Dsc1458crop.jpg_thumb90

Patricio Rodrigo Orio Alvarez

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Líneas de Investigación


Computational Neuroscience; Dynamical Systems in Neuroscience; Neural Network Dynamics; Conductance-based models of neural excitability

Educación

  •  Ciencias, m/Biología Molecular Celular Neurociencia, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Profesor Adjunto Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaíso, Chile

    2012 - 2019

  •   Profesor Auxiliar Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaíso, Chile

    2007 - 2011

  •   Investigador Postdoctoral Full Time

    UMH/CSIC

    Instituto de Neurociencias de Alicante

    Alicante, España

    2005 - 2007

  •   Profesor Titular Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaíso, Chile

    2019 - At present

Formación de Capital Humano


Supervisión de Tesis de Postgrado
- Samy Castro, Doctorado en Ciencias, mención Neurociencia, Universidad de Valparaíso. Graduado, Julio 2020. "The mesoscale organization of human connectome shapes ignition in cortical activity".
- Miguel Piñeiro, Doctorado en Ciencias, mención Neurociencia, Universidad de Valparaíso. Graduado, Marzo 2018. “Estudio de las propiedades del circuito asociado a las neuronas CCAP AN1 – AN4 y motoneuronas durante la ecdisis a pupa en Drosophila Melanogaster”.
- Erick Olivares, Doctorado en Ciencias, mención Neurociencia, Universidad de Valparaíso. Graduado marzo, 2014. “Estudio a través de modelación matemática del rol de TRPM8 en el patrón de disparo de terminales nerviosos sensibles a frío.”

Supervisión de Tesis de Pregrado.
- Jean Paul Maidana, Ingeniero Civil Matemático, Universidad Técnica Federico Santa María. Graduado en Diciembre 2015. “Análisis matemático de spike-trains con aplicaciones en termoreceptores de frío”.
- Marilyn Gatica, Ingeniero Matemático, Universidad de Santiago de Chile. Graduada en Noviembre 2014. “Efecto del ruido multiplicativo en sistemas de ecuaciones diferenciales estocásticas aplicadas a la neurociencia”.
- Mauricio Caviedes, Licenciatura en Física, Universidad de Valparaíso. Graduado en Agosto 2014. “Análisis Geométrico de un modelo de excitabilidad neuronal”.



 

Article (41)

Elevating understanding: Linking high-altitude hypoxia to brain aging through EEG functional connectivity and spectral analyses
Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling
Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness
Dynamical noise can enhance high-order statistical structure in complex systems
Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling
Whole-brain modeling explains the context-dependent effects of cholinergic neuromodulation
Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models
Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function
Diversity of neuronal activity is provided by hybrid synapses
Extracting temporal relationships between weakly coupled peptidergic and motoneuronal signaling: Application to Drosophila ecdysis behavior.
High-Order Interdependencies in the Aging Brain
Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model
Structural Features of the Human Connectome That Facilitate the Switching of Brain Dynamics via Noradrenergic Neuromodulation
Cortical ignition dynamics is tightly linked to the core organisation of the human connectome
Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons
Neurophysiological Muscle Activation Scheme for Controlling Vocal Fold Models
Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage
An integrate-and-fire model to generate spike trains with long-range dependence
Chaos versus noise as drivers of multistability in neural networks
Synchronization transition in neuronal networks composed of chaotic or non-chaotic oscillators
Hyperpolarization-Activated Current Induces Period-Doubling Cascades and Chaos in a Cold Thermoreceptor Model
I-KD Current in Cold Transduction and Damage-Triggered Cold Hypersensitivity
Role of the Excitability Brake Potassium Current I-KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury
Modeling neural activity with cumulative damage distributions
TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor
Diffusion approximation-based simulation of stochastic ion channels: which method to use?
Quantitative Analysis of Cell Migration Using Optical Flow
Role of I-h in the firing pattern of mammalian cold thermoreceptor endings
Simple, Fast and Accurate Implementation of the Diffusion Approximation Algorithm for Stochastic Ion Channels with Multiple States
Voltage Sensing in Thermo-TRP Channels
Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel
Differential effects of beta 1 and beta 2 subunits on BK channel activity
Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
New disguises for an old channel: MaxiK channel ?-subunits
New disguises for an old channel: MaxiK channel beta-subunits
Apical sorting of a voltage- and Ca2+-activated K+ channel alpha-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation
Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit
Neuropeptide Y induced inhibition of noradrenaline release in rat hypothalamus: role of receptor subtype and nitric oxide

Abstract (3)

IKD CURRENT AS A DETERMINANT FOR PAINFUL HYPERSENSITIVITY TO COLD AFTER CHRONIC PERIPHERAL NERVE INJURY
Molecular basis of BK modulation by beta subunits and channel activation by estrogens.
MaxiK channel activation by estradiol and tamoxifen: Role of the extracellular domain of the beta 1-subunit

BookSection (2)

Mathematical Modeling in Neuroscience
Mutagenesis and Temperature-Sensitive Little Machines

Proyecto (16)

Emergence of Collective Behavior in Learning Neuronal Networks
In silico modeling of single-subject neuroimaging data for the characterization and prognosis of patients with disorders of consciousness
REVEALING THE RELATIONSHIP BETWEEN HIGH-ORDER INTERDEPENDENCIES AND CRITICAL-LIKE BEHAVIOR IN BIOPHYSICAL NEURAL NETWORKS
CHAOS VERSUS NOISE AS DRIVERS OF MULTISTABILITY IN NEURAL NETWORKS
Dispositivo neuroingenieril para mejorar el control de la atención de trabajadores en minas a gran altura
MECHANISMS OF WORKING MEMORY IN CHAOTIC NEURAL NETWORKS
Sensor de Voltage de Canales de Iones=> Desde la Estructura a la Función
Advanced Center for Electrical and Electronical Engineering
Cellular and Molecular Determinants of the Abnormal Cold Sensitivity of Primary Sensory Neurons in Response to Axonal Damage
Conductance-based modeling of the dynamic response of cold thermoreceptors
Estudio Del Papel Fisiológico De Los Canales TRP En La Termotransducción Y La Plasticidad Sináptica
Centro Interdisciplinario de Neurociencia de Valparaíso
Effect of stochastic channel gating and axonal geometry on sensory transduction and encoding in cold-sensitive nerve endings
Modelos de respuesta dinámica en neuronas y terminaciones nerviosas sensibles a frío
Inserción de académicos en la Facultad de Ciencias de la Universidad de Valparaíso con perspectivas a la creación de un programa de Doctorado en Ciencias, mención Modelación Estocástica
Definición Molecular del sitio de unión de 17-b-estradiol presente en la subunidad b del canal de potasio activado por calcio de alta conductancia (Maxi-KCa)”.

Review (3)

The Conscious Nematode: Exploring Hall- marks of Minimal Phenomenal Conscious- ness in Caenorhabditis Elegans
Mathematical analysis and modeling of motion direction selectivity in the retina
A Cool Channel in Cold Transduction
53
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

12
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

5
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

5
Rodolfo Madrid

Full Professor

Departamento de Biología

UNIVERSIDAD DE SANTIGO DE CHILE

Santiago, Chile

5
Jean Maidana

Profesor Asistente

Ingeniería

Universidad Andrés Bello

Viña del Mar, Chile

4
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

3
Pavel Prado

Lead Researcher

Universidad Adolfo Ibáñez

Latin American Brain Health Institute (BrainLat)

Santiago de Chile, Chile

3
Matias Campos

Jefe Negocios

Centro Tecnológico para la innovación alimentaria

Santiago, Chile

2
Vicente Medel

Lead Investigator

Latin American Brain Health Institute (BrainLat)

Universidad Adolfo Ibánez

Santiago, Chile

2
Gonzalo Ugarte

Asistente de Investigación

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Agustin Ibanez

Profesor Titular

Psicologia

Universidad Adolfo Ibánez

Santiago, Chile

1
Alan Neely

Pofesor

Instituto de Neurociencias

Universidad de Valparaíso

Valparaiso, Estados Unidos

1
Ingrid Carvacho

Assistant Professor

Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

1
Matias Zañartu

Full Professor

Electronic Engineering

Universidad Técnica Federico Santa María

Valparaiso, Chile

1
Marcela Bitran

Profesor Asociado

Escuela de Medicina

Pontificia Universidad Catolica de Chile

Santiago , Chile

1
Julio Amigo

Assistant Professor

Physiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Marilyn Gatica

Estudiante de doctorado

Universidad de Valparaíso

Valparaiso, Chile

1
María Pertusa

Profesor Asociado

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

1
Pablo Aguirre

Profesor

Matemática

Universidad Técnica Federico Santa María

Valparaíso, Chile

1
christian tapia

ACADEMICO

QUIMICA Y FARMACIA

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

1
Oliver Schmachtenberg

Investigador titular

Instituto de Biología

Universidad de Valparaíso, CINV

Valparaíso, Chile

1
Pierre Guiraud

Profesor Adjunto

Universidad de Valparaíso

Valparaiso, Chile

1
Cecilia Vergara

Profesor Asociado

Biología

DEPARTAMENTO BIOLOGIA, FACULTAD DE CIENCIAS, U. DE CHILE

Santiago, Chile

1
GUSTAVO CONTRERAS

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

1
Bastian Rivera

Postdoctorado/ Profesor Adjunto I

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Kathleen Whitlock

Full Professor

Instituto de Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

1
Maria-Jose Escobar

Associate Professor

Departamento de Electrónica

Universidad Técnica Federico Santa María

Valparaíso, Chile

1
Ricardo Piña

Profesor Asociado

Biología

Universidad Metropolitana de Ciencias de la Educación

Ñuñoa , Chile

1
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

1
WAEL EL-DEREDY

Profesor Titular

Ingenieria Biomedica

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Enzo Tagliazucchi

Profesor

Latin American Brain Health Institute (BrainLat)

Universidad Adolfo Ibánez

Santiago, Chile

1
Gabriel Galindo

PostDoc

Ingeniería Electrónica

UTFSM

Valparaíso, Chile