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Leyla Morelia Alegria Vargas

Profesor Asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Epidemiología, Sueño en paciente crítico, sindrome post UCI

Educación

  •  Epidemiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2017
  •  Enfermera Matrona, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Enfermera de Investigación Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2012 - 2023

  •   Profesor Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago , Chile

    2023 - A la fecha

  •   Profesor Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago , Chile

    2023 - A la fecha

Experiencia Profesional

  •   Enfermera Clínica Unidad de Cuidados Intensivos Full Time

    Hospital Clínico de la Universidad Católica de Chile

    Chile

    2005 - 2012

  •   Comité Editorial Other

    Revista Chilena de Medicina Intensiva

    Chile

    2015 - A la fecha

  •   Comité Cientifico Part Time

    Sociedad Chilena de Medicina Intensiva

    Santiago, Chile

    2017 - A la fecha

Formación de Capital Humano


Tutora de tesis de Magíster de Epidemiología, Facultad de Medicina, Pontificia Universidad Católica de Chile
Co-Tutora de tesis de Magíster en Psicología de la Salud, Escuela de Psicología, Pontificia Universidad Católica de Chile



 

Article (23)

Customized normothermic machine perfusion decreases ischemia-reperfusion injury compared with static cold storage in a porcine model of liver transplantation
Improve sleep in critically ill patients: Study protocol for a randomized controlled trial for a multi-component intervention of environment control in the ICU
Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile
Exploring the relationship between capillary refill time, skin blood flow and microcirculatory reactivity during early resuscitation of patients with septic shock: a pilot study
Reduction of Respiratory Rate in COVID-19-Associated ARDS
Effect of positive end-expiratory pressure on lung injury and haemodynamics during experimental acute respiratory distress syndrome treated with extracorporeal membrane oxygenation and near-apnoeic ventilation
Implementation and design of customized ex vivo machine perfusion. Analysis of its first results
Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial
Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications
Low Spontaneous Breathing Effort during Extracorporeal Membrane Oxygenation in a Porcine Model of Severe Acute Respiratory Distress Syndrome
Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial
Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?
Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock=> The ANDROMEDA-SHOCK Randomized Clinical Trial.
Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an Acute Respiratory Distress Syndrome Model with Extracorporeal Membrane Oxygenation.
Early goal-directed therapy using a physiological holistic view=> the ANDROMEDA-SHOCK-a randomized controlled trial.
Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP -Lactamase Biosensor.
Statistical analysis plan for early goal-directed therapy using a physiological holistic view - The andromeda-shock: A randomized controlled trial
The practice of intensive care in Latin America: a survey of academic intensivists
A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study
Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock.
Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome
Method Based on the beta-Lactamase PenPC Fluorescent Labeled for beta-Lactam Antibiotic Quantification in Human Plasma
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion

Proyecto (5)

Impacto de una estrategia de comunicación precoz e integral en la prevención de síntomas depresivos en pacientes con Covid-19 grave, sus familiares y el personal de salud
Capillary refill time response to a rapid fluid challenge in septic shock patients: pathophysiological determinants, and relation to changes in systemic, regional and microcirculatory blood flow.
Impact of the use a multifaceted intervention of environment control in the ICU to optimize quantity and quality of sleep in critically ill patients.
“Secuelas psicológicas en pacientes críticos a los tres meses del alta de la Unidad de Cuidados Intensivos”
PERIPHERAL PERFUSION VERSUS LACTATE-TARGETED FLUID RESUSCITATION IN SEPTIC SHOCK=> A RANDOMIZED CONTROLLED STUDY
21
Leyla Alegria

Profesor Asistente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Vanessa Oviedo

ENFERMERA DE INVESTIGACIÓN

DEPARTAMENTO DE MEDICINA INTENSIVA

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

4
Guillermo Bugedo

Staff Medicina Intensiva

Medicina Intensiva

Pontifica Universidad Catolica de Chile

Santiago, Chile

4
María Vera

Académico

Medicina Intensiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

4
Jaime Retamal

Profesor Asociado

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Dagoberto Soto

Investigador

Universidad Católica de Chile

santiago, Chile

2
Alejandro Bruhn

Jefe Unidad de Paciente Critico

Hospital Clinico de la Universidad Catolica

Santiago, Chile

2
Sebastián Dubo

Profesor Asistente/Director de Departamento

Kinesiología

Universidad de Concepción

Concpeción, Chile

2
Luis Damiani

Profesor Asistente

Kinesiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

1
Jorge Dreyse

Medico Broncopulmonar

Centro Enfermedades Respiratorias y Cirugia de Tórax

Clinica Las Condes

Las Condes, Chile

1
Tania Medina

Enfermera clínica

Hospital El Carmen

Santiago, Chile

1
Sebastian Bravo

Profesor Asistente

Medicina Intenciva

Pontificia Universidad Católica de Chile

santiago, Chile

1
Carolina Henriquez

Enfermera coodinadora

Infectologia Pediátrica / Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Guzmán

Pathologist

Hospital Regional Dr. Hernán Henríquez Araven

Temuco, Chile

1
David Carpio

Residente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago , Chile

1
Benjamín Erranz

Investigador-Docente

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Max Andresen

profesor asociado categoria ordinaria

medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Macarena Amthauer

Enfermera de Investigación

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Cruces

MEDICO RESIDENTE

PEDIATRIA

HOSPITAL EL CARMEN DE MAIPU

SANTIAGO, Chile

1
Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

1
Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile