Man

Marcelo Andres Lopez Lastra

Profesor Titular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Virologia Molecular; Virus de RNA; Interaccion virus-hospedero; Mecanismos de iniciacion de la traduccion de mRNAs virales.

Educación

  •  Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1994
  •  Microbiology, UNIVERSIDAD DE CHILE. Chile, 1999
  •  Clinical Research, UNIVERSITE CLAUDE BERNARD LYON I. Francia, 1999

Experiencia Académica

  •   Post-Doctoral Fellow Full Time

    ECOLE NORMALE SUPERIEURE DE LYON

    Unité de Virologie Humaine

    Lyon, Francia

    1999 - 2000

  •   Post-Doctoral Fellow Full Time

    MCGILL UNIVERSITY

    Medicine

    Montreal, Canada

    2000 - 2004

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2004 - 2010

  •   Associated Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2011 - 2018

  •   Full Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2018 - At present

Experiencia Profesional

  •   ANRS Post-Doctoral Fellow Full Time

    Ecole Normal Superior de Lyon

    Lyon, Francia

    1999 - 2000

  •   Professor Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2004 - At present

  •   CIHR Post-Doctoral Fellow Full Time

    McGill University

    Montreal, Canada

    2000 - 2004

Formación de Capital Humano


Training of Students:

a- Supervised Undergraduate theses or dissertations.

1- Alejandra Vásquez. Use of DNA shuffling as a tool to identify functional domains required for IRES activity. Biologist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.
Awarded June 2007.
2- Karla Tapia. Study of the 5'UTR of the MMTV retrovirus possible role in translation initiation. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded
December 2008.
3- Cristian Holzmann. The function of the HIV-1 REV protein on translation initiation of the full-length viral mRNA. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de
Chile. Awarded May 2009.
4- Pablo Rambohr. Development of an in vitro system to study HIV-1 IRES activity. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded March 2010.
5- Matías Rivero. Study of the translation initiation mechanism of the full-length HIV-1 mRNA; characterization of a dual mechanism of initiation. Biochemist. Universidad de Chile. Awarded September
2011.
6- Carla del Barrio. Study of the putative Gag-IRES in the context of the full-length HIV-1 mRNA. Biologist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded in June
2011.
7- Fernando Lowy. Characterization of the IRES activity present within the full-length mRNA of MMTV. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded
April 2012.
8- Felipe Carvajal. Study of the HIV-1 IRES activity in mRNAs isolated from clinical samples. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded
September 2012.
9- Federico Rossi. Study of cap-independent translation initiation of the full-length HIV-1 mRNA. Biologist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded, July 4,
2012.
10- Carlos Joaquin Caceres. IRES activity as a target for the development of novel antiviral strategies. Biochemist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded,
April 19, 2013.
11- Hade Ramos. Staufen-1 and snRNP70 play a role in HIV-1 IRES-mediated translation initiation. Biochemist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded,
September 3, 2020.

b- Supervised Medical Residence Thesis:

Patricio Astudillo. Correlation between IL28B genotype and the clinical severity of bronchiolitis in pediatric patients. Residency thesis in Pediatrics. Awarded, April 2018.

c- Supervised Master Thesis:

1- Constanza Pino. PTB is an ITAF for the MMTV-IRES. Biochemist/Master’s Degree. Awarded in September 2011. Facultad de Ciencias de la Salud. Universidad Andrés Bello.
2- Patricio Astudillo. Clinical phenotyping of viral bronchiolitis patients at hospitalization: clinical characteristics and associated outcomes. Master’s in medical research, School of Medicine, Pontificia
Universidad Católica de Chile. Awarded on October 12, 2022.

d- Supervised Graduate Thesis (Ph.D.):

1- Maria Inés Barría. "Study of the HCV IRES identifying novel targets for developing antiviral compounds". Doctor en Ciencias, mención Microbiología. Universidad de Chile. Awarded in November
2008. Current position: Professor Universidad San Sebastian, Puerto Montt, Chile.
2- Andrea Rivas-Aravena. "Study of the mechanism of translation initiation of the full-length HIV-1 mRNA; the role of cellular protein on IRES activity". Doctor en Biología mención Biología Molecular y
Celular. Pontificia Universidad Católica de Chile. Awarded in May 2009. Current position: Professor Universidad San Sebastian, Santiago, Chile.
3- Jorge Vera-Otarola. "Study of the mechanism of translation initiation of the small Andes virus mRNA". Doctor en Microbiología, Universidad de Santiago. Awarded in March 2010. Current position:
Research Associate, Applied Virology Unit, Pontificia Universidad Católica de Chile, Pontificia Universidad Catolica de Chile.
4- Fernando Valiente-Echeverría. "Regulation of the HIV-1 IRES by INS elements present within the Gag coding region". Doctor en Microbiología, Universidad de Santiago. Awarded in May 2010.
Current position: Professor Universidad de Chile, Santiago, Chile.
5- Maricarmen Vallejos García. "Structural and functional study of 5'UTR of the full-length HIV-1 mRNA". Doctor en Ciencias Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile.
Awarded in September 2011. Current position: Post-Doctoral fellow, Institut Curi, France.
6- Alejandro Letelier. "Identifying novel Cis-acting elements that modulate retroviral IRES activity". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded in October 2013.
7- Jenniffer Angulo. "Host-virus relationship in the context of an HCV infection". Awarded on May 13, 2014. Doctorado en Microbiología, Universidad de Santiago. Current position: Professor, School
of Medicine, Pontificia Universidad Catolica de Chile.
8- Eduardo Olivares. "Study of the mechanism of translation initiation driven by the 5'UTR of the HTLV-1 full-length mRNA". Doctorado en Microbiología, Universidad de Santiago. Awarded on April 1,
2015. Current position: Senior Oncology Medical Science Liaison (MSL), AstraZeneca Oncology and Immunotherapy Medical Science Liaison (MSL), AstraZeneca, Santiago, Chile.
9- Estefanía Castillo. "Study of the mechanism of translation initiation of the Small Andes virus mRNA". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded, 19-Agosto. 2015. Current Position: Oncology Medical Science Liaison, AstraZeneca.
10- Loretto Solis. "The Small RNA of ANDV encodes for the NSs protein; A possible role as an antagonist of Type I INF response". Doctorado en Ciencias, mención Microbiología. Universidad de Chile.
Awarded, 5-October, 2015.
11- Fernando Lowy. "ANDV NSs protein induces eIF2-alfa phosphorylation and stress granule formation". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded, October 26, 2016.
12- Carlos Joaquin Caceres. "Study of the mechanism of translation initiation of the HTLV-1 mRNAs encoding the HBZ proteins". Doctorado en Ciencias, mención Microbiología. Universidad de Chile.
Awarded, June 30, 2017. Current Position: Research Associate, University of Georgia, USA.
13- Natalia Contreras. "Implications of cellular proteins PTB, nucleolin, and hnRNP U on IRES-mediated translation initiation of retroviral mRNAs". Doctorado en Biología, mención Microbiología.
Universidad de Chile. Awarded, April 27, 2018. Current position: Professor Universidad Andres Bello, Santiago, Chile.
14- Felipe Carvajal. "RNA structures and their impact on translation initiation of the HIV-1 and ANDV mRNAs". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded, March 28, 2019. Post-Doctoral Fellow.
15- Valeria Olguín. "The heterogeneous ribonuclear protein K (hnRNP K) is an IRES trans-acting factor for the HIV-1, HTLV-1, and MMTV internal ribosome entry sites". Doctorado en Ciencias
Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile. Awarded, January 15, 2020. Current position: Research Associate, Universidad del Desarrollo, Santiago, Chile.
16- Leandro Fernández. "Characterization of Dengue virus mRNA IRES-dependent translation initiation; the role of PTB as an ITAF". Doctorado en Ciencias, mención Microbiología. Universidad de
Chile. Awarded, August 31, 2020. Current position: Research Associate, University of Virginia
17- Aldo Barrera. "Post-translational modifications of IRES trans-acting factors hnRNP A1 and HuR impact on the activity of retroviral IRESs". Doctorado en Ciencias Biológicas mención Genética
Molecular y Microbiología, Pontificia Universidad Católica de Chile. Awarded, November 4, 2020. Current position: Post-Doctoral Fellow, School of Medicine, Pontificia Universidad Catolica de Chil.
18- Fabian Díaz. "Development of recombinant BCG vaccines targeting Andes orthohantaviruses and Respiratory syncytial virus: Evaluation on murine and bovine models. Doctorado en Ciencias
Biológicas mención Genética Molecular y Microbiología, Pontificia Universidad Católica de Chile. Awarded, August 3, 2021. Co-Tutor together with Dr. Alexis Kalergis.
19- Yazmin Fuentes. "HnRNPK post-translational modifications regulate HIV-1 IRES activity". Doctorado en Microbiología, Universidad de Santiago. Awarded, May 12, 2023. Postdoctoral fellow
Universidad de Concepción.
20- Brenda López-Ulloa. “HnRNPA1 and HuR differentially modulate cap-independent translation initiation from the HTLV-1 IRES and the sHBZ IRES”. Doctorado en Ciencias Biológicas mención
Genética Molecular y Microbiología, Pontificia Universidad Católica de Chile. Awarded, October 10, 2023. Current position: Professor, Universidad Politécnica Salesiana, UPS, Grupo de
Investigación en Aplicaciones Biotecnologicas, GIAB, Carrera de Biotecnología,
21- Dafne Mendonca (in progress). Doctorado en Ciencias Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile.
22- Patricio Astudillo (in progress). Doctorado en Ciencias Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile.

e- Post-Doctoral trainees:

1- Dr. Delphine Marsac. "Ex vivo infection of human dendritic cells (DCs) with Andes Hantavirus: Effect on the production of cytokines and matrix metalloproteases by DCs" FONDECYT-
POSTDOCTORADO-2008–3085029 (November 2007-November 2010).
2- Dr. Maricarmen Vallejos García. "Translational control of HIV-1 gene expression", IMII-Post-Doctoral fellow (September 2011-March 2013).
3- Dr. Julio Cartagena "Characterization of cytoplasmic granules associated with the expression of the ANDV NSs protein". IMII-post-doctoral fellow (March 2012-April 2013).
4- Dr. Jenniffer Angulo. "Mechanism of translation initiation on the ANDV SmRNA; selection of the initiation codon". ACT 1408 Post-Doctoral Fellow (November 2016-November 2018).
5- Dr. Barbara Rojas "Evaluation of the impact of lncRNAs on retroviral IRES function" (April 2023-April 2024).


Premios y Distinciones

  •   Abraham Stekel fellowship

    UNIVERSIDAD DE CHILE

    Chile, 1993

    Talented young scientist award granted by Nestle International Corporation and Universidad de Chile (INTA)

  •   Abraham Stekel fellowship

    INTA

    Chile, 1994

    Talented young scientist award granted by Nestle International Corporation and Universidad de Chile (INTA)

  •   Abraham Stekel fellowship

    UNIVERSIDAD DE CHILE

    Chile, 1995

    Talented young scientist award granted by Nestle International Corporation and Universidad de Chile (INTA)

  •   Doctoral Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 1995

    CONICYT Doctoral fellowship

  •   Rhone-Alpes Doctoral Fellowship

    Rhone-Alpes

    Francia, 1996

    Fellowship given by the Rhone-Aples region. Lyon, France.

  •   Post-Doctoral followship

    Agence national de recherches sur le Sida

    Francia, 1999

    Post-Doctoral fellowship granted by the Frence Agence national de recherches sur le Sida.

  •   Post-Doctoral Fellowship

    Canadian Institutes of Health Research

    Canada, 2001

    Canadian Institutes of Health Research (CIHR) Post-Doctoral fellowship (#MFE–47704), Canada [Ranked 11th from 350 total applicants].

  •   Visiting Professor

    FIOCRUZ Institute at Rio de Janeiro

    Brasil, 2013

    Visisting Professor at the Fiocruz Institute at Rio de Janairo, Brasil.


 

Article (60)

Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs.
Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs
Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site
LDL particle size and antioxidant HDL function improve after sustained virological response in patients with chronic HCV
RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation
The double-stranded RNA-binding protein, Staufen1 is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation
The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited
The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA
Cap-independent translation initiation of the unspliced RNA of retroviruses
Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients
Infectious and non-infectious diseases burden among Haitian immigrants in Chile: a cross-sectional study
Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling
A Single-Nucleotide Polymorphism of (V3) Integrin Is Associated with the Andes Virus Infection Susceptibility
Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?
Hepatitis A outbreak since November 2016 affecting men who have sex with men (MSM) in Chile connected to the current outbreak in MSM in Europe, situation up to October 2017
IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients
Non-canonical translation initiation of the spliced mRNA encoding the human T-cell leukemia virus type 1 basic leucine zipper protein
Detection of high biliary and fecal viral loads in patients with chronic hepatitis C virus infection
Hepatitis C virus may have an entero-hepatic cycle which could be blocked with ezetimibe
Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus
Effect of ezetimibe in HCV viral load after liver transplantation.
LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex.
Polypyrimidine tract-binding protein binds to the 5? untranslated region of the mouse mammary tumor virus mRNA and stimulates cap-independent translation initiation
Structural domains within the HIV-1 mRNA and the ribosomal protein S25 influence cap-independent translation initiation
Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs
Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma
Association of Single-Nucleotide Polymorphisms in IL28B, but Not TNF-alpha, With Severity of Disease Caused by Andes Virus
LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex
Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case-control study
The 5 ' Untranslated Region of the Human T-Cell Lymphotropic Virus Type 1 mRNA Enables Cap-Independent Translation Initiation
Translation initiation of the HIV-1 mRNA
A cis-Acting Element Present within the gag Open Reading Frame Negatively Impacts on the Activity of the HIV-1 IRES
Dual Mechanisms of Translation Initiation of the Full-Length HIV-1 mRNA Contribute to Gag Synthesis
Genetic variations in host IL28B links to the detection of peripheral blood mononuclear cells-associated hepatitis C virus RNA in chronically infected patients
IL28B Polymorphisms Among Latin American HCV Patients
Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs
Functional and Structural Analysis of the Internal Ribosome Entry Site Present in the mRNA of Natural Variants of the HIV-1
The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism
Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors
Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances proinflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability
The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
The 5'-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation
Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation
Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome
Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients
Human Immunodeficiency Virus Type 1 (HIV-1) Induces the Cytoplasmic Retention of Heterogeneous Nuclear Ribonucleoprotein A1 by Disrupting Nuclear Import IMPLICATIONS FOR HIV-1 GENE EXPRESSION
Is Single-Strand Conformation Polymorphism Analysis of the Full 5 ' Untranslated Region an Adequate Approach To Study Hepatitis C Virus Quasispecies Distribution?
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites
Influence of extrahepatic viral infection on the natural history of hepatitis C
Hepatitis C in Chile: Burden of the disease Hepatitis C en Chile: Magnitud del problema
Complete translation of the hepatitis C virus genome in vitro: Membranes play a critical role in the maturation of all virus proteins except for NS3
Dicistronic MLV-retroviral vectors transduce neural precursors in vivo and co-express two genes in their differentiated neuronal progeny
Protein synthesis in eukaryotes: The growing biological relevance of cap-independent translation initiation
Detection of the infectious hematopoietic necrosis virus directly from infected fish tissues by dot blot hybridization with a non-radioactive probe
Determination of Gizzerosine Activity in Fish Meal with a Homologous Radioimmunoassay
Inhibitors of infectious pancreatic necrosis virus (IPNV) replication
A DETECTION METHOD FOR INFECTIOUS PANCREATIC NECROSIS VIRUS (IPNV) BASED ON REVERSE TRANSCRIPTION (RT)-POLYMERASE CHAIN-REACTION (PCR)
Hepatitis C in Chile: Burden of the disease

Abstract (4)

PILOT STUDY OF EZETIMIBE FOR CHRONIC HEPATITIS C INFECTION: EFFECT OF TREATMENT IN PLASMA, BILE AND STOOL VIRAL LOAD IN HUMANS
Analysis of genetic determinants associated with therapy response against hepatitis C virus: first study of IL28B polymorphisms in Uruguayan patients
Impact of RNA nuclear experience on protein synthesis: the case of the HIV-1 mRNA
ApOH-capture technology enhances Andes hantavirus detection allowing virus concentration from plasma and urine samples of patients with acute hantavirus cardiopulmonary syndrome

BookSection (2)

Virus de la inmunodeficiencia humana
Virus Hepatitis C

Proyecto (27)

EGULATING THE REGULATORS; THE IMPACT OF IRES-TRANSACTING FACTORS AND THEIR POST-TRANSLATIONAL MODIFICATIONS ON RETROVIRAL-IRES ACTIVITY.
Hepatitis B virus (HBV) infection in Haitian immigrants in Chile=> Determination of HBV genotypes, viral escape mutants and host factors influencing response to vaccination.
Laboratoire International Associé/CNRS International Associated Laboratory
Identifying RNA-Binding Proteins (RBP) that act as Transacting factors for retroviral internal ribosome entry sites (IRESs); role RBP in retroviral IRES-mediated protein synthesis
Understanding the role of the DEAD-box helicase DDX3 in viral and cellular messenger RNA metabolism.
Patogeneis Molecular de Virus Emergentes.
Mejoramiento del equipamiento estratégico del laboratorio de bioseguridad de nivel 3 (BSL-3) de la Escuela de Medicina de la Pontificia Universidad Católica de Chile
Hepatitis C virus exploits the hepatic lipid pathways=> Role of NPC1L1 in HCV infection
Laboratoire International Associé/CNRS International Associated Laboratory
Study of the mechanism of translation initiation of retroviral mRNAs; the role of cellular proteins and RNA structure
The atlas of the HIV-1 genomic messenger ribonucleoprotein (mRNP) complex
Characterization of cellular factors involved in HIV-1 and HIV-2 genomic RNA translational control
Investigación y desarrollo de herramientas bioinformáticas para el diseño costo‐efectivo de biosensores y biointerruptores moleculares
Andes virus transmission and pathogenesis in Chile.
Institito de Inmunologia e Inmunoterapia
Characterization and inhibition of the Gc multistep fusion mechanism used by Hantavirases to infect target cells
Molecular mechanism ruling HIV and HCV translation initiation
Núcleo Milenio de Inmunología e Inmunoterapia
Translation of the HIV-1 full length mRNA is regulated by cellular proteins that modulate the shift from cap-dependent to an IRES-dependent mode of initiation=> unveiling the basis of HIV-1 mRNA translational control
Rol de la replicación extrahepática del virus de hepatitis C en la predicción de la respuesta a la terapia antiviral
IDENTIFICACION DE LAS PROTEINAS Y LOS ELEMENTOS CIS QUE PARTICIPAN EN LA REGULACION DE LA INICIACION DE LA TRADUCCION DEPENDIENTE DE SITIO INTERNO DE ENTRADA DE RIBOSOMAS (IRES) DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA
CAPTURE AND ENRICHMENT OF EMERGING PATHOGENS FOR MULTIPLE AND ULTRA-SENSITIVE DIAGNOSTIC (USDEP)
Development of lead compounds as fusion inhibitors for Dengue virus.
Human immunodeficiency virus type 1 (HIV-1) internal ribosome entry segment (IRES); Identification of trans-acting factors and cis-acting elements involved in IRES function
Investigating and Targeting the mechanism of HIV-1 protein synthesis.
Recherches sur le plans diagnostic et physiopathologique chez les Virus Emergents
Rol de la replicación extra-hepática del virus de la hepatitis C en la expresión clinica e historia natural de la enfermedad

Review (3)

Translation initiation of viral mRNAs
Translational control of retroviruses
Hepatitis C en Chile: Magnitud del problema
90
Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

10
Jenniffer Angulo

Asistente de Investigación

Pediatría e Inmunologia Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

9
Marcela Ferres

Head of Department

Pediatric Infectious Diseases and Immunology

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Aldo Barrera

Postdoctor

Enfermedades Infecciosas e Inmunología pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

5
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

4
Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

3
Valeria Olguín

Lab Manager

Universidad del Desarrollo

Santiago, Chile

3
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Hugo Monrroy

Instructor Adjunto

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Felipe Carvajal

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Eduardo Olivares

Director area biomedicina

Diagnóstico molecular

Bioingentech

santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Paulina Orellana

Coordinadora traslacional

Universidad de Chile

Santiago, Chile

1
Constanza Martinez

Investigador asistente

Enfermedades infecciosas e inmunologia pediatrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Claudia Marco

Jefe de Unidad

Gerencia de Innovación y transformación Digital

Red de Salud UC CHRISTUS

Santiago, Chile

1
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
Patricio Astudillo

Residente Pediatría

Urgencia General

Clínica Alemana De Santiago

Santiago, Chile

1
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Karen Bohmwald

Académico Investigador

Universidad Autónoma de Chile

Santiago, Chile

1
Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

1
Nicole Tischler

Investigadora Titular

Molecular Virology Laboratory

Fundación Ciencia para la Vida

Santiago, Chile

1
Monique Le Corre

Assistant Professor

Faculty of medicine, Pediatric division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Jose Ignacio Vargas

Assistant Professor

GASTROENTEROLOGY

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
CARLOS FLORES

JEFE UTI

PEDIATRIA

HOSPITAL DE OVALLE

OVALLE, Chile

1
Marcela Cárcamo

Profesor

Epidemiología y Estudios en Salud

Universidad de Los Andes

Santiago, Chile

1
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Estefania Castillo

Asistente de Investigación

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Cristián Holzmann

Director ejecutivo

Kelumilla

Santiago, Chile

1
Ana Sandino

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Katherine Rivera

PhD (c) student in Medical Science

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

1
Jose Martínez

Investigador

ICIM

Universidad del Desarrollo

LAS CONDES, Chile

1
Pablo Vial

Professor

School of Medicine

ICIM/UNIVERSIDAD DEL DESARROLLO - CLÍNICA ALEMANA

Santiago, Chile

1
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile