Man

Manuel Alejandro Maliqueo Yevilao

Profesor asociado

LAB. DE ENDOCRINOLOGIA Y METABOLISMO. FACULTAD DE MEDICINA OCCIDENTE. UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Líneas de Investigación


Obesidad, embarazo, función de la placenta, endocrinología reproductiva, metabolismo energético

Educación

  •  Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 1997
  •  en Ciencias con mención en Biología de la Reproducción, UNIVERSIDAD DE CHILE. Chile, 2001
  •  Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Profesor asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    SANTIAGO, Chile

    2005 - 2018

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2018 - A la fecha

  •   Instructor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1999 - 2005

Experiencia Profesional

  •   Postdoctorado Full Time

    Goteborg Universitet

    Gotembuergo, Chile

    2011 - 2014

  •   Académico Full Time

    Universidad de Chile

    Santiago, Chile

    1999 - A la fecha

  •   Investigador Visitante Other

    Karolisnka Institutet

    Estocolomo, Suecia

    2015 - 2017

Formación de Capital Humano


2017 Tesis de Magíster en Ciencias Biológicas Mención Neurociencia, Alumno: Pablo Ruíz Pérez. EFECTO DEL ESTRÉS POR DERROTA SOCIAL SOBRE LAS POBLACIONES NEURONALES DEL CLAUSTRO QUE EXPRESAN LOS GENES MARCADORES NURR1 Y PRSS12, Y SU ASOCIACIÓN CON ALTERACIONES CONDUCTUALES. Directores Dr. Manuel Maliqueo, Dr. Juan Montiel, Dr, Alexis Dagnino-Subiabre (Tutor Académico). Facultad de Ciencias. Universidad de Valparaíso.
2014 Tesis de Doctorado (PhD), Romina Fornes, MSc. ROLE OF ANDROGENS AND OBESITY ON PLACENTAL FUNCTION AND DEVELOPMENT OF POLYCYSTIC OVARY SYNDROME (PCOS). Karolinska. Institutet, Stockholm, Sweden. En Desarrollo. Directores: Elisabet Stener-Victorin, Manuel Maliqueo, Anna Benrick.
2016 Tesis de Titulo Química y Farmacia. Carolina Espina. EXPRESION DEL RECEPTOR DE ANDROGENOS Y ENZIMAS RELACIONADAS A LA SINTESIS DE ANDROGENOS EN LA PLACENTA DE MUJERES OBESAS. Universidad de Valparaíso. Directores: Manuel Maliqueo y Gonzalo Cruz
2016 Tesis de Titulo Química y Farmacia. Isabella Contreras. EFECTOS DE LA OBESIDAD MATERNA EN LA ACCIÓN Y SINTESIS DE PROGESTERONA EN LA PLACENTA HUMANA. Universidad de Valparaíso. Directores: Manuel Maliqueo y Gonzalo Cruz.
2013 Tesis de Magíster en Biomedicina, Pegah Kavyani. ROLE OF ANDROGEN AND ESTROGEN IN PLACENTAL FUNCTION IN PRENATAL ANDROGENIZED RATS. Directores: Elisabet Stener-Victorin y Manuel Maliqueo.University of Skövde, Suecia.
2012 Tesis de Magíster en Biología Molecular. Asif Alvi LETROZOLE INDUCED POLYCYSTIC OVARY SYNDROME IN RATS: EFFECTS OF CYCLIC ESTROGEN TREATMENT. Elisabet Stener-Victorin y Manuel Maliqueo. University of Skövde, Suecia


Premios y Distinciones

  •   PREIMIO AL MEJOR TRABAJO PUBLICADO

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2018

    Premio al mejor trabajo publicado en 2017


 

Article (83)

Biotic and abiotic sounds affect calling activity but not plasma testosterone levels in male frogs (Batrachyla taeniata) in the field and in captivity
DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS
Higher luteinizing hormone levels associated with antimullerian hormone in postmenarchal daughters of women with polycystic ovary syndrome
Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome
Cell and molecular mechanisms behind diet-induced hypothalamic inflammation and obesity
Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome
Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the offspring
Pregnancy outcomes in women with polycystic ovary syndrome in two Latin American populations
Prenatal metformin treatment improves ovarian function in offspring of obese rats
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome
Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome.
Hypothalamic transcriptional expression of the kis-speptin system and sex steroid receptors differs among polycystic ovary syndrome rat models with different endocrine phenotypes
Obesity during pregnancy affects sex steroid concentrations depending on fetal gender.
Reproductive and metabolic features during puberty in sons of women with polycystic ovary syndrome
Testosterone increases CCL-2 expression in visceral adipose tissue from obese women of reproductive age.
The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture.
Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
Maternal testosterone and placental function: Effect of electroacupuncture on placental expression of angiogenic markers and fetal growth.
Metabolic Features Across The Female Life Span In Women With PCOS.
Metabolic profile in women with polycystic ovary syndrome across adult life.
Metabolic profile in women with polycystic ovary syndrome across adult life.
Neuroendocrine Regulation of Metabolism.
Sex Steroids Modulate Uterine-Placental Vasculature: Implications for Obstetrics and Neonatal Outcomes.
Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or B-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome
Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring
Measurement of a Comprehensive Sex Steroid Profile in Rodent Serum by High-Sensitive Gas Chromatography-Tandem Mass Spectrometry.
Placental STAT3 signaling is activated in women with polycystic ovary syndrome
Placental STAT3 signaling is activated in women with polycystic ovary syndrome
Enhanced insulin sensitivity and acute regulation of metabolic genes and signaling pathways after a single electrical or manual acupuncture session in female insulin-resistant rats.
Rodent models of polycystic ovary syndrome: phenotypic presentation, pathophysiology, and the effects of different interventions.
Continuous Administration of a P450 Aromatase Inhibitor Induces Polycystic Ovary Syndrome with a Metabolic and Endocrine Phenotype in Female Rats at Adult Age
Maternal-fetal unit interactions and eutherian neocortical development and evolution
Placental steroidogenesis in pregnant women with polycystic ovary syndrome
Resveratrol is not as effective as physical exercise for improving reproductive and metabolic functions in rats with dihydrotestosterone-induced polycystic ovary syndrome.
CAG repeat polymorphism of androgen receptor gene and X-chromosome inactivation in daughters of women with polycystic ovary syndrome (PCOS): relationship with endocrine and metabolic parameters.
Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters
Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring
Relationship Between Anti-Mullerian Hormone (AMH) and Insulin Levels During Different Tanner Stages in Daughters of Women With Polycystic Ovary Syndrome
Relationship between anti-Mullerian hormone (AMH) and insulin levels during different tanner stages in daughters of women with polycystic ovary syndrome
Relationship of serum adipocyte-derived proteins with insulin sensitivity and reproductive features in pre-pubertal and pubertal daughters of polycystic ovary syndrome women
Effects of Birth Weight on Anti-Mullerian Hormone Serum Concentrations in Infant Girls
Expression of Androgen and FSH Receptors and AMH in Testis of Lambs Prenatally Exposed to an Excess of Testosterone.
Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams
Serological markers of autoimmunity in pregnant women with polycystic ovary syndrome: a pilot study
Adrenal Function during Childhood and Puberty in Daughters of Women with Polycystic Ovary Syndrome
Metabolic and Reproductive Features before and during Puberty in Daughters of Women with Polycystic Ovary Syndrome
Metabolic parameters in cord blood of newborns of women with polycystic ovary syndrome
Testosterone-induced downregulation of anti-Mullerian hormone expression in granulosa cells from small bovine follicles
Metabolic profile in sons of women with polycystic ovary syndrome
Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood
Polymorphism T -> C (-34 base pairs) of gene CYP17 promoter in women with polycystic ovary syndrome is associated with increased body weight and insulin resistance: a preliminary study
Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck.
[Polycystic ovary syndrome and pregnancy: clinical experience].
Anti-Mullerian hormone levels in peripubertal daughters of women with polycystic ovary syndrome.
Early metabolic derangements in daughters of women with polycystic ovary syndrome.
Gonadal function in low birth weight infants: a pilot study.
Sex hormone-binding globulin expression in the endometria of women with polycystic ovary syndrome.
[Prenatal exposure to androgens as a factor of fetal programming].
Increased Anti-Mullerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome.
Birth weight in offspring of mothers with polycystic ovarian syndrome.
Tryptophan 64 --> arginine polymorphism of beta-3-adrenergic receptor in Chilean women with polycystic ovary syndrome.
Differential in vitro actions of nitric oxide on human endometrial cell survival.
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load.
Patterns of hormonal response to the GnRH agonist leuprolide in brothers of women with polycystic ovary syndrome: a pilot study.
Potential action of androstenedione on the proliferation and apoptosis of stromal endometrial cells
Expression of steroid receptors and proteins related to apoptosis in endometria of women with polycystic ovary syndrome.
Proinsulin serum concentrations in women with polycystic ovary syndrome: a marker of beta-cell dysfunction?
Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization.
Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome.
[Polycystic ovary syndrome: the importance of establishing diagnosis].
[Prevalence of metabolic disorders among family members of patients with polycystic ovary syndrome].
G972R polymorphism of IRS-1 in women with polycystic ovary syndrome.
Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: endocrine aspects.
Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: metabolic aspects.
Secretory pattern of leptin and LH during lactational amenorrhoea in breastfeeding normal and polycystic ovarian syndrome women.
[Evaluation of acute effect of GnRH administration on leptin secretion in normal and hyperandrogenic women].
[Relationship between leptin and insulin sensitivity in patients with polycystic ovary syndrome].
Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome?
Episodic leptin release is independent of luteinizing hormone secretion.
[Polycystic ovary syndrome: relationship of insulin tissular sensitivity, LH secretion and ovarian morphophysiologic changes].

BookSection (3)

PERINATAL NUTRITION AND METABOLIC DISEASE
ACUPUNCTURE
LA PROGRAMACIÓN FETAL Y LA SALUD DEL ADULTO

Proyecto (7)

Alterations in spermatozoa DNA methylation in sons of women with polycystic ovary syndrome (PCOS): a male intergenerational inheritance approach
Association between maternal metabolic disturbances during the first pregnancy and breast density
Effect Of Intrauterine Environment On Epigenetic Changes Of Selected Genes Linked With Metabolic And Reproductive Dysfunction In The Offspring Of Hyperandrogenic Mothers: A Translational Approach
Maternal obesity influences placental fatty acid transport. Are there an impact on fatty acid metabolism in the fetal liver?
Maternal obesity influences fetal hepatic lipid accumulation. Role of placental lipid transport
Effects of maternal obesity on steroid levels during pregnancy. A possible relationship between adipose tissue and inflammatory factors on placental steroidogenesis
Reproductive and metabolic features during the menopausal transition and the early postmenopausal period in women with polycystic ovary syndrome (PCOS): deepning into the pathophysiology of PCOS
25
Manuel Maliqueo

Profesor asociado

Medicina Occidente

LAB. DE ENDOCRINOLOGIA Y METABOLISMO. FACULTAD DE MEDICINA OCCIDENTE. UNIVERSIDAD DE CHILE

SANTIAGO, Chile

6
Bárbara Echiburú

Profesor Asistente

Medicina Interna

Universidad de Chile

Santiago, Chile

4
Nicolas Crisosto

Profesor Asistente

Medicina Interna Occidente

Universidad de Chile

Santiago, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Francisco Pérez

DIRECTOR

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Francisca Salas

Asistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile