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Marcelo Alejandro Alarcón Lozano

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

Cardiovasuclar Disease, Chemistry and biological activity of natural product

Cell Biology and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2013
Tecnólogo Médico, UNIVERSIDAD DE TALCA. Chile, 1997

Profesor Full Time

UNIVERSIDAD DE TALCA

Ciencias de la Salud

Talca, Chile

1997 - At present

Profesor Full Time

Universidad de Talca

Talca, Chile

1997 - At present

- Desde el año 2006 a la Fecha con Tesistas de Pre-grado de la Carrera de Tecnología Médica

- Dos Tesistas del Magister de Ciencias Biomédicas de la Universidad de Talca

- Un Tesista de Doctorado del Doctorado de Ciencias Biomédicas de la Universidad de Talca


An Overview of Two Old Friends Associated with Platelet Redox Signaling, the Protein Disulfide Isomerase and NADPH Oxidase Trostchansky, Andres; Alarcon, Marcelo Article ISI BIOMOLECULES (2023)
Characterization by Gender of Frailty Syndrome in Elderly People according to Frail Trait Scale and Fried Frailty Phenotype Palomo, Ivan; Garcia, Francisco; Albala, Cecilia; Wehinger, Sergio; Fuentes, Manuel; Alarcon, Marcelo; Arauna, Diego; Montecino, Hector; Mendez, Diego; Sepulveda, Magdalena; Fuica, Peggy; FUENTES, EDUARDO Article ISI JOURNAL OF PERSONALIZED MEDICINE (2022)
Effects of the age/rage axis in the platelet activation Recabarren-Leiva, D.; Burgos, C. F.; Hernandez, B.; Garcia-Garcia, F. J.; Castro, R., I; Guzman, L.; Fuentes, E.; Palomo, I; Alarcon, M. Article ISI INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)
Effects of the age/rage axis in the platelet activation. Recabarren-Leiva, D; Burgos, CF; Hernández B.; Garcia-Garcia F.J.; Castro RI.; Guzman, L; Fuentes E.; Palomo I.; Alarcon M. Article INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)
Non-nutrients and nutrients from Latin American fruits for the prevention of cardiovascular diseases Aguiar, Lais Marinho; Bicas, Juliano Lemos; Fuentes, Eduardo; Alarcon, Marcelo; Gonzalez, Ivan Palomo; Pastore, Glaucia Maria; Marostica Junior, Mario Roberto; Cazarin, Cinthia Bau Betim Article ISI FOOD RESEARCH INTERNATIONAL (2021)
In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation Alarcon, Marcelo; Bustos, Michelle; Mendez, Diego; FUENTES, EDUARDO; Palomo, Ivan; Lutz, Mariane Article ISI SCOPUS PLANT FOODS FOR HUMAN NUTRITION (2020)
In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation. Alarcón M, Bustos M, Mendez D, Fuentes E, Palomo I, Lutz M. Article PLANT FOODS FOR HUMAN NUTRITION (2020)
Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels Mendez, Diego; Arauna, Diego; Fuentes, Francisco; Araya-Maturana, Ramiro; Palomo, Ivan; Alarcon, Marcelo; Sebastian, David; Zorzano, Antonio; FUENTES, EDUARDO Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels. A. Mendez D.; Arauna D.; Fuentes F.; Araya-Maturana, R; Palomo I.; Alarcón M.; Sebastián D.; Zorzano, A; Fuentes E. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging. Arauna D, Furrianca M, Espinosa-Parrilla Y, Fuentes E, Alarcón M, Palomo I. Article MOLECULES (2020)
Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15 Arauna, Diego; Garcia, Francisco; Rodriguez-Manas, Leocadio; Marrugat, Jaume; Saez, Claudia; Alarcon, Marcelo; Wehinger, Sergio; Espinosa-Parrilla, Yolanda; Palomo, Ivan; FUENTES, EDUARDO Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2020)
Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15. Arauna D, García F, Rodríguez-Mañas L, Marrugat J, Sáez C, Alarcón M, Wehinger S, Espinosa-Parrilla Y, Palomo I, Fuentes E. Article FREE RADICAL BIOLOGY AND MEDICINE (2020)
Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study Arauna, Diego; Cerda, Alvaro; Garcia, Jose Francisco; Wehinger, Sergio; Castro, Felipe; Mendez, Diego; Alarcon, Marcelo; FUENTES, EDUARDO; Palomo, Ivan Article ISI CLINICAL INTERVENTIONS IN AGING (2020)
Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study. Arauna D, Cerda A, García-García JF, Wehinger S, Castro F, Méndez D, Alarcón M, Fuentes E, Palomo I. Article CLINICAL INTERVENTIONS IN AGING (2020)
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6 Méndez, Diego; Urra, Félix A.; Millas-Vargas, Juan Pablo; Alarcón, Marcelo; Rodríguez-Lavado, Julio; Palomo, Iván; Trostchansky, Andrés; Araya-Maturana, Ramiro; FUENTES, EDUARDO Article ISI SCOPUS (2020)
Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. Alarcón M, Bustos M, Mendez D, Fuentes E, Palomo I, Lutz M. Article PLANT FOODS FOR HUMAN NUTRITION (2020)
Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study. Palomo I, Giacaman RA, León S, Lobos G, Bustamante M, Wehinger S, Tapia JC, Fuentes M, Alarcón M, García F, Albala C, Fuentes E. Article ARCHIVES OF GERONTOLOGY AND GERIATRICS (2019)
Anti-aggregation effect on platelets of Indiplon a hypnotic sedative non-benzodiazepine drug Burgos, C F; Sanchéz, C; Sepúlveda, C; Fuentes, E; Palomo, I; Alarcón, M Article BIOMEDICINE AND PHARMACOTHERAPY (2019)
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders Espinosa-Parrilla, Yolanda; Gonzalez-Billault, Christian; FUENTES, EDUARDO; Palomo, Ivan; Alarcon, Marcelo Article ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2019)
Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders. Espinosa-Parrilla Y, Gonzalez-Billault C, Fuentes E, Palomo I, Alarcón M. Article FRONTIERS IN AGING NEUROSCIENCE (2019)
Generation of platelet-derived microparticles through the activation of the toll-like receptor 4. Alarcon M. Article HELIYON (2019)
Increased platelet function during frailty Hernandez, Blanca; FUENTES, EDUARDO; Palomo, Ivan; Alarcon, Marcelo Article ISI SCOPUS EXPERIMENTAL HEMATOLOGY (2019)
Increased platelet function during frailty. Hernández B, Fuentes E, Palomo I, Alarcón M. Article EXPERIMENTAL HEMATOLOGY (2019)
Methodology of generation and purification of anti-beta 2 glycoprotein I antibodies. Alarcon M, Fuentes E, Maldonado X, Mardones C, Palomo I. Article METHODSX (2019)
Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging Arauna, Diego; Furrianca, Maria; Espinosa-Parrilla, Yolanda; FUENTES, EDUARDO; Alarcon, Marcelo; Palomo, Ivan Article ISI SCOPUS MOLECULES (2019)
Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases Lutz, Mariane; Fuentes, Eduardo; Ávila, Felipe; Alarcón, Marcelo; Palomo, Iván Article MOLECULES (2019)
Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases. Lutz M, Fuentes E, Ávila F, Alarcón M, Palomo I. Article MOLECULES (2019)
The cAMP/PKA Pathway Inhibits Beta-amyloid Peptide Release from Human Platelets. Sepúlveda, C; Hernández, B; Burgos, C F; Fuentes, E; Palomo, I; Alarcón, M Article Neuroscience (2019)
New insights into the gene expression associated to amyotrophic lateral sclerosis. Recabarren-Leiva, Daniela; Alarcón, Marcelo Article Life sciences (2018)
Standardization of a fast and effective method for the generation and detection of platelet-derived microparticles by a flow cytometer. Recabarren-Leiva, Daniela; Alarcón, Marcelo Article Immunology letters (2018)
Gene networks in neurodegenerative disorders. Recabarren D, Alarcón M. Article LIFE SCIENCES (2017)
Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling Fuentes, Francisco; Alarcón, Marcelo; Badimon, Lina; Fuentes, Manuel; Klotz, Karl-Norbert; Vilahur, Gemma; Kachler, Sonja; Padró, Teresa; Palomo, Iván; Fuentes, Eduardo Article INTERNATIONAL JOURNAL OF CARDIOLOGY (2017)
Immune System Dysfunction in the Elderly Fuentes, Eduardo; Fuentes, Manuel; ALARCÓN, MARCELO; PALOMO, IVÁN Article ISI SCOPUS ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2017)
Aqueous Extract of Tomato (Solanum lycopersicum L.) and Ferulic Acid Reduce the Expression of TNF-alpha and IL-1 beta in LPS-Activated Macrophages Navarrete, S; Alarcon M.; Palomo I. Article ISI SCOPUS MOLECULES (2015)
Inhibitory effects of Cyperus digitatus extract on human platelet function in vitro Fuentes E.; Forero-Doria, O; Alarcon M.; Palomo I. Article ISI SCOPUS Platelets (2015)
Platelets miRNAs and Cardiovascular Diseases Eduardo Fuentes, Iván Palomo, Marcelo Alarcón, Article Life Sciences (2015)
Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1 beta) and thrombus formation Alarcon M.; Fuentes E.; Olate, N; Navarrete, S; Carrasco, G; Palomo I. Article ISI SCOPUS Platelets (2015)
A novel role of Eruca sativa Mill. (rocket) extract: antiplatelet (NF-κB inhibition) and antithrombotic activities. Fuentes E, Alarcón M, Fuentes M, Carrasco G, Palomo I. Article Nutrients (2014)
A Novel Role of Eruca sativa Mill. (Rocket) Extract: Antiplatelet (NF-kappa B Inhibition) and Antithrombotic Activities Fuentes E.; Alarcon M.; Fuentes M.; Carrasco, G; Palomo I. Article ISI SCOPUS NUTRIENTS (2014)
Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation Fuentes, E.; Caballero, J.; Alarcón, M.; Rojas, A.; Palomo, I. Article ISI SCOPUS PLOS ONE (2014)
Chlorogenic acid inhibits human platelet activation and thrombus formation. Fuentes, Eduardo; Caballero, Julio; Alarcón, Marcelo; Rojas, Armando; Palomo, Iván Article PloS one (2014)
Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling Fuentes E.; Pereira J.; Mezzano D.; Alarcon M.; Caballero, J; Palomo I. Article ISI SCOPUS PLOS ONE (2014)
Inhibition of platelet activation and thrombus formation by adenosine and inosine: studies on their relative contribution and molecular modeling. Fuentes E, Pereira J, Mezzano D, Alarcón M, Caballero J, Palomo I. Article PLoS One (2014)
Inhibitory effects of Cyperus digitatus extract on human platelet function in vitro. Fuentes E, Forero-Doria O, Alarcón M, Palomo I. Article Platelets (2014)
Overrepresentation of Glutamate Signaling in Network-Based Pathway Analyses of Genome-Wide Association Studies in Alzheimer's Disease Eduardo Pérez-Palma; Bernabé I. Bustos; Camilo Villamán; Marcelo A. Alarcón; Miguel E. Avila; Ariel E. Reyes; Carlos Opazo; Giancarlo V. De Ferrari Article PLOS ONE (2014)
Protective mechanisms of adenosine 5 '-monophosphate in platelet activation and thrombus formation Fuentes, Eduardo; Badimon, Lina; Caballero, Julio; Padro, Teresa; Vilahur, Gemma; Alarcon, Marcelo; Perez, Pablo; Palomo, Ivan Article THROMBOSIS AND HAEMOSTASIS (2014)
Protective mechanisms of adenosine 5’-monophosphate in platelet activation and thrombus formation Fuentes E, Badimon L, Caballero J, Padró T, Vilahur G, Alarcón M, Pérez P, Palomo I. Article Thromb Haemost. (2014)
Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation. Alarcón M, Fuentes E, Olate N, Navarrete S, Carrasco G, Palomo I. Article Platelets (2014)
Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation. Alarcón M, Fuentes E, Olate N, Navarrete S, Carrasco G, Palomo I. Article PLATELETS (2014)
Thrombus formation induced by laser in a mouse model Pérez P, Alarcón M, Fuentes E, Palomo I. Article ISI SCOPUS EXPERIMENTAL AND THERAPEUTIC MEDICINE (2014)
Thrombus formation induced by laser in a mouse model. Pérez P, Alarcón M, Fuentes E, Palomo I. Article Exp Ther Med (2014)
A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease. Alarcón MA; Medina MA; Hu Q; Avila ME; Bustos BI; Pérez-Palma E; Peralta A; Salazar P; Ugarte GD; Reyes AE; Martin GM; Opazo C; Moon RT; De Ferrari GV Article Neurobiol Aging (2013)
Effect of tomato industrial processing on phenolic profile and antiplatelet activity. Fuentes, Eduardo; Forero-Doria, Oscar; Carrasco, Gilda; Maricán, Adolfo; Santos, Leonardo S; Alarcón, Marcelo; Palomo, Iván Article Molecules (Basel, Switzerland) (2013)
Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities Fuentes E.; Rodriguez-Perez, W; Guzman, L; Alarcon M.; Navarrete, S; Forero-Doria, O; Palomo I. Article ISI SCOPUS Evidence-based Complementary and Alternative Medicine (2013)
Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities. Fuentes E, Rodríguez-Pérez W, Guzmán L, Alarcón M, Navarrete S, Forero-Doria O, Palomo I. Article Evid Based Complement Alternat Med. (2013)
PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy Durán-Lara, Esteban; Guzmán, Luis; John, Amalraj; Fuentes, Eduardo; Alarcón, Marcelo; Palomo, Iván; Santos, Leonardo S Article Eur J Med Chem. (2013)
PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy Durán-Lara E, Guzmán L, John A, Fuentes E, Alarcón M, Palomo I, Santos LS. Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Protective mechanisms of adenosine 5'-monophosphate in platelet activation and thrombus formation. Fuentes, E.; Badimon, L.; Caballero, J.; Padró, T.; Vilahur, G.; Alarcón, M.; Pérez, P.; Palomo, I. Article ISI SCOPUS THROMBOSIS AND HAEMOSTASIS (2013)
Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced Platelet Activation: Role of sCD40L Fuentes E, Alarcón M, Astudillo L, Valenzuela C, Gutiérrez M, Palomo I. Article ISI SCOPUS MOLECULES (2013)
Protective mechanisms of guanosine from Solanum lycopersicum on agonist-induced platelet activation: role of sCD40L. Fuentes, Eduardo; Alarcón, Marcelo; Astudillo, Luis; Valenzuela, Claudio; Gutiérrez, Margarita; Palomo, Iván Article Molecules (Basel, Switzerland) (2013)
Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation: In Vitro, Ex Vivo and In Vivo Studies. Fuentes, Eduardo; Pereira, Jaime; Alarcón, Marcelo; Valenzuela, Claudio; Pérez, Pablo; Astudillo, Luis; Palomo, Iván Article Evid Based Complement Alternat Med. (2013)
Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation: In Vitro, Ex Vivo and In Vivo Studies Fuentes E, Pereira J, Alarcón M, Valenzuela C, Pérez P, Astudillo L, Palomo I. Article ISI SCOPUS Evidence-based Complementary and Alternative Medicine (2013)
Wnt/b-catenin signaling in Alzheimer’s disease Giancarlo V. De Ferrari; Miguel E. Avila; Matías A. Medina; Eduardo Pérez-Palma; Bernabé I. Bustos; Marcelo A. Alarcón Article CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2013)
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum. Fuentes E Article Evid Based Complement Alternat Med. (2012)
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum Fuentes E.; Castro R.; Astudillo, L; Carrasco, G; Alarcon M.; Gutiérrez M; Palomo I. Article ISI SCOPUS Evidence-based Complementary and Alternative Medicine (2012)
Bioassay-guided Isolation and Identification of Bioactive Compound from Solanum lycopersicum with Antiplatelet Activity: food drug interaction Fuentes E; Carrasco G Article Journal of Functional Foods (2012)
Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity Fuentes E.J.; Contreras S.O.; Bustamante L.O.; Rubio P.I.; Moore-Carrasco R.; Alarcon M.A.; Fuentes J.A.; Palomo I.F.; Astudillo L.A.; Gutierrez M.I.; Gonzalez D.E. Article Blood Coagulation and Fibrinolysis (2012)
Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity Fuentes E.J.; Astudillo L.A.; Gutierrez M.I.; Contreras S.O.; Bustamante L.O.; Rubio P.I.; Moore-Carrasco, R; Alarcón M.A.; Fuentes, J. A.; Gonzalez D.E.; Palomo I.F. Article ISI SCOPUS Blood Coagulation and Fibrinolysis (2012)
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables Torres-Urrutia C.; Guzman, L; Schmeda-Hirschmann, G; Moore-Carrasco, R; Alarcon M.; Astudillo, L; Gutiérrez M; Carrasco, G; Yuri, JA.; Aranda, E; Palomo I. Article ISI SCOPUS Blood Coagulation and Fibrinolysis (2011)
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables. Torres-Urrutia, Constanza; Guzmán, Luis; Schmeda-Hirschmann, Guillermo; Moore-Carrasco, Rodrigo; Alarcón, Marcelo; Astudillo, Luís; Gutierrez, Margarita; Carrasco, Gilda; Yuri, José A; Aranda, Eduardo; Palomo, Iván Article Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (2011)
Pathophysiology of the proatherothrombotic state in the metabolic syndrome Palomo I.; Moore-Carrasco R.; Alarcon M.; Rojas A.; Espana F.; Andres V.; Gonzalez-Navarro H. Article SCOPUS Frontiers in Bioscience - Scholar (2010)
Pathophysiology of the proatherothrombotic state in the metabolic syndrome. Palomo I, Moore-Carrasco R, Alarcon M, Rojas A, Espana F, Andres V, Gonzalez-Navarro H. Article Front Biosci (Schol Ed). (2010)
Pathophysiology of the proatherothrombotic state in the metabolic syndrome. Palomo I.; Moore-Carrasco, R; Alarcon M.; Rojas A.; Espana F.; Andrés V; Gonzalez-Navarro H. Article Frontiers in bioscience (Scholar edition) (2010)
Physical activity reduces circulating TNF-alpha but not pro-thrombotic factors levels in patients with metabolic syndrome Palomo I.; Herrera J.; Cancino, V.; Alarcon M.; Leiva E.; Vásquez M; Moore-Carrasco, R; Mujica, V; Díaz N; Icaza G.; Urzúa, A; Gonzalez D.R. Article SCOPUS Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2010)
Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome. Palomo IG; Gutiérrez CL; Alarcón ML; Jaramillo JC; Segovia FM; Leiva EM; Mujica VE; Icaza GN; Díaz NS; Moore-Carrasco R Article Mol Med Rep (2009)
Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome. Palomo IG; Jaramillo JC; Alarcón ML; Gutiérrez CL; Moore-Carrasco R; Segovia FM; Leiva EM; Mujica VE; Icaza G; Dí NS Article Mol Med Rep (2009)
Low prevalence of Factor V Leiden and the prothrombin G20210A mutation in a healthy population from the central-south region of Chile Baixa prevalência do Fator V Leiden e da mutação da protrombina g20210a em uma população sã da região centro-sul do Chile Palomo I.; Segovia, F; Parra, D; Alarcon M.; Rojas, E Article Revista Brasileira de Hematologia e Hemoterapia (2009)
Low prevalence of Factor V Leiden and the prothrombin G20210A mutation in a healthy population from the central-south region of Chile Baixa prevalência do Fator V Leiden e da mutação da protrombina g20210a em uma população sã da região centro-sul do Chile Palomo I.; Segovia F.; Parra D.; Alarcon M.; Rojas E. Article Revista Brasileira de Hematologia e Hemoterapia (2009)
The role of platelets in the pathophysiology of atherosclerosis (Review) Palomo I.; Toro C.; Alarcon M. Article MOLECULAR MEDICINE REPORTS (2008)
An insight into the pathophysiology of thrombosis in antiphospholipid syndrome Palomo I; Segovia FM; Alarcon ML; Fuentes BY; Pereira JG; Rojas A; Forastiero R Article Front Biosci (2007)
An insight into the pathophysiology of thrombosis in antiphospholipid syndrome. Palomo IG; Segovia FM; Alarcon ML; Fuentes BY; Pereira JG; Rojas A.; Forastiero R Article Front Biosci. (2007)
Prevalence of cardiovascular risk factors in adult from Talca, Chile Palomo I.; Icaza G.; Mujica, V; Nuñez L.; Leiva E.; Vásquez M; Alarcon M.; Moyano E. Article ISI REVISTA MEDICA DE CHILE (2007)
Val/Leu(247) and Trp/Ser(316) polymorphisms in beta(2) glycoprotein I and their association with thrombosis in unselected Chilean patients Palomo I.; Pereira J.; Alarcon M.; Vásquez M; Pinochet, C; Poblete F.; Mendez, E; Sandoval, J; Vidal, R; Pierangeli, S Article ISI SCOPUS CLINICAL RHEUMATOLOGY (2007)
Val/Leu247 and Trp/Ser316 polymorphisms in beta 2 glycoprotein I and their association with thrombosis in unselected Chilean patients. Palomo I; Pereira J; Alarcón M; Vásquez M; Pinochet C; Poblete F; Mendez E; Pierangeli S Article Clin Rheumatol (2007)
Hemostasis alterations in metabolic syndrome Palomo I; Alarcón M; Moore-Carrasco R; Argilés JM Article Int J Mol Med (2006)
High prevalence of classic cardiovascular risk factors in a population of university students from south central Chile Palomo I; Torres GI; Alarcón MA; Maragaño PJ; Leiva E; Mujica V Article Rev Esp Cardiol (2006)
High prevalence of classic cardiovascular risk factors in a population of university students from South Central Chile Alta prevalencia de factores de riesgo cardiovascular clásicos en una población de estudiantes universitarios de la región centro-sur de Chile Palomo I.F.; Alarcón M.A.; Leiva E.; Torres G.I.; Maragano P.J.; Mujica, V Article REVISTA ESPANOLA DE CARDIOLOGIA (2006)
Prevalence of antiphospholipid antibodies in Chilean patients with rheumatoid arthritis Palomo I; Pinochet C; Alarcón M; Sandoval R; Gonzalez J; Monsalves F; Forastiero R Article J Clin Lab Anal (2006)
Prevalence of antiphospholipid antibodies in Chilean patients with rheumatoid arthritis Palomo I.; Pinochet, C; Alarcon M.; Sandoval, R; Gonzalez, J; Monsalves, F; Forastiero R Article ISI SCOPUS JOURNAL OF CLINICAL LABORATORY ANALYSIS (2006)
Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis Palomo I; Pereira J; Alarcón M; Pinochet C; Vélez MT; Hidalgo P; Skagerberg K; Poblete F Article Rev Med Chil (2005)
Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis Palomo I.; Pereira J.; Alarcon M.; Pinochet, C; Velez, MT; Hidalgo, P.; Skagerberg K.; Poblete F. Article ISI REVISTA MEDICA DE CHILE (2005)
Prevalence of antiphospholipid antibodies is not different in Chilean diabetic patients and normal individuals. Palomo IG; Mujica VE; Alarcón ML; Pereira JG; Vásquez MR Article J Diabetes Complications (2005)
Prevalence of antiphospholipid antibodies is not different in Chilean diabetic patients and normal individuals Palomo IG; Mujica VE; Alarcon ML; Pereira JG; Vasquez, MR Article ISI SCOPUS JOURNAL OF DIABETES AND ITS COMPLICATIONS (2005)
Prevalence of heparin-induced antibodies in patients with chronic renal failure undergoing hemodialysis Palomo I; Pereira J; Alarcón M; Díaz G; Hidalgo P; Pizarro I; Jara E; Rojas P; Quiroga G; Moore-Carrasco R Article J Clin Lab Anal (2005)
Prevalence of heparin-induced antibodies in patients with chronic renal failure undergoing hemodialysis Palomo I.; Pereira J.; Alarcon M.; Diaz G.; Hidalgo, P.; Pizarro, I ; Jara, E; Rojas P.; Quiroga G; Moore-Carrasco, R Article ISI SCOPUS JOURNAL OF CLINICAL LABORATORY ANALYSIS (2005)
Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis. Palomo I; Pereira J; Alarcon M; Vásquez M; Pinochet C; Vélez MT; Sandoval J; Icaza G; Pierangeli S Article Clin Rheumatol (2004)
Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis Palomo I.; Pereira J.; Alarcon M.; Vásquez M; Pinochet, C; Velez, MT; Sandoval, J; Icaza G.; Pierangeli, S Article ISI CLINICAL RHEUMATOLOGY (2004)
Patients with essential hypertension present higher levels of sE-selectin and sVCAM-1 than normotensive volunteers. Palomo I; Marín P; Alarcón M; Gubelin G; Viñambre X; Mora E; Icaza G Article Clin Exp Hypertens. (2003)
Patients with essential hypertension present higher levels of sE-selectin and sVCAM-1 than normotensive volunteers Palomo I.; Marin, P; Alarcon M.; Gubelin, G; Vinambre, X; Mora, E; Icaza G. Article ISI SCOPUS CLINICAL AND EXPERIMENTAL HYPERTENSION (2003)
Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients. Palomo I; Alarcón M; Sepulveda C; Pereira J; Espinola R; Pierangeli S Article J Clin Lab Anal. (2003)
Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients Palomo I.; Alarcon M.; Sepulveda, C; Pereira J.; Espinola, R; Pierangeli, S Article ISI SCOPUS JOURNAL OF CLINICAL LABORATORY ANALYSIS (2003)
Anti phospholipid antibodies in Chilean patients with systemic lupus erythematosus Palomo I.; Pereira J.; Alarcon M.; Larrain, AM; Pinochet, C; Vásquez M; Velez, MT; Leon, M; Espinola, R; Pierangeli, S Article ISI JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2002)
Antiphospholipid antibodies in Chilean patients with systemic lupus erythematosus. Palomo I; Pereira J; Alarcon M; Larrain AM; Pinochet C; Vasquez M; Velez MT; Leon M; Espinola R; Pierangeli S Article J Lab Clin Med (2002)
ANTIPHOSPHOLIPID ANTIBODIES IN CHILEAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Palomo, Iván; Pereira, Jaime; Alarcon M.; Arredondo, C; Larrain, Ana; Pinochet, Carmen; Vásquez M Article JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2002)
Prevalence of antiphospholipid antibodies in pregnancies without obstetric risk factors in Talca, Chile Vásquez M; Arias F; Palomo I Article Med Clin (Barc). (2002)
Vascular access thrombosis is not related to presence of antiphospholipid antibodies in patients on chronic hemodialysis. Palomo I; Pereira J; Alarcón M; Vasquez M; Pierangeli S Article Nephron (2002)
A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease. Alarcón MA, Medina MA, Hu Q, Avila ME, Bustos BI, Pérez-Palma E, Peralta A, Salazar P, Ugarte GD, Reyes AE, Martin GM, Opazo C, Moon RT, De Ferrari GV. Article NEUROBIOLOGY OF AGING
Effect of tomato industrial processing on phenolic profile and antiplatelet activity. Fuentes E, Forero-Doria O, Carrasco G, Maricán A, Santos LS, Alarcón M, Palomo I. Article ISI MOLECULES
Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome. Palomo IG, Gutiérrez CL, Alarcón ML, Jaramillo JC, Segovia FM, Leiva EM, Mujica VE, Icaza GN, Díaz NS, Moore-Carrasco R. Article MOLECULAR MEDICINE REPORTS
Increased concentrations of soluble vascular cell adhesion molecule-1 and soluble CD40L in subjects with metabolic syndrome. Palomo IG, Jaramillo JC, Alarcón ML, Gutiérrez CL, Moore-Carrasco R, Segovia FM, Leiva EM, Mujica VE, Icaza G, Dí NS. Article MOLECULAR MEDICINE REPORTS
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. Pérez-Palma E, Bustos BI, Villamán CF, Alarcón MA, Avila ME, Ugarte GD, Reyes AE, Opazo C, De Ferrari GV Article PLOS ONE
Thrombus formation induced by laser in a mouse model. Pérez P, Alarcón M, Fuentes E, Palomo I. Article EXPERIMENTAL AND THERAPEUTIC MEDICINE
Wnt/β-catenin signaling in Alzheimer's disease. De Ferrari GV, Avila ME, Medina MA, Perez-Palma E, Bustos BI, Alarcon MA. Article CNS Neurol Disord Drug Targets.


Inhibition of RhoA-RHO kinase pathway attenuates cocaine-induced microvascular endothelial cell dysfunction: studies under static and shear flow conditions Pereira J.; Saez CG; Pereira-Flores, K; Leguina A.; Fuentes E.; Alarcon M.; Palomo I.; Mezzano D. Abstract ISI JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)
Mechanism of antiplatelet action induced by guanosine via increase in camp levels and its antithrombotic activity Fuentes E.; Alarcon M.; Caballero, J; Palomo I. Abstract ISI JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)
Relation between the mechanism of antiplatelet action of adenosine from Solanum lycopersicum and its derivate inosine Fuentes E.; Pereira J.; Caballero, J; Alarcon M.; Perez, P.; Astudillo, L; Palomo I. Abstract ISI JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)


Prevalence of antiphospholipid antibodies in pregnancies without obstetric risk factors in Talca, Chile Vásquez M; Arias, F; Alarcon M.; Palomo I. Letter MEDICINA CLINICA (2002)
Vascular access thrombosis is not related to presence of antiphospholipid antibodies in patients on chronic hemodialysis Palomo I.; Pereira J.; Alarcon M.; Vásquez M; Pierangeli, S Letter ISI Nephron (2002)


ESTUDIO MULTIDISCIPLINARIO SOBRE COMPUESTOS BIOACTIVOS DE VARIEDADES LOCALES CHILENAS DE PHASEOLUS VULGARIS L. Y SUS POTENCIALES EFECTOS EN LA PREVENCIÓN DE ENFERMEDADES CRÓNICAS NO TRANSMISIBLES Carrasco, Basilio; CEAP; Universidad de Talca; INTA; Universidad Católica del Maule Proyecto (2021)
Synthesis and Pharmacological Evaluation of Mitochondria-Targeted Hydroquinone Derivatives with Antiplatelet Activity FONDECYT (1180427) Proyecto 2018-2021 Coinvestigador(a)
Network to construct the know-how for production of health promoting compounds of Aristotelia chilensis in bioreactors. PCI (CONICYT RE) Proyecto 2016-2017 Investigador(a)
Programa de Investigación de Excelencia Interdisciplinaria en Envejecimiento y Adulto Mayor (PIEI-ES) Universidad de Talca Proyecto 2013-2018 Investigador(a)
Research on Mechanisms of Antiplatelet Action of Adenosine and other Bioactive Compounds from Solanum lycopersicum L FONDECYT (1139216) Proyecto 2013-2016 Coinvestigador(a)
RESEARCH ON MECHANISMS OF ANTIPLATELET ACTION OF ADENOSINE AND OTHER BIOACTIVE COMPOUNDS FROM SOLANUM LYCOPERSICUM L FONDECYT (1130216) Proyecto 2013-2016 Coinvestigador(a)
Characterization of the platelet antiaggregant and protecting cardiovascular activities of tomatoes (Solanum lycopersicum L.) extracts. Proyectos enlace fondecyt (Fondos Internos Utalca) Proyecto 2011-2013 Coinvestigador(a)
Centro de Estudios en Alimentos Procesados (CEAP) REGIONAL (R09I2011) Proyecto 2009-2014 Investigador(a)
Identificación y caracterización funcional de eventos de splicing aberrantes enel coreceptor de la señal Wnt, la proteína LRP6 PFCHA (24090174) Proyecto 2009-2009 Inv. Responsable
Programa de Investigación en Factores de Riesgo de Enfermedades Cardiovasculares (PIFRECV) Dirección de Investigación, U de Talca Proyecto 2005-2010 Investigador(a)


MicroRNA expression in male infertility Burgos, C. F.; Cikutovic, R.; Alarcon, M. Review ISI REPRODUCTION FERTILITY AND DEVELOPMENT (2022)
Role of Non-Coding RNA of Human Platelet in Cardiovascular Disease Inzulza-Tapia, Angela; Alarcon, Marcelo Review ISI CURRENT MEDICINAL CHEMISTRY (2022)
The Immune Response to SARS-CoV-2: Mechanisms, Aging, Sequelae, and Vaccines Espinoza, Carolina; Alarcon, Marcelo Review ISI MINI-REVIEWS IN MEDICINAL CHEMISTRY (2022)
Platelet miRNAs and cardiovascular diseases Fuentes E.; Palomo I.; Alarcon M. Review ISI SCOPUS Life Sciences (2015)
The role of platelets in the pathophysiology of atherosclerosis (Review) Palomo I.; Toro, C.; Alarcon M. Review MOLECULAR MEDICINE REPORTS (2008)
Hemostasis alterations in metabolic syndrome (review) Palomo I.; Alarcon M.; Moore-Carrasco, R; Argiles, JM Review INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2006)

Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

Eduardo Fuentes

Profesor Titular

Universidad de Talca

Talca, Chile

Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

MARCELA VASQUEZ

Prof. Asistente

Bioquímica Clínica e Inmunohematología

Universidad de Talca

Talca, Chile

Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

Gilda Carrasco

PROFESOR TITULAR

HORTICULTURA

UNIVERSIDAD DE TALCA

Talca, Chile

Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

Diego Arauna

Investigador Postdoctorante

Universidad de Talca

Talca, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Oscar Forero

Asesor científico

Instituto de química de productos naturales

Universidad de Talca

Talca, Chile

Maria Yolanda Espinosa

Full Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

Ramiro Araya Maturana

Profesor Titular

Universidad de Talca

SantiaTalcago, Chile

DANIEL GONZALEZ

PROFESOR ASOCIADO

CIENCIAS BASICAS BIOMEDICAS

UNIVERSIDAD DE TALCA

Talca, Chile

Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

PABLO PEREZ

Profesor investigador

Programa de Comunicación en Cáncer

Universidad del Desarrollo

Santiago, Chile

Claudio Valenzuela

CONFERENCIANTE

ESCUELA DE MEDICINA

Universidad de Talca

Talca, Chile

Miguel Ávila

Docente/Investigador

Universidad de las Américas

Santiago, Chile

Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

Alvaro Cerda

Académico

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Esteban Durán

Associate Professor

Depto de Microbiologia

UNIVERSIDAD DE TALCA

Talca, Chile

veronica mujica

Julio Rodríguez

Docente

Quimica Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Jose Yuri

Profesor Titular y Director del Centro de Pomáceas

Producción Agrícola

UNIVERSIDAD DE TALCA

Talca, Chile

María Furrianca

PROFESOR ASOCIADO

DEPARTAMENTO DE ENFERMERÍA

Universidad de Magallanes

Punta Arenas, Chile

Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

John Amalraj

Associate Professor

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

luis Urzua

DIRECTOR DE CARRERA

SALUD

Universidad Santo Tomás

Talca, Chile

Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Hector Montecino

Investigador Postdoctoral

Centro de Estudios en Alimentos Procesados

Talca, Chile

Nora Lutz

Directora Departamento Salud Pública

Salud Pública

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Emilio Moyano

Académico Invstigador

Psicologia Social y de las Organizaciones

UNIVERSIDAD DE TALCA

Talca, Chile

Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

Marcelo Alejandro Alarcón Lozano

Líneas de Investigación

Educación

Cell Biology and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2013

Tecnólogo Médico, UNIVERSIDAD DE TALCA. Chile, 1997

Experiencia Académica

Profesor Full Time

Experiencia Profesional

Profesor Full Time

Formación de Capital Humano

Article (113)

Abstract (3)

Letter (2)

Proyecto (10)

Synthesis and Pharmacological Evaluation of Mitochondria-Targeted Hydroquinone Derivatives with Antiplatelet Activity

Network to construct the know-how for production of health promoting compounds of Aristotelia chilensis in bioreactors.

Programa de Investigación de Excelencia Interdisciplinaria en Envejecimiento y Adulto Mayor (PIEI-ES)

Research on Mechanisms of Antiplatelet Action of Adenosine and other Bioactive Compounds from Solanum lycopersicum L

RESEARCH ON MECHANISMS OF ANTIPLATELET ACTION OF ADENOSINE AND OTHER BIOACTIVE COMPOUNDS FROM SOLANUM LYCOPERSICUM L

Characterization of the platelet antiaggregant and protecting cardiovascular activities of tomatoes (Solanum lycopersicum L.) extracts.

Centro de Estudios en Alimentos Procesados (CEAP)

Identificación y caracterización funcional de eventos de splicing aberrantes enel coreceptor de la señal Wnt, la proteína LRP6

Programa de Investigación en Factores de Riesgo de Enfermedades Cardiovasculares (PIFRECV)

Review (6)