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Alexandre Iarkov

Assistant professor

Universidad San Sebastián

Concepcion, Chile

Líneas de Investigación


*Studies of the neuronal mechanisms of the influence of cotinine on behavioral and neurophysiological aberrations caused by post-traumatic stress disorder (PTSD). *Search for new therapeutic approaches to the treatment of neurodegenerative diseases.

Educación

  •  Physiology, MOSCOW STATE UNIVERSITY. Rusia, 1981
  •  Neurophysiology, MOSCOW STATE UNIVERSITY. Rusia, 1994

Experiencia Académica

  •   Post-Doctoral Fellow Full Time

    Research Institute of Experimental and Theoretical Biophysics, Pushchino, Moscow Region, Russia

    Laboratory of Functional Neurochemistry

    Pushchino, Mosow region, Rusia

    1994 - 1998

  •   Research Professor Full Time

    University of Colima

    Colima, México

    1998 - 2001

  •   Staff Scientist Full Time

    Sun Health Research Institute

    Phoenix, Estados Unidos

    2001 - 2004

  •   Research Scientist Full Time

    Arizona State University

    Tempe, Estados Unidos

    2004 - 2011

  •   Research Scientist Full Time

    Bay Pines VA Healthcare System (VAHCS)

    Bay Pines, Estados Unidos

    2011 - 2014

  •   Assistant professor Full Time

    Universidad San Sebastián

    Ciencias de la Salud

    Concepcion, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Research Scientist Full Time

    Bay Pines VA Healthcare System (VAHCS)

    Bay Pines, FL 33744, Estados Unidos

    2012 - 2014

  •   Research Scientist Full Time

    Center for Adaptive Neural Systems at the Arizona State University

    Tempe, Estados Unidos

    2004 - 2011

  •   Staff Scientist Full Time

    Thomas H. Christopher Center for Parkinson’s Research, Sun Health Research Institute

    Sun City, Estados Unidos

    2001 - 2004

  •   Research Professor Full Time

    Neuroendocrinology of C.U.I.B. (Centro Universitario de Investigasiones Biomedicas), University of Colima

    Colima, México

    1998 - 2001

  •   Post-Doctoral Fellow Full Time

    Laboratory of Functional Neurochemistry, Institute of Experimental and Theoretical Biophysics, Pushchino, Moscow Region, Russia

    Pushchino, Rusia

    1994 - 1998

  •   Assistant professor Full Time

    Universidad San Sebastián

    Concepcion, Chile

    2015 - A la fecha


 

Article (26)

Cotinine enhances fear extinction and astrocyte survival by mechanisms involving the nicotinic acetylcholine receptors signaling
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress
Cotinine=> A Therapy for Memory Extinction in Post-traumatic Stress Disorder.
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice.
Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP plus cells loss induced by restraint stress in mice
Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease
Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder
Nicotine-derived compounds as therapeutic tools against post-traumatic stress disorder.
Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice
Cotinine Reduces Depressive-Like Behavior and Hippocampal Vascular Endothelial Growth Factor Downregulation After Forced Swim Stress in Mice
Cotinine reduces depressive-like behavior and hippocampal vascular endothelial growth factor downregulation after forced swim stress in mice.
Cotinine reduces depressive-like behavior, working memory deficits and synaptic loss associated with chronic stress in mice
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice.
Potential Mechanisms Underlying the Facilitation of Fear Memory Extinction by Cotinine
Age-related differences in MK-801 induced behaviors in dopamine D-3 receptor knock out mice
Characteristics and Organization of Discharge Properties in Rat Hindlimb Motoneurons
Locomotor activity induced by MK-801 is enhanced in dopamine D-3 receptor knockout mice but suppression by dopamine D-3/D-2 antagonists does not occur through the dopamine D-3 receptor
Repetetive hindlimb movement using intermittent adaptive neuromuscular electrical stimulation in an incomplete spinal cord injury rodent model
Adaptive Control of Movement for Neuromuscular Stimulation-Assisted Therapy in a Rodent Model
Carotid chemoreceptor reflex modulation by arginine-vasopressin microinjected into the nucleus tractus solitarius in rats
Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D-3 receptor knockout mice
Arginine-vasopressin in nucleus of the tractus solitarius induces hyperglycemia and brain glucose retention
Comparative Analysis of Electrical Brain Activity After GABA and Glutamate Administration: Is It Possible to Have Correlation Between Specific Neurochemical Changes in the Brain and in the EEG?
Changes in the Electrical Activity of the Rat Brain During the Central Administration of Different Doses of GABA Agonists and Antagonists
The action of agonists and an antagonist of GABA on the frequency composition of the electrical activity of various brain structures of rats

BookSection (2)

Chemoreception
Carotid chemoreceptors participation in brain glucose regulation. Role of arginine-vasopressin.

Proyecto (3)

INVESTIGATING COTININE AS A THERAPY FOR POST-TRAUMATIC STRESS DISORDER
Cotinine reduces Chemotherapy-induced Cognitive Impairment
Memory enhancing effects of high-energy compounds plus cotinine in aged mice

Review (3)

Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine
Positive modulators of the alpha 7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease
23
Alexandre Iarkov

Assistant professor

Ciencias de la Salud

Universidad San Sebastián

Concepcion, Chile

4
George Sampaio

Investigador

Universidad Autónoma de Chile

Santiafo, Chile

3
Valentina Echeverria

Profesora

Universidad San Sebastian

Concepcion, Chile

2
CRISTHIAN MENDOZA

Docente Investigador Laboratorio de Neurobiología

Facultad Ciencias de la Salud

Universidad San Sebastián

Concepción, Chile

2
George Sampaio

Presidente

Colégio Colombiano de Neurociencias