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Horacio Nelson Germán Poblete Vilches

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

Nanotechnology; Computational Chemistry; Structural Biology of Membrane Proteins

Profesor Conferenciante Part Time

UNIVERSIDAD DE TALCA

2016 - At present

Profesor

Universidad de Talca

Chile

2011 - 2011
Profesor

Universidad de Talca

Chile

2012 - 2012
Profesor

Universidad Austral de Chile

Chile

2010 - 2010
Profesor

Sociedad Bioquimica Colombiana

Colombia

2011 - 2011
Profesor

PEDECIBA

Uruguay

2010 - 2010
Post- Doctorado

NHLBI (NIH)

Estados Unidos

2014 - 2015
Post-Doctoral Reaserch

NICKS Kansas State University

Estados Unidos

2015 - 2016
Postdoctorado

Universidad de Talca

Chile

2013 - 2014
Profesor Conferenciante

Universidad de Talca

Chile

2016 - At present


Cinnamoyl–coumarin hybrid derivatives with remarkable fluorescent molecular-rotor properties in mixtures of DPPC:DOPC LUVs ZÃºÃ±iga-NÃºÃ±ez D.; Mura F.; Zamora R.A.; Poblete H.; Fuentealba D.; AspÃ©e A. Article SCOPUS Dyes and Pigments (2020)
KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis Rivas, Jose; Diaz, Nicolas; Silva, Ian; Morales, Danna; Lavanderos, Boris; Alvarez, Alhejandra; Paz Saldias, Maria; Pulgar, Eduardo; Cruz, Pablo; Maureira, Diego; Flores, Guillermo; Colombo, Alicia; Blanco, Constanza; Contreras, Hector R.; Jana, Fabian; G Article ISI FASEB JOURNAL (2020)
A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels Vergara-Jaque A.; Palma-Cerda F.; Lowet A.S.; de la Cruz Landrau A.; Poblete H.; Sukharev A.; Comer J.; Holmgren M. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2019)
Large-scale state-dependent membrane remodeling by a transporter protein Zhou, WC; Fiorin, G; Anselmi, C; Karimi-Varzaneh, HA; Section, HP; Horacio Poblete; Forrest, LR; Faraldo-Gomez, JD Article ISI ELIFE (2019)
Light-Activated Peptide-Based Materials for Sutureless Wound Closure McTiernan C.D.; Cortes D.C.; Lazurko C.; Amrani S.; Rosales-Rojas R.; ZuÃ±iga-Bustos M.; Sedlakova V.; Poblete H.; Stamplecoskie K.; Suuronen E.J.; Alarcon E.I. Article ISI ACS APPLIED MATERIALS & INTERFACES (2019)
Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials Goel, K; Zuniga-Bustos, M; Lazurko, C; Jacques, E; Galaz-Araya, C; Valenzuela-Henriquez, F; Pacioni, NL; Couture, JF; Poblete, H; Alarcon, EI Article ISI ACS APPLIED MATERIALS & INTERFACES (2019)
Thermodynamics of Adsorption on Graphenic Surfaces from Aqueous Solution. Azhagiya Singam, E R; Zhang, Yuntao; Magnin, Geraldine; Miranda-Carvajal, Ingrid; Coates, Logan; Thakkar, Ravindra; Poblete, Horacio; Comer, Jeffrey Article Journal of chemical theory and computation (2019)
Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states Moldenhauer, Hans; Diaz-Franulic, Ignacio; Poblete, Horacio; Naranjo, David Article ISI ELIFE (2019)
Effect of nanosilver surfaces on peptide reactivity towards reactive oxygen species Jacques, E; Ahumada, M; Rector, B; Yousefalizadeh, G; Galaz- Araya, C; Recabarren, R; Stamplecoskie, K; Poblete, H; Alarcon, EI Article ISI NANOSCALE (2018)
Experimental and Computational Characterization of the Interaction between Gold Nanoparticles and Polyamidoamine Dendrimers. Camarada, M B; Comer, J; Poblete, H; Azhagiya Singam, E R; Marquez-Miranda, V; Morales-Verdejo, C; Gonzalez-Nilo, F D Article Langmuir => the ACS journal of surfaces and colloids (2018)
Study of the affinity between the protein kinase PKA and homoarginine-containing peptides derived from kemptide=> Free energy perturbation (FEP) calculations. Mena-Ulecia, Karel; Gonzalez-Norambuena, Fabian; Vergara-Jaque, Ariela; Poblete, Horacio; Tiznado, William; Caballero, Julio Article Journal of computational chemistry (2018)
Theoretical rationalisation of the photophysics of a TICT excited state of cinnamoyl-coumarin derivatives in homogeneous and biological membrane models. Zúñiga-Núñez, Daniel; Zamora, Ricardo A; Barrias, Pablo; Tirapegui, Cristian; Poblete, Horacio; Cárdenas-Jirón, Gloria; Alarcon, Emilio I; Aspée, Alexis Article Physical chemistry chemical physics => PCCP (2018)
Determinants of Alanine Dipeptide Conformational Equilibria on Graphene and Hydroxylated Derivatives Poblete, Horacio; Miranda-Carvajal, Ingrid; Comer, Jeffrey Article ISI JOURNAL OF PHYSICAL CHEMISTRY B (2017)
Novel specific peptides as superior surface stabilizers for silver nano structures: role of peptide chain length Ahumada, M; Jacques, E; Andronic, C; Comer, J; Poblete, H; Alarcon, EI Article ISI JOURNAL OF MATERIALS CHEMISTRY B (2017)
Rose Bengal Binding to Collagen and Tissue Photobonding Alarcon, EI*; Poblete, H; Roh, H; Couture, JF; Comer, J; Kochevar, IE Article ISI SCOPUS ACS Omega (2017)
Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels. Diaz-Franulic, I; Poblete, H; Mino-Galaz, G; Gonzalez, C; Latorre, R Article ISI ANNUAL REVIEW OF BIOPHYSICS (2016)
New Insights into Peptide-Silver Nanoparticle Interaction: Deciphering the Role of Cysteine and Lysine in the Peptide Sequence Poblete, Horacio; Agarwal, Anirudh; Thomas, Suma S.; Bohne, Cornelia; Ravichandran, Ranjithkumar; Phospase, Jaywant; Comer, Jeffrey; Alarcon, Emilio I. Article ISI LANGMUIR (2016)
Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity. Ramírez-Barrantes, R; Cordova, C; Poblete, H; Muñoz, P; Marchant, I; Wianny, F; Olivero, P Article Neural plasticity (2016)
Synthesis and in silico analysis of the quantitative structure-activity relationship of heteroaryl-acrylonitriles as AChE inhibitors De-La-Torre, P; Treuer, AV; Gutiérrez M; Poblete, H.; Alzate-Morales, JH; Trilleras, J; Astudillo Saavedra L.; Caballero, J Article ISI SCOPUS Journal of the Taiwan Institute of Chemical Engineers (2016)
The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. Sharma, Rajni K; Espinoza-Moraga, Marlene; Poblete, Horacio; Douglas, Ross G; Sturrock, Edward D; Caballero, Julio; Chibale, Kelly Article Journal of chemical information and modeling (2016)
Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P-2) Binding to Transient Receptor Potential V1 (TRPV1) Channels Poblete, H; Oyarzun, I; Olivero, P; Comer, J; Zuniga, M; Sepulveda, RV; Baez-Nieto, D; Leon, CG; Gonzalez-Nilo, F; Latorre, R Article JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation Comer, Jeffrey; Chen, Ran; Poblete, Horacio; Vergara-Jaque, Ariela; Riviere, Jim E. Article ISI ACS NANO (2015)
Study of the affinity between the protein kinase PKA and peptide substrates derived from kemptide using molecular dynamics simulations and MM/GBSA. Mena-Ulecia, Karel; Vergara-Jaque, Ariela; Poblete, Horacio; Tiznado, William; Caballero, Julio Article PloS one (2014)
Association of nicotinic acid with a poly(amidoamine) dendrimer studied by molecular dynamics simulations Caballero, Julio; Poblete, Horacio; Navarro, Cristel; Alzate-Morales, Jans Article JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2013)
Human serum albumin as protecting agent of silver nanoparticles: role of the protein conformation and amine groups in the nanoparticle stabilization Emilio I. Alarcon • Carlos J. Bueno-Alejo • Christopher W. Noel • Kevin G. Stamplecoskie • Natalia L. Pacioni • Horacio Poblete • J. C. Scaiano Article Journal of Nanoparticles Research (2013)
Impact of Dye-Protein Interaction and Silver Nanoparticles on Rose Bengal Photophysical Behavior and Protein Photocrosslinking Simpson, MJ; Poblete H.; Griffith M.; Alarcon, EI; Scaiano, JC Article PHOTOCHEMISTRY AND PHOTOBIOLOGY (2013)
Molecular Basis of Drug Resistance in A/H1N1 Virus Schulten, Klaus; Vergara, Ariela; Poblete, Horacio; Lee, EH; Chipot, Christophe Article JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Photophysics and photochemistry of dyes bound to human serum albumin are determined by the dye localization Alarcon, Emilio;; Maria Edwards, Ana; Aspee, Alexis; Moran, Faustino; Borsarelli, Claudio; Lissi, Eduardo; Gonzalez-Nilo, Danilo; Poblete, Horacio; Scaiano, J. C. Article PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2010)
Stereoselective Interaction of Epimeric Naproxen-RGD Peptides with Human Serum Albumin Gonzalez-Bejar, Maria; Alarcon, Emilio; Poblete, Horacio; Scaiano, JC.; Perez-Prieto, Julia Article BIOMACROMOLECULES (2010)
Antioxidant reactivity toward nitroxide probes anchored into human serum albumin. A new model for studying antioxidant repairing capacity of protein radicals Aspee, Alexis; Orrego, Alejandra; Alarcon, Emilio; Lopez-Alarcon, Camilo.; Poblete, Horacio; Gonzalez-Nilo, Fernando Article BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)


Estimating residence time in protein-ligand complexes=> New computational protocols for understanding binding kinetics of drugs. FONDECYT (1181253) Proyecto 2018-2021 Coinvestigador(a)
Fondecyt Regular=> New Insights into conformational equilibria of proteins absorbed to nanometal surfaces using molecular dynamics simulations=> structural effects and protein camouflage applicable to nanomedicine. FONDECYT (1171155) Proyecto 2017-2021 Inv. Principal
ESTUDIO DE LOS DETERMINANTES ESTRUCTURALES QUE CONTROLAN EL FUNCIONAMIENTO DE LA BOMBA Na+/K+ FONDECYT (3140288) Proyecto 2013-2016 Inv. Responsable
INSIGHTS INTO THE STRUCTURAL BASIS OF THE INTERACTIONS BETWEEN CAMP-DEPENDENT PROTEIN KINASE (PKA) AND ITS SUBSTRATES. DEVELOPMENT OF PREDICTIVE MOLECULAR MODELS AND TESTING IN THE STUDY OF THE INTERACTIONS BETWEEN PKA AND POTASSIUM CHANNEL AKT2. FONDECYT (1130141) Proyecto 2013-2016 Personal técnico y/o de apoyo
Análisis estructural de la bola de inactivación en canales tipo Shaker. National Institute of Health Proyecto 2011-2015 Coinvestigador(a)
MOLECULAR MODELLING STUDIES OF ENZYME-INHIBITOR INTERACTIONS IN HUMAN PLATELET LIPOXYGENASES. FONDECYT (11075047) Proyecto 2007-2009 Tesista