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Roberto Alejandro Ebensperger González

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Cellular therapy and regenerative medicine. Specialized in the biology and clinical application of human adult mesenchymal stem cells, particularly wound healing and bone regeneration. We also investigate on cell and drug targeting.

Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2000
Pharmacist, UNIVERSIDAD DE CHILE. Chile, 1992

Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chemistry

Santiago, Chile

1999 - At present

Associate Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

1999 - At present

Undergraduate Theses directed since 2010:

DANIEL JORDI HACHIM DIAZ. “Nanoencapsulación de células madre mesenquimales provenientes de tejido adiposo”. 2010

MARINA ROSSI. “Inmunomodulación de células madre mesenquimales”. 2012
Descripción. Estudiar los mecanismos de inmunotolerancia e inmunorregulación alogénica de las células mesenquimales derivadas de tejido graso sobre células del sistema inmune.

ANGELO ESTEFANE. “"Desarrollo de una formulación de aplicación tópica de células madres para el tratamiento de heridas". 2012
Descripción. Desarrollar una forma y formulación farmacéutica que permita la administración de células madres derivadas de tejido adiposo en heridas.

ALEJANDRA CISTERNAS. “Diferenciación de células madres derivadas de tejido adiposo a células endoteliales”. 2012
Descripción. Estudiar los factores y condiciones que favorecen la diferenciación de las células madre derivadas de tejido adiposo en endotelio y su potencial angiogénico para posibles aplicaciones clínicas en trastornos isquémicos.

MOISES PALMA. "Efecto inmunomodulador de las células madre mesenquimales derivadas de tejido adiposo sobre la respuesta proliferativa de linfocitos T". 2012
Descripción. Estudiar los mecanismos inmunorreguladores que ejercen las células mesenquimales derivadas de tejido graso sobre linfocitos activados.

MARIA IGNACIA PAVON. “Estudio de capacidades antioxidantes de células madre mesenquimales derivadas de tejido adiposo frente a estrés oxidativo”. 2013 (2013)
Descripción. Estudiar la capacidad de respuesta antioxidante de las células madre mesenquimales cuando se encuentran en un ambiente de estrés oxidativo.

Proyecto: “Validación técnica y comercial de una tecnología de Cell Targeting”
Investigador Principal: Roberto Ebensperger
Fuente: CORFO – Programa Go To Market 2.0 (código # 12GTM-16659)
año: 2012

Proyecto: “Stem cell based therapy product for chronic wound healing”
Investigador Principal: Roberto Ebensperger
Fuente: CORFO – Programa Go To Market 3.0 (código # 13GTM-21983)
año: 2013


Nanoencapsulation of Human Adipose Mesenchymal Stem Cells: experimental factors role to successfully preserve viability and functionality of cells Hachim Daniel; Melendez, Jaime; Ebensperger, Roberto Article 1604-2004: SUPERNOVAE AS COSMOLOGICAL LIGHTHOUSES (2013)
Different cell death mechanisms are induced by a hydrophobic flavin in human tumor cells after visible light irradiation Munoz, MA; Pacheco A.; Becker, MI; Silva, E.; Ebensperger, R; Garcia, AM; De Ioannes, AE; Edwards, AM Article ISI SCOPUS Journal of Photochemistry and Photobiology B: Biology (2011)
GLUCOSE EFFECT IN THE EXPRESSION OF ENDOTHELIAL LIPASE IN HUMAN ENDOTHELIAL CELLS AND IN PATIENTS WITH DIABETES MELLITUS TYPE 2 Pierart, C; Serrano, V; Rubio, L.; Ebensperger, R; Foncea, R Article ISI SCOPUS Nutricion Hospitalaria (2011)
Glucose effect in the expression of endothelial lipase in human endothelial cells and in patients with diabetes mellitus type 2 Efecto de glucosa en la expresión de lipasa endotelial en células endotelialeshumanas y en sujetos con diabetes mellitus tipo 2 Pierart, C; Serrano, V; Rubio, L.; Foncea, R; Ebensperger, R Article Nutricion Hospitalaria (2011)
Photophysical characterization of atorvastatin (Lipitor (R)) ortho-hydroxy metabolite: role of hydroxyl group on the drug photochemistry Alarcon, E.; Gonzalez-Bejar, M; Gorelsky, S; Ebensperger, R; Lopez-Alarcon, C; Netto-Ferreira, JC; Scaiano, JC Article ISI SCOPUS Photochemical and Photobiological Sciences (2010)
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion Galarce, GD; Foncea, RE; Edwards, AM; Pessoa-Mahana H.; Pessoa-Mahana, CD; Ebensperger, RA Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2008)
1-BENZOYL-2-(2-NITROPHENYL)-1H-BENZIMIDAZOLE DERIVATIVES: A NOVEL APPROACH TO THE DEVELOPMENT OF NEW HIV-1 REVERSE TRANSCRIPTASE INHIBITORS Vásquez D.; Lagos, CF; Mella-Raipan J.; Gonzalez L.; Ebensperger, R; Alvarez Figueroa MJ; Sáez E.; Pessoa-Mahana H.; Araya-Secchi R.; Gonzalez-Wong, A; Perez-Acle, T; Pessoa-Mahana, CD Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2007)
Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products San Martin, A; Foncea, R; Laurindo, FR; Ebensperger, R; Griendling, KK; Leighton F. Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2007)
Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis Ocaranza, MP; Diaz-Araya, G; Chiong M.; Muñoz D; Riveros, JP; Ebensperger, R; Sabat, S; Irarrázaval P.; JALIL, JE; Lavandero S. Article ISI SCOPUS JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2002)
Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat Jalil J.E.; Ebensperger, R; Meléndez J.; Acevedo, E; Sapag-Hagar, M; Gonzalez-Jara, F; Galvez A.; Perez-Montes V.; Lavandero S. Article LIFE SCIENCES (1999)
Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy Ebensperger, R; Acevedo, E; Meléndez J.; Sapag-Hagar, M; Lavandero S.; Corbalan, R; Acevedo M.; Jalil J.E. Article BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1998)
Cyclic AMP dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction Piddo A.M.; Sanchez M.I.; Sapag-Hagar, M; Corbalan, R; Foncea, R; Ebensperger, R; Godoy, I.; Meléndez J.; Jalil J.E.; Lavandero S. Article JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (1996)


Induction of endotelial dysfunction by homocysteine is mediated by a redox-sensitive map kinase signaling Foncea, R; Reyes, F.; Rubio, L.; Lagunas, R; Serrano, V; Maiz A.; Ebensperger, R Abstract ISI ATHEROSCLEROSIS SUPPLEMENTS (2006)
Hyperinsulinemia and TNF alpha supress the expression of endothelial NO synthase but promote proatherogenic processes induced by insulin in endothelial cells. Bavendiek, U; Ebensperger, R; Dellwisch, C; Gottschalk, D; Schieffer, B Abstract JOURNAL OF VASCULAR RESEARCH (2005)
Advanced glycated products induce the expression of iNOS in VSMC San Martin, A; Foncea, R; Ebensperger, R; Leighton F. Abstract FREE RADICAL BIOLOGY AND MEDICINE (2003)
Cyclooxygenase-2 is induced by bradykinin in vascular smooth muscle cells Rodriguez J.; de la Cerda, P; Ebensperger, R; Foncea, R; Vio, C; Velarde, V Abstract FREE RADICAL BIOLOGY AND MEDICINE (2003)


METODO DE DIRECCIÓN SELECTIVA DE CÉLULAS NANOENCAPSULADAS A ÓRGANOS O TEJIDOS BLANCO Ebensperger, Roberto; Hachim Daniel Patent
SPRAY FORMULATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF CHRONIC WOUNDS Ebensperger, Roberto Patent