Man

Juan Francisco Calderon Giadrosic

Investigador

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Modifier genes of cardiovascular phenotypes in connective tissue disorders: Functional genetics using genome-editing techniques

Educación

  •  Ingenieria en Biotecnologia Molecular, Universidad de Chile. Chile, 2005
  •  Ph.D in Human Genetics and Molecular Biology, The Johns Hopkins University. Estados Unidos, 2014

Experiencia Académica

  •   Postdoctoral Fellow Full Time

    JOHNS HOPKINS UNIVERSITY

    Medicine

    Baltimore, Chile

    2014 - 2014

  •   Profesor Asociado Full Time

    Universidad del Desarrollo

    Medicine

    Santiago, Chile

    2014 - At present

Experiencia Profesional

  •   Research Assistant Full Time

    Facultad de Medicina, Universidad del Desarrollo

    Santiago, Chile

    2006 - 2008

  •   Technician Part Time

    INTA, Universidad de Chile

    Santiago, Chile

    2004 - 2006

Formación de Capital Humano


None


Difusión y Transferencia


Programa 1000 Científicos, 1000 Aulas 2018, 2019


Premios y Distinciones

  •   ASHG/Charles J. Epstein Trainee Award for Excellence in Human Genetics Research

    American Society of Human Genetics

    Estados Unidos, 2013

    ASHG honors excellence in research conducted by predoctoral and postdoctoral trainees (including genetic counseling trainees) through merit-based awards that recognize highly competitive abstracts submitted and presented at the ASHG Annual Meeting. These awards were renamed in 2012 to honor the late Dr. Charles Epstein, who was a past president of ASHG, former editor of AJHG, and winner of both the William Allan Award and the McKusick Leadership Award. The Program Committee and Awards Committee, in consultation with the ASHG Board of Directors, determine the number of awards, the categories for which they are given, and the prize amounts of each award (currently $750 plus complimentary registration for approximately 60 semifinalists). Abstract scoring is completed by the Program Committee, and the top-ranking abstracts (semifinalists) are submitted to the Awards Committee, which selects 18 finalists (who receive an additional $250) prior to the Annual Meeting. Six winners, receiving an additional $1,000 each, are chosen after the committee members judge the finalists' presentations

  •   Beca Fulbright – CONICYT para estudios de Doctorado en el extranjero

    COMISION FULBRIGHT-CHILE

    Chile, 2008

    La Comisión Fulbright y la Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) establecieron en 2002 un programa de becas cuya finalidad es apoyar a profesionales de nacionalidad chilena que deseen obtener un doctorado en universidades estadounidenses. En este marco, se postula en primera instancia a la Comisión Fulbright. Las personas preseleccionadas en esta etapa que reciban una carta de admisión de una universidad de los Estados Unidos ubicada en los primeros 150 lugares de los rankings Times Higher Education (THE) o Academic Ranking of World Universities (Shanghai, ARWU), o de un programa académico ubicado en los primeros 50 lugares de los rankings ya señalados, podrán postular en segunda instancia a la convocatoria de doctorado de Becas Chile


 

Article (13)

CRISPR/Cas13-Based Platforms for a Potential Next-Generation Diagnosis of Colorectal Cancer through Exosomes Micro-RNA Detection: A Review

Duran-Vinet, Benjamin; Araya-Castro, Karla; Calderon, Juan; Vergara, Luis; Weber, Helga; Retamales, Javier; Araya-Castro, Paulina; Leal-Rojas, Pamela

Article ISI
CANCERS  (2021)

Identification of genetic modifiers of murine hepatic beta-glucocerebrosidase activity

Duran, Anyelo; Rebolledo-Jaramillo, Boris; Olguin, Valeria; Rojas-Herrera, Marcelo; Heras, Macarena Las; Calderon, Juan F.; Zanlungo, Silvana; Priestman, David A.; Platt, Frances M.; Klein, Andres D.

Article ISI
BIOCHEMISTRY AND BIOPHYSICS REPORTS  (2021)

NPC1 as a Modulator of Disease Severity and Viral Entry of SARS-CoV-2

; Vial, Cecilia; Francisco Calderon, Juan; Klein, Andres D.

Article ISI
CURRENT MOLECULAR MEDICINE  (2021)

Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome

Bowen C.J.; Giadrosic J.F.C.; Burger Z.; Rykiel G.; Davis E.C.; Helmers M.R.; Benke K.; MacFarlane E.G.; Dietz H.C.

Article ISI SCOPUS
JOURNAL OF CLINICAL INVESTIGATION  (2020)

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome

MacFarlane, EG; Parker, SJ; Shin, JY; Ziegler, SG; Creamer, TJ; Bagirzadeh, R; Bedja, D; Chen, YC; Calderon JF; Weissler, K; Frischmeyer-Guerrerio, PA; Lindsay, ME; Habashi, JP; Dietz, HC

Article ISI SCOPUS
JOURNAL OF CLINICAL INVESTIGATION  (2019)

Rare diseases in Chile: challenges and recommendations in universal health coverage context

Encina, Gonzalo; Castillo-Laborde, Carla.; Lecaros, Juan A.; Dubois-Camacho, Karen; Calderon, Juan F.; Aguilera, Ximena; Klein, Andres D.; Repetto, Gabriela M.

Article ISI SCOPUS
ORPHANET JOURNAL OF RARE DISEASES  (2019)

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer

Weber, H; Valbuena, JR; Barbhuiya, MA; Stein, S; Kunkel, H; García, P; Bizama, C; Riquelme, I; Espinoza, JA; Kurtz, SE; Tyner, J; Calderon, JF; Corvalán, AH; Grez, M; Pandey, A; Leal-Rojas, P; Roa, JC

Article ISI SCOPUS
ONCOTARGET  (2017)

Regulation of Connexins Expression Levels by MicroRNAs, an Update.

Calderón, Juan F; Retamal, Mauricio A

Article
Frontiers in physiology  (2016)

Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Madan syndrome

Busnadiego, O.; Gorbenko del Blanco, D.; Gonzalez-Santamaria, J.; Habashi, J. P.; Calderon, J. F.; Sandoval, P.; Bedja, D.; Guinea-Viniegra, J.; Lopez-Cabrera, M.; Rosell-Garcia, T.; Snabel, J. M.; Hanemaaijer, R.; Forteza, A.; Dietz, H. C.; Egea, G.; Rodriguez-Pascual, F.

Article ISI
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY  (2015)

Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis

Gahllo, Elena M.; Loch, David C.; Habashi, Jennifer R.; Calderon, Juan F.; Chen, Yichun; Bedja, Djahida; van Erp, Christel; Gerber, Elizabeth E.; Parker, Sarah J.; Sauls, Kimberly; Judge, Daniel P.; Cooke, Sara K.; Lindsay, Mark E.; Rouf, Rosanne; Myers, Loretha; ap Rhys, Colette M.; Kent, Kathleen C.; Norris, Russell A.; Huso, David L.; Dietz, Harry C.

Article ISI
JOURNAL OF CLINICAL INVESTIGATION  (2014)

GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum

Adamczyk, Abby; Mejias, Rebeca; Takamiya, Kogo; Yocum, Jennifer; Krasnova, Irina N.; Calderon, Juan; Cadet, Jean Lud; Huganir, Richard L.; Pletnikov, Mikhail V.; Wang, Tao

Article ISI
BEHAVIOURAL BRAIN RESEARCH  (2012)

Clinical features of chromosome 22q11.2 microdeletion syndrome in 208 Chilean patients

Repetto, GM; Guzman, ML; Puga, A; Calderon JF; Astete, CP; Aracena, M; Arriaza, M; Aravena T.; Sanz P

Article ISI SCOPUS
CLINICAL GENETICS  (2009)

VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study

Calderon JF; Puga, AR; Guzman, ML; Astete, CP; Arriaza, M; Aracena, M; Aravena T.; Sanz P; Repetto, GM

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2009)

Letter (1)

Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease

Calderon JF; Klein, AD

Letter ISI SCOPUS
MOLECULAR GENETICS AND METABOLISM REPORTS  (2018)

Proyecto (5)

Equipamiento para análisis masivo de expresión génica global aplicado a problemas de biomedicina

Calderon JF

Proyecto
 (2019)

Genomics of cervical artery dissection=> A comprehensive characterization of micro RNA expression and genetic polymorphisms

FONDECYT (1181238)

Proyecto
2018-2021
Coinvestigador(a)

Identifying genetic modifiers of clinical severity in Chilean patients with Inheritable Connective Tissue Disorders through genotype-phenotype correlations and Whole Exome Sequencing

FONDECYT (11170353)

Proyecto
2017-2019
Inv. Principal

Generation of a new model for Osteoarthritis therapy focused in a Cx43-engineered human cell line

Proyecto PMI UDD 1204 (PMI UDD 1204)

Proyecto
2016-2017
Inv. Responsable

USO DE HERRAMIENTAS DE INGENIERÍA GENÓMICA PARA LA CARACTERIZACIÓN FUNCIONAL DE VARIANTES COMUNES ASOCIADAS A FENOTIPOS CARDIOVASCULARES GENERADOS POR PERTURBACIONES EN LA VIA DE TGF-beta

Interno Universidad del Desarrollo

Proyecto
2015-2016
Inv. Principal

Review (2)

Regulation of Connexins Expression Levels by MicroRNAs, an Update

Calderon, JF; Retamal, MA

Review ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2016)

Current Controversies in Diagnosis and Management of Cleft Palate and Velopharyngeal Insufficiency

Ysunza, Pablo Antonio; Repetto, Gabriela M.; Pamplona, Maria Carmen; Calderon, Juan F.; Shaheen, Kenneth; Chaiyasate, Konkgrit; Rontal, Matthew

Review ISI SCOPUS
BioMed Research International  (2015)

16
Juan Calderon

Investigador

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

3
Maria Repetto

Profesor Titular

Center for Genetics and Genomics

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

2
Teresa Aravena

Profesor asistente

Medicina

UNIVERSIDAD DE CHILE

santiago, Chile

2
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

2
Carla Castillo

Assistant Professor

Centro de Epidemiología y Políticas de Salud / Center of Epidemiology and Health Policy

Universidad del Desarrollo

Santiago, Chile

2
Marta Arriaza

Medico staff

Pediatría

Hospital Dr. Gustavo Fricke

Viña del Mar, Chile

1
Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

1
KAREN DUBOIS

Postdoctoral fellow Fondef IDeA ID17I10064 IDI17

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile

1
Juan Lecaros

Associate professor

Observatory of Bioethics and Law

Universidad del Desarrollo

Santiago, Chile

1
Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
PAMELA LEAL

Profesor Asociado

Departamento de Ciencias Agronómicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Helga Weber

Investigador

Vicerrectoría de Investigación y Post Grado

Universidad de la Frontera

Temuco, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

1
Carolina Bizama

Assistant professor

Department of Pathology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Macarena Las Heras

Investigadora postdoctoral

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Paulina Araya

COORDINADORA ACADEMICA

Facultad de Medicina

Universidad del Desarrollo

SANTIAGO, Chile

1
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile