Man

Jose Manuel Munita Sepulveda

Profesor Asociado

FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Líneas de Investigación


Mechanisms of bacterial resistance to antimicrobials Molecular epidemiology and transmission dynamics of antibiotic-resistant organisms Clinical impact of bacterial resistance

Educación

  •  Medico Cirujano, UNIVERSIDAD DE LOS ANDES. Chile, 2004
  •  Infectious Diseases, University of Texas Health Science Center at Houston. Estados Unidos, 2014
  •  Internal Medicine, Facultad de Medicina Clinica Alemana - Universidad del Desarrollo. Chile, 2007
  •  Physician, UNIVERSIDAD DE LOS ANDES. Chile

Experiencia Académica

  •   Docente Part Time

    FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

    2007 - 2011

  •   Profesor Asociado Part Time

    FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

    2016 - At present

  •   Profesor Asistente Adjunto Part Time

    THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON

    2016 - At present

Experiencia Profesional

  •   Medico Internista Full Time

    Hospital Padre Hurtado

    Santiago, Chile

    2007 - 2011

  •   Staff, Unidad de Paciente Critico Part Time

    Clinica Alemana de Santiago

    Santiago, Chile

    2008 - 2011

Premios y Distinciones

  •   ASM Infectious Disease Fellow Travel Grant

    American Society for Microbiology

    Estados Unidos, 2012

    Travel grant awarded to fellows with presenting outstanding work in the annual ASM meeting

  •   ASM ICAAC Infectious Diseases Fellows Grant Program

    American Society for Microbiology

    Chile, 2013

    Travel grant awarded to outstanding fellows who were invited for a Fellows Program to be held during the annual ICAAC meeting

  •   IDWeek Trainee Travel Grant

    Infectious Diseases Society of America

    Chile, 2013

    Travel Grant awarded by the Infectious Diseases Society of America to outstanding fellows to present their work at the annual IDSA meeting

  •   Scholarship for Clinical and Research Training

    Clinica Alemana de Santiago

    Chile, 2011

    Beca para formación de especialistas en el extranjero otorgada a medico de Clínica Alemana por medio de un concurso competitivo. En este caso la beca otorgada fue por los años 2011 al 2014

  •   Scholarship for Medical Subspecialties Abroad

    CONICYT

    Chile, 2014

    Becas de sub especialidades medicas para formación en el extranjero

  •   Fellow

    American College of Physicians

    Estados Unidos, 2017

    Nombramiento oficial como Fellow del American College of Physicians


 

Article (65)

Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals
Multiomics characterization of methicillin-resistant Staphylococcus aureus (MRSA) isolates with heterogeneous intermediate resistance to vancomycin (hVISA) in Latin America
Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida
A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player
Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two bla(KPC-2) gene copies without losing carbapenem resistance
Antimicrobial Susceptibility Testing for Enterococci
Clinical characteristics, microbiology and outcomes of a cohort of patients treated with ceftolozane/tazobactam in acute care inpatient facilities, Houston, Texas, USA
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries
Contemporary Clinical and Molecular Epidemiology of Vancomycin-Resistant Enterococcal Bacteremia: A Prospective Multicenter Cohort Study (VENOUS I)
First wave of SARS-CoV-2 in Santiago Chile: Seroprevalence, asymptomatic infection and infection fatality rate
Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in China, 2016-20
Molecular mechanisms leading to ceftolozane/tazobactam resistance in clinical isolates of Pseudomonas aeruginosa from five Latin American countries
New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides
Phenotypic and Genotypic Characterization of Macrolide, Lincosamide and Streptogramin B Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates in Chile
Real-World Performance of Susceptibility Testing for Ceftolozane/Tazobactam against Non-Carbapenemase-Producing Carbapenem-Resistant Pseudomonas aeruginosa
Role of the multi-drug efflux systems on the baseline susceptibility to ceftazidime/avibactam and ceftolozane/tazobactam in clinical isolates of non-carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa
Transmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: a modelling study for bloodstream infections
Antimicrobial resistance in wildlife and in the built environment in a wildlife rehabilitation center
ESBL-Producing Escherichia coli Carrying CTX-M Genes Circulating among Livestock, Dogs, and Wild Mammals in Small-Scale Farms of Central Chile
Evaluation of two fluorescence immunoassays for the rapid detection of SARS-CoV-2 antigen-new tool to detect infective COVID-19 patients
Isolation of Ciprofloxacin and Ceftazidime-Resistant Enterobacterales From Vegetables and River Water Is Strongly Associated With the Season and the Sample Type
Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
Multi-country cross-sectional study of colonization with multidrug-resistant organisms: protocol and methods for the Antibiotic Resistance in Communities and Hospitals (ARCH) studies
Selective digestive decontamination with oral colistin plus gentamicin for persistent bacteraemia caused by non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae in a neutropenic patient
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa
Detection of heterogeneous vancomycin intermediate resistance in MRSA isolates from Latin America
Genomic Epidemiology of Vancomycin-Resistant Enterococcus faecium (VREfm) in Latin America: Revisiting The Global VRE Population Structure
In Vitro Susceptibility to Ceftazidime/Avibactam and Comparators in Clinical Isolates of Enterobacterales from Five Latin American Countries
A Multicenter Study To Evaluate Ceftaroline Breakpoints: Performance in an Area with High Prevalence of Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Lineage
A One Health - One World initiative to control antibiotic resistance: A Chile - Sweden collaboration
Higher MICs (> 2 mg/L) Predict 30-Day Mortality in Patients With Lower Respiratory Tract Infections Caused by Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa Treated With Ceftolozane/Tazobactam
A Natural Deep Eutectic Solvent Formulated to Stabilize beta-Lactam Antibiotics
In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways
Influence of inoculum effect on the efficacy of daptomycin monotherapy and in combination with -lactams against daptomycin-susceptible enterococcus faecium harboring liasr substitutions
Influence of Inoculum Effect on the Efficacy of Daptomycin Monotherapy and in Combination with beta-Lactams against Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions
The Cefazolin Inoculum Effect Is Associated With Increased Mortality in Methicillin-Susceptible Staphylococcus aureus Bacteremia
A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries.
Ceftaroline-Resistant, DaptomycinTolerant, and Heterogeneous Vancomycin-Intermediate MethicillinResistant Staphylococcus aureus Causing Infective Endocarditis
Daptomycin non-susceptible Enterococcus faecium in leukemia patients: Role of prior daptomycin exposure
Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group
Multicenter Evaluation of Ceftolozane/Tazobactam for Serious Infections Caused by Carbapenem-Resistant Pseudomonas aeruginosa
Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum beta-Lactams for Major Gram-Negative Bacterial Pathogens
Fungal empyema thoracis in cancer patients
Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated with Daptomycin: Is it Time to Change the Breakpoint?
Mechanisms of Antibiotic Resistance.
A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalis
Deletion of liaR Reverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic Background
Evolving Resistance Among Gram-positive Pathogens
Mechanisms of drug resistance: daptomycin resistance
Methicillin-Susceptible, Vancomycin-Resistant Staphylococcus aureus, Brazil
Transferable Vancomycin Resistance in a Community-Associated MRSA Lineage
What's New in the Treatment of Enterococcal Endocarditis?
Whole-Genome Analyses of Enterococcus faecium Isolates with Diverse Daptomycin MICs
A liaF Codon Deletion Abolishes Daptomycin Bactericidal Activity against Vancomycin-Resistant Enterococcus faecalis
Daptomycin-Resistant Enterococcus faecalis Diverts the Antibiotic Molecule from the Division Septum and Remodels Cell Membrane Phospholipids
Dissecting the Mechanisms of Linezolid Resistance in a Drosophila melanogaster Infection Model of Staphylococcus aureus
Whole-Genome Analysis of a Daptomycin-Susceptible Enterococcus faecium Strain and Its Daptomycin-Resistant Variant Arising during Therapy
Correlation between Mutations in liaFSR of Enterococcus faecium and MIC of Daptomycin: Revisiting Daptomycin Breakpoints
Enterococcal Endocarditis: Can We Win the War?
Bacteremia in patients with liver cirrhosis
Cat scratch disease associated neuroretinitis: Clinical report and review of the literature
Pandemic influenza A (H1N1) 2009 with neurological manifestations, a case series
Cirugía pulmonar en tuberculosis
Surgery for pulmonary tuberculosis. Review of 33 operated patients
Community acquired infections with methicillin resistant strains of Staphylococcus aureus. Report of five cases

Abstract (1)

DO INTERNATIONAL MIGRANTS FACE HIGHER BACTERIAL DRUG RESISTANCE COMPARED TO NATIVES? A SYSTEMATIC REVIEW

BookSection (4)

Mechanisms of Antibiotic Resistance
Antimicrobial Resistance: Selection vs. Induction
Skin and soft tissue infections
Vancomycin-resistant enterococcal infections in the ICU

CaseReport (1)

Staphylococcus aureus comunitario resistente a cloxacilina: Comunicación de los primeros cinco casos descritos en Chile

EditorialMaterial (2)

Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions
Enterococcus faecalis Infective Endocarditis: Is It Time to Abandon Aminoglycosides?

Errata (1)

A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries (vol 61, e00816-17, 2017)

Proyecto (6)

Millennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R)
Collaborative Effort to Study Multidrug-Resistant Gram-Negatives in Chile
Phylogenomic Analysis of the Chilean-Cordobes MRSA Clone and the Role of Heavy Metal Resistance in its Ability to Prevail in Chile
Genomic Characteristics of VRE Bloodstream Infections in Patients with Hematological Malignancies in Six Geographical Locations
Prospective Evaluation of Clinical Outcomes of Cancer Patients with Vancomycin-Resistant E. faecium Bacteremia
Prospective Evaluation of Clinical Outcomes of Cancer Patients with Vancomycin-Resistant Enterococcal Bacteremia

Review (3)

Daptomycin for the treatment of bacteraemia due to vancomycin-resistant enterococci
Mechanisms of antibiotic resistance in enterococci
Resistance to last resort antibiotics in Gram-positive cocci: The post-vancomycin era
77
Jose Munita

Profesor Asociado

Internal Medicine

FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

20
Sandra Diaz

Associate Professor

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

5
Jose Martínez

Investigador

ICIM

Universidad del Desarrollo

LAS CONDES, Chile

5
Patricia García

Jefe de Laboratorio de Microbiologia

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, LABORATORIO DE MICROBIOLOGÍA

Santiago, Chile

4
Gerardo Gonzalez

Full Professor

Microbiology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Andres Opazo

Profesor Asistente

Microbiología

Universidad de Concepción

Concepción, Chile

3
Pablo Vial

Professor

School of Medicine

ICIM/UNIVERSIDAD DEL DESARROLLO - CLÍNICA ALEMANA

Santiago, Chile

3
Aniela Wozniak

Coordinador de Investigación

Dept Laboratorios Clínicos

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Rafael Araos

Principal Investigator

Universidad del De

Santiago, Chile

2
Andrea Moreno

Profesor Asociado

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
SANDRA CORTES

ASSOCIATED PROFESSOR

PUBLIC HEALTH

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Ana Sandino

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Roberto Riquelme

Académico Investigador

Universidad de Las Américas

Santiago, Chile

1
Juan Ugalde

Assistant Professor

Facultad de Ciencias de la Vida

Universidad Andrés Bello

Santiago, Chile

1
Thomas Weitzel

Head Travel Medicine Program

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Maria Olivares

Docente Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Mauricio Apablaza

Research Director

Gobierno

Universidad del Desarrollo

Santiago, Chile

1
Aiko Adell

Profesor Asociado

Universidad Andrés Bello

Santiago, Chile

1
Pamela Rojas

Médico

Microbiología

Hospital Padre Hurtado

Santiago, Chile

1
Lorena Porte

Jefe Sección Microbiología

Laboratorio Clínico

Clínica Alemana

Santiago, Chile

1
Paola Campodonico

Director of Centro de Química Médica and Associate Professor

CENTRE OF MEDICINAL CHEMISTRY, FACULTY OF MEDICINE, UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Jaime Cabrera

Assistant Professor

Chemistry

Universidad del Bio Bio

Concepcion, Chile

1
cristian calderon

inestigador/profesor

Centro de Química Medica

Universidad del Desarollo

Santiago, Chile

1
Daniel Ibáñez

Profesional

Laboratorio Biomédico

Instituto de Salud Pública de Chile

Santiago, Chile

1
pamela araya

JEFE DE SECCIÓN

BIOMEDICO

INSTITUTO DE SALUD PUBLICA DE CHILE

SANTIAGO, Chile

1
Juan Hormazabal

Jefe

Departamento Biomédico

Public Health Institute of Chile

Santiago, Chile

1
Mauricio Canals

PROFESOR TITULAR

MEDICINA

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

SANTIAGO, Chile

1
JUAN LOPEZ

OFTALMOLOGO

OFTALMOLOGIA

HOSPITAL DEL SALVADOR Y HLCM

SANTIAGO, Chile