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Ricardo Mauricio Cabrera Paucar

Assitant Pofessor

UNIVERSIDAD DE CHILE

Santiago, Chile

Origin of Life, Structure and evolution of enzymes; metabolic fluxes in bacteria

Structural Biology, Metabolism, UNIVERSIDAD DE CHILE. Chile, 2004

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

2010 - At present

Assitant Professor Full Time

Universidad de Chile

Santiago, Chile

2010 - At present


Oxidation of chlortetracycline and its isomers by Botrytis aclada laccase in the absence of mediators: pH dependence and identification of transformation products by LC-MS de Fatima, Nadia Gavilan; Barriga, Andres; Caceres, Juan Carlos; Pinto, Ernani; Cabrera, Ricardo Article ISI BIODEGRADATION (2023)
Engineering an acetoacetyl-CoA reductase from Cupriavidus necator toward NADH preference under physiological conditions Olavarria, Karel; Pijman, Yared O.; Cabrera, Ricardo; van Loosdrecht, Mark C. M.; Wahl, S. Aljoscha Article ISI SCIENTIFIC REPORTS (2022)
An NADH preferring acetoacetyl-CoA reductase is engaged in poly-3-hydroxybutyrate accumulation in Escherichia coli Olavarria, Karel; Carnet, Alexandre; van Renselaar, Joachim; Quakkelaar, Caspar; Cabrera, Ricardo; da Silva, Leonor Guedes; Smids, Aron L.; Andres Villalobos, Pablo; van Loosdrecht, Mark C. M.; Wahl, S. Aljoscha Article ISI JOURNAL OF BIOTECHNOLOGY (2021)
Comparative characterization of the hemocyanin-derived phenol oxidase activity from spiders inhabiting different thermal habitats Cubillos, Claudio; Caceres, Juan Carlos; Villablanca, Cristopher; Barriga, Andres; Cabrera, Ricardo; Veloso, Claudio Article ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2021)
Crystal structure of the 6-phosphogluconate dehydrogenase from Gluconobacter oxydans reveals tetrameric 6PGDHs as the crucial intermediate in the evolution of structure and cofactor preference in the 6PGHD family Maturana, Pablo; Tobar-Calfucoy, Eduardo; Fuentealba, Matias; Roversi, Pietro; Garratt, Richard C.; Cabrera, Ricardo Article Wellcome Open Research (2021)
Deletion and Randomization of Structurally Variable Regions in B. subtilis Lipase A (BSLA) Alter Its Stability and Hydrolytic Performance Against Long Chain Fatty Acid Esters Martínez, Ronny; Bernal, Claudia; Álvarez, Rodrigo; Concha, Christopher; Araya, Fernando; Cabrera, Ricardo; Dhoke, Gaurao V.; Davari, Mehdi D. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Functional characterisation and in silico modelling of MdPSY2 variants and MdPSY5 phytoene synthases from Malus domestica Cerda, Ariel; Moreno, Juan C.; Acosta, Daniel; Godoy, Francisca; Caceres, Juan Carlos; Cabrera, Ricardo; Stange, Claudia Article ISI JOURNAL OF PLANT PHYSIOLOGY (2020)
Fluorescence enzymatic assay for bacterial polyphosphate kinase 1 (PPK1) as a platform for screening antivirulence molecules Campos, Francisca; Alvarez, Javiera A.; Ortiz-Severin, Javiera; Varas, Macarena A.; Lagos, Carlos F; Cabrera, Ricardo; Alvarez, Sergio A.; Chavez, Francisco P. Article ISI INFECTION AND DRUG RESISTANCE (2019)
Studying the phosphoryl transfer mechanism of the E. coli phosphofructokinase-2=> from X-ray structure to Quantum Mechanics/Molecular Mechanics simulations Murillo-López, Juliana; Zinovjev, Kirill; Pereira, Humberto; Caniuguir, Andrés; Garratt, Richard; Babul, Jorge; Recabarren, Rodrigo; Alzate-Morales, Jans; Caballero, Julio; Tuñón, Iñaki; Cabrera, Ricardo Article CHEMICAL SCIENCE (2019)
Surfaces based on amino acid functionalized polyelectrolyte films towards active surfaces for enzyme immobilization Briones, Ximena; VILLALOBOS, VALERIA; Queneau, Yves; Silva Danna, Caroline; Munoz, Rodrigo; Rios, Hernan E.; Pavez, Jorge.; Paez, Maritza; Cabrera, Ricardo; Tamayo, Laura; Urzua, Marcela D. Article ISI SCOPUS MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)
Cold tolerance mechanisms of two arthropods from the Andean Range of Central Chile=> Agathemera crassa (Insecta=> Agathemeridae) and Euathlus condorito (Arachnida=> Theraphosidae) Cubillos, Claudio; Cáceres, Juan Carlos; Villablanca, Cristopher; Villarreal, Pablo; Baeza, Marcelo; Cabrera, Ricardo; Graether, Steffen P; Veloso, Claudio Article Journal of Thermal Biology (2018)
Inorganic Polyphosphate, Exopolyphosphatase, and Pho84-Like transporters may be Involved in copper resistance in Metallosphaera sedula DSM 5348T Rivero, Matias; Torres-Paris, Constanza; Muñoz, Rodrigo; Cabrera, Ricardo; Navarro, C.A.; Jerez, Carlos Article Archaea (2018)
Understanding the impact of the cofactor swapping of isocitrate dehydrogenase over the growth phenotype of Escherichia coli on acetate by using constraint-based modeling Armingol, Erick; Tobar, Eduardo; Cabrera, Ricardo Article PLOS ONE (2018)
Datasets for transcriptomics, q-proteomics and phenotype microarrays of polyphosphate metabolism mutants from Escherichia coli. Varas, Macarena; Valdivieso, Camilo; Mauriaca, Cecilia; Ortíz-Severín, Javiera; Paradela, Alberto; Poblete-Castro, Ignacio; Cabrera, Ricardo; Chávez, Francisco P Article Data in brief (2017)
Multi-level evaluation of Escherichia coli polyphosphate related mutants using global transcriptomic, proteomic and phenomic analyses Varas, Macarena; Valdivieso, Camilo; Mauriaca, Cecilia; Ortíz-Severín, Javiera; Paradela, Alberto; Poblete-Castro, Ignacio; Cabrera, Ricardo; Chávez, Francisco P Article BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
Determinants of Cofactor Specificity for the Glucose-6-Phosphate Dehydrogenase from Escherichia coli: Simulation, Kinetics and Evolutionary Studies fuentealba, m; Munoz, R.; Maturana P.; Krapp, A; Cabrera, R Article ISI SCOPUS PLOS ONE (2016)
Dictyostelium discoideum as a surrogate host-microbe model for antivirulence screening in Pseudomonas aeruginosa PAO1 Bravo-Toncio, C; Álvarez JA; Campos F; Ortíz-Severín J; Varas M; Cabrera R; Lagos CF; Chávez FP Article INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2016)
Polyol specificity of recombinant Arabidopsis thaliana sorbitol dehydrogenase studied by enzyme kinetics and in silico modeling Aguayo M.F.; Caceres J.C.; fuentealba, m; Munoz, R.; Stange, C.; Cabrera, R; Handford, M. Article ISI SCOPUS FRONTIERS IN PLANT SCIENCE (2015)
Metabolic impact of an NADH-producing glucose-6-phosphate dehydrogenase in Escherichia coli Olavarria, K; De Ingeniis, J; Zielinski, DC; fuentealba, m; Munoz, R.; McCloskey, D; Feist, AM; Cabrera, R Article ISI SCOPUS MICROBIOLOGY-SGM (2014)
A Ribokinase Family Conserved Monovalent Cation Binding Site Enhances the MgATP-induced Inhibition in E . coli Phosphofructokinase-2 Baez, Mauricio; Cabrera, Ricardo; Pereira, Humberto M; Blanco, Alejandro; Villalobos, Pablo; Ramírez-Sarmiento, César A; Caniuguir, Andrés; Guixé, Victoria; Garratt, Richard C; Babul, Jorge Article BIOPHYSICAL JOURNAL (2013)
Sorbitol dehydrogenase is a cytosolic protein required for sorbitol metabolism in Arabidopsis thaliana Aguayo, MF; Ampuero, D.; Mandujano, P,; Parada R.; Munoz, R.; Gallart, M; Altabella, T; Cabrera, R; Stange, C.; Handford, M. Article ISI SCOPUS Plant Science (2013)
Modeling the Interfacial Interactions between CrtS and CrtR from Xanthophyllomyces dendrorhous, a P450 System Involved in Astaxanthin Production Alcaíno J.; fuentealba, m; Cabrera, R; Baeza, M.; Cifuentes, V Article ISI SCOPUS Journal of Agricultural and Food Chemistry (2012)
The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli- modeling the physiological production of reduced cofactors Olavarria, K; Valdes, D.; Cabrera, R Article ISI SCOPUS FEBS Journal (2012)
The Crystal Complex of Phosphofructokinase-2 of Escherichia coli with Fructose-6-phosphate KINETIC AND STRUCTURAL ANALYSIS OF THE ALLOSTERIC ATP INHIBITION Cabrera, R; Baez, M; Caniuguir A.S.; Babul, J.; Pereira H.M.; Garratt R.C. Article ISI SCOPUS Journal of Biological Chemistry (2011)
Ribokinase family evolution and the role of conserved residues at the active site of the PfkB subfamily representative, Pfk-2 from Escherichia coli Cabrera, R; Babul, J.; Guixe, V Article ISI SCOPUS Archives of Biochemistry and Biophysics (2010)
Crystallographic Structure of Phosphofructokinase-2 from Escherichia coli in Complex with Two ATP Molecules. Implications for Substrate Inhibition Cabrera, R; Ambrosio, ALB; Garratt, RC; Guixe, V; Babul, J. Article ISI SCOPUS JOURNAL OF MOLECULAR BIOLOGY (2008)
Unfolding pathway of the dimeric and tetrameric forms of phosphofructokinase-2 from Escherichia coli Baez, M; Cabrera, R; Guixe, V; Babul, J. Article ISI SCOPUS BIOCHEMISTRY (2007)
Crystallization and preliminary crystallographic analysis of the tetrameric form of phosphofructokinase-2 from Escherichia coli, a member of the ribokinase family Cabrera, R; Caniuguir, A; Ambrosio, ALB; Guixe, V; Garratt, RC; Babul, J. Article ISI SCOPUS ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS (2006)
Evidence for a catalytic Mg2+ ion and effect of phosphate on the activity of Escherichia coli phosphofructokinase-2: Regulatory properties of a ribokinase family member Parducci, RE; Cabrera, R; Baez, M; Guixe, V Article ISI SCOPUS BIOCHEMISTRY (2006)
Role of Cys-295 on subunit interactions and allosteric regulation of phosphofructokinase-2 from Escherichia coli Caniuguir, A; Cabrera, R; Baez, M; Vásquez CC; Babul, J.; Guixe, V Article ISI SCOPUS FEBS LETTERS (2005)
Undergraduate teaching of evolution in chile: more than natural selection Ahumada P.; astorga, g; Bull-Herenu, K; Cabrera, R; caputo, L; Carmona, C.; Cecchi, MC; Cortes N.; Cortez, S; Dorador, C.; Fredes, F; Guerrero-Bosagna, C; Henny, P; Libedinsky, C; Marcelo W.; Marquez, IN; Martinez, J.; Medina, MC; Parra, D; Pohl, N; Pottstock, H; Ossandón T.; Razeto P.; Rubilar D.; Salas C.; Salinas, F.; Sepulveda E.; Soto C.; Suarez, R; Vargas A.; Vega-Zuniga T.; Velásquez N.; Vidal, J; Villagra, CA; Villavicencio, CP Article ISI SCIELO SCOPUS Revista chilena de historia natural (2005)
Domain motions and quaternary packing of phosphofructokinase-2 from Escherichia coli studied by small angle X-ray scattering and homology modeling Cabrera, R; Fischer, H; Trapani, S; Craievich, AF; Garratt, RC; Guixe, V; Babul, J. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Ligand-dependent structural changes and limited proteolysis of Escherichia coli phosphofructokinase-2 Cabrera, R; Guixe, V; Alfaro, J; Rodriguez, PH; Babul, J. Article ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)


Atomic Force Microscopy Imaging Reveals Structural and Mechanical Properties of Dissociated Hemocyanins by Temperature Navarrete C.; Villar, J; Aguilar, Y; Cabrera, R; Barrera, NP Abstract ISI BIOPHYSICAL JOURNAL (2014)
Role of the conserved N187 residue of E-coli Pfk-2 in catalysis and allosteric regulation Guixe, V; Caniuguir, A; Cabrera, R Abstract ISI FEBS JOURNAL (2007)
Thermal unfolding of the dimeric wild-type and a monomeric mutant phosphofructokinase-2 from E-coli Babul, J.; Baez, M; Cabrera, R Abstract ISI FEBS JOURNAL (2007)
Dimer-tetramer transition and the allosteric regulation of phosphofructokinase-2 from E-coli Baez, M; Caniuguir, A; Cabrera, R; Babul, J. Abstract ISI FEBS JOURNAL (2005)
On the catalytic role of conserved active site residues D256 and E190 of Escherichia coli Phosphofructokinase-2, a member of the ribokinase family Cabrera, R; Parducci, R; Guixe, V Abstract ISI FEBS JOURNAL (2005)
Allosteric control of the oligomerization of phosphofructokinase-2 from E-coli. Guixe, V; Cabrera, R; Baez, M; Babul, J. Abstract ISI FASEB JOURNAL (2002)


Prebiotic oxidation of Glyceraldehyde(3P) catalyzed by W/Mo: the evolutionary origin of an energy-conserving metabolic pathway Blamey Jenny M.; Maracaja, Vinicius; Murillo-López, Juliana A. Proyecto (2022)
A novel deletion/randomization protein engineering strategy and its validation through improvement of B. subtilis lipase A for applied biocatalysis FONDECYT (1170219) Proyecto 2017-2019 Coinvestigador(a)
Desarrollo, producción y caracterización de anticuerpo recombinante humano contra MIC-A con potencial terapéutico para el tratamiento de cáncer gástrico FONDEF (ID16I10027) Proyecto 2016-2017 Investigador(a)
Growth bioenergetics and electricity generation at high reducing power in Escherichia coli=> Testing the NADH-NADPH dichotomy UNIVERSIDAD DE CHILE - FAC. CIENCIAS (Fondos PAIFAC 2016 - Ricardo Cabrera) Proyecto 2016-2016 Inv. Principal
Rewiring supply-demand of reduced power in E. coli=> consequences in growth and bioelectricity UNIVERSIDAD DE CHILE - VID (VID Ricardo Cabrera) Proyecto 2016-2016 Inv. Principal
Ingeniería metabólica en plantas, levaduras y bacterias UNIVERSIDAD DE CHILE (U-REDES) Proyecto 2013-2013 Inv. Principal
EQUIPO DE CRISTALIZACION HIGH-TROUGHPUT DE PROTEINAS FONDEQUIP (EQM120208) Proyecto 2012-2013 Investigador(a)
REDUCING POWER PRODUCTION IN E. COLI=> A ROLE FOR SPECIFICITY TO NICOTINAMIDE DINUCLEOTIDES OF CENTRAL DEHYDROGENASES FONDECYT (1121170) Proyecto 2012-2016 Inv. Responsable
INTEGRACION DE LA BIOLOGIA ESTRUCTURAL AL DESARROLLO DE LA BIONANOTECNOLOGIA PIA (ACT1107) Proyecto 2011-2015 Investigador(a)
A COMPREHENSIVE MODEL FOR THE MECHANISM OF ALLOSTERIC REGULATION OF E. COLI PHOSPHOFRUCTOKINASE-2. INTEGRATION OF KINETIC, STRUCTURAL, DYNAMIC AND MECHANIC ASPECTS. FONDECYT (1090336) Proyecto 2009-2013 Coinvestigador(a)
METABOLIC EFFECTS OF AN ENGINEERED GLUCOSE-6-P DEHYDROGENASE WITH REVERSED NADP-NAD COFACTOR SPECIFICITY FONDECYT (11080290) Proyecto 2008-2011 Inv. Responsable
Distribución de flujos y balance de cofactores en el metabolismo del acetato de E. coli UNIVERSIDAD DE CHILE (DI I2 06/02-2) Proyecto 2006-2008 Inv. Responsable

Ricardo Cabrera

Assitant Pofessor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Jorge Babul

UNIVERSIDAD DE CHILE

Santiago, Chile

Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Mauricio Baez

Assistant Professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Claudia Stange

Titular Professor

Department of Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Michael Handford

Full Professor

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

Pablo Maturana

Estudiante de Doctorado

Departamento de Biología

Universidad de Chile

Santiago, Chile

CHRISTOPHER CONCHA

Investigador

Acuicultura

Universidad Católica del Norte

Coquimbo, Chile

Ronny Martinez

Profesor Asociado

Ingenieria en Alimentos

UNIVERSIDAD DE LA SERENA

La Serena, Chile

Marcela Urzúa

Associate Professor

Chemistry

UNIVERSIDAD DE CHILE

Santiago, Chile

Laura Tamayo

PROFESOR ASISTENTE

DEPARTAMENTO DE QUÍMICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

JORGE PAVEZ

Professor

Materials Chemistry

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Francisco Chávez

Profesor Asistente

Departamento de Biología

Universidad de Chile

Santiago, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

Jaime Martinez

Investigador

Instituto de Investigaciones Agropecuarias, INIA - La Cruz

La Cruz, Chile

Nelson Barrera

Associate Professor

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Marcelo Baeza

Valeria Villalobos

Profesor asistente

Universidad Autónoma de Chile

Santiago, Chile

David Rubilar

Curator

Museo Nacional de Historia Natural

Santiago, Chile

Tomás Ossandón

Associate Professor

Medical School, Department of Psychiatry

Pontificia Universidad Católica de Chile

Santiago, Chile

Alexander Vargas

Profesor Asociado

Biología

Universidad de Chile

Santiago, Chile

Sergio Álvarez

Profesor Asistente

Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE. FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Claudia Bernal

Academica

Departamento de Química

Universidad de La Serena

La Serena, Chile

Cristina Dorador

PROFESSOR

Biotechnology

UNIVERSIDAD DE ANTOFAGASTA

ANTOFAGASTA, Chile

Víctor Cifuentes

Prof. Titular

Departamento de Ciencias Ecológicas

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE.

Santiago, Chile

Marcelo Baeza

Profesor Titular

Ciencias Ecologicas

Universidad de Chile

Santiago, Chile

Mauricio Fuentealba

Profesor Adjunto

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

Jennifer Alcaíno

Profesor Asociado

Ciencias Ecológicas

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS

Santiago, Chile

Nelson Velásquez

Auxiliary Professor

Biology and Chemistry

Catholic University of the Maule

Talca, Chile

Pablo Razeto

Researcher

CENTRO NACIONAL DEL MEDIO AMBIENTE

Santiago, Chile

Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

luciano caputo

Assistant professor

Institute of Marine and Limnology Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Maria Godoy

Jefa de Proyectos Internacionales

Universidad Andrés Bello

Santiago, Chile

Caroline Silva

Profesor Asistente

Instituto de Materiales y Procesos Termomecánicos

Universidad Austral de Chile

Valdivia, Chile

Carlos Salas

Gerente de Innovación y Desarrollo

Vivero del Maipo Ltda.

San José de Maipo, Chile

Pablo Villalobos

Investigador postdoctoral

Biología

Universidad de Chile

Santiago, Chile

Ricardo Mauricio Cabrera Paucar

Líneas de Investigación

Educación

Structural Biology, Metabolism, UNIVERSIDAD DE CHILE. Chile, 2004

Experiencia Académica

Profesor Asistente Full Time

Experiencia Profesional

Assitant Professor Full Time

Article (33)

Abstract (6)

Proyecto (12)

A novel deletion/randomization protein engineering strategy and its validation through improvement of B. subtilis lipase A for applied biocatalysis

Desarrollo, producción y caracterización de anticuerpo recombinante humano contra MIC-A con potencial terapéutico para el tratamiento de cáncer gástrico

Growth bioenergetics and electricity generation at high reducing power in Escherichia coli=> Testing the NADH-NADPH dichotomy

Rewiring supply-demand of reduced power in E. coli=> consequences in growth and bioelectricity

Ingeniería metabólica en plantas, levaduras y bacterias

EQUIPO DE CRISTALIZACION HIGH-TROUGHPUT DE PROTEINAS

REDUCING POWER PRODUCTION IN E. COLI=> A ROLE FOR SPECIFICITY TO NICOTINAMIDE DINUCLEOTIDES OF CENTRAL DEHYDROGENASES

INTEGRACION DE LA BIOLOGIA ESTRUCTURAL AL DESARROLLO DE LA BIONANOTECNOLOGIA

A COMPREHENSIVE MODEL FOR THE MECHANISM OF ALLOSTERIC REGULATION OF E. COLI PHOSPHOFRUCTOKINASE-2. INTEGRATION OF KINETIC, STRUCTURAL, DYNAMIC AND MECHANIC ASPECTS.

METABOLIC EFFECTS OF AN ENGINEERED GLUCOSE-6-P DEHYDROGENASE WITH REVERSED NADP-NAD COFACTOR SPECIFICITY

Distribución de flujos y balance de cofactores en el metabolismo del acetato de E. coli