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George Emilio Sampaio Barreto

Investigador

Universidad Autónoma de Chile

Santiafo, Chile

Líneas de Investigación


Neurobiology and neuroendocrine aspects of glial cells; Neuroinflammation; Mitochondria; Menopause; Hormonal therapy; Biological role of brain-targeted drugs

Educación

  •  Neurosciences, UNIVERSIDAD COMPLUTENSE DE MADRID. España, 2009
  •  Neurobiochemistry, UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE. Brasil, 2005

Experiencia Académica

  •   PhD student Full Time

    Instituto Cajal

    Dept Neurobiology

    Madrid, España

    2006 - 2009

  •   Postdoctoral Fellow Full Time

    STANFORD UNIVERSITY

    Medicine

    Stanford, Estados Unidos

    2009 - 2011

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD JAVERIANA

    Sciences

    Bogotá, Colombia

    2011 - 2016

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepción, Chile

    2016 - 2017

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD JAVERIANA

    Sciences

    Bogotá, Colombia

    2017 - 2019

Formación de Capital Humano


Undergraduate Students

María Santos Galindo. Effects of early treatment with estrogenic compounds in glial reactivity in a model of brain injury (B.Sc. in Biology), Autonomous University of Madrid, Spain. (Director: George E. Barreto) (Period: 2006-2007)

Sara Rodriguez. Effects of late treatment with estrogenic compounds in glial reactivity and proliferation after brain injury (B.Sc. in Biology), Autonomous University of Madrid, Spain. (Director: George E. Barreto) (Period: 2007-2008)

Ana Carla Araújo de Souza. Analysis of the expiratory peak and 6-minutes walking test in smokers (B.Sc. in Physical Therapy). Southeastern State University of Bahia. Brazil, 2010. (Director: George E. Barreto)

Altair Brito dos Santos. Influence of sleep disorders and cognition in Parkinson’s Disease (B.Sc. in Physical Therapy). Southeastern State University of Bahia. Brazil, 2010. (Director: George E. Barreto)

Guillermo Villamil. 3D structure prediction and functional characterization of the proteoglycan phosphacan following brain injury (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2011. (Director: George E. Barreto)

Andrés Tolosa. Mapping of the H1N1 sequences and mutations and their relation to specific binding sites in drugs (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2011.

Angelica Sabogal. Molecular dynamics of sea anemone neurotoxins and potassium channels (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2012.

Viviana Barreto. In-silico prediction of structural and functional aspects of a hypothetical protein Leptospira interrogans serovar Copenhageni (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2012.

Samuel David Suarez. Tertiary structural prediction of phospholipase A2 and binding interactions with nifedipine (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2012. (Director: George E. Barreto)

Omar Sierra Bello. Mapping of mutations in Amyotrophic Lateral Syndrome (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2012. (Director: George E. Barreto)

Daniel Torrente. Neuroprotection by mesenchymal stem cells following brain injury: An in vitro, in vivo and in silico study (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia. (Director: George E. Barreto) (Period: 2013-2014)

Nicolas Toro Urrego. Effects of testosterone on glucose deprived cells. (B.Sc. in Microbiology). Pontificia Universidad Javeriana, Colombia, 2015. (Director: George E. Barreto)

Daniel Sandoval. TSPO-induced steroidogenesis by chlorodiazepam to reduce oxidative stress in astrocytes (B.Sc. in Microbiology). Pontificia Universidad Javeriana, Colombia, 2015. (Director: George E. Barreto)

Juan Camilo. Potential neuroprotective role of nicotine analogues in an in vitro model of Parkinson´s Disease (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2015. (Director: George Barreto). Grade: Summa Cum Laude.

Angie Valeria Garzón. Effects of tibolone on cell viability and nuclear translocator protein NF-kB in astrocytes submitted to glucose deprivation (B.Sc. in Bacteriology). Pontificia Universidad Javeriana, Colombia, 2016. (Director: George E. Barreto).

Diego Julián Vesga. Evaluation of the effects of raloxifene in an astroglial model of glucose deprivation (B.Sc. in Biology). Pontificia Universidad Javeriana, Colombia, 2016. (Director: George Barreto).

Graduate Students

Diego Salazar Barreto. Metabolic pathways in mucopolisacaridosis: A secretome study (M.Sc. in Biological Sciences) Pontificia Universidad Javeriana, Colombia. (Co-Director: George E. Barreto) (Period: 2013-2014)

Cynthia Martin Jiménez. Genomic Scale metabolic reconstruction of human astrocyte: Application to brain ischemia (M.Sc. in Biological Sciences). Pontificia Universidad Javeriana, Colombia. (Co-Director: George E. Barreto) (Period: 2015-2016)

Marco Fidel Ávila-Rodriguez. Cellular and molecular mechanisms induced by estradiol and tibolone on an astroglial model of glucose deprivation (Ph.D. in Biological Sciences). Pontificia Universidad Javeriana, Colombia. (Director: George E. Barreto). (Period: 2011-2016) Calification: Laureate.

Jenny Natalia Areiza Mazo. Effects of extracts from Physalis peruviana and bioactive compounds in the response of astrocytes to neurotoxic stimuli with rotenone (M.Sc. in Food Science and Human Nutrition). University of Antioquia, Colombia. (Director: George E. Barreto). (Period: 2017-2018) Calification: Excellent

Oscar Alejandro Hidalgo Lanussa. Neuroprotective effects of tibolone in microglial cells stimulated with palmitic acid (M.Sc. in Biological Sciences). Pontificia Universidad Javeriana, Colombia. (Director: George E. Barreto; Co-Director: Luis Miguel Garcia-Segura). (Period: 2016-2017). Calification: Laureate

Ricardo Julián Cabezas Perez. Mecanisms of protection exerted by PDGF-BB upon neurotoxic damage induced by rotenone in astrocytes (Ph.D. in Biological Sciences). Pontificia Universidad Javeriana, Colombia. (Director: George E. Barreto). (Period: 2011-2017)

Eliana Baez Jurado. Potential effect of the conditioned medium of mesenchymal stem cells derived from adipose tissue on human astrocytes under an in vitro model of scratch and glucose deprivation. Ph.D. in Biological Sciences. Pontificia Universidad Javeriana. (Director: George Barreto). (Period: 2014-2018). Calification: Laureate and Summa Cum Laude.

Natalia Alicia Aguilef Barría. Contraceptive use and its effects on women's cognition and memory. Autonomous University of Chile. M.Sc in Neurosciences. (Director: George E. Barreto). Period: 2018-2019.

Paola Gajardo Ametínez. Sex differences in the anatomy and function of the brain: Actions of estrogens on mitochondria. Autonomous University of Chile. M.Sc in Neurosciences. (Director: George E. Barreto). Period: 2018-2019.

Yeimy González. Molecular mechanisms involved in the protective effects of tibolone in astrocytic cells treated with palmitic acid. Ph.D. in Biological Sciences. Pontificia Universidad Javeriana. (Director: George Barreto). (Period: 2015-2019). Calification: Laureate and Summa Cum Laude

Postdoctoral Fellows

Diego Gómez, Ph.D. Postdoctoral Fellow. Astrocytes-neurons crosstalk as a protective mechanism in brain injuries: An in silico approach. Pontificia Universidad Javeriana, Colombia. Mentor: George E. Barreto (Period: 2014-2015).

Biviana Barrera-Bailón, Ph.D. Postdoctoral Fellow. Use of natural estrogenic-like compounds derived from Physalis peruviana as therapeutic approaches against cytotoxic damage. Pontificia Universidad Javeriana, Colombia. Mentor: George E. Barreto. (Period: 2017-2018).


Premios y Distinciones

  •   Mejor Professor 2018

    PONTIFICIA UNIVERSIDAD JAVERIANA

    Colombia, 2018

    Award Mejor Profesor 2018


 

Article (148)

Circadian and sleep dysfunction in Alzheimer's disease
Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling
Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system
Developmental lead (Pb)-induced deficits in redox and bioenergetic status of cerebellar synapses are ameliorated by ascorbate supplementation
Effects of curcumin on mitochondria in neurodegenerative diseases
Effects of curcumin on neurological diseases: focus on astrocytes
Epigenetic aspects of multiple sclerosis and future therapeutic options
Estrogen Signaling in Alzheimer's Disease: Molecular Insights and Therapeutic Targets for Alzheimer's Dementia
Exploring the Potential of Neuroproteomics in Alzheimer's Disease
Lipid-based nanoformulations in the treatment of neurological disorders
Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer's Disease
Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease
Multiple Pathways Involved in Palmitic Acid-Induced Toxicity: A System Biology Approach
Neuroprotection by curcumin: A review on brain delivery strategies
Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review
Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease
Raloxifene potentiates the effect of fluoxetine against maximal electroshock induced seizures in mice
Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins
Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease
Scientific productivity in neurosciences in Latin America: a scientometrics perspective
Strategies for the Treatment of Parkinson's Disease: Beyond Dopamine
Tibolone as Hormonal Therapy and Neuroprotective Agent
Vitamin D receptor genetic polymorphisms and the risk of multiple sclerosis: A systematic review and meta-analysis
(E)-Nicotinaldehyde O-Cinnamyloxime, a Nicotine Analog, Attenuates Neuronal Cells Death Against Rotenone-Induced Neurotoxicity
Anti-androgen drugs in the treatment of obsessive-compulsive disorder: a systematic review
Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury
Cellular and Molecular Aspects of Parkinson Treatment: Future Therapeutic Perspectives
Copper and Neurotoxicity in Autism Spectrum Disorder
Curcumin as a therapeutic agent in leukemia
Higher zinc concentrations in hair of Parkinson's disease are associated with psychotic complications and depression
In silico evidence of direct interaction between statins and beta-amyloid
Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury
Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells
Neuroactive steroids, neurosteroidogenesis and sex
NeuroMuscleDB: a Database of Genes Associated with Muscle Development, Neuromuscular Diseases, Ageing, and Neurodegeneration
Nootropic and Anti-Alzheimer's Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer's Neuropathology
Pharmacoinformatics and molecular docking reveal potential drug candidates against Schizophrenia to target TAAR6
Protein modeling, molecular network and molecular dynamics study of newly sequenced interleukin-18 (IL-18) gene in Mus musculus
qPCR-based methods for expression analysis of miRNAs
Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation
TERT inhibition leads to reduction of IL-6 expression induced by palmitic acid and interferes with the protective effects of tibolone in an astrocytic cell model
The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review
The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy
Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta
Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay
Combined Strategy for a Reliable Evaluation of Spinal Cord Injury Using an in vivo Model
Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress
Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder
Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder (vol 55, pg 6700, 2018)
Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone
Genome-Wide Expression Profiles for Ischemic Stroke: A Meta-Analysis
Hair in Parkinsons disease patients exhibits differences in Calcium, Iron and Zinc concentrations measured by flame atomic absorption spectrometry - FAAS
Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice (vol 55, pg 7949, 2018)
Mixture Design and Doehlert Matrix for the Optimization of the Extraction of Phenolic Compounds from Spondias mombin L Apple Bagasse Agroindustrial Residues
New ABCC2 RS3740066 and RS2273697 polymorphisms identified in a healthy colombian cohort
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult
Sleep disorders associated with Alzheimer's disease: A perspective
The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury
Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid
Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta
4 '-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation
A Systematic in-silico Analysis of Helicobacter pylori Pathogenic Islands for Identification of Novel Drug Target Candidates
Anthocyanins: Multi-Target Agents for Prevention and Therapy of Chronic Diseases
Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases
Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice
Genome-Scale Reconstruction of the Human Astrocyte Metabolic Network
Genomics and Epigenomics of Tumor and Aging Cells
Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice
Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP plus cells loss induced by restraint stress in mice
Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs
Mitochondrial Permeability Transition Pore as a Suitable Target for Neuroprotective Agents Against Alzheimer's Disease
Neuroglial cell cryopreservation in appropriate inductive conditions
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
Portacaval shunting causes differential mitochondrial superoxide production in brain regions
Securinine Derivatives as Potential Anti-amyloid Therapeutic Approach
Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities
A Synopsis on the Linkage Between Age-Related Dementias and Vascular Disorders
Alterations in Glucose Metabolism on Cognition: A Possible Link Between Diabetes and Dementia
Approaches for the Development of Drugs for Treatment of Obesity and Metabolic Syndrome
Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor
Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease
Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System
Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis
Meta-analysis of Telomere Length in Alzheimer's Disease
Microglial Dependent Protective Effects of Neuroactive Steroids
Neuroinflammation: A Therapeutic Target of Cotinine for the Treatment of Psychiatric Disorders?
Protection by Neuroglobin expression in Brain Pathologies
Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions
Role of Microfluidics in Blood-Brain Barrier Permeability Cell Culture Modeling: Relevance to CNS Disorders
Role of neuroinflammation and sex hormones in war-related PTSD
SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson
Systems biology study of mucopolysaccharidosis using a human metabolic reconstruction network
Targeting astrocytes in brain injuries: A translational research approach
Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease
Telomere length in Parkinson's disease: A meta-analysis
Testosterone Protects Mitochondria! Function and Regulates Neuroglobin Expression in Astrocytic Cells Exposed to Glucose Deprivation
Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression
Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
Unsuspected Intrinsic Property of Melanin to Dissociate Water Can Be Used for the Treatment of CNS Diseases
Updates on the Production of Therapeutic Antibodies Using Human Hybridoma Technique
Are Sleep Disturbances Preclinical Markers of Parkinson's Disease?
Computational Analysis and Functional Prediction of Ubiquitin Hypothetical Protein: A Possible Target in Parkinson Disease
Conjugates of gamma-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease
Editorial on Cerebral endothelial and glial cells are more than bricks in the Great Wall of the brain: insights into the way the blood-brain barrier actually works (celebrating the centenary of Goldman's experiments)
Nanoparticles as Alternative Strategies for Drug Delivery to the Alzheimer Brain: Electron Microscopy Ultrastructural Analysis
Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder
NMDARs in neurological diseases: a potential therapeutic target
PDGF-BB Protects Mitochondria from Rotenone in T98G Cells
The Innate Immunity in Alzheimer Disease-Relevance to Pathogenesis and Therapy
Astrocytic modulation of blood brain barrier: perspectives on parkinson's disease
Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel
Cortical spreading depression and mitochondrial dysfunction with aging: lessons from ethanol abuse
Cortical spreading depression in traumatic brain injuries: Is there a role for astrocytes?
Increased calcium influx triggers and accelerates cortical spreading depression in vivo in male adult rats
Leishmania braziliensis replication protein A subunit 1: molecular modelling, protein expression and analysis of its affinity for both DNA and RNA
Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model
Protection after stroke: cellular effectors of neurovascular unit integrity
Selective estrogen receptor modulators regulate reactive rnicroglia after penetrating brain injury
Special Issue: Astrocytes in the Injured Brain: Is Gliosis Adaptive or Maladaptive? Introduction
Structural insights from GRP78-NF-kappa B binding interactions: A computational approach to understand a possible neuroprotective pathway in brain injuries
Tibolone protects T98G cells from glucose deprivation
Treatment of sleeping disorders should be considered in clinical management of Parkinson's disease
In Silico Insights of L-Glutamate: Structural Features in Vacuum and in Complex with Its Receptor
Integrative Approach for Computationally Inferring Interactions between the Alpha and Beta Subunits of the Calcium-Activated Potassium Channel (BK): A Docking Study
Novel interactions of GRP78: UPR and estrogen responses in the brain
Nuclear Factor-kappa B/Bcl-XL Pathway is Involved in the Protective Effect of Hydrogen-Rich Saline on the Brain Following Experimental Subarachnoid Hemorrhage in Rabbits
Cellular and molecular mechanisms of antioxidants in Parkinson's disease
Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse
Effects of natural antioxidants in neurodegenerative disease
Hippocampal Dendritic Spines Modifications Induced by Perinatal Asphyxia
In silico docking reveals possible Riluzole binding sites on Nav1.6 sodium channel: Implications for amyotrophic lateral sclerosis therapy
Mitochondrial functions in astrocytes: Neuroprotective implications from oxidative damage by rotenone
Neuroprotection from Stroke in the Absence of MHCI or PirB
Neuroprotective Agents in Brain Injury: A Partial Failure?
Polyphenols and neurodegenerative diseases
Astrocyte Proliferation Following Stroke in the Mouse Depends on Distance from the Infarct
Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury
Heat Shock Protein 72 Overexpression Prevents Early Postoperative Memory Decline after Orthopedic Surgery under General Anesthesia in Mice
Increased Brain Injury and Worsened Neurological Outcome in Interleukin-4 Knockout Mice After Transient Focal Cerebral Ischemia
Long-lasting effects of perinatal asphyxia on exploration, memory and incentive downshift
Neuroprotection by Estradiol: Some Important Considerations
Age-related Defects in Sensorimotor Activity, Spatial Learning, and Memory in C57BL/6 Mice
Selective Estrogen Receptor Modulators Decrease Reactive Astrogliosis in the Injured Brain: Effects of Aging and Prolonged Depletion of Ovarian Hormones
Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
Catecol inibe FADH2 ligado à respiração na fração mitochondrial do fígado do rato

Errata (4)

Publisher Correction: Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities (Scientific Reports, (2017), 7, 1, (8309), 10.1038/s41598-017-05832-w)
Endothelial PPAR gamma Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK (vol 36, pg 1, 2019)
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress (vol 56, pg 2339, 2019)
Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention (vol 129, pg 216, 2018)

Review (63)

Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds
Neuroprotective effects of curcumin through autophagy modulation
The role of nuclear factors as “Find-Me”/alarmin signals and immunostimulation in defective efferocytosis and related disorders
A review of the pharmacological and therapeutic effects of auraptene
Anti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways
Antidiabetic potential of saffron and its active constituents
Antioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients
APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis
Autophagic dysfunction in Alzheimer's disease: Cellular and molecular mechanistic approaches to halt Alzheimer's pathogenesis
Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?
Chitosan-based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects
Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning
Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets
Effects of Curcumin on Microglial Cells
Effects of estrogens and androgens on mitochondria under normal and pathological conditions
Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies
Emerging roles for high-density lipoproteins in neurodegenerative disorders
Endothelial PPAR gamma Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress
Hormetic effects of curcumin: What is the evidence?
Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders
Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent
Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited
Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology
Metabolic effects of antidiabetic drugs on adipocytes and adipokine expression
PCSK9 and inflammation: a review of experimental and clinical evidence
Prevalence, pathological mechanisms, and genetic basis of limb-girdle muscular dystrophies: A review
Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System
Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders
Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies
The Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in Treatment of Neurodegenerative Diseases
Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease
Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)
Gold nanoparticles: A plausible tool to combat neurological bacterial infections in humans
Impact of fibrates on circulating cystatin C levels: a systematic review and meta-analysis of clinical trials
Ionic gradient liposomes: Recent advances in the stable entrapment and prolonged released of local anesthetics and anticancer drugs
Metabolic Abnormalities of Erythrocytes as a Risk Factor for Alzheimer's Disease
Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention
Modulation of heat shock proteins by statins
Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
Pharmacological Aspects of Neuro-Immune Interactions
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Sex differences in Parkinsons disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics
The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
The effect of fasting or calorie restriction on autophagy induction: A review of the literature
The Role of Efferocytosis in Autoimmune Diseases
Urotensin II: Molecular Mechanisms of Biological Activity
Advances in Medicinal Plants with Effects on Anxiety Behavior Associated to Mental and Health Conditions
Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications
Ginkgo biloba as an Alternative Medicine in the Treatment of Anxiety in Dementia and other Psychiatric Disorders
Gliomas: New Perspectives in Diagnosis, Treatment and Prognosis
Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease?
L-Type Calcium Channels Modulation by Estradiol
Medicinal Plants as Protective Strategies Against Parkinson's Disease
Nanotechnology for Alzheimer Disease
Nanotechnology in Neurosciences: An Approach
Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells
Relationship Between Obesity, Alzheimer's Disease, and Parkinson's Disease: an Astrocentric View
Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons
Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system
Novel Approaches in Astrocyte Protection: from Experimental Methods to Computational Approaches
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease
Dual role of astrocytes in perinatal asphyxia injury and neuroprotection
215
George Sampaio

Investigador

Universidad Autónoma de Chile

Santiafo, Chile

13
Valentina Echeverria

Profesora

Universidad San Sebastian

Concepcion, Chile

8
George Sampaio

Presidente

Colégio Colombiano de Neurociencias

8
CRISTHIAN MENDOZA

Docente Investigador

Facultad de Medicina y Ciencia

Universidad San Sebastián

Concepción, Chile

4
Alexandre Iarkov

Assistant professor

Ciencias de la Salud

Universidad San Sebastián

Concepcion, Chile

1
EDUARDO BAEZ

Docente

Deporte y Recreación

Universidad de Playa Ancha

Valpraíso, Chile