subjects with Cognitive Impairment due to Psychiatric Disorders
Cotinine as a Therapeutic Tool against Alzheimer’s disease
Molecular Mechanisms Underlying the Neuroprotective Actions of Cotinine
Role of cRaf-1/ERK Pathway on Cotinine Neurotoxicity
CARACTERIZACION FUNCIONAL DEL DOMINIO HELICOIDAL DE LA SUBUNIDAD GAS DE LA PROTEINA G

Review (6)

Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds
Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine
Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Sex differences in Parkinsons disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics
Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system
36
Valentina Echeverria

Profesora

Universidad San Sebastian

Concepcion, Chile

14
George Sampaio

Investigador

Universidad Autónoma de Chile

Santiafo, Chile

4
CRISTHIAN MENDOZA

Docente Investigador Laboratorio de Neurobiología

Facultad Ciencias de la Salud

Universidad San Sebastián

Concepción, Chile

3
Alexandre Iarkov

Assistant professor

Ciencias de la Salud

Universidad San Sebastián

Concepcion, Chile

2
José Martínez

Associate professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
George Sampaio

Presidente

Colégio Colombiano de Neurociencias

1
Marcela Torrejon

Associate Professor

Biochemistry and Molecular Biology

Biological Sciences Faculty

Concepcion, Chile