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FIDEL OVIDIO CASTRO REBOREDO

DIRECTOR LABORATORIO

UNIVERSIDAD DE CONCEPCIÓN

Chillan, Chile

Líneas de Investigación


BIOTECNOLOGIA ANIMAL, CELULAS MADRE, TERAPIAS REGENERATIVAS, REPRODUCCION ASISTIDA, EXOSOMAS

Educación

  •  Ciencias Veterinarias, UNIVERSIDAD DE LA HABANA. Cuba, 1993
  •  CIENCIAS AGRICOLAS, ACADEMIA AGRICOLA DE BIELORUSIA. Bielorrusia, 1986
  •  INGENIERO ZOOTECNISTA, ACADEMIA AGRICOLA DE BIELORUSIA. Chile, 1984

Experiencia Académica

  •   PROFESOR TITULAR Full Time

    Universidad de Concepción

    CIENCIAS VETERINARIAS

    Chillán, Chile

    2004 - A la fecha

  •   DIRECTOR DEPARTAMENTO BIOTECNOLOGIA ANIMAL Full Time

    CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA

    LA HABANA, Cuba

    1986 - 2004

Experiencia Profesional

  •   DIRECTOR DEPARTAMENTO BIOTECNOLOGIA ANIMAL Full Time

    CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA

    LA HABANA, Cuba

    1986 - 2004

  •   PROFESOR TITULAR Full Time

    UNIVERSIDAD DE CONCEPCION

    Chillan, Chile

    2004 - A la fecha


 

Article (51)

Assessment of the anti-inflammatory and engraftment potential of horse endometrial and adipose mesenchymal stem cells in an in vivo model of post breeding induced endometritis
Characterization of mesenchymal stem cells derived from adipose tissue of a cougar (Puma concolor)
Complimentary Diagnostic Tools for Endometrosis in Biopsies of Mares with Clinical Subfertility
Edition of Prostaglandin E2 Receptors EP2 and EP4 by CRISPR/Cas9 Technology in Equine Adipose Mesenchymal Stem Cells
In vitro and in vivo development of domestic cat embryos generated by in vitro fertilization after eCG priming and oocyte in vitro maturation
Differentiation and multipotential characteristics of mesenchymal stem cells derived from adipose tissue of an endangered wild cat (Leopardus guigna)
Effect of BMP15 and/or AMH during in vitro maturation of oocytes from involuntarily culled dairy cows
Extracellular vesicles secreted during blastulation show viability of bovine embryos
The expression level of SOX2 at the blastocyst stage regulates the developmental capacity of bovine embryos up to day-13 of in vitro culture
eCG stimulation in domestic cats increases the expression of gonadotrophin-induced genes improving oocyte competence during the non-breeding season
Equine mesenchymal stem cells derived from endometrial or adipose tissue share significant biological properties, but have distinctive pattern of surface markers and migration
TIEMPO A PRIMERA DIVISIÓN EMBRIONARIA IN VITRO PUEDE PREDECIR LA CAPACIDAD DE DESARROLLO A BLASTOCISTO EN BOVINOS
Cell cycle synchronization and analysis of apoptosis-related gene in skin fibroblasts from domestic cat (Felis silvestris catus) and kodkod (Leopardus guigna)
Characterization of mesenchymal stem cells in bovine endometrium during follicular phase of oestrous cycle
Embryo splitting affects the transcriptome during elongation stage of in vitro-produced bovine blastocysts
Endometritis and In Vitro PGE(2) Challenge Modify Properties of Cattle Endometrial Mesenchymal Stem Cells and Their Transcriptomic Profile
FSH stimulation of anestrous cats improves oocyte quality and development of parthenogenetic embryos
Identification and characteristics of extracellular vesicles from bovine blastocysts produced in vitro
Embryo splitting affects the transcriptome of in vitro-produced bovine blastocysts
FSH stimulation of anestrous cats improves oocyte quality and development of parthenogenetic embryos
Splitting of IVP bovine blastocyst affects morphology and gene expression of resulting demi-embryos during in vitro culture and in vivo elongation
Splitting of IVP bovine blastocyst affects morphology and gene expression of resulting demi-embryos during in vitro culture and in vivo elongation
Transient Expression of Functional Glucocerebrosidase for Treatment of Gaucher's Disease in the Goat Mammary Gland
Clinical spectrum of chronic inflammatory demyelinating polyradiculoneuropathy (cidp) in a chilean pediatric cohort
Combined use of platelet rich plasma and vitamin C positively affects differentiation in vitro to mesodermal lineage of adult adipose equine mesenchymal stem cells
Distribution and prevalence of honey bee (Apis mellifera L.) viral diseases and their association with other honey bee pathogens in the Biobío Region, Chile
Prevalence and phylogenetic analysis of honey bee viruses in the Biobio Region of Chile and their association with other honey bee pathogens
The Endometrium of Cycling Cows Contains Populations of Putative Mesenchymal Progenitor Cells
Adenoviral vector-mediated expression of recombinant human glucocerebrosidase in the mammary gland of rats
Constitutive expression of the embryonic stem cell marker OCT4 in bovine somatic donor cells influences blastocysts rate and quality after nucleus transfer
Constitutive expression of the embryonic stem cell marker OCT4 in bovine somatic donor cells influences blastocysts rate and quality after nucleus transfer
Effect of zona pellucida removal on early development of in vitro produced bovine embryos
Effect of zona pellucida removal on early development of in vitro produced bovine embryos
Feasibility of 3-Dimensional Sonographic Examination of the Fetal Secondary Palate During the Second-Trimester Anatomy Scan
Differential gene expression in bovine elongated (Day 17) embryos produced by somatic cell nucleus transfer and in vitro fertilization.
All roads lead to milk: Transgenic and non-transgenic approaches for expression of recombinant proteins in the mammary gland
Changes in the expression of pluripotency associated genes during pre and periimplantation stages in bovine cloned and in vitro produced embryos
Changes in the expression of pluripotency-associated genes during preimplantation and pen-implantation stages in bovine cloned and in vitro produced embryos
Differential gene expression in bovine elongated (Day 17) embryos produced by somatic cell nucleus transfer and in vitro fertilization
Effect of nucleus transfer on gene expression in bovine embryos during early development
MicroRNA expression profiling of elongated cloned and in vitro-fertilized bovine embryos
The Impact of Conservation on the Status of the World's Vertebrates
The short peritoneal equilibration test in pediatric peritoneal dialysis
Elongation and gene expression in bovine cloned embryos transferred to temporary recipients
Elongation and gene expression in bovine cloned embryos transferred to temporary recipients
Cold storage of biopsies from wild endangered native Chilean species in field conditions and subsequent isolation of primary culture cell lines
High developmental potential in vitro and in vivo of cattle embryos cloned without micromanipulators
Cell confluency is as efficient as serum starvation for inducing arrest in the G0/G1 phase of the cell cycle in granulosa and fibroblast cells of cattle
Effect of cryopreservation on fusion efficiency and in vitro development into blastocysts of bovine cell lines used in somatic cell cloning
Effect of cryopreservation on fusion efficiency and in vitro development into blastocysts of bovine cell lines used in somatic cell cloning
The endometrium of cycling cows expresses stem cell markers

Abstract (5)

ADENOVIRAL VECTOR-MEDIATED EXPRESSION OF RECOMBINANT HUMAN GLUCOCEREBROSIDASE IN THE MAMMARY GLAND OF RATS
Bovine endometrial cells express markers of pluripotence and display osteogenic and chondrogenic differentiation potential in vitro
The expression of pluripotency markers in donor cells increases gene expression variability in bovine cloned embryos
CHANGES IN GENE EXPRESSION PATTERN DURING PRE- AND PERI-IMPLANTATION STAGES IN BOVINE CLONED EMBRYOS
REPROGRAMMING OF MICRO RNA IN BOVINE CLONED ELONGATED EMBRYOS

Editorial (1)

Journal of pharmacy & pharmacognosy research: For specialists working in the pharmaceutical and herbal fields

Patent (4)

METHOD FOR THE PRODUCTION OF RECOMBINANT PROTEINS IN THE MAMMARY GLAND OF NON TRANSGENIC MAMMALS
PROCEDIMIENTO DE PREACONDICIONAMIENTO CELULAR IN VITRO PARA LA OBTENCION DE CELULAS MADRE MESENQUIMALES (MSC) CON CARACTERISTICAS INMUNOMODULADORAS
Proceso in vitro de manipulación del eje Prostaglandina E2 y sus receptores EP2 y EP4 en células madre mesenquimales equinas (eMSC).
SISTEMA NO INVASIVO PARA LA PREDICCION DE CALIDAD Y EL DIAGNOSTICO GENETICO PREIMPLANTATORIO PARA EMBRIONES PRODUCIDOS IN VITRO

Proyecto (26)

Desarrollo de un sistema no invasivo para la predicción de calidad y el diagnóstico genético pre-implantatorio para embriones bovinos producidos in vitro
DESARROLLO DE UNSISTEMA DE PREDICCIÓN DE CALIDAD Y DE DIAGNÓSTICO GENÉTICO PRE-IMPLANTATORIO NO INVASIVO PARA EMBRIONES PRODUCIDOS IN VITRO EN LA CLÍNICA HUMAN CORFO-Contrato Tecnológico 2017 - 2019
MANIPULATING THE PGE2-EP2 RECEPTOR AXIS OF EQUINE MESENCHYMAL STEM CELLS AS A STRATEGY TO IMPROVE THEIR MIGRATING, HOMING AND BIOLOGICAL POTENTIAL IN VITRO
Secretion of microvesicles and exosomes by bovine preimplantation embryos=> Implications for a new mechanism of embryo-maternal cross-talk
Implementacion de una plataforma para la deteccion y caracterizacion de nanoparticulas en muestras biologicas con fines diagnosticos, biotecnologicos y de terapias regeneratvias de vanguardia. Investigador Responsable
COMPARISON OF THE MAIN BIOLOGICAL ATTRIBUTES OF EQUINE MESENQUIMAL STEM CELLS DERIVED FROM DIFFERENT TISSUES
Desarrollo de soluciones tecnológicas para la conservación, recuperación y producción de recursos genéticos requeridos por el sector bovino de leche.
Innovar en nuevas estrategias de precondicionamiento de células madre mesenquimlaes para su uso en bioingeniería tisular en medicina veterinaria y como modelos para aplicaciones transnacionales futuras a seres humanos
“IDENTIFICATION OF EQUINE ENDOMETRIAL STEM CELL POPULATIONS=> ANALYSIS OF THEIR IN VITRO DIFFERENTIATION AND MIGRATION COMPETENCE “
Establecimiento de una plataforma de análisis transcriptómico basada en microarreglos
Establecimiento de una plataforma de análisis trasncriptómico por microarreglos
Terapia regenerativa en perros por medio de la aplicación de células madre mesenquimales obtenidas a partir de tejido adiposo código=> VIU110024
"IDENTIFICATION OF PLURIPOTENCE AND INFLAMMATORY MARKERS IN THE UTERINE ENDOMETRIUM OF HEALTHY AND ENDOMETRITIS DIAGNOSED COWS AND THEIR ROLE IN ENDOMETRIAL FUNCTION."
Empleo de plasma rico en plaquetas y de vitamina c en la generación y proliferación de células madres pluripotentes inducidas equinas
Identification of Pluripotency ad Inflammatory Markers in the Uterine Endometrium of Healthy and Endometritis Diagnosed Cows
Innovar en la tecnología de proceso para la producción de Proteínas recombinantes complejas en la leche de mamíferos no transgénicos. Producción de eritropoyetina humana recombinante para su uso como biofármaco
Desenvolvimento das técnicas de clonagem e transgênese em pequenos e grandes ruminantes criados na América do Sul
Identification of Pluripotency Markers in the Uterine Endometrium of Healthy and Endometritis Diagnosed Cows and their Possible Role as Markers of Correct Endometrial Function
Descubriendo la clonación=> Bases y herramientas para comprender el proceso de clonación y sus usos
ESTUDIO DE LA EXPRESION GENICA Y DE LOS MARCADORES DE PLURIPOTENCIA EN EL ENDOMETRIO UTERINO DE BOVINOS, EN RESPUESTA A LA PRESENCIA DE UN EMBRION ELONGADO
Estudio de la expresion génica y de los marcadores de pluripotencia en el endometrio uterino de bovinos, en respuesta a la presencia de un embrión elongado
Generación de saltos de valor en ganadería de crianza mediante la producción de mellizos de vaquillas Holstein Friesian de alto valor por medio de la tecnología de embriones sexados
Influencia de la Línea Celular Utilizada como Donante de Núcleo Sobre la Capacidad de Desarrollo de Embriones Bovinos Clonados
Optimización de un proceso para la producción de bovinos clonados
Establishment of a miRNA profile of bovine cloned embryos
Conservación de genofondos de especies animales silvestres nativas y endémicas en peligro de extinción

Review (1)

Endometrial stem cells in farm animals: Potential role in uterine physiology and pathology
53
FIDEL CASTRO

DIRECTOR LABORATORIO

FACULTAD DE CIENCIAS VETERINARIAS

UNIVERSIDAD DE CONCEPCIÓN

Chillan, Chile

18
Lleretny Rodriguez

Profesor Asociado

Ciencia Animal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

9
Joel Cabezas

Ph.D. in Veterinary Sciences

Ciencia Animal

Universidad de Concepción

Chillan , Chile

3
fernando saravia

Profesor Asociado

Ciencia Animal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

3
Jorge Toledo

Director de Departamento

Fisiopatología

Universidad de Concepción

Concepcion, Chile

3
Daniela Rojas

Tecnólogo Médico

Patología y Medicina Preventiva

Universidad de Concepción

Chillán, Chile

2
Mario Briones

Profesor Asociado

Ciencia Animal

Universidad de Concepción

Chillán, Chile

1
Yolanda Vargas

Profesor Asociado

Producción Vegetal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

1
Nelson Zapata

Profesor Asociado

Producción Vegetal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

1
José Cox

Associated Professor

Animal Science

Universidad de Concepción

Chillán, Chile

1
Carolina Heresi

Medico, encargada GES epilepsia

Hospital de niños Dr. Roberto del Río

Santiago, Chile

1
juan manriquez

professor

Chemistry

Pontificia Universidad Catòlica de Chile

santiago, Chile

1
Oliberto Sanchez

Associate Professor

Pharmacology

University of Concepción

Concepción, Chile

1
Orozimba Delgado

Profesor Asociado

Facultad de Medicina Clinica Alemana Universidad del Desarrollo

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Maria de los Angeles Avaria

Directora Escuela de Postgrado

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile