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Jaime Roberto Cabrera Pardo

Assistant Professor

Universidad del Bio Bio

Concepcion, Chile

Líneas de Investigación


organic chemistry, organic synthesis, secondary metabolites of plants and fungi, reaction discovery and optimization, chemical libraries, biotechnology, molecular biology.

Educación

  •  Organic Chemistry, UNIVERSITY OF CHICAGO. Estados Unidos, 2013
  •  Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 2007
  •  Organic Chemistry, UNIVERSITY OF CHICAGO. Estados Unidos, 2010

Experiencia Académica

  •   Marie Curie Postdoctoral Fellow Full Time

    UNIVERSITY OF CAMBRIDGE

    Chemistry

    Cambridge, Reino Unido

    2014 - 2018

  •   Profesor Asistente Full Time

    UNIVERSIDAD DEL BIO-BIO

    Ciencias

    Concepcion, Chile

    2019 - At present

  •   Assistant Research Professor Full Time

    UNIVERSITY OF UTAH

    Science

    Salt Lake City, Estados Unidos

    2020 - 2022

Experiencia Profesional

  •   Research Associate Part Time

    Universidad de Concepcion

    Concepcion, Chile

    2018 - 2019

  •   Technical Assistant Part Time

    Sociedad Comercial y de inversiones Socooil limitada

    Concepcion, Chile

    2008 - 2009

  •   Intern in Clinical Chemistry Part Time

    Laboratorio Sommer

    Concepcion, Chile

    2006 - 2006

  •   Research Associate Part Time

    Biotechnology Center, Universidad de Concepcion

    Concepcion, Chile

    2006 - 2007

Formación de Capital Humano


Postdoctoral researchers

Omar Alvarado Carripan Concepción, Chile
Universidad del Bio Bio 2021 – 2022

Computational chemistry projects on the effect of electric fields on chemical reactivity and the design of inhibitors targeting the replication process of the COVID-19 virus

Graduate Students

Valentina Parada Haquin (Natural Sciences MSc student) Concepción, Chile
Supervisor, Universidad del Bio Bio 2024 –

Bernardo Candia Herrera (Natural Sciences MSc student) Concepción, Chile
Supervisor, Universidad del Bio Bio 2024 –

Enzo Romero Villegas (Natural Sciences MSc student) Concepción, Chile
Supervisor, Universidad del Bio Bio 2024 –

Jonhatan Gómez Espinoza (Natural Sciences Ph.D student) Concepción, Chile
Supervisor, Universidad del Bio Bio 2023 –

Yaíma Sánchez Mustelier (Chemistry Ph.D Student) Concepción, Chile
Cosupervised with Prof. Claudio Jiménez, Universidad de Concepción 2019 –

Thesis title: “Neuroprotective bioactivity of Benzofuran synthetic derivatives in Alzheimer’s disease models”

Zhuang Mao Png (Chemistry Ph.D Student) Cambridge, UK
Cosupervised with Prof. Matthew Gaunt, University of Cambridge 2016 – 2020

Thesis title: “C-H activation of functional materials”

Jorge Peiró Cadahía (Chemistry Ph.D Student) Cambridge, UK
Cosupervised with Prof. Matthew Gaunt, University of Cambridge 2014 – 2018

Thesis title: “Novel strategies for the synthesis, evaluation, and delivery of biologically active molecules”

Aaron Trowbridge (Chemistry Ph.D Student) Cambridge, UK
Cosupervised with Prof. Matthew Gaunt, University of Cambridge 2014 – 2018

Thesis title: “New strategies for the synthesis and functionalization of aliphatic amines”

Undergraduate Students

Javiera Gajardo (undergraduate Biology student) Valdivia, Chile
Cosupervised with Prof. Sigisfredo Garnica, Universidad Austral de Chile 2022 – 2023

Thesis title: “Isolation and characterization of lignocellulolytic fungi from the Valdivian Forests”

Enzo Romero Villegas (undergraduate Biology student) Concepción, Chile
Supervisor, Universidad del Bio Bio 2022 – 2023

Thesis title: “Antioxidant and neuroprotective properties of polysaccharides isolated from Russulales fungi”

Jonhatan Gómez Espinoza (undergraduate Biology student) Concepción, Chile
Supervisor, Universidad del Bio Bio 2022 – 2023

Thesis title: “Study of the antioxidant capacity and antimicrobial activity against multidrug resistant bacteria of Russulales fungi”

Javiera Gormaz Mendez (undergraduate Biology student) Valdivia, Chile
Cosupervised with Prof. Sigisfredo Garnica, Universidad Austral de Chile 2021 – 2022

Thesis title: “Isolation and characterization of lignocellulolytic fungi from the polyporales order”

Claudia Rivera Medina (undergraduate Bioengineering student) Concepción, Chile
Cosupervised with Prof. Jose Becerra, Universidad de Concepción 2021 – 2022

Thesis title: “Chemical study of fugnal species of the genus Aleurodiscus investigating the presence of benzuforan scaffolds by GC-MS”

Camila Millar Obreque (undergraduate Biotechnology student, Universidad de la Frontera) Concepción, Chile
Cosupervised with Prof. Felipe Burgos, Universidad de Concepción 2021 – 2022

Thesis title: “Computational docking studies of eudesmin with peptide beta amyloid”

Aline Wendt Serra (undergraduate Bioengineering student) Concepción, Chile
Cosupervised with Prof. Jorge Fuentealba, Universidad de Concepción 2019 – 2020

Thesis title: “Evaluation of the neuroprotective effects of Eudesmin against the toxicity of the ?-Amyloid peptide”

Bernardo Candia Herrera (undergraduate Biochemistry student) Concepción, Chile
Supervisor, Universidad de Concepción 2019 – 2020

Thesis title: “Study of the biological activity of secondary metabolites produced by different fungal species of the genus Aleurodiscus”


Difusión y Transferencia


Conferences:
1. XI Chilean Environmental Chemistry Society Meeting. Oral presentation: “Mycoremediation of oxytetracyclines: metabolic routes and potential applications”. 2023, Pucón, Chile.

2. 264th American Chemical Society National Meeting & Exposition. Poster: “Click activated protodrugs against cancer (CAPAC): A modular platform for tumor-directed oncology therapeutics”. 2022, Chicago, IL, USA.

3. III Argentinian Mycology Meeting. Poster: “Isolation, identification and preservation of fruiting bodies of ligninolytic fungi from the Valdivian Forest, Chile”. 2022, Cordova, Argentina.

4. LXIII Annual meeting of the Chilean Biology Society. Poster: “Isolation of halogenated hydroquinones metabolites from the Andean patagonian fungus Phylloporia boldo”. 2020, Santiago, Chile.

5. LXIII Annual meeting of the Chilean Biology Society. Poster: “Biological activity of secondary metabolites from different strains of Aleurodiscus”. 2020, Santiago, Chile.

6. LXIII Annual meeting of the Chilean Biology Society. Poster: “Neuroprotective effects of Eudesminem a lignand from Araucaria Araucana, against the amyloid beta peptide”. 2020, Santiago, Chile

7. X LATAM Mycology Conference. Poster: “The phylogenetic disposition of Aleurodiscus s.l. (Russulales, Basidiomycota) from Patagonia (Argentina and Chile)”. 2020, Santiago, Chile

8. XVII Annual Meeting of the Chilean Neuroscience Society. Poster: “Optimization of the neuroprotective effect of eudesmin on amyloid beta peptide in different states of aggregation using in silico simulations”. 2020, Santiago, Chile

9. International Conference: “Current applications in chemistry and biology: from catalysis to genetics” Talk: “Label-assisted mass spectrometry for high-throughput reaction discovery and palladium-catalyzed carbonylation of methylene C–H bonds in aliphatic amines”. October 2019, Universidad del Bio-Bio, Concepción, Chile.

10. Academic Collaboration Chile – Sweden (ACCESS). Academic Forum Chile – Sweden. Member of working sessions. November 2018, Santiago, Chile.

11. 252nd American Chemical Society National Meeting & Exposition. Talk: “Palladium-catalyzed carbonylation of methylene C–H bonds in aliphatic amines”. 2016, Philadelphia, PA, USA.

12. 43rd National Organic Chemistry Symposium. Poster Presentation. 2013, Seattle, WA, USA.

13. Gordon Research Conferences: High Throughput Chemistry & Chemical Biology. Poster Presentation. 2013, New London, NH, USA.

14. VI International Symposium of Natural Chemistry Products and their Applications. Poster presentation. 2007, Chillan, Chile.

15. XXIII Biochemistry students national conference. Poster presentation. Universidad Católica de Valparaíso, 2006, Valparaíso, Chile.

16. XXVIII Annual meeting of Chile’s Biochemistry and Molecular Biology Society. Poster presentation. 2005, Talca, Chile.

17. XLVIII Annual meeting of Chile’s Biology Society. Poster presentation, 2005, Pucón, Chile.

18. XXII Biochemistry students national conference. Universidad Andrés Bello, 2005, Santiago, Chile.

19. XXI Biochemistry students national conference. Universidad Austral. 2004, Valdivia, Chile

Invited Talks

University of Alaska Fairbanks, AK, USA
Department of Chemistry and Biochemistry May, 2023

Universidad de Antioquia Medellín, Colombia
Facultad de Ciencias Exactas y Naturales April, 2023

Pontificia Universidad Católica de Chile Santiago, Chile
Facultad de Química March, 2022

Universidad Austral de Chile Valdivia, Chile
Instituto de Bioquímica y Microbiología October, 2021

King Fahd University of Petroleum & Minerals Dhahran, Saudi Arabia
Department of Chemistry October, 2020

Universidad de la Frontera Temuco, Chile
Departamento de Ciencias Básicas November, 2019

Universidad de Talca Talca, Chile
Instituto de Química y Recursos Naturales September 2018

Instituto de Salud Pública - Chile (Chilean CDC) Santiago, Chile
Environmental Chemistry September 2018

University of Oregon Eugene, OR, USA
Department of Chemistry and Biochemistry April 2018

The Pennsylvania State University State College, PA, USA
Department of Chemistry October 2017

Pontificia Universidad Católica de Chile Santiago, Chile
Facultad de Química March 2014

Universidad de Concepción Concepción, Chile
Facultad de Química February 2014

Chicago Tri-institutional Center for Chemical Methods and Library Development Chicago, IL, USA
The University of Chicago October 2011


Premios y Distinciones

  •   Fondecyt Regular 1190652

    FONDECYT

    Chile, 2019

    Expanding the multi–target neuroprotective chemical space of benzofuran scaffolds from fungal and synthetic sources: establishing the basis for drug development in Alzheimer’s disease.

  •   Univeristy of Talca Postdoctoral Fellowship

    UNIVERSIDAD DE TALCA

    Chile, 2019

    Postdoctoral fellowship to attract scientist that pursued their Phd. abroad.

  •   Marie Curie Postdoctoral Fellowship

    UNIVERSITY OF CAMBRIDGE

    Reino Unido, 2014

    Discovery of novel ?-lactam analogs oriented to control multidrug-resistant bacteria enabled by Pd-catalyzed C–H activation of aliphatic amines

  •   Becas Chile - Postdoctoral Fellowship

    UNIVERSITY OF CAMBRIDGE

    Chile, 2014

    Discovery of novel ?-lactam analogs oriented to control multidrug-resistant bacteria enabled by Pd-catalyzed C–H activation of aliphatic amine

  •   Fulbright Scholarship

    UNIVERSITY OF CHICAGO

    Estados Unidos, 2009

    DEVELOPMENT OF A NOVEL LABEL-ASSISTED MASS SPECTROMETRY PLATFORM FOR HIGH-THROUGHPUT REACTION DISCOVERY

  •   Graduate School Full Scholarship

    UNIVERSITY OF CHICAGO

    Estados Unidos, 2009

    Full tuition waiver

  •   Mecesup Research Fellowship

    UNIVERSIDAD DE CONCEPCION

    Chile, 2007

    Grant to undergo research in natural product chemistry

  •   Magna Cum Laude

    UNIVERSIDAD DE CONCEPCION

    Chile, 2007

    top 5% of the class

  •   Highest Regional Score in P.A.A. in Mathematics

    UNIVERSIDAD DE CONCEPCION

    Chile, 2002

    P.A.A is a national test required for application to universities.

  •   CONICYT MEC 80190048

    UNIVERSIDAD DEL BIO-BIO

    Chile, 2020

    Concurso Nacional de Atracción de Capital Humano Avanzado del Extranjero Modalidad de Estadías Cortas (MEC80190048)

  •   Member of Chilean Academy of Science - Frontier Science Program

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2022

    2022-2024


 

Article (34)

<i>In vitro</i> anti-tumoral and immunomodulatory effects of acidic polysaccharides isolated from the fungus <i>Gloeosoma mirabile</i>
Diversity of Agaricomycetes in southern South America and their bioactive natural products
Natural Compounds Purified from the Leaves of <i>Aristotelia chilensis</i>: Makomakinol, a New Alkaloid and the Effect of Aristoteline and Hobartine on Na<sub>V</sub> Channels
Neuroprotective Properties of Eudesmin on a Cellular Model of Amyloid-beta Peptide Toxicity
Water footprint and virtual water flows from the Global South: Foundations for sustainable agriculture in periods of drought
Bromination of eudesmin isolated from araucaria araucana induces epimerization and give bromine derivatives with loss of anti-Candida activity
Drimane Sesquiterpene Alcohols with Activity against <i>Candida</i> Yeast Obtained by Biotransformation with <i>Cladosporium antarcticum</i>
Drimane Sesquiterpene Aldehydes Control <i>Candida</i> Yeast Isolated from Candidemia in Chilean Patients
EVALUATION OF CYTOTOXIC EFFECT AGAINST TUMOUR CELLS OF THE ACIDIC POLYSACCHARIDES OF THE FUNGUS Nothophellinus andinopatagonicus
In vitro cytotoxic capacity against tumor cell lines and antioxidant activity of acidic polysaccharides isolated from the Andean Patagonian fungus Phylloporia boldo
New records of Aphyllophoroid funga (Basidiomycota, Agaricomycotina) from Chile Nuevos registros para la funga afiloforoide (Basidiomycota, Agaricomycotina) de Chile
Advances in Electrochemical Modification Strategies of 5-Hydroxymethylfurfural
Microplastics Pollution in Chile: Current Situation and Future Prospects
Mycoremediation of oxytetracycline by marine fungi mycelium isolated from salmon farming areas in the south of Chile
Electrochemical Advances in Non-Aqueous Redox Flow Batteries
Exploring the multi-target neuroprotective chemical space of benzofuran scaffolds: A new strategy in drug development for Alzheimer's disease
Invasive diatom Didymosphenia geminata as a source of polysaccharides with antioxidant and immunomodulatory effects on macrophage cell lines
Recent advancements in rational design of non-aqueous organic redox flow batteries
The de novo production of halogenated hydroquinone metabolites by the Andean-Patagonian white-rot fungus Phylloporia boldo
A One Health - One World initiative to control antibiotic resistance: A Chile - Sweden collaboration
ADSORPTION ABILITY OF ACTIVATED CARBON OBTAINED FROM SUB-BITUMINOUS COAL (LEBU, CHILE) TO CAPTURE TRIMETHYLAMINE
Exposure to UV-B Radiation Leads to Increased Deposition of Cell Wall-Associated Xerocomic Acid in Cultures of Serpula himantioides
Genetic analysis of the first mcr-1 positive Escherichia coli isolate collected from an outpatient in Chile
Diastereoselective C-H carbonylative annulation of aliphatic amines: a rapid route to functionalized gamma-lactams
Selective Palladium(II)-Catalyzed Carbonylation of Methylene beta-C-H Bonds in Aliphatic Amines
(-)-8-Oxohobartine a New İndole Alkaloid from Aristotelia chilensis (Mol.) Stuntz
CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION
Changes in Secondary Metabolites Profiles and Biological Activity of the Fresh Fruiting Bodies of Stereum hirsutum Exposed to High-dose UV-B Radiation
Label-Assisted Mass Spectrometry for the Acceleration of Reaction Discovery and Optimization
Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization.
Silver-Promoted Benzannulations of Siloxy Alkynes with Pyridinium and Isoquinolinium Salts
Three Component Reaction Discovery Enabled by Mass Spectrometry of Self-Assembled Monolayers
Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers
Species and genera in Aleurodiscus sensu lato as viewed from the Southern Hemisphere

Patent (1)

USO DE ESPONJAS DE PLA Y PHB COMO SOPORTE DE LIBERACIÓN CONTROLADA EN EL TIEMPO DE ACEITES ESENCIALES, PARA EL CONTROL SIN CONTACTO DEL HONGO BOTRYTIS CINEREA

Proyecto (12)

VALIDACIÓN DE UN NANOMATERIAL FILTRANTE BASADO EN REDES METAL-ORGÁNICAS (MOFS) Y CARBÓN MINERAL PARA LA ADSORCIÓN DE TRIMETILAMINA
EXPLORING THE NEUROPROTECTIVE CHEMICAL SPACE OF FUNGI ISOLATED FROM THE ANTARCTIC CONTINENT: A NEW POTENTIAL SOURCE OF CHEMICALS TO CONTROL ALZHEIMER S DISEASE.
GRUPO DE INVESTIGACIÓN EN QUÍMICA APLICADA Y SUSTENTABLE (GIQAS)
GRUPOS DE INVESTIGACIÓN VALORIZACIÓN DE BIOMASA Y BIOPRODUCTOS (VB&B)
IMPLEMENTACIÓN DE UNA NUEVA PLATAFORMA DE ALMACENAMIENTO EFECTIVO DE CEPAS FÚNGICAS MEDIANTE LA ADQUISICIÓN DE UNA ESTUFA Y UN ULTRA FREEZER PARA EL LABORATORIO DE QUÍMICA APLICADA Y SUSTENTABLE ? DEPARTAMENTO DE QUÍMICA
BIOCOMPOST FORTIFICADO CONTROL BIOLÓGICO EN AGRICULTURA.
Antimicrobial activity on multi resistant bacteria and neuroprotective effect on Alzheimer’ disease of fungi isolated from Andean-Patagonian environments in the south of Chile
CIENCIA PARA LA INNOVACIÓN 2030, CONSORCIO SUR-SUBANTÁRTICO, CI2030, ETAPA DE IMPLEMENTACIÓN
Expanding the multi–target neuroprotective chemical space of benzofuran scaffolds from fungal and synthetic sources=> establishing the basis for drug development in Alzheimer’s disease.
Synthesis and biological evaluation of Chalcone-benzodihydrofuran hybrid cores
Discovery of novel beta-lactam analogs oriented to control multidrug-resistant bacteria enabled by Pd-catalyzed C–H activation of aliphatic amines
Desarrollo e implementacio&#769;n de nuevas reacciones qui&#769;micas basadas en activacion de enlaces C-H catalizadas por Pd y su aplicacio&#769;n en la si&#769;ntesis de isoschizogalina

Review (2)

Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance
Advances on the Merger of Electrochemistry and Transition Metal Catalysis for Organic Synthesis
40
Jaime Cabrera

Assistant Professor

Chemistry

Universidad del Bio Bio

Concepcion, Chile

4
Fabián Figueroa

Investigador

Departamento de Botánica

Universidad de Concepción

Concepción, Chile

4
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

4
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
Ramón Ahumada

Academico

de Química

Universidad del Bío-Bío

Concepción, Chile

3
Victor Hernandez

Associate Professor (and Vicedean Faculty)

Botany Department

UNIVERSIDAD DE CONCEPCION, LABORATORIO DE QUÍMICA DE PRODUCTOS NATURALES

Concepcion, Chile

3
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

3
JAVIERA GAVILAN

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

3
Andres Opazo

Profesor Asistente

Microbiología

Universidad de Concepción

Concepción, Chile

2
Gerardo Gonzalez

Full Professor

Microbiology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Gastón Bravo

Docente-Investigador

Ciencias Basicas

Universidad San Sebastián

Concepcion, Chile

2
Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

2
Paola Méndez

Investigadora

Química

Universidad del Bío-Bío

Concepción, Chile

2
Götz Palfner

Profesor Asociado

Botánica

Universidad de Concepción

Concepción, Chile

2
Vanessa Novoa

Investigador

Facultad de Educación y Humanidades

Universidad de Tarapacá

Concepción, Chile

2
Cristian Paz

Académico

Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

1
Carolina Rojas

Titular Professor

Institute of Urban and Territorial Studies

Pontificia Universidad Católica de Chile

56223545513, Chile

1
CARLOS PEÑA

PROFESOR

INSTITUTO DE CIENCIAS QUIMICAS APLICADAS

Universidad Autónoma de Chile

TEMUCO, Chile

1
OCTAVIO ROJAS

Profesor Asociado

Planificación Territorial y Sistemas Urbanos

Universidad de Concepción

Concepción, Chile

1
Helia Bello

Full Professor

Microbiologia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Solange Torres

Investigador Postdoctoral

Botánica

Universidad de Concepción

Concepción, Chile

1
Francisco de la Barrera

Profesor asociado

Planificación Territorial y Sistemas Urbanos

Universidad de Concepción

Concepción, Chile

1
Jose Arumi

Profesor Titular

Water Resources

UNIVERSIDAD DE CONCEPCIÓN

Chillan, Chile

1
Jose Munita

Profesor Asociado

Internal Medicine

FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Karla Pozo

ACADÉMICO MEDIA JORNADA

FACULTAD DE INGENIERIA Y TECNOLOGIA

UNIVERSIDAD SAN SEBASTIÁN

CONCEPCION, Chile

1
Paulina Bahamonde

Profesora Asistente

Centro Resiliencia, Adaptación y Mitigación

Universidad Mayor de Chile

TEMUCO, Chile

1
Mario Aranda

Associate Professor

Pharmacy

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Paola Durán

Profesor Asociado

Producción Agropecuaria

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Paulette Legarraga

Sub jefe técnico Laboratorio

Laboratorios Clínicos

Clínica Alemana de Santiago

Santiago, Chile

1
Christian Nuñez

Director Departamento de Química

Química

Universidad del Bío Bío

Concepción, Chile

1
Esteban Paredes

Encargado de Laboratorio

Salud Ambiental

Instituto Salud Pública

Santiago, Chile

1
Leandro Ortiz

Académico

Química

Universidad Austral de Chile

Valdivia, Chile

1
AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile