Man

Monica Andrea Farias Leon

Investigadora Postdoctoral

Instituto Milenio de Inmunología e Inmunoterapia, Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Líneas de Investigación


Immunology, Virology, Respiratory viruses, Herpes simplex virus, Lipid Metabolism, Immunometabolism.

Educación

  •  Genética Molecular y Microbiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2023
  •  Genética Molecular y Microbiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2019
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018

Experiencia Profesional

  •   Investigadora Postdoctoral Full Time

    Instituto Milenio en Inmunología e Inmunoterapia/Pontificia Universidad Católica de Chile

    Santiago, Chile

    2023 - A la fecha

Premios y Distinciones

  •   FOCIS FCE Travel Award

    FOCIS´s Center of Excellence (FCE)

    Estados Unidos, 2025

    FOCIS FCE Travel Award to attend the FCE Fusion event, June 23, 2025, during the FOCIS 2025 Annual Meeting.


 

Article (12)

HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells
Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease
Contribution of carbohydrate-related metabolism in Herpesvirus infections
Heme Oxygenase-1 Expression in Dendritic Cells Contributes to Protective Immunity against Herpes Simplex Virus Skin Infection
Herpes Simplex Viruses Type 1 and Type 2
Limited Heme Oxygenase Contribution to Modulating the Severity of Salmonella enterica serovar Typhimurium Infection
Pharmacological Inhibition of IRE-1 Alpha Activity in Herpes Simplex Virus Type 1 and Type 2-Infected Dendritic Cells Enhances T Cell Activation
Crosstalk Between Epithelial Cells, Neurons and Immune Mediators in HSV-1 Skin Infection
Anti-herpetic Activity ofMacrocystis pyriferaandDurvillaea antarcticaAlgae Extracts Against HSV-1 and HSV-2
Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection
Experimental Dissection of the Lytic Replication Cycles of Herpes Simplex Viruses in vitro
Pharmacological induction of Heme oxygenate-1 impairs nuclear accumulation of Herpes Simplex virus capsids upon infection

ConferencePoster (20)

Exploring the role of monoclonal antibody therapy and lipid metabolic alteration in human respiratory syncytial virus and herpes simplex virus type 1
Exploring the role of monoclonal antibody therapy and lipid metabolic alteration in human Respiratory Syncytial Virus and Herpes Simplex Virus Type 1..
Asymptomatic Brain Infection with Herpes Simplex Virus Induces the Expression of Senescence-related Biomarkers in the Central Nervous System.
Development of a Nucleoprotein-Specific Humanized Monoclonal Antibody That Protects Against Respiratory Syncytial Virus Infection
Humanized monoclonal antibody targeting the nucleoprotein of human Respiratory Syncytial Virus elicits protective cellular immunity in a murine infection model.
Role of Cyclooxigenases Cox-1 and Cox-2 over the Function of Herpes Simplex Virus Type 1-Infected Dendritic Cells.
Analysis of the Unfolded Protein Response IRE-1a Pathway in Dendritic cells Infected with Herpes Simplex Virus Type 1.
Herpes simplex virus type 1 modulation of neutral lipid metabolism in dendritic cells affects the function of these cells.
Herpes simplex virus type 1 regulates neutral lipid metabolism in dendritic cells affecting their functionality.
Role of CNS-infiltrating immune cells in mice undergoing experimental autoimmune encephalomyelitis after asymptomatic HSV-1 infection.
¿Es la infección por HSV-1 una pieza del rompecabezas en el desarrollo de la esclerosis múltiple?
Herpes simplex virus type 1 induces lipid droplets accumulation in dendritic cells.
Herpes simplex virus type 1 modulates neutral lipid metabolism in dendritic cells.
Pharmacological modulation of lipid droplets synthesis impairs Herpes simplex virus type 1 infection in dendritic cells.
Herpes simplex viruses induce lipid droplets formation in dendritic cells.
Herpes simplex viruses induce neutral lipids accumulation in dendritic cells
Pharmacological activation of Heme Oxygenase-1 and its products Carbon monoxide interfere with the replication cycle of Herpes Simplex virus type 2 in human neuronal SH-SY5Y cells.
Pharmacological Induction of Heme Oxygenase-1 Hinders Herpes Simplex Virus Replication by Interfering with the Nuclear Accumulation of Viral Capsids after Infection.
Pharmacological Induction of Heme Oxygenase-1 Activity Blocks Herpes Simplex Virus Infection.
Pharmacological modulation of heme oxygenase-1 activity blocks herpes simplex virus infection of human neuronal SH-SY5Y cells.

Proyecto (4)

Respiratory syncytial virus promotes neutral lipid metabolism remodelling the central nervous system cells to promote neuroinflammation and neurocognitive virus-associated disease.
Desarrollo clínico de anticuerpo humanizado anti-Nucleoproteína y escalamiento comercial, contra el Virus Respiratorio Sincicial.
Rol de la enzima Hemo oxigenasa-1 en la modulación de la infección con el virus herpes simple.
Kit De Diagnóstico Rápido Para La Detección De Virus Herpes Simplex 1 Y Varicela Zoster

Review (7)

Cell-Based Therapeutic Strategies for Autoimmune Diseases
Immunomodulatory markers and therapies for the management of infant respiratory syncytial virus infection
Interplay between lipid metabolism, lipid droplets and RNA virus replication
Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections
Herpes simplex virus interference with immunity: Focus on dendritic cells
Impact of Hypoxia over Human Viral Infections and Key Cellular Processes
Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders
1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

4
Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

6
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

4
Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

2
Cristian Agurto

Prof. Dr. Laboratory Director

Centro de Biotecnología. CB-UDEC. Dept. Food Science and Technology

Universidad de Concepción

Concepción, Chile

1
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

1
Omar Vallejos

Lab Manager y Coordinador

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Francisco Ibañez

Phd(c)

Genética Molecular y Microbiología

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Estefania Castillo

Asistente de Investigación

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Catalina Pardo

Profesor Asistente

Dpto. de Salud del Niño y Adolescente

Pontificia Universidad Católica de Chile

Region Metropolitana, Chile

2
Adolfo Henríquez

Profesor Asistente

Departamento de Química Analítica e Inorgánica

Universidad de Concepción

Concepción, Chile

1
ANGELLO RETAMAL

Profesor Asistente

Biotecnología

Universidad de Antofagasta

Antofagasta, Chile

1
FELIPE MELO

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

3
DIANA ALVAREZ

Profesora Asistente

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

8
LUISA DUARTE

Assistant Researcher Professor

Instituto de Ciencias e innovación en Medicina, Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

1
Mario Ramirez

Académico Honorarios

Ciencias de la Vida

Universidad Andrés Bello

Chile , Chile

2
Antonia Reyes

Coordinadora de Estudios Clínicos

Pontificia Universidad Católica de Chile

Santiago, Chile

40
Monica Farias

Investigadora Postdoctoral

Instituto Milenio de Inmunología e Inmunoterapia, Pontificia Universidad Católica de Chile

SANTIAGO, Chile