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Daniel Elías Castillo Bermúdez

Head

PhageLab SpA

Santiago, Chile

Mis lineas de investigación están enfocadas en los siguientes tópicos: 1. Genómica comparativa de bacteria patógenas y bacteriófagos 2. Biocontrol de bacteria patógenas en acuicultura. 3. Ecología y diversidad de bacterias y bacteriófagos.

Microbiología, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2012
Bioquímico, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2008
Licenciado en Bioquimica, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2007

Profesor Asistente Full Time

Universidad SEK

Santiago , Chile

2020 - 2021
Profesor Asistente Full Time

Universidad de Copenhague

Elsinore, Dinamarca

2018 - 2020
Investigador Postdoctoral Full Time

Universidad de Copenhague

Elsinore, Dinamarca

2017 - 2018
Investigador Postdoctoral Full Time

Universidad de Copenhague

Elsinore, Chile

2013 - 2016
Investigador Postdoctoral Full Time

Universidad de Copenhague

Elsinore, Chile

2012 - 2013
Principal Scientist Discovery Full Time

PhageLab SpA

Santiago, Chile

2021 - 2022
Head of Manufacturing, Science and Technology (MSAT) Full Time

PhageLab SpA

Santiago, Chile

2022 - A la fecha

Profesor Asistente Full Time

Universidad SEK

Santiago, Chile

2020 - 2021
Profesor Asistente Full Time

Universidad de Copenhague

Elsinore, Dinamarca

2018 - 2020
Investigador Postdoctoral Full Time

Universidad de Copenhague

Elsinore, Chile

2017 - 2018
Investigador Postdoctoral Full Time

Universidad de Copenhague

Elsinore, Chile

2013 - 2016
Investigador Postdoctoral Full Time

Universidad de Copenhague

Elsinore, Chile

2012 - 2013
Principal Scientist Full Time

PhageLab SpA

Chile

2021 - 2022
Head of Manufacturing, Science and Technology Full Time

PhageLab SpA

Santiago, Chile

2022 - A la fecha


Development and characterization of a bacteriophage cocktail with high lytic efficacy against field-isolated Salmonella enterica Aguilera, Matias; Tobar-Calfucoy, Eduardo; Rojas-Martinez, Victoria; Norambuena, rodrigo; Serrano, María Jesús; Onix, Cifuentes; María Sofía Zamudio; Daniel San Martín; Pabla Lara; Andrea Sabag; Zabner, Marcela; Daniel Tichy; Pamela Camejo; Luis León; Pino, Michael; Soledad Ulloa; Rojas, Felipe; Pieringer, Christian; Cecilia Muster; Castillo, Daniel; Ferreira, Nicolás; Camilo Avendaño; Mauro Canaval; Pieringer, Hans; Pablo Cifuentes; Cifuentes Muñoz, Nicolás Article POULTRY SCIENCE (2023)
Reversible mutations in gliding motility and virulence genes: A flexible and efficient phage defence mechanism in Flavobacterium psychrophilum Jorgensen, Johanna; Sundell, Krister; Castillo, Daniel; Liv S Dramshøj; Natasja B Jørgensen; Susie B Madsen; Landor, Lotta; Wiklund, Tom; Donati, Valentina Laura; Madsen, Lone; Dalsgaard, Inger; Middelboe, Mathias Article ENVIRONMENTAL MICROBIOLOGY (2022)
Comparative Genomic Analyses of <i>Flavobacterium psychrophilum</i> Isolates Reveals New Putative Genetic Determinants of Virulence Traits Castillo, Daniel; Donati, Valentina L.; Jorgensen, Johanna; Sundell, Krister; Dalsgaard, Inger; Madsen, Lone; Wiklund, Tom; Middelboe, Mathias Article ISI SCOPUS Microorganisms (2021)
Genome-informed approach to identify genetic determinants of <i>Flavobacterium psychrophilum</i> phage susceptibility Daniel, Castillo; Johanna, Jorgensen; Krister, Sundell; Madsen, Lone; Inger, Dalsgaard; Tom, Wiklund; Middelboe, Mathias Article ISI SCOPUS ENVIRONMENTAL MICROBIOLOGY (2021)
Interactions between Rainbow Trout Eyed Eggs and Flavobacterium spp. Using a Bath Challenge Model: Preliminary Evaluation of Bacteriophages as Pathogen Control Agents Donati, Valentina L.; Dalsgaard, Inger; Runtuvuori-Salmela, Anniina; Kunttu, Heidi; Jorgensen, Johanna; Castillo, Daniel; Sundberg, Lotta-Riina; Middelboe, Mathias; Madsen, Lone Article ISI SCOPUS Microorganisms (2021)
Phage-Mediated Control of Flavobacterium psychrophilum in Aquaculture: In vivo Experiments to Compare Delivery Methods Donati, Valentina Laura; Dalsgaard, Inger; Sundell, Krister; Castillo, Daniel; Er-Rafik, Meriem; Clark, Jason; Wiklund, Tom; Middelboe, Mathias; Madsen, Lone Article ISI FRONTIERS IN MICROBIOLOGY (2021)
Beyond Cholera: Characterization of zot-Encoding Filamentous Phages in the Marine Fish Pathogen Vibrio anguillarum Mauritzen, Jesper Juel; Castillo, Daniel; Tan, Demeng; Svenningsen, Sine Lo; Middelboe, Mathias Article VIRUSES-BASEL (2020)
Complete Genome Sequence of Vibrio anguillarum Nontailed Bacteriophage NO16 Kalatzis, Panos G.; Carstens, Alexander B.; Katharios, Pantelis; Castillo, Daniel; Hansen, Lars H.; Middelboe, Mathias Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2019)
Conservation of Small Regulatory RNAs in Vibrio parahaemolyticus: Possible role of RNA-OUT Encoded by the Pathogenicity Island (VPaI-7) of Pandemic Strains Plaza, Nicolas; Perez-Reytor, Diliana; Ramirez-Araya, Sebastian; Pavon, Alequis; Corsini, Gino; Loyola, David E.; Jana, Victor; Pavez, Leonardo; Navarrete, Paola; Bastias, Roberto; Castillo, Daniel; Garcia, Katherine Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Diversification of Vibrio anguillarum Driven by the Bacteriophage CHOED LeÃ³n M.; Kokkari C.; GarcÃa K.; Castillo D.; Katharios P.; BastÃas R. Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2019)
Large Phenotypic and Genetic Diversity of Prophages Induced from the Fish Pathogen Vibrio anguillarum Castillo, Daniel; Andersen, Nana; Kalatzis, Panos G.; Middelboe, Mathias Article ISI VIRUSES-BASEL (2019)
Phage defense mechanisms and their genomic and phenotypic implications in the fish pathogen Vibrio anguillarum Castillo, Daniel; Rorbo, Nanna; Jorgensen, Johanna; Lange, Janina; Tan, Demeng; Kalatzis, Panos G.; Lo Svenningsen, Sine; Middelboe, Mathias Article ISI FEMS MICROBIOLOGY ECOLOGY (2019)
Phenotypic and Genetic Predictors of Pathogenicity and Virulence in Flavobacterium psychrophilum Sundell, Krister; Landor, Lotta; Nicolas, Pierre; Jorgensen, Johanna; Castillo, Daniel; Middelboe, Mathias; Dalsgaard, Inger; Donati, Valentina Laura; Madsen, Lone; Wiklund, Tom Article ISI FRONTIERS IN MICROBIOLOGY (2019)
Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy Kalatzis, Panos G.; Castillo, Daniel; Katharios, Pantelis; Middelboe, Mathias Article ISI ANTIBIOTICS-BASEL (2018)
Complete Genome Sequence of Shewanella sp. WE21, a Rare Isolate with Multiple Novel Large Genomic Islands Castillo, Daniel; Gram, Lone; Dailey, Frank E. Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2018)
Draft Genome Sequences of Six Vibrio diazotrophicus Strains Isolated from Deep Subsurface Sediments of the Baltic Sea Castillo, Daniel; Vandieken, Verona; Engelen, Bert; Engelhardt, Tim; Middelboe, Mathias Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2018)
Exploring the Genomic Traits of Non-toxigenic Vibrio parahaemolyticus Strains Isolated in Southern Chile Garcia, Katherine; Corsini, Gino; Castillo, Daniel; Bastias, Roberto; Plaza, Nicolas; Loyola, David E.; Blondel, Carlos J.; Jana, Victor; Ramirez-Araya, Sebastian; Pavez, Leonardo; Perez-Reytor, Diliana Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2018)
Genome Sequences of Shewanella baltica and Shewanella morhuae Strains Isolated from the Gastrointestinal Tract of Freshwater Fish Castillo, Daniel; Gram, Lone; Dailey, Frank E. Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2018)
Widespread distribution of prophage-encoded virulence factors in marine Vibrio communities Castillo, Daniel; Kauffman, Kathryn; Hussain, Fatima; Kalatzis, Panos; Rorbo, Nanna; Polz, Martin F.; Middelboe, Mathias Article ISI Scientific Reports (2018)
Comparative assessment of Vibrio virulence in marine fish larvae Ronneseth, A.; Castillo, D.; D'Alvise, P.; Tonnesen, O.; Haugland, G.; Grotkjaer, T.; Engell-Sorensen, K.; Norremark, L.; Bergh, O.; Wergeland, H. I.; Gram, L. Article ISI JOURNAL OF FISH DISEASES (2017)
Comparative Genome Analyses of Vibrio anguillarum Strains Reveal a Link with Pathogenicity Traits Castillo, Daniel; Alvise, Paul D.; Xu, Ruiqi; Zhang, Faxing; Middelboe, Mathias; Gram, Lone Article ISI mSystems (2017)
Draft Genome Sequence of Bacillus sp. Strain K2I17, Isolated from the Rhizosphere of Deschampsia antarctica Desv. Pavón, Alequis; Orellana, Paz; Salazar, Lorena; Céspedes, Sandra; Muiño, Laura; Gutiérrez, Ana; Castillo, Daniel; Corsini, Gino Article WOS-ESCI SCOPUS Genome Announcements (2017)
Draft Genome Sequence of Chilean Antarctic Pseudomonas sp. Strain K2I15 Orellana, Paz; Pavón, Alequis; Céspedes, Sandra; Salazar, Lorena; Gutiérrez, Ana; Castillo, Daniel; Corsini, Gino Article WOS-ESCI SCOPUS Genome Announcements (2017)
Stumbling across the Same Phage: Comparative Genomics of Widespread Temperate Phages Infecting the Fish Pathogen Vibrio anguillarum Kalatzis, Panos G.; Rorbo, Nanna; Castillo, Daniel; Mauritzen, Jesper Juel; Jorgensen, Johanna; Kokkari, Constantina; Zhang, Faxing; Katharios, Pantelis; Middelboe, Mathias Article ISI VIRUSES-BASEL (2017)
Comparative genome analysis provides insights into the pathogenicity of flavobacterium psychrophilum Castillo, D.; Christiansen R.H.; Dalsgaard, I; Madsen, L; Espejo, R.; Middelboe M. Article ISI SCOPUS PLOS ONE (2016)
Effect of Bacteriophages on the Growth of Flavobacterium psychrophilum and Development of Phage-Resistant Strains Christiansen, Roi Hammershaimb; Madsen, Lone; Dalsgaard, Inger; Castillo, Daniel; Kalatzis, Panos G.; Middelboe, Mathias Article ISI MICROBIAL ECOLOGY (2016)
Genomic diversity of bacteriophages infecting the fish pathogen Flavobacterium psychrophilum Castillo, Daniel; Middelboe, Mathias Article ISI FEMS MICROBIOLOGY LETTERS (2016)
Bacteriophage Resistance Mechanisms in the Fish Pathogen Flavobacterium psychrophilum: Linking Genomic Mutations to Changes in Bacterial Virulence Factors Castillo, Daniel; Cristiansen, Roi Hammershaimb; Dalsgaard, Inger; Madsen, Lone; Middelboe, Mathias Article ISI APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)
Draft Genome Sequence of Vibrio parahaemolyticus VH3, Isolated from an Aquaculture Environment in Greece Castillo, Daniel; Jun, Jin Woo; D'Alvise, Paul; Middelboe, Mathias; Gram, Lone; Liu, Siyang; Katharios, Pantelis Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2015)
Draft Genome Sequences of the Fish Pathogen Vibrio harveyi Strains VH2 and VH5 Castillo, Daniel; D'Alvise, Paul; Middelboe, Mathias; Gram, Lone; Liu, Siyang; Kalatzis, Panos G.; Kokkari, Constantina; Katharios, Pantelis Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2015)
Draft Genome Sequences of Vibrio alginolyticus Strains V1 and V2, Opportunistic Marine Pathogens Castillo, Daniel; D'Alvise, Paul; Kalatzis, Panos G.; Kokkari, Constantina; Middelboe, Mathias; Gram, Lone; Liu, Siyang; Katharios, Pantelis Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2015)
Complete Genome Sequence of Vibrio anguillarum Phage CHOED Successfully Used for Phage Therapy in Aquaculture Romero, J.; Higuera, G.; Gajardo, F.; Castillo, D.; Middleboe, M.; Garcia, K.; Ramirez, C.; Espejo, R. T. Article SCOPUS Genome Announcements (2014)
Diversity and Geographical Distribution of Flavobacterium psychrophilum Isolates and Their Phages: Patterns of Susceptibility to Phage Infection and Phage Host Range Castillo, D.; Christiansen, RH; Espejo, R.; Middelboe M. Article ISI SCOPUS MICROBIAL ECOLOGY (2014)
Genomic structure of bacteriophage 6H and its distribution as prophage in Flavobacterium psychrophilum strains Castillo, D.; Espejo, R.; Middelboe M. Article ISI FEMS MICROBIOLOGY LETTERS (2014)
Diversity of Flavobacterium psychrophilum and the potential use of its phages for protection against bacterial cold water disease in salmonids Castillo, D.; Higuera G; Villa, M; Middelboe M.; Dalsgaard, I; Madsen, L; Espejo R.T. Article ISI SCOPUS Journal of Fish Diseases (2012)
Functional evaluation of serine 252 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase Castillo, D.; Sepulveda, C; Cardemil, E; Jabalquinto, AM Article ISI SCOPUS BIOCHIMIE (2009)


Bacteriophages in the control of pathogenic vibrios Plaza, N; Castillo, D; Perez-Reytor, D; Higuera, G; Garcia, K; Bastias, R Review ISI SCOPUS ELECTRONIC JOURNAL OF BIOTECHNOLOGY (2018)