Enzo.jpg_thumb90

Enzo Rodolfo Tagliazucchi

Profesor

Universidad Adolfo Ibánez

Santiago, Chile

Líneas de Investigación


Development and application of tools from artificial inteligence, deep learning and dynamical systems modeling to multimodal neuroimaging data to unveil the neurobiological mechanisms underlying different physiological and pathological brain states.

Educación

  •  FISICA, UNIVERSIDAD DE BUENOS AIRES . Argentina, 2010
  •  FISICA, Johann-Wolfgang Goethe University Frankfurt am Main. Alemania, 2015

Experiencia Académica

  •   Profesor Asociado Part Time

    Universidad de Buenos Aires

    Fisica

    Argentina

    2019 - A la fecha

  •   Investigador Adjunto Part Time

    CONICET

    Chile

    2017 - Sin Información

  •   Profesoer visitante Part Time

    UNIVERSIDAD DE VALPARAISO

    Chile

    2019 - 2019

  •   Profesor adjunto en la Maestría en Neurociencia Part Time

    Universidad Favaloro

    Argentina

    2018 - 2019

  •   Profesor invitado Part Time

    Universidad de Buenos Aires

    Argentina

    2017 - 2017

  •   Profesor Adjunto Part Time

    Universidad de San Martin

    Chile

    2017 - 2018

  •   Profesor invitado Part Time

    Universidad de San Andrés

    Buenos Aires, Chile

    2016 - 2016

  •   Profesor invitado Part Time

    Jagiellonian University Krakow

    Krakow, Polonia

    2014 - 2014

  •   Profesor invitado Part Time

    Hamburg-Eppendorf University Hospital

    Hamburgo, Alemania

    2012 - 2016

  •   Ayudante docente Part Time

    Universidad de San Andrés

    Argentina

    2010 - 2011

  •   Ayudante docente Part Time

    Universidad de Buenos Aires

    Fisica

    CABA, Argentina

    2008 - 2010

  •   Ayudante docente Part Time

    Universidad de Buenos Aires

    CABA, Argentina

    2006 - 2008

Experiencia Profesional

  •   Investigador Full Time

    Instituto del Cerebro y la Médula Espinal, INSERM

    Francia

    2017 - 2018

  •   Investigador Postdoctoral Full Time

    Instituto de Neurociencias de Holanda,

    Holanda

    2016 - 2017

  •   Investigador Postdoctoral Full Time

    Christian Albrechts University Kiel

    Kiel, Alemania

    2015 - 2015

  •   Investigador Postdoctoral Full Time

    Johann Wolfgang Goethe University Frankfurt am Main

    Frankfurt am Main, Chile

    2011 - 2015

  •   Investigador Doctoral Full Time

    Universidad de Buenos Aires

    Buenos Aires , Argentina

    2010 - 2011

  •   Sr. Data Scientist Full Time

    Globant, Inc

    Los Angeles , Estados Unidos

    2013 - 2014

Formación de Capital Humano


Co-director de carrera de inv. científico (asistente) de Yonatan Sanz Perl.

Tesis de licenciatura de en física de Camila Sanz, Universidad de Buenos Aires (2017-finalizada)

Tesis de licenciatura en física de Sofia del Pozo, Universidad de Buenos Aires (2017-finalizada)

Tesis de licenciatura en física de Alejandro Pardo Pintos, Universidad de Buenos Aires (2017-finalizada)

Tesis de licenciatura en computación de Matías Laporte, Universidad de Buenos Aires (2018-finalizada)

Tesis de bachiller en ingeniería de Stefan Bossen, Kiel University, Alemania (2015, finalizada)

Tesis de licenciatura en psicología de Federico Cavanna, Universidad de Buenos Aires (2016-finalizada)

Tesis de maestría en neurociencias cognitivas de Yayla Ilksoy, Universidad de Amsterdam (2019-finalizada)

Tesis de licenciatura en física de Ignacio Pérez Ipiña, Universidad de Buenos Aires (2018-finalizada)

Tesis doctoral de Martina Gonzalez-Vilas, Universidad de San Martin (2017-2018)

Tesis doctoral de Matias Palmucci, Universidad de San Martin (2017-actual)

Tesis doctoral de Federico Zamberlan, Universidad de Buenos Aires (2017-actual)

Tesis doctoral de Camila Sanz, Universidad de Buenos Aires (2019-actual)

Tesis doctoral de Juan Piccini, Universidad de Buenos Aires (2019-actual)

Tesis doctoral de Débora Copa, Universidad de Buenos Aires (2019-actual)

Beca postdoctoral de Rocio Martinez Vivot, Universidad de Buenos Aires (2017-actual)

Beca postdoctoral de Carla Pallavicini, Universidad de Buenos Aires (2017-actual)

Tesis de licenciatura en física de Matías Battochia, Universidad de Buenos Aires (2018-actual)

Tesis de licenciatura en física Ariel Berardino, Universidad de Buenos Aires (2019-actual)

Tesis de licenciatura en física Martín Bálsamo, Universidad de Buenos Aires (2020-actual)

Tesis de licenciatura en física de Mariano Nicolini, Universidad de Buenos Aires (2020-actual)

Tesis de licenciatura en computación de Martín González Coll, Universidad de Buenos Aires (2020-actual)

Tesis de licenciatura en biología de Ivan Caro, Universidad de Buenos Aires (2020-actual)


Difusión y Transferencia


Investigaciones sobre el uso de neuroimágenes y métodos de la física estadística para comprender los estados no-ordinarios de conciencia y la dinámica cerebral general (publicados, entre otras revistas, en Neuron, PNAS, Current Biology, Physical Review Letters, Science Advances, Nature Communications) han sido cubiertas por Time Magazine, Huffington Post, La Nación, Página 12, New Scientist, VICE, IFLscience, además de otros medios escritos y diversas entrevistas radiales y televisivas, tanto nacionales como internacionales.

Nuestro trabajo reciente sobre la cuantificación de niveles de conciencia en pacientes vegetativos y con otros desórdenes de conciencia recibió amplia cobertura nacional (Página 12, La Nación) e internacional. Un resumen del trabajo en relación a mi tarea como investigador hasta el momento puede encontrarse en la siguiente nota: https://www.statnews.com/2019/02/06/detecting-consciousness-in-flickering-brain-signals/

Para más información sobre la cobertura de nuestro trabajo en medios de comunicación, visitar https://www.cocucolab.org

Periódicamente y junto con otros miembros de mi laboratorio realizamos tareas de extensión pro bono en escuelas secundarias e instituciones privadas y gubernamentales para proporcionar información sobre adicción, consumo problemático de sustancias, y minimización de riesgos (e.g. Colegio Nacional de Buenos Aires, Comisión Nacional de Energía Atómica – Centro Atómico Ezeiza, Escuela de Teatro Niní Marshal). Los contenidos se basan en el libro que escribimos en colaboración con varios colegas del ámbito científico nacional: www.sobredrogas.com.ar

Algunas de mis notas de extensión destinadas a público amplio se encuentran en la plataforma de El Gato y la Caja, y pueden accederse mediante el siguiente link: https://elgatoylacaja.com.ar/author/enzo/


Premios y Distinciones

  •   Scholar Award in Understanding Human Cognition

    James S. McDonnell

    Estados Unidos, 2018

    Nominado y finalista para el premio “Scholar Award in Understanding Human Cognition“ de la fundación James S. McDonnell (600.000 dólares)

  •   Premio Enrique Gaviola en Física y Matemática

    Academia Nacional de Ciencias

    Argentina, 2021

    Premio anual a investigadores jóvenes.


 

Article (110)

A whole-brain model of the neural entropy increase elicited by psychedelic drugs
Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness
Human brain effects of DMT assessed via EEG-fMRI
Low-dimensional organization of global brain states of reduced consciousness
Model-based whole-brain perturbational landscape of neurodegenerative diseases
One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
Source space connectomics of neurodegeneration: One-metric approach does not fit all
Temporal Irreversibility of Large-Scale Brain Dynamics in Alzheimer's Disease
Temporal irreversibility of neural dynamics as a signature of consciousness
The impact of regional heterogeneity in whole-brain dynamics in the presence of oscillations
The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task
Visual deep learning of unprocessed neuroimaging characterises dementia subtypes and generalises across non-stereotypic samples
Automated text-level semantic markers of Alzheimer's disease
Cognitive forces shape the dynamics of word usage across multiple languages
Dementia ConnEEGtome: Towards multicentric harmonization of EEG connectivity in neurodegeneration
Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
fMRI spectral signatures of sleep
From brain-body function to conscious interactions
Genuine high-order interactions in brain networks and neurodegeneration
Language as a Window Into the Altered State of Consciousness Elicited by Psychedelic Drugs
Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
Multi-feature computational framework for combined signatures of dementia in underrepresented settings
Natural language signatures of psilocybin microdosing
News sharing on Twitter reveals emergent fragmentation of media agenda and persistent polarization
Strength-dependent perturbation of whole-brain model working in different regimes reveals the role of fluctuations in brain dynamics
The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
Unifying turbulent dynamics framework distinguishes different brain states
Baseline Power of Theta Oscillations Predicts Mystical-Type Experiences Induced by DMT in a Natural Setting
Capturing the non-stationarity of whole-brain dynamics underlying human brain states
Decoding brain states on the intrinsic manifold of human brain dynamics across wakefulness and sleep
Dynamic brain fluctuations outperform connectivity measures and mirror pathophysiological profiles across dementia subtypes: A multicenter study
Moral responses to the COVID-19 crisis
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings
Noise-driven multistability vs deterministic chaos in phenomenological semi-empirical models of whole-brain activity
Nonequilibrium brain dynamics as a signature of consciousness
Pabell acute accent on I, Ciudad Universitaria (1428), CABA, Argentina.
Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness
Rare long-range cortical connections enhance human information processing
Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals
The entropic tongue: Disorganization of natural language under LSD
Unconsciousness reconfigures modular brain network dynamics
A mechanistic model of the neural entropy increase elicited by psychedelic drugs
Connectivity dynamics from wakefulness to sleep
Data augmentation based on dynamical systems for the classification of brain states
Generative Embeddings of Brain Collective Dynamics Using Variational Autoencoders
Lessons from being challenged by COVID-19
Linking the nature and functions of sleep: insights from multimodal imaging of the sleeping
Meditation increases the entropy of brain oscillatory activity will be published in Neuroscience
Modeling regional changes in dynamic stability during sleep and wakefulness
Relationship among subjective responses, flavor, and chemical composition across more than 800 commercial cannabis varieties
Whole-Brain Models to Explore Altered States of Consciousness from the Bottom Up
Awakening: Predicting external stimulation to force transitions between different brain states
Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep
Human consciousness is supported by temporally evolving brain processes
Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine.
Neurochemical models of near-death experiences: a large-scale study based on the semantic similarity of written reports.
Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives.
The avalanche-like behaviour of large-scale hemodynamic activity from wakefulness to deep sleep
The Ethics of Psychedelic Research in Disorders of Consciousness.
Time is a river which sweeps consciousness along, but consciousness is the river: Comment on “Is temporo-spatial dynamics the “common currency” of brain and mind? In Quest of “Spatiotemporal Neuroscience” ” by Georg Northoff et al
A combinatorial framework to quantify peak/pit asymmetries in complex dynamics.
Dynamic functional connectivity and brain metastability during altered states of consciousness
Endogenous modulation of human visual cortex activity improves perception at twilight
Human non-REM sleep and the mean global BOLD signal
Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
Mutual information identifies spurious Hurst phenomena in resting state EEG and fMRI data
The experience elicited by hallucinogens presents the highest similarity to dreaming within a large database of psychoactive substance reports.
The varieties of the psychedelic experience: association between the reported subjective effects, binding affinity profiles and molecular structures of eighteen psychoactive compounds
Increased Stability and Breakdown of Brain Effective Connectivity During Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
Information-theoretical analysis of resting state EEG microstate sequences non-Markovianity, non-stationarity and periodicities
Mapping visual dominance in human sleep
Novel Intrinsic Ignition Method Measuring Local-Global Integration Characterizes Wakefulness and Deep Sleep
On the Stability of BOLD fMRI Correlations
On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
The large-scale functional connectivity correlates of consciousness and arousal during the healthy and pathological human sleep cycle
The signatures of conscious access and its phenomenology are consistent with large-scale brain communication at criticality
Transcranial Direct Current Stimulation Modulates Neuronal Networks in Attention Deficit Hyperactivity Disorder
Analytical and empirical fluctuation functions of the EEG microstate random walk - Short-range vs. long-range correlations
Deep sleep divides the cortex into opposite modes of anatomical-functional coupling
Dynamical Signatures of Structural Connectivity Damage to a Model of the Brain Posed at Criticality
Human cortical-hippocampal dialogue in wake and slow-wave sleep
Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution
Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics
Neural correlates of the LSD experience revealed by multimodal neuroimaging
Progression to deep sleep is characterized by changes to BOLD dynamics in sensory cortices
The brain functional connectome is robustly altered by lack of sleep
The Voxel-Wise Functional Connectome Can Be Efficiently Derived from Co-activations in a Sparse Spatio-Temporal Point-Process
Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia
How we move is universal: Scaling in the average shape of human
Multimodal imaging of dynamic functional connectivity
Narcoleptic Patients Show Fragmented EEG-Microstructure During Early NREM Sleep
Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
Altered fMRI connectivity dynamics in temporal lobe epilepsy might explain seizure semiology
Decoding Wakefulness Levels from Typical fMRI Resting-State Data Reveals Reliable Drifts between Wakefulness and Sleep
Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs
Working memory performance of early MS patients correlates inversely with modularity increases in resting state functional connectivity networks
Brain Organization into Resting State Networks Emerges at Criticality on a Model of the Human Connectome
Breakdown of long-range temporal dependence in default mode and attention networks during deep sleep
Large-scale brain functional modularity is reflected in slow electroencephalographic rhythms across the human non-rapid eye movement sleep cycle
Sleep neuroimaging and models of consciousness
Small perturbations in a finger-tapping task reveal inherent nonlinearities of the underlying error correction mechanism
Automatic sleep staging using fMRI functional connectivity data
Criticality in large-scale brain fMRI dynamics unveiled by a novel point process analysis
Dynamic BOLD functional connectivity in humans and its electrophysiological correlates
EEG microstates of wakefulness and NREM sleep
Spontaneous BOLD event triggered averages for estimating functional connectivity at resting state
Brain resting state is disrupted in chronic back pain patients

BookSection (5)

To sleep, perchance to trip: Is dreaming a nightly psychedelic experience?
Drogas de diseño
Potencial científico y terapéutico de los psicodélicos
Psicodelicos
The collective brain is critical
115
Enzo Tagliazucchi

Profesor

Latin American Brain Health Institute (BrainLat)

Universidad Adolfo Ibánez

Santiago, Chile

9
Agustin Ibanez

Profesor Titular

Psicologia

Universidad Adolfo Ibánez

Santiago, Chile

7
Josefina Cruzat

Profesor Asistente

Psicología

Universidad Adolfo Ibánez

Santiago, Chile

5
Pavel Prado

Lead Researcher

Universidad Adolfo Ibáñez

Latin American Brain Health Institute (BrainLat)

Santiago de Chile, Chile

1
Adolfo García

Investigador Asociado

Facultad de Humanidades

Universidad de Santiago de Chile

Santiago de Chile, Chile

1
Mónica Otero

Académico-Investigador

Facultad de Ingeniería, Arquitectura y Diseño

Universidad San Sebastián

Santiago de Chile, Chile

1
Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

1
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile