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Alejandro Bruhn Cruz

Jefe Unidad de Paciente Critico

Hospital Clinico de la Universidad Catolica

Santiago, Chile

Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
Especialidad en Anestesiologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000
Ciencias Medicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006

Jefe Unidad de Paciente Critico Full Time

Hospital Clinico de la Universidad Catolica

Santiago, Chile

2010 - 2012
Jefe Departamento Medicina Intensiva Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2014 - A la fecha


Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Ospina-Tascon, GA; Umana, M; Bermudez, WF; Bautista-Rincon, DF; Valencia, JD; Madrinan, HJ; Hernández, G; Bruhn, A; Arango-Davila, C; de Backer, D Article ISI SCOPUS INTENSIVE CARE MEDICINE (2016)
Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome Araos, J; Alegría, L.; Garcia, P.; Damiani, F; Tapia, P; Soto, D; Salomon T.; Rodriguez,F; Amthauer M.; Erranz, B; et al. Article SCOPUS American Journal of Translational Research (2016)
High respiratory rate is associated with early reduction of lung edema clearance in an experimental model of ARDS Retamal, J; Borges JB; Bruhn, A; Cao, X; Feinstein, R; Hedenstierna, G; Johansson, S; Suarez-Sipmann, F; Larsson, A Article ISI SCOPUS ACTA ANAESTHESIOLOGICA SCANDINAVICA (2016)
Improving the Accuracy of Registration-Based Biomechanical Analysis: A Finite Element Approach to Lung Regional Strain Quantification Villarroel N.; Retamal, J; Bugedo, G; Bruhn, A Article ISI SCOPUS IEEE TRANSACTIONS ON MEDICAL IMAGING (2016)
Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O-2 content difference ratio as markers of resuscitation in patients with septic shock Ospina-Tascon, GA; Umana, M; Bermudez, W; Bautista-Rincon, DF; Hernández, G; Bruhn, A; Granados, M; Salazar, B; Arango-Davila, C; de Backer, D Article ISI SCOPUS Intensive Care Medicine (2015)
High PEEP levels are associated with overdistension and tidal recruitment/derecruitment in ARDS patients Retamal, J; Bugedo, G; Larsson, A; Bruhn, A Article ISI SCOPUS Acta Anaesthesiologica Scandinavica (2015)
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion Tapia, P; Soto, D; Bruhn, A; Alegría, L.; Jarufe, N.; Luengo C.; Kattan, E; Regueira T.; Meissner, A; Menchaca, R; et al. Article ISI SCOPUS Critical Care (2015)
Non-lobar atelectasis generates inflammation and structural alveolar injury in the surrounding healthy tissue during mechanical ventilation Retamal, J; Bergamini, BC; Carvalho, AR; Bozza, FA; Borzone, G; Borges JB; Larsson, A; Hedenstierna, G; Bugedo, G; Bruhn, A Article ISI SCOPUS CRITICAL CARE (2014)
When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring Hernández, G; Luengo C.; Bruhn, A; Kattan, E; Friedman, G; Ospina-Tascon, GA; Fuentealba, A.; Castro, R; Regueira T.; Romero, C; et al. Article ISI SCOPUS ANNALS OF INTENSIVE CARE (2014)
Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study Hernández, G; Bruhn, A; Luengo C.; Regueira T.; Kattan, E; Fuentealba, A.; Florez, J; Castro, R; Aquevedo, A; Pairumani R.; et al. Article ISI SCOPUS Intensive Care Medicine (2013)
Microcirculation in Sepsis: New Perspectives Hernández, G; Bruhn, A; Ince C. Article ISI CURRENT VASCULAR PHARMACOLOGY (2013)
Mini-report: Microcirculatory flow abnormalities in a patient with severe hyperviscosity syndrome Ruiz, C; Hernández, G; Andresen M.; Ince C.; Bruhn, A Article ISI SCOPUS Clinical Hemorheology and Microcirculation (2013)
Ministry of Health Intensive Care Medicine Commission. Proposals for the development of the discipline Galvez, S; Gonzalez, H; Labarca, E; Cornejo R.; Bruhn, A; Ugarte H.; Canteros, J; Tobar, E; Soto, R; Castillo, L Article ISI REVISTA MEDICA DE CHILE (2013)
Preliminary study of ventilation with 4 ml/kg tidal volume in acute respiratory distress syndrome: feasibility and effects on cyclic recruitment - derecruitment and hyperinflation Retamal, J; Libuy, J; Jimenez M.; Delgado, M.; Besa C.; Bugedo, G; Bruhn, A Article ISI SCOPUS Critical Care (2013)
Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients Hernández, G; Boerma, EC; Dubin, A; Bruhn, A; Koopmans, M; Edul, VK; Ruiz, C; Castro, R; Pozo, MO; Pedreros, C; et al. Article ISI SCOPUS Journal of Critical Care (2013)
Airway humidification practices in Chilean intensive care units Retamal, J; Castillo, J; Bugedo, G; Bruhn, A Article ISI REVISTA MEDICA DE CHILE (2012)
Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study Hernández, G; Pedreros, C; Veas E; Bruhn, A; Romero, C; Rovegno, M; Neira, R; Bravo, S; Castro, R; Kattan, E; et al. Article ISI SCOPUS Journal of Critical Care (2012)
Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study Hernández, G; Regueira T.; Bruhn, A; Castro, R; Rovegno, M; Fuentealba, A.; Veas E; Berrutti, D; Florez, J; Kattan, E; et al. Article ISI SCOPUS Annals of Intensive Care (2012)
Persistent sepsis-induced hypotension without hyperlactatemia: Is it really septic shock? Hernández, G; Castro, R; Romero, C; De la Hoz, C.; Angulo D; Aranguiz I.; Larrondo, J; Bujes, A; Bruhn, A Article ISI SCOPUS Journal of Critical Care (2011)
Tidal volume is a major determinant of cyclic recruitment-derecruitment in acute respiratory distress syndrome Bruhn, A; Bugedo, D; Riquelme, F; Varas J; Retamal, J; Besa C.; Cabrera, C; Bugedo, G Article ISI SCOPUS Minerva Anestesiologica (2011)
Sublingual microcirculatory changes during high-volume hemofiltration in hyperdynamic septic shock patients Ruiz, C; Hernández, G; Godoy, C; Downey P.; Andresen M.; Bruhn, A Article ISI SCOPUS Critical Care (2010)
Gastric tonometry versus cardiac index as resuscitation goals in septic shock: a multicenter, randomized, controlled trial Palizas, F; Dubin, A; Regueira T.; Bruhn, A; Knobel, E; Lazzeri, S; Baredes, N; Hernández, G Article ISI SCOPUS CRITICAL CARE (2009)
Impact of emergency intubation on central venous oxygen saturation in critically ill patients: a multicenter observational study Hernández, G; Pena, H; Cornejo R.; Rovegno, M; Retamal, J; Navarro, JL; Aranguiz I.; Castro, R; Bruhn, A Article ISI SCOPUS CRITICAL CARE (2009)
An evidence-based resuscitation algorithm applied from the emergency room to the ICU improves survival of severe septic shock Castro, R; Regueira T.; Aguirre, ML; Llanos, OP; Bruhn, A; Bugedo, G; Dougnac, A; Castillo, L; Andresen M.; Hernández, G Article ISI SCOPUS MINERVA ANESTESIOLOGICA (2008)
Evaluation of sublingual microcirculation in septic shock. Report of one patient treated with high volume hemofiltration Ruiz, C; Bruhn, A; Hernández, G; Andresen M. Article ISI REVISTA MEDICA DE CHILE (2008)
Intra-abdominal hypertension: Incidence and association with organ dysfunction during early septic shock Regueira T.; Bruhn, A; Hasbun, P; Aguirre, M; Romero, C; Llanos, O.; Castro, R; Bugedo, G; Hernández, G Article ISI SCOPUS JOURNAL OF CRITICAL CARE (2008)
Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock Andresen M.; Regueira T.; Bruhn, A; PEREZ, D.; Strobel P.; Dougnac, A; Marshall G.; Leighton F. Article ISI SCOPUS MEDIATORS OF INFLAMMATION (2008)
Splanchnic ischemia and gut permeability after acute brain injury secondary to intracranial hemorrhage Hernández, G; Hasbun, P; Velasco N.; Wainstein, C; Bugedo, G; Bruhn, A; Klaassen J.; Castillo, L Article ISI SCOPUS NEUROCRITICAL CARE (2007)
Implementation of a norepinephrine-based protocol for management of septic shock: A pilot feasibility study Hernández, G; Bruhn, A; Romero, C; Larrondo, FJ; De la Fuente, R.; Cornejo R.; Castillo, L; Bugedo, G Article ISI SCOPUS JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE (2006)
Limitations of the technique to determine hydrogen peroxide levels in exhaled breath condensate from patients with adult respiratory distress syndrome Bruhn, A; Liberona, L; Lisboa, C; Borzone, G Article ISI SCOPUS ARCHIVOS DE BRONCONEUMOLOGIA (2005)
Management of septic shock with a norepinephrine-based haemodynamic algorithm Hernández, G; Bruhn, A; Romero, C; Larrondo, FJ; De la Fuente, R.; Castillo, L; Bugedo, G Article ISI SCOPUS RESUSCITATION (2005)
Effects of positive end-expiratory pressure on gastric mucosal perfusion in acute respiratory distress syndrome Bruhn, A; Hernández, G; Bugedo, G; Castillo, L Article ISI CRITICAL CARE (2004)
Lung computed tomography during a lung recruitment maneuver in patients with acute lung injury Bugedo, G; Bruhn, A; Hernández, G; Rojas, G; Varela, C; Castillo, L Article ISI INTENSIVE CARE MEDICINE (2003)
Use of dinamic lung computed tomography to orient mechanical ventilation in adult respiratory distress syndrome. Report of one case with acute mediastinitis Bugedo, G; Bruhn, A; Hernández, G; Rojas, G; Aparicio R.; Castillo, L Article ISI REVISTA MEDICA DE CHILE (2003)
Influence of polymeric enteral nutrition supplemented with different doses of glutamine on gut permeability in critically ill patients Velasco N.; Hernández, G; Wainstein, C; Castillo, L; Maiz A.; Lopez, F; Guzmán, S.; Bugedo, G; Acosta, AM; Bruhn, A Article ISI SCOPUS NUTRITION (2001)
Suprahepatic vein oxygen saturation monitoring and gastric tonometry in the management of severe septic shock. Report of four cases Inzunza, C; Cornu, M; Bruhn, A; Castillo, L; Bugedo, G; Acuña, D; Medeiros S.; Hernández, G Article ISI REVISTA MEDICA DE CHILE (2001)


EFFECTS OF DOBUTAMINE ON SYSTEMIC. REGIONAL AND MICROCIRCULATORY PERFUSION PARAMETERS IN SEPTIC SHOCK, A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, CROSSOVER STUDY Hernández, G; Bruhn, A; Luengo C.; Regueira T.; Kattan, E; Fuentealba, A.; Florez, J; Aquevedo, A; Pairumani R.; Ince C. Abstract ISI INTENSIVE CARE MEDICINE (2013)
PERFUSION PARAMETERS EXHIBIT MARKEDLY DIFFERENT RECOVERY TIME COURSES THROUGHOUT RESUSCITATION IN A COHORT OF SEPTIC SHOCK SURVIVORS Hernández, G; Luengo C.; Bruhn, A; Kattan, E; Fuentealba, A.; Friedman, G; Ospina-Tascón, G; Regueira T.; Florez, J; Rovegno, M; et al. Abstract ISI INTENSIVE CARE MEDICINE (2013)
RELATIONSHIP OF SYSTEMIC, HEPATOSPLANCHNIC AND MICROCIRCULATORY PERFUSION PARAMETERS WITH SIX-HOUR LACTATE CLEARANCE IN HYPERDYNAMIC SEPTIC SHOCK PATIENTS: AN ACUTE CLINICAL-PHYSIOLOGICAL PILOT STUDY Hernández, G; Regueira T.; Bruhn, A; Castro, R; Rovegno, M; Fuentealba, A.; Veas E; Kattan, E; Martín, C; Berrutti, D; et al. Abstract ISI INTENSIVE CARE MEDICINE (2012)
EFFECTS OF DOBUTAMINE ON MICROCIRCULATION, REGIONAL AND PERIPHERAL PERFUSION IN SEPTIC SHOCK PATIENTS: A RANDOMIZED DOUBLE BLIND CROSSOVER TRIAL. PRELIMINARY REPORT Hernández, G; Regueira T.; Bruhn, A; Pedreros, C; Ruiz, C; Veas E; Ramirez J.; Martín, C; Bugedo, G; Castro, R; et al. Abstract ISI INTENSIVE CARE MEDICINE (2011)
THE RELATIONSHIP BETWEEN MICROCIRCULATORY FLOW ABNORMALITIES AND SYSTEMIC HEMODYNAMIC VARIABLES IN SEPTIC SHOCK PATIENTS. A MULTICENTRE CROSS-SECTIONAL STUDY Hernández, G; Boerma, EC; Dubin, A; Pedreros, C; Bruhn, A; Koopmans, M; Pozo M.; Edul, VK; Ruiz, C; Kattan, E; et al. Abstract ISI INTENSIVE CARE MEDICINE (2011)
DEFINING THE PLACE OF MICROCIRCULATORY ASSESSMENT DURING SEPTIC SHOCK Hernández, G; Ruiz, C; Godoy, C; Bravo, S; Eduardo, K; Morales E.; Martín, C; Andresen M.; Rovegno, M; Bruhn, A Abstract ISI INTENSIVE CARE MEDICINE (2010)
DYNAMICS OF RECOVERY OF PERIPHERAL AND METABOLIC PERFUSION PARAMETERS DURING SEVERE SEPSIS RESUSCITATION: A PRELIMINARY REPORT Hernández, G; Bruhn, A; Romero, C; Bravo, S; Pedreros, C; Ramirez J.; Godoy, C; Bujes, A; Kattan, E; Navarro, JL; et al. Abstract ISI INTENSIVE CARE MEDICINE (2010)
EARLY NORMALIZATION OF CENTRAL VENOUS O-2 SATURATION AFTER EMERGENCY INTUBATION IN SEPTIC PATIENTS DOES NOT ASSURE AN IMPROVEMENT IN GLOBAL DYSOXIA Hernández, G; Pena, H; Cornejo R.; Castro, R; Retamal, J; Rovegno, M; Aranguiz I.; Angulo D; Bujes, A; Pérez, C; et al. Abstract ISI INTENSIVE CARE MEDICINE (2009)
HEMODYNAMIC IMPACT OF RECRUITMENT MANEUVERS IN ARDS PATIENTS AFTER PRELOAD OPTIMIZATION BY PULMONARY ARTERY CATHETER OR VIGILEO CRITERIA Rovegno, M; Bruhn, A; Tobar, E; De la Hoz, C.; Hernández, G Abstract ISI INTENSIVE CARE MEDICINE (2009)
Severity stratification of septic shock according to noradrenaline requirement Hernández, G; Bruhn, A; Acuña, D; Larrondo, FJ; Martínez, R; Medeiros S.; Fierro C.; De la Fuente, R.; Castillo, L; Bugedo, G Abstract ISI INTENSIVE CARE MEDICINE (2001)


Fisiopatología de las alteraciones agudas del tubo digestivo en los pacientes críticos. Bruhn, Alejandro; Tapia, Pablo; Hernandez, Glenn; Rodriguez, Alejandro; Bodi, Maria; Do Pico, Jose Luis; Restrepo, Marcos BookSection


Is maximal lung recruitment worth it? Bugedo, G; Bruhn, A Letter ISI AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)


The holistic view on perfusion monitoring in septic shock Hernández, G; Bruhn, A; Castro, R; Regueira T. Review ISI SCOPUS Current Opinion in Critical Care (2012)

Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

Rodrigo Cornejo

Jefe de Servicio

Medicina

UNIVERSAIDAD DE CHILE-HOSPITAL CLINICO UNIVERSIDAD DE CHILE

Santiago, Chile

Pablo Cruces

MEDICO RESIDENTE

PEDIATRIA

HOSPITAL EL CARMEN DE MAIPU

SANTIAGO, Chile

Eduardo Tobar

Medico Intensivista

Medicina Interna Norte

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE. 2° PISO SECTOR C UNIDAD DE PACIENTE CRÍTICO

Santiago, Chile

Daniel Hurtado

Associate Professor

Structural and Geotechnical Engineering

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, DEPTO. INGENIERIA ESTRUCTURAL Y GEOTECNICA

Santiago, Chile

Alejandro Bruhn

Profesor Titular. Director de Investigación y Postgrado, Facultad de Medicina

Departamento de Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

Benjamín Erranz

Investigador-Docente

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Max Andresen

profesor asociado categoria ordinaria

medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Jaime Retamal

Profesor Asociado

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Julián Varas

Director Alterno Centro de Simulación, miembro directorio Simulación UC

Departamento de Cirugía Digestiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Dagoberto Soto

Investigador

Universidad Católica de Chile

santiago, Chile

Guillermo Bugedo

Staff Medicina Intensiva

Medicina Intensiva

Pontifica Universidad Catolica de Chile

Santiago, Chile

Ronald Pairumani

Médico intensivista

UCI

Hospital Barros Luco

Santiago, Chile

Leyla Alegria

Profesor Asistente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

RICARDO CASTRO

Jefe de unidad

Pontificia Universidad Católica de Chile

Santiago, Chile

Alejandro Bruhn

Jefe Unidad de Paciente Critico

Hospital Clinico de la Universidad Catolica

Santiago, Chile

Andres Aquevedo

Instructor Adjunto

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

Gonzalo Rojas

Eduardo Kattan

Profesor Asistente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

Carolina Ruiz

Medico Jefe UPC

Unidad de Paciente Crítico

Complejo Asistencial Sotero del Rio

Santiago, Chile

Cecilia Besa

Associate Professor

Radiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Tania Medina

Enfermera clínica

Hospital El Carmen

Santiago, Chile

Guillermo Marshall

Macarena Amthauer

Enfermera de Investigación

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

cesar pedreros

médico intensivista

centro paciente critico

clinica las condes

santiago, Chile

Alejandro Bruhn Cruz

Líneas de Investigación

Educación

Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997

Especialidad en Anestesiologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Ciencias Medicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006

Experiencia Profesional

Jefe Unidad de Paciente Critico Full Time

Jefe Departamento Medicina Intensiva Full Time

Article (36)

Abstract (10)

BookSection (1)

Letter (1)

Review (1)