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Ronny Ernesto Martinez Moya

Profesor Asociado

UNIVERSIDAD DE LA SERENA

La Serena, Chile

Protein Engineering; Enzyme Technology; High Throughput Screening; Bioprocessing

Biochemical Engineering, JACOBS UNIVERSITY BREMEN. Alemania, 2010
Ingenieria en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2006
Ingeniero en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2007

Profesor Asociado Full Time

UNIVERSIDAD DE LA SERENA

Ingeniería

La Serena, Chile

2016 - At present
Head of High Throughput Screening Full Time

RWTH AACHEN UNIVERSITY

Biology

Aachen, Alemania

2010 - 2014

Group Leader High Throughput Screening Full Time

RWTH Aachen University

Aachen, Alemania

2010 - 2014
PhD fellow Part Time

Jacobs University Bremen

Bremen, Alemania

2007 - 2010
Principal Scientist Biochemistry Full Time

EW-Nutrition GmbH

Cologne, Alemania

2014 - 2016
Académico Full Time

Universidad de La Serena

La Serena, Chile

2016 - At present


Enzymatic detection of histamine: Applications, challenges, and improvement potential through biocatalyst engineering Rodriguez-Nunez, Karen; Serey, Marcela; Pasten, Maria-Jose; Bernal, Claudia; Ensari, Yunus; Davari, Mehdi D.; Martinez, Ronny Article ISI FOOD CONTROL (2024)
Immobilized biocatalyst engineering: Biocatalytic tool to obtain attractive enzymes for industry Rodriguez-Nunez, Karen; Lopez-Gallego, Fernando; Martinez, Ronny; Bernal, Claudia Article ISI INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)
Modulating Substrate Specificity of Rhizobium sp. Histamine Dehydrogenase through Protein Engineering for Food Quality Applications Rodriguez-Nunez, Karen; Cortes-Monroy, Alejandra; Serey, Marcela; Ensari, Yunus; Davari, Mehdi D.; Bernal, Claudia; Martinez, Ronny Article ISI MOLECULES (2023)
Valorization of shrimp (Heterocarpus reedi) processing waste via enzymatic hydrolysis: Protein extractions, hydrolysates and antioxidant peptide fractions Leiva-Portilla, D.; Martinez, R.; Bernal, C. Article ISI BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2023)
Combinatorial InVitroFlow-assisted mutagenesis (CombIMut) yields a 41-fold improved CelA2 cellulase Koerfer, Georgette; Besirlioglu, Volkan; Davari, Mehdi D.; Martinez, Ronny; Vojcic, Ljubica; Schwaneberg, Ulrich Article ISI BIOTECHNOLOGY AND BIOENGINEERING (2022)
Effect of process parameters and surfactant additives on the obtained activity of recombinant tryptophan hydroxylase (TPH1) for enzymatic synthesis of 5-hydroxytryptophan (5-HTP) Vargas, Marta A. A.; Deive, Francisco J. J.; Alvarez, Maria S. S.; Longo, Maria A. A.; Rodriguez, Ana; Bernal, Claudia; Martinez, Ronny Article ISI ENZYME AND MICROBIAL TECHNOLOGY (2022)
Effect of the immobilization of pectinase on the molecular weight distribution of pectin oligosaccharides obtained from citrus pectin Muller, Stefanny; Concha, Darly; Vasquez, Pamela; Rodriguez-Nunez, Karen; Martinez, Ronny; Bernal, Claudia Article ISI BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2022)
Galactaric acid production by engineering substrate specificity in glucose oxidase from Aspergillus niger Concha, Darly; Rodriguez-Nunez, Karen; Castillo, Luis; Martinez, Ronny; Bernal, Claudia Article ISI BIOCHEMICAL ENGINEERING JOURNAL (2022)
Protease-assisted process for tryptophan release from pumpkin (Cucurbita maxima) seed protein extracts Vargas, Marta A.; Bernal, Claudia; Martinez, Ronny Article ISI JOURNAL OF FOOD PROCESSING AND PRESERVATION (2022)
Immobilized Biocatalyst Engineering: High throughput enzyme immobilization for the integration of biocatalyst improvement strategies Rodriguez-Nunez, Karen; Bernal, Claudia; Martinez, Ronny Article ISI INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)
Deletion and Randomization of Structurally Variable Regions in B. subtilis Lipase A (BSLA) Alter Its Stability and Hydrolytic Performance Against Long Chain Fatty Acid Esters Martínez, Ronny; Bernal, Claudia; Álvarez, Rodrigo; Concha, Christopher; Araya, Fernando; Cabrera, Ricardo; Dhoke, Gaurao V.; Davari, Mehdi D. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Development of alginate-pectin microcapsules by the extrusion for encapsulation and controlled release of polyphenols from papaya (Carica papayaL.) Vallejo-Castillo, Vladimir; Rodriguez-Stouvenel, Aida; Martinez, Ronny; Bernal, Claudia Article ISI JOURNAL OF FOOD BIOCHEMISTRY (2020)
Improvement of enzymatic performance of Asclepias curassavica L. proteases by immobilization. Application to the synthesis of an antihypertensive peptide Origone, Anabella; Barberis, Sonia; Illanes, Andres; Guzman, Fanny; Cami, Gerardo; Liggieri, Constanza; Martinez, Ronny; Bernal, Claudia Article ISI PROCESS BIOCHEMISTRY (2020)
Insights on intermolecular FMN-heme domain interaction and the role of linker length in cytochrome P450cin fusion proteins Belsare, Ketaki D.; Ruff, Anna Joelle; Martinez, Ronny; Schwaneberg, Ulrich Article ISI BIOLOGICAL CHEMISTRY (2020)
Selective immobilization of Bacillus subtilis lipase A from cell culture supernatant: Improving catalytic performance and thermal resistance Rodríguez, Karen; Martinez, Ronny; Bernal, Claudia Article ISI SCOPUS Process Biochemistry (2020)
Enzyme-assisted extraction of proteins from the seaweeds Macrocystis pyrifera and Chondracanthus chamissoi: characterization of the extracts and their bioactive potential VÃ¡squez V.; MartÃnez R.; Bernal C. Article ISI SCOPUS JOURNAL OF APPLIED PHYCOLOGY (2019)
Enzyme-assisted extraction of proteins from the seaweeds Macrocystis pyrifera and Chondracanthus chamissoi=> characterization of the extracts and their bioactive potential Vásquez, Valeria; Martínez, Ronny; Bernal, Claudia Article JOURNAL OF APPLIED PHYCOLOGY (2019)
KnowVolution of a Fungal Laccase toward Alkaline pH Novoa, Catalina; Dhoke, Gaurao, V; Mate, Diana M.; Martinez, Ronny; Haarmann, Thomas; Schreiter, Martina; Eidner, Jasmin; Schwerdtfeger, Ruth; Lorenz, Patrick; Davari, Mehdi D.; Jakob, Felix; Schwaneberg, Ulrich Article ISI SCOPUS CHEMBIOCHEM (2019)
KnowVolution of a Fungal Laccase toward Alkaline pH Novoa C, Dhoke GV; Mate DM, Martínez R; Haarmann T, Schreiter M; Eidner J, Schwerdtfeger R; Lorenz P, Davari MD; Jakob F, Schwaneberg U. Article CHEMBIOCHEM (2019)
A robust protocol for directed aryl sulfotransferase evolution toward the carbohydrate building block GlcNAc Islam, Shohana; Mate, Diana M.; Martínez, Ronny; Jakob, Felix; Schwaneberg, Ulrich Article BIOTECHNOLOGY AND BIOENGINEERING (2018)
A robust protocol for directed aryl sulfotransferase evolution toward the carbohydrate building block GlcNAc. Islam, Shohana; Mate, Diana M; Martínez, Ronny; Jakob, Felix; Schwaneberg, Ulrich Article Biotechnology and bioengineering (2018)
Directed evolution of an acid Yersinia mollaretii phytase for broadened activity at neutral pH Körfer, Georgette; Novoa, Catalina; Kern, Janina; Balla, Elisabeta; Grütering, Carolin; Davari, Mehdi D.; Martinez, Ronny; Vojcic, Ljubica; Schwaneberg, Ulrich Article Applied Microbiology and Biotechnology (2018)
Directed evolution of an acid Yersinia mollaretii phytase for broadened activity at neutral pH Körfer, Georgette; Novoa, Catalina; Kern, Janina; Balla, Elisabeta; Grütering, Carolin; Davari, Mehdi D.; Martinez, Ronny; Vojcic, Ljubica; Schwaneberg, Ulrich Article ISI SCOPUS Applied Microbiology and Biotechnology (2018)
Integrating enzyme immobilization and protein engineering: An alternative path for the development of novel and improved industrial biocatalysts Bernal, Claudia; Rodríguez, Karen; Martínez, Ronny Article ISI SCOPUS BIOTECHNOLOGY ADVANCES (2018)
Integrating enzyme immobilization and protein engineering=> An alternative path for the development of novel and improved industrial biocatalysts Claudia Bernal, Karen Rodríguez Article Biotechnology Advances (2018)
Directed evolution of P450cin for mediated electron transfer. Belsare, Ketaki D; Horn, Thomas; Ruff, Anna Joëlle; Martinez, Ronny; Magnusson, Anders; Holtmann, Dirk; Schrader, Jens; Schwaneberg, Ulrich Article Protein engineering, design & selection : PEDS (2017)
In vitro flow cytometry-based screening platform for cellulase engineering. Körfer, Georgette; Pitzler, Christian; Vojcic, Ljubica; Martinez, Ronny; Schwaneberg, Ulrich Article Scientific reports (2016)
Reporter Immobilization Assay (REIA) for Bioconjugating Reactions. Schatte, Martin; Bocola, Marco; Roth, Teresa; Martinez, Ronny; Kopetzki, Erhard; Schwaneberg, Ulrich; Bönitz-Dulat, Mara Article Bioconjugate chemistry (2016)
A first continuous 4-aminoantipyrine (4-AAP)-based screening system for directed esterase evolution. Lülsdorf, Nina; Vojcic, Ljubica; Hellmuth, Hendrik; Weber, Thomas T; Mußmann, Nina; Martinez, Ronny; Schwaneberg, Ulrich Article Applied microbiology and biotechnology (2015)
A flow cytometer-based whole cell screening toolbox for directed hydrolase evolution through fluorescent hydrogels. Lülsdorf, Nina; Pitzler, Christian; Biggel, Michael; Martinez, Ronny; Vojcic, Ljubica; Schwaneberg, Ulrich Article Chemical communications (Cambridge, England) (2015)
Advances in protease engineering for laundry detergents Vojcic, Ljubica; Pitzler, Christian; Körfer, Georgette; Jakob, Felix; Martinez, Ronny, Maurer, Karl-Heinz; Schwaneberg, Ulrich. Article New Biotechnology (2015)
A fluorescent hydrogel-based flow cytometry high-throughput screening platform for hydrolytic enzymes. Pitzler, Christian; Wirtz, Georgette; Vojcic, Ljubica; Hiltl, Stephanie; Böker, Alexander; Martinez, Ronny; Schwaneberg, Ulrich Article Chemistry & biology (2014)
Insights on activity and stability of subtilisin E towards guanidinium chloride and sodium dodecylsulfate. Li, Zhenwei; Roccatano, Danilo; Lorenz, Michael; Martinez, Ronny; Schwaneberg, Ulrich Article Journal of biotechnology (2014)
Ionic liquid and deep eutectic solvent-activated CelA2 variants generated by directed evolution. Lehmann, Christian; Bocola, Marco; Streit, Wolfgang R; Martinez, Ronny; Schwaneberg, Ulrich Article Applied microbiology and biotechnology (2014)
P-LinK: A method for generating multicomponent cytochrome P450 fusions with variable linker length. Belsare, Ketaki D; Ruff, Anna Joëlle; Martinez, Ronny; Shivange, Amol V; Mundhada, Hemanshu; Holtmann, Dirk; Schrader, Jens; Schwaneberg, Ulrich Article BioTechniques (2014)
A roadmap to directed enzyme evolution and screening systems for biotechnological applications. Martínez, Ronny; Schwaneberg, Ulrich Article Biological research (2013)
Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution Martinez, Ronny; Jakob, Felix; Tu, Ran; Siegert, Petra; Maurer, Karl-Heinz; Schwaneberg, Ulrich Article Biotechnology and Bioengineering (2013)
Increasing protein production by directed vector backbone evolution. Jakob, Felix; Lehmann, Christian; Martinez, Ronny; Schwaneberg, Ulrich Article AMB Express (2013)
Redirecting catalysis from proteolysis to perhydrolysis in subtilisin Carlsberg. Despotovic, Dragana; Vojcic, Ljubica; Blanusa, Milan; Maurer, Karl-Heinz; Zacharias, Martin; Bocola, Marco; Martinez, Ronny; Schwaneberg, Ulrich Article Journal of biotechnology (2013)
Reengineering of subtilisin Carlsberg for oxidative resistance Vojcic, Ljubica; Despotovic, Dragana, Maurer, Karl-Heinz; Zacharias, Martin; Bocola, Marco; Martinez, Ronny; Schwaneberg, Ulrich Article Biological Chemistry (2013)
Surface charge engineering of a Bacillus gibsonii subtilisin protease. Jakob, Felix; Martinez, Ronny; Mandawe, John; Hellmuth, Hendrik; Siegert, Petra; Maurer, Karl-Heinz; Schwaneberg, Ulrich Article Applied microbiology and biotechnology (2013)
An efficient transformation method for Bacillus subtilis DB104 Vojcic, Ljubica; Despotovic, Dragana; Martinez, Ronny; Maurer, Karl-Heinz; Schwaneberg, Ulrich Article Applied Microbiology and Biotechnology (2012)
Fluorescent Assay for Directed Evolution of Perhydrolases Despotovic, Dragana; Vojcic, Ljubica; Prodanovic, Radivoje; Martinez, Ronny; Maurer, Karl-Héinz; Schwaneberg, Ulrich Article Journal of Biomolecular Screening (2012)
Reengineering CelA2 cellulase for hydrolysis in aqueous solutions of deep eutectic solvents and concentrated seawater Lehmann, Chrtistian; Sibilla, Fabrizio; Maugeri, Zaira; Streit, Wolfgang R.; Dominguez de María, Pablo; Martinez, Ronny; Schwaneberg, Ulrich. Article Green Chemistry (2012)
A Flow Cytometry–Based Screening System for Directed Evolution of Proteases Tu, Ran; Martinez, Ronny; Prodanovic, Radivoje; Klein, Matthias; Schwaneberg, Ulrich Article Journal of Biomolecular Screening (2011)
Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells Landerer, E.; Villegas, J; Burzio, VA; Oliveira L.; Villota, C; López C.; Restovic, F; Martínez R.; Castillo O.; Burzio, LO Article ISI SCOPUS Cellular Oncology (2011)
Temperature effects on structure and dynamics of the psychrophilic protease subtilisin S41 and its thermostable mutants in solution Martinez, Ronny; Schwaneberg, Ulrich; Roccatano, Danilo Article Protein Engineering Design and Selection (2011)
Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells Burzio, VA; Villota, C; Villegas, J; Landerer, E.; Boccardo, E; Villa, LL; Martínez R.; López C.; Gaete, F; Toro V.; Rodríguez X; Burzio, LO Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Expression of a novel non-coding mitochondrial RNA in human proliferating cells Villegas, J; Burzio V; Villota, C; Landerer, E.; Martínez R.; Santander, M; Pinto, R; Vera, MI; Boccardo, E; Villa, LL; Burzio, LO Article ISI NUCLEIC ACIDS RESEARCH (2007)
Inhibition of iron and copper uptake by iron, copper and zinc Arredondo M.; Martínez R.; Nunez, MT; Ruz, M; Olivares M. Article ISI SCIELO BIOLOGICAL RESEARCH (2006)


A novel deletion/randomization protein engineering strategy and its validation through improvement of B. subtilis lipase A for applied biocatalysis FONDECYT (1170219) Proyecto 2017-2019 Inv. Principal
“Functionalization of polymers –Project part F” BMBF Alemania (FKZ 031A227F) Proyecto 2012-2015 Investigador(a)
“In vitro Durchmusterungstechnologie für eine Gelenkte Evolutionsrunde pro Tag” BMBF Alemania (FKZ 031A165) Proyecto 2011-2014 Investigador(a)
“BioIndustrie2021=> Biokatalyse2021=> Development of new perhydrolases=> Increasing specific perhydrolytic activity and simultaneously decreasing hydrolytic activity” BMBF Alemania (FKZ 0315250) Proyecto 2010-2013 Investigador(a)
"BioEnergy 2021=> Research for Biomass utilization" BMBF Alemania (FKZ 0315487A) Proyecto 2009-2012 Investigador(a)
“Hydrolases from extremophiles for technical applications” BMBF Alemania (FKZ 0315035A) Proyecto 2007-2010 Tesista