Man

Claudia Patricia Bernal Zuluaga

Academica

Universidad de La Serena

La Serena, Chile

Líneas de Investigación


Enzymatic Biocatalysis, Enzyme Immobilization; Materials Science design and characterization; Enzyme engineering

Educación

  •  Quimcia, Universidad de Antioquia. Colombia, 2007
  •  Ciencias Quimicas, Universidad de Antioquia. Colombia, 2012

Experiencia Académica

  •   Postdoc Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Facultad de Ingenieria

    Valparaiso, Chile

    2011 - 2016

  •   Academico Investigador Full Time

    UNIVERSIDAD DE LA SERENA

    Facultad de Ingenieria

    La Serena, Chile

    2016 - 2023

  •   Academica Full Time

    UNIVERSIDAD DE LA SERENA

    Facultad de Ciencias

    La Serena, Chile

    2023 - At present

Experiencia Profesional

  •   Postdoc Full Time

    Pontificia Universidad Catolica de Valparaiso

    Valparaiso, Chile

    2011 - 2016

  •   Académico Investigador Full Time

    Universidad de La Serena

    La Serena, Chile

    2016 - At present

Formación de Capital Humano


DIRECCION DE TESIS DE POSTGRADO
1 Pamela Vasquez. Hidrolisis enzimática de pectina de orujo de uva pisquera y su efecto en las propiedades fisco-químicas y actividad prebiótica de los oligosacáridos obtenidos. Tesis para optar al título de doctor en Ingeniería en Alimentos y Bioprocesos. Facultad de Ingeniería. Universidad de La Serena, Chile. 2023
2. Diana Leiva. Desarrollo de un polimero a base de quitosano enriquecido con péptidos bioactivos obtenidos vía enzimática, empleando subproductos de camarón (Heterocarpus reedi) para su potencial aplicación en la industria alimentaria. Tesis para optar al título de doctor en Ingeniería en Alimentos y Bioprocesos. Facultad de Ingeniería. Universidad de La Serena, Chile. 2023
3. Valeria Vasquez. Péptidos antihipertensivos de las macroalgas Macrocystis pyrifera y Chondracanthus chamissoi obtenidos mediante extracción asistida por enzimas. Tesis para optar al título de doctor en Ingeniería en Alimentos y Bioprocesos. Facultad de Ingeniería. Universidad de La Serena, Chile. 2021
4. Johnatan Diosa Arango. Inmovilización del péptido KR-12 sobre partículas híbridas de quitosano/sílice para su potencial aplicación como agente antimicrobiano en formulaciones de apósitos. Tesis para optar al título de doctor en Ciencias Química. Instituto de Química. Facultad de Ciencias Exactas y Naturales. Universidad de Antioquia. Colombia. 2020
5. Viviana Ospina Guarín Enzyme immobilization mediated by metal-chelates through silica sol-gel process. Trabajo para optar al título de Maestría en Ciencias Química. Instituto de Química. Facultad de Ciencias Exactas y Naturales. Universidad de Antioquia. Colombia. 2018
6. Escobar, S. Co-tutoria. Inmovilización de Thermomyces lanuginosus mediante encapsulación por el metodo sol-gel asistido por surfactante triton x-100. Aplicación a la síntesis de 4-metoxicinamoilglicerol. Tesis para optar al título de doctor en Ciencias Química. Instituto de Química. Facultad de Ciencias Exactas y Naturales. Universidad de Antioquia. Colombia. 2018
7. Escobar, S. Co-tutoria. Evaluación de estrategias de estabilización de la ?-galactosidasa de Bacillus circulans para su uso a nivel industria. Trabajo para optar al título de Maestria en Ciencias Química. Instituto de Química. Facultad de Ciencias Exactas y Naturales. Universidad de Antioquia. Colombia. 2015

DIRECCION DE TRABAJOS DE PREGRADO
1. Aylin Díaz Ramirez. Estudio de las características emulsificantes de Lipoaminoácidos derivados del ácido láurico. Trabajo para optar al Grado de Licenciada en Química. Universidad de La Serena. Chile. 2018
2. Nicolás Frez Flores. Extracción de Pectina asistida por Enzimas a partir de subproductos obtenidos de la Agroindustria de Zanahoria (Daucus Carota): Evaluación de las propiedades fisicoquímicas y funcionales. Trabajo para optar al titulo de ingeniería en Alimentos. Universidad de La Serena. Chile. 2020
3. Daniela Cortés Díaz. Aplicación de distintos métodos de secado a desechos agrícolas de zanahoria (Daucus Carota): Evaluación de la cinética de secado, propiedades funcionales y extracción de pectina. Trabajo para optar al titulo de ingeniería en Alimentos. Universidad de La Serena. Chile. 2020
4. Stefanny Carmen Müller Parra. Inmovilización de pectinasa en soporte a base de sílica heterofuncional con grupos amino-glioxil. Trabajo para optar al Grado de Licenciada en Química. Universidad de La Serena. Chile. 2020



 

Article (57)

Enzymatic Synthesis of Ascorbyl Palmitate in a Rotating Bed Reactor
Immobilized biocatalyst engineering: Biocatalytic tool to obtain attractive enzymes for industry
Modulating Substrate Specificity of Rhizobium sp. Histamine Dehydrogenase through Protein Engineering for Food Quality Applications
The effect of sintering temperature on the properties of the BiOCl films for potential application in DSSC
Valorization of shrimp (Heterocarpus reedi) processing waste via enzymatic hydrolysis: Protein extractions, hydrolysates and antioxidant peptide fractions
Effect of process parameters and surfactant additives on the obtained activity of recombinant tryptophan hydroxylase (TPH1) for enzymatic synthesis of 5-hydroxytryptophan (5-HTP)
Effect of the immobilization of pectinase on the molecular weight distribution of pectin oligosaccharides obtained from citrus pectin
Galactaric acid production by engineering substrate specificity in glucose oxidase from Aspergillus niger
Production of antioxidant pectin fractions, drying pretreatment methods and physicochemical properties: towards pisco grape pomace revalue
Protease-assisted process for tryptophan release from pumpkin (Cucurbita maxima) seed protein extracts
Biosynthesis of a Novel Antibacterial Dipeptide, Using Proteases From South American Native Fruits, Useful as a Food Preservative
Immobilized Biocatalyst Engineering: High throughput enzyme immobilization for the integration of biocatalyst improvement strategies
Deletion and Randomization of Structurally Variable Regions in B. subtilis Lipase A (BSLA) Alter Its Stability and Hydrolytic Performance Against Long Chain Fatty Acid Esters
Development of alginate-pectin microcapsules by the extrusion for encapsulation and controlled release of polyphenols from papaya (Carica papayaL.)
Formation mechanisms of chitosan-silica hybrid materials and its performance as solid support for KR-12 peptide adsorption: Impact on KR-12 antimicrobial activity and proteolytic stability
Improvement of enzymatic performance of Asclepias curassavica L. proteases by immobilization. Application to the synthesis of an antihypertensive peptide
Selective immobilization of Bacillus subtilis lipase A from cell culture supernatant: Improving catalytic performance and thermal resistance
Síntesis enzimática del filtro UV 4-metoxicinamoilglicerol mediado por lipasa inmovilizada y formación de nanopartículas N-succinilquitosano
Enzyme-assisted extraction of proteins from the seaweeds Macrocystis pyrifera and Chondracanthus chamissoi: characterization of the extracts and their bioactive potential
Synthesis with Immobilized Lipases and Downstream Processing of Ascorbyl Palmitate
Thermal Hyperactivation and Stabilization of ?-Galactosidase from Bacillus circulans through a Silica Sol-Gel Process Mediated by Chitosan-Metal Chelates
Enhanced long-chain fatty alcohol oxidation by immobilization of alcohol dehydrogenase from S-cerevisiae
How the Triton X-100 modulates the activity/stability of the Thermomyces lanuginose lipase: Insights from experimental and molecular docking approaches
Integrating enzyme immobilization and protein engineering: An alternative path for the development of novel and improved industrial biocatalysts
Raising the enzymatic performance of lipase and protease in the synthesis of sugar fatty acid esters, by combined ionic exchange - hydrophobic immobilization process on aminopropyl silica support
Selective and eco-friendly synthesis of lipoaminoacid-based surfactants for food, using immobilized lipase and protease biocatalysts
Understanding the silica-based sol-gel encapsulation mechanism of Thermomyces lanuginosus lipase: The role of polyethylenimine
Use of chitosan heterofunctionality for enzyme immobilization: beta-galactosidase immobilization for galacto-oligosaccharide synthesis
New non-covalent functionalized phenyl-methyl-silica for biomolecules immobilization: Experimental and theoretical insights of interactions
Structure-activity relationships on the study of beta-galactosidase folding/unfolding due to interactions with immobilization additives: Triton X-100 and ethanol
Understanding the functional properties of bio-inorganic nanoflowers as biocatalysts by deciphering the metal-binding sites of enzymes
In situ immobilization of ?-galactosidase from Bacillus circulans in silica by sol-gel process: Application in prebiotic synthesis
Synthesis of the kyotorphin precursor benzoyl-L-tyrosine-L-argininamide with immobilized -chymotrypsin in sequential batch with enzyme reactivation
Asymmetric hydrolysis of dimethyl-3-phenylglutarate in sequential batch reactor operation catalyzed by immobilized Geobacillus thermocatenulatus lipase
Improvement of Efficiency in the Enzymatic Synthesis of Lactulose Palmitate
Relationship between sol-gel conditions and enzyme stability: a case study with beta-galactosidase/silica biocatalyst for whey hydrolysis
Selectivity of R-alpha-monobenzoate glycerol synthesis catalyzed by Candida antarctica lipase B immobilized on heterofunctional supports
Carbonaceous-siliceous composite materials as immobilization support for lipase from Alcaligenes sp.: Application to the synthesis of antioxidants
Design of beta-galactosidase/silica biocatalysts: Impact of the enzyme properties and immobilization pathways on their catalytic performance
Design of β-galactosidase/silica biocatalysts: Impact of the enzyme properties and immobilization pathways on their catalytic performance
Heterofunctional Hydrophilic Hydrophobic Porous Silica as Support for Multipoint Covalent Immobilization of Lipases: Application to Lactulose Palmitate Synthesis
Improvement of Chitosan Derivatization for the Immobilization of Bacillus circulans beta-Galactosidase and Its Further Application in Galacto-oligosaccharide Synthesis
Influence of Chitosan Derivatization on Its Physicochemical Characteristics and Its Use as Enzyme Support
Interplay of carbon-silica sources on the formation of hierarchical porous composite materials for biological applications such as lipase immobilization
Interplay of carbon–silica sources on the formation of hierarchical porous composite materials for biological applications such as lipase immobilization
Hierarchical meso-macroporous silica grafted with glyoxyl groups: opportunities for covalent immobilization of enzymes
Immobilisation and stabilisation of beta-galactosidase from Kluyveromyces lactis using a glyoxyl support
Immobilisation and stabilisation of β-galactosidase from Kluyveromyces lactis using a glyoxyl support
Kinetic study of the colloidal and enzymatic stability of beta-galactosidase, for designing its encapsulation route through sol-gel route assisted by Triton X-100 surfactant
Kinetic study of the colloidal and enzymatic stability of β-galactosidase, for designing its encapsulation route through sol–gel route assisted by Triton X-100 surfactant
Molecular characterization of calcineurin B from the non-virulent Trypanosoma rangeli kinetoplastid indicates high gene conservation
Contribution to the understanding of the formation mechanism of bimodal mesoporous MCM41-type silica with large defect cavities
Improvement of thermal stability of beta-galactosidase from Bacillus circulans by multipoint covalent immobilization in hierarchical macro-mesoporous silica
Improvement of thermal stability of β-galactosidase from Bacillus circulans by multipoint covalent immobilization in hierarchical macro-mesoporous silica
Synthesis of new silicas with high stable and large mesopores and macropores for biocatalysis applications
Application of Hierarchical Porous Silica with a Stable Large Porosity for ss-Galactosidase Immobilization
Application of Hierarchical Porous Silica with a Stable Large Porosity for β-Galactosidase Immobilization

BookSection (2)

Enzyme Biocatalysis and Sustainability
Design and Characterization of Hierarchical Porous Inorganic Solids for Enzyme Immobilization: Potential Application in Industrial Processes

Proyecto (13)

Obtaining bulky chiral amines using improved immobilized transaminases: the next step for immobilized biocatalyst engineering
Towards enzyme-based chitosan production from shrimp processing waste: Improving the performance of chitinase and chitin deacetylase using enzyme engineering
Fortalecimiento de las capacidades de detección y cuantificación de nanopartículas y su carga superficial para el avance de la investigación en la Región de Coquimbo y zona norte de Chile mediante un equipo DLS y potencial zeta
Immobilized Biocatalyst Engineering of glucose oxidase and galactose oxidase toward enzymatic toolbox generation for sugar acid production
Recuperación de Bioproductos de Alto Valor para Aumentar la Sustentabilidad de la Industria Pesquera en Chile (ReBiS)
Improving enzymatic detection of histamine through protein engineering for food quality applications
Galactaric acid production from pectin=> Integration of multienzymatic systems through enzyme co-immobilization on glyoxyl silica
Calamar Gigante=> Desarrollo de Bioproductos Marinos
Deletion/randomization protein engineering strategy and its validation through improvement of b. Subtilis lipase a for applied biocatalysis
Enzymatical synthesis of lipo-amino acid based surfactants
Estudiio de los factores involucrados en la preparacion de biocatalizadores heterogeneos de lipasa de Thermomyces lanuginosus mediante inmovilizacion por adsorcion y encapsulacion en soportes siliceos porosos
Synthesis of lactulose fatty acid esters to produce food-grade biosurfactants using eco-friendly solvents and lipases immobilized in meso-macroporous silica
Evaluation and optimization of heterogeneous enzymatic hydrolysis of lactose in whey as previus step for fermentation by ethanol production
65
Claudia Bernal

Academica

Departamento de Química

Universidad de La Serena

La Serena, Chile

13
Ronny Martinez

Profesor Asociado

Ingenieria en Alimentos

UNIVERSIDAD DE LA SERENA

La Serena, Chile

12
Andrés Illanes

Profesor Títular

Escuela de Ingeniería Bioquímica

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

5
Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

4
Paulina Urrutia

Profesor Asociado

Ingeniería Bioquímica

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

2
Constanza Cárdenas

Associate Researcher

Nucleo Biotecnologia Curauma

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

2
Nadia Guajardo

Académica

Ingeniería Quimica y Bioprocesos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carminna Ottone

Profesora asociada

Escuela de Ing. Bioquímica

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Ricardo Cabrera

Assitant Pofessor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carola Bahamondes

Académico

Biotecnología

Universidad Tecnológica Metropolitana

Santiago, Chile

1
CHRISTOPHER CONCHA

Investigador

Acuicultura

Universidad Católica del Norte

Coquimbo, Chile

1
Claudia Carrasco

Profesor Titular

Ingeniería de materiales

Universidad de Concepción

Concepción, Chile

1
Diana Leiva

Académica e Investigadora

Departamento de Medicina Veterinaria

Universidad del Alba

La Serena, Chile

1
CARLOS RODRIGUEZ

Académico Investigador

Instituto de Investigación Multidisciplinario en Ciencia y tecnología

UNIVERSIDAD DE LA SERENA

La Serena, Chile

1
Néstor Serna

Postdoctoral

Centro de Biotecnología Daniel Alkalay Lowitt

Universidad Técnica Federico Santa María

Valparaíso, Chile