1a66cfa4-34ed-4a12-8963-53b5a3d41907_4_5005_c.jpeg_thumb90

Leyla Morelia Alegria Vargas

Profesor Asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Epidemiología, Sueño en paciente crítico, sindrome post UCI

Educación

  •  Epidemiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2017
  •  Enfermera Matrona, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Enfermera de Investigación Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2012 - 2023

  •   Profesor Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago , Chile

    2023 - A la fecha

  •   Profesor Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago , Chile

    2023 - A la fecha

Experiencia Profesional

  •   Enfermera Clínica Unidad de Cuidados Intensivos Full Time

    Hospital Clínico de la Universidad Católica de Chile

    Chile

    2005 - 2012

  •   Comité Editorial Other

    Revista Chilena de Medicina Intensiva

    Chile

    2015 - A la fecha

  •   Comité Cientifico Part Time

    Sociedad Chilena de Medicina Intensiva

    Santiago, Chile

    2017 - A la fecha

Formación de Capital Humano


Tutora de tesis de Magíster de Epidemiología, Facultad de Medicina, Pontificia Universidad Católica de Chile
Co-Tutora de tesis de Magíster en Psicología de la Salud, Escuela de Psicología, Pontificia Universidad Católica de Chile



 

Article (23)

Customized normothermic machine perfusion decreases ischemia-reperfusion injury compared with static cold storage in a porcine model of liver transplantation

Jose Zenteno, Maria; San Martin, Sebastian

Article ISI
ARTIFICIAL ORGANS  (2023)

Improve sleep in critically ill patients: Study protocol for a randomized controlled trial for a multi-component intervention of environment control in the ICU

Repetto,Paula; Leonard, Douglas; Cadiz, Rodrigo; Rojas, Idalid; Moya, Ana

Article ISI
PLOS ONE  (2023)

Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile

Cornejo, Rodrigo A.; Montoya, Jorge; Graf, Jeronimo; Baghetti, Romyna; Irarrazaval, Anita; Leighton, Sofia; Tomicic, Vinko; Morales, Daniel; Ruiz, Carolina; Navarrete, Pablo; et al.

Article ISI
ANNALS OF INTENSIVE CARE  (2022)

Exploring the relationship between capillary refill time, skin blood flow and microcirculatory reactivity during early resuscitation of patients with septic shock: a pilot study

Hernandez, Glenn; Gonzalez, Cecilia; Ulloa, Rodrigo; Castro, Ricardo; Guzman, Camila; Adolfo Ospina-Tascon, Gustavo

Article ISI
JOURNAL OF CLINICAL MONITORING AND COMPUTING  (2022)

Reduction of Respiratory Rate in COVID-19-Associated ARDS

Felipe Damiani, L.; Soto, Dagoberto.; Consuelo Bachmann, M.; Retamal, Jaime; Bruhn, Alejandro.; Bugedo, Guillermo.

Article ISI
Respiratory Care  (2022)

Effect of positive end-expiratory pressure on lung injury and haemodynamics during experimental acute respiratory distress syndrome treated with extracorporeal membrane oxygenation and near-apnoeic ventilation

Cruces, Pablo; Soto, Dagoberto.; Valenzuela, Emilio D.; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo.; Bruhn, Alejandro.

Article ISI
BRITISH JOURNAL OF ANAESTHESIA  (2021)

Implementation and design of customized ex vivo machine perfusion. Analysis of its first results

Morales, Emilio; Soto, Dagoberto.; Josefina Zenteno, Maria; Rebolledo, Rolando A.

Article ISI
ARTIFICIAL ORGANS  (2021)

Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial

Castro, Ricardo; Astudillo, Brusela; Cid, Maria Alicia; Hernandez, Glenn

Article ISI
ANNALS OF INTENSIVE CARE  (2020)

Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications

Pavez, Nicolas; Ferri, Giorgio; Daniel Valenzuela, Emilio; Pairumani, Ronald; Santis, Cesar; Oviedo, Vanessa; Soto, Dagoberto.; Hernandez, Glenn; Castro, Ricardo

Article ISI
ANNALS OF TRANSLATIONAL MEDICINE  (2020)

Low Spontaneous Breathing Effort during Extracorporeal Membrane Oxygenation in a Porcine Model of Severe Acute Respiratory Distress Syndrome

Oviedo, Vanesa; Garcia, Alinee; Bachmann, Maria Consuelo; Basoalto, Roque; Soto, Dagoberto.; Cruces, Pablo; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo.; Bruhn, Alejandro.

Article ISI
ANESTHESIOLOGY  (2020)

Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial

Ospina-Tascón G.A.; Pairumani R.; Holger P.; Cook D.; Kavanagh B.P.; Dellinger P.; Rietdijk W.

Article ISI SCOPUS
CRITICAL CARE  (2020)

Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?

Dubo, Sebastian; Valenzuela, Emilio Daniel; Jibaja, Manuel; Berrutti, Dolores; Labra, Christian; Lagos, Rossana; García, María Fernanda; Ramírez, Vanessa; Tobar, Milton; Picoita, Fabricio; et al.

Article ISI SCOPUS
PLOS ONE  (2019)

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock=> The ANDROMEDA-SHOCK Randomized Clinical Trial.

Hernández, Glenn; Ospina-Tascón, Gustavo A; Damiani, Lucas Petri; Estenssoro, Elisa; Dubin, Arnaldo; Hurtado, Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Teboul, Jean-Louis; Cecconi, Maurizio; Ferri, Giorgio; Jibaja, Manuel; Pairumani, Ronald; Fernández, Paula; Barahona, Diego; Granda-Luna, Vladimir; Cavalcanti, Alexandre Biasi; Bakker, Jan; Hernández, Glenn; Ospina-Tascón, Gustavo; Petri Damiani, Lucas; Estenssoro, Elisa; Dubin, Arnaldo; Hurtado, Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Teboul, Jean-Louis; Cecconi, Maurizio; Cecconi, Maurizio; Ferri, Giorgio; Jibaja, Manuel; Pairumani, Ronald; Fernández, Paula; Barahona, Diego; Cavalcanti, Alexandre Biasi; Bakker, Jan; Hernández, Glenn; Alegría, Leyla; Ferri, Giorgio; Rodriguez, Nicolás; Holger, Patricia; Soto, Natalia; Pozo, Mario; Bakker, Jan; Cook, Deborah; Vincent, Jean-Louis; Rhodes, Andrew; Kavanagh, Bryan P; Dellinger, Phil; Rietdijk, Wim; Carpio, David; Pavéz, Nicolás; Henriquez, Elizabeth; Bravo, Sebastian

Article
JAMA  (2019)

Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an Acute Respiratory Distress Syndrome Model with Extracorporeal Membrane Oxygenation.

Araos, Joaquin; Alegria, Leyla; Garcia, Patricio; Cruces, Pablo; Soto, Dagoberto; Erranz, Benjamín; Amthauer, Macarena; Salomon, Tatiana; Medina, Tania; Rodriguez, Felipe; Ayala, Pedro; Borzone, Gisella R; Meneses, Manuel; Damiani, Felipe; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo; Bruhn, Alejandro

Article
American journal of respiratory and critical care medicine  (2019)

Early goal-directed therapy using a physiological holistic view=> the ANDROMEDA-SHOCK-a randomized controlled trial.

Hernández, Glenn; Cavalcanti, Alexandre Biasi; Ospina-Tascón, Gustavo; Zampieri, Fernando Godinho; Dubin, Arnaldo; Hurtado, F Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Cecconi, Maurizio; Teboul, Jean-Louis; Bakker, Jan

Article
Annals of intensive care  (2018)

Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP -Lactamase Biosensor.

Andresen, Max; Araos, Joaquin; Wong, Kwok-Yin; Leung, Yun-Chung; So, Lok-Yan; Wong, Wai-Ting; Cabrera, Salvador; Silva, Camila; Alegria, Leyla; Bruhn, Alejandro; Soto, Dagoberto

Article
Sensors (Basel, Switzerland)  (2018)

Statistical analysis plan for early goal-directed therapy using a physiological holistic view - The andromeda-shock: A randomized controlled trial

Ospina-Tascón G.; Damiani L.P.; Alegría L.

Article ISI SCOPUS
Revista Brasileira de Terapia Intensiva  (2018)

The practice of intensive care in Latin America: a survey of academic intensivists

Nin N.; Alegria, L; Estenssoro, E; Murias, G; Friedman, G; Marin, MD; Machado, FR; Cavalcanti, AB; Dubin, A; Cecconi, M

Article ISI SCOPUS
CRITICAL CARE  (2018)

A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study

Alegría Leyla; Bakker, Jan; Teboul Louis; Ospina-Tascon, Gustavo

Article ISI SCOPUS
ANNALS OF INTENSIVE CARE  (2017)

Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock.

Hernández, Glenn; Tapia, Pablo; Alegría, Leyla; Soto, Dagoberto; Luengo, Cecilia; Gomez, Jussara; Jarufe, Nicolas; Achurra, Pablo; Rebolledo, Rolando; Bruhn, Alejandro; Castro, Ricardo; Kattan, Eduardo; Ospina-Tascón, Gustavo; Bakker, Jan

Article
Critical care (London, England)  (2016)

Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome

Araos, J; Alegria, L; Garcia P.; Damiani, F; Tapia, P; Soto, D; Salomon T.; Rodriguez,F; Amthauer M.; Erranz B.; et al.

Article SCOPUS
American Journal of Translational Research  (2016)

Method Based on the beta-Lactamase PenPC Fluorescent Labeled for beta-Lactam Antibiotic Quantification in Human Plasma

Andresen M.; Wong, KY; Leung, YC; Wong, WT; Chan, PH; Andresen-Vasquez, M; Alegria, L; Silva C.; Tapia, P; Downey P.; et al.

Article ISI SCOPUS
BIOMED RESEARCH INTERNATIONAL  (2016)

Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion

Tapia, P; Soto, D; Bruhn A.; Alegria, L; Jarufe, N; Luengo C.; Kattan E.; Regueira T.; Meissner, A; Menchaca, R; et al.

Article ISI SCOPUS
Critical Care  (2015)

Proyecto (5)

Impacto de una estrategia de comunicación precoz e integral en la prevención de síntomas depresivos en pacientes con Covid-19 grave, sus familiares y el personal de salud

Eduardo Tobar A.; Paula Repetto L.; Manuel Ortiz; María Pilar Celis

Proyecto ClinicalTrials NCT05035563
 (2021)

Capillary refill time response to a rapid fluid challenge in septic shock patients: pathophysiological determinants, and relation to changes in systemic, regional and microcirculatory blood flow.



Proyecto
 (2020)

Impact of the use a multifaceted intervention of environment control in the ICU to optimize quantity and quality of sleep in critically ill patients.



Proyecto
 (2020)

“Secuelas psicológicas en pacientes críticos a los tres meses del alta de la Unidad de Cuidados Intensivos”

Pontificia Universidad Católica de Chile (180904004)

Proyecto
2019-2020
Tesista

PERIPHERAL PERFUSION VERSUS LACTATE-TARGETED FLUID RESUSCITATION IN SEPTIC SHOCK=> A RANDOMIZED CONTROLLED STUDY

FONDECYT (1170043)

Proyecto
2017-2020
Coinvestigador(a)

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

1
Pablo Cruces

MEDICO RESIDENTE

PEDIATRIA

HOSPITAL EL CARMEN DE MAIPU

SANTIAGO, Chile

1
Rodrigo Cadiz

Professor

Electrical Engineering

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, Chile

7
Alejandro Bruhn

Profesor Titular. Director de Investigación y Postgrado, Facultad de Medicina

Departamento de Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

1
Benjamín Erranz

Investigador-Docente

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Max Andresen

profesor asociado categoria ordinaria

medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

4
Jaime Retamal

Profesor Asociado

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Dagoberto Soto

Investigador

Universidad Católica de Chile

santiago, Chile

4
Guillermo Bugedo

Staff Medicina Intensiva

Medicina Intensiva

Pontifica Universidad Catolica de Chile

Santiago, Chile

5
María Vera

Académico

Medicina Intensiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
David Carpio

Residente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago , Chile

21
Leyla Alegria

Profesor Asistente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Alejandro Bruhn

Jefe Unidad de Paciente Critico

Hospital Clinico de la Universidad Catolica

Santiago, Chile

1
Eduardo Kattan

3
Sebastián Dubo

Profesor Asociado

Kinesiología

Universidad de Concepción

Concpeción, Chile

1
Christian Labra

kinesiólogo

kinesiología

Hospital red de salud UC

santiago, Chile

1
Pablo Guzmán

Pathologist

Hospital Regional Dr. Hernán Henríquez Araven

Temuco, Chile

1
Jorge Dreyse

Medico Broncopulmonar

Centro Enfermedades Respiratorias y Cirugia de Tórax

Clinica Las Condes

Las Condes, Chile

1
Carolina Henriquez

Enfermera coodinadora

Infectologia Pediátrica / Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Vanessa Oviedo

ENFERMERA DE INVESTIGACIÓN

DEPARTAMENTO DE MEDICINA INTENSIVA

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Sebastian Bravo

Profesor Asistente

Medicina Intenciva

Pontificia Universidad Católica de Chile

santiago, Chile

1
Tania Medina

Enfermera clínica

Hospital El Carmen

Santiago, Chile

6
Emilio Valenzuela

2
Luis Damiani

Profesor Asistente

Kinesiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Macarena Amthauer

Enfermera de Investigación

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Cesar Santis

Médico

Unidad Cuidados Intensivos

Hospital Barros Luco

Santiago, Chile