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Diego Andrés Valenzuela Miranda

PostDoc

Universidad de Concepción

Concepción, Chile

Líneas de Investigación


Enfoque hologenómico aplicado a la acuicultura de peces e invertebrados, Genética y genómica de organismos marinos

Educación

  •  Doctorado en Ciencias con mención en Manejo de Recursos Acuáticos Renovables, UNIVERSIDAD DE CONCEPCION. Chile, 2019

Experiencia Académica

  •   Investigador Responsable Full Time

    FONDECYT Postdoc

    Untangling the sea lice microbiome: A potential threat for Chilean salmon farming

    Chile

    2020 - 2023

  •   Investigador asociado Other

    Centro de Biotecnologia

    Chile

    2022 - A la fecha

  •   Investigador Adjunto Full Time

    Centro INCAR

    Chile

    2020 - A la fecha

Experiencia Profesional

  •   asistente de investigación Full Time

    universidad de concepción

    Chile

    2013 - 2019

Formación de Capital Humano


2. Director de tesis, Estudiante de Ingeniería en biotecnología Marina y Acuicultura de la Universidad de Concepción. “Evaluación del potencial inmunogénico de bacterias asociadas al piojo de mar (Caligus rogercresseyi) para el desarrollo de una vacuna antimicrobiota contra la caligidosis”.
2022
2. Director de tesis, Estudiante de Biología Marina de la Universidad de Concepción. “Caracterización de RNAs largos no codificantes (lncRNAs) en cepas de C. rogercresseyi mediante tecnologías de secuenciación y evaluación de la regulación transcripcional ante la exposición farmacológica”.


Difusión y Transferencia


Congress.
2024
1. D. Valenzuela-Miranda. El genoma de Caligus rogercresseyi como insumo para el control de la caligidosis. Taller difusión convenio de desempeño 2023-2024. IFOP 2024
2. D. Valenzuela-Miranda; M. Morales-Rivera; C. Gallardo-Escarate; A. Gonçalves. Functional diets increase the survival of Atlantic salmons to Piscirikettsia salmonis infection by modulating the host microbiome. Mucosal Health in Aquaculture 2024, Oporto, Portugal.
2023
3. D. Valenzuela-Miranda, B. Benavente, M. Muñoz, V. Valenzuela-Muñoz, G. Nuñez-Acuña, A.T. Gonçalves & C. Gallardo-Escárate. Understanding sea lice (Caligus rogercresseyi) parasitism on the Atlantic salmon (Salmo salar) from the holobiont perspective. Plant and Animal Genome 2023, San Diego, United States
2022
4. D. Valenzuela-Miranda, M. Montúfar, V. Valenzuela-Muñoz, G. Nuñez-Acuña, C. Gallardo-Escárate. Functional Interplaying Between Epigenetics And Microbiome In The Mussel Mytilus Chilensis During Hypoxia Conditions. EpiMar 2022, Woods Hole, Massachusetts, United States.
5. D. Valenzuela-Miranda, A. Teresa-Gonçalves, V. Valenzuela-Muñoz, G. Nuñez-Acuña, C. Gallardo-Escárate. The sea lice microbiota: a potential threat for salmon aquaculture BioAqua 2022, Cuba, Varadero.
6. D. Valenzuela-Miranda, A. Teresa-Gonçalves, M. Morales-Rivera, V. Valenzuela-Muñoz, G. Nuñez-Acuña, C. Gallardo-Escárate. Untangling sea lice microbiota: novel insights in the biological role and potential threat associated with the salmon aquaculture. World Aquaculture society 2022, USA, San Diego, February 28 – March 4.
7. D. Valenzuela-Miranda. “The sea lice microbiota: a potential threat for salmon aquaculture”. Nuevas perspectivas para el manejo integrado y control de Caligidosis, Webinar, 4 marzo 2022.
2021
8. D. Valenzuela-Miranda. “Explorando la microbiota del piojo de mar: nuevas evidencias de interacción entre Caligus y Tenacibaculum”. Primera Conferencia Internacional de Salud de Peces, 2021 (Seminario online). 15 de Junio 2021
2019
9. V. Valenzuela-Muñoz, D. Valenzuela-Miranda, C. Gallardo-Escárate. Iron overdosis in atlantic salmons leads to an immune depression and increase the susceptibility to piscirickettsia salmonis infection. 3rd International Conference of Fish & Shellfish Immunology 2019, Spain, Las Palmas, 16th – 20th June.
10. Cristian Gallardo-Escárate, Valentina Valenzuela-Muñoz, Gustavo Núñez-Acuña, Diego Valenzuela-Miranda. Reverse Vaccinology: Functional Genomics Applied to the Development of Vaccines against Caligus rogercresseyi. Plant & Animal Genome XXVII 2019, USA, San Diego, 12 – 16 January.
2018
11. Núñez-Acuña, G., Valenzuela-Muñoz, V., Arriagada, G., Valenzuela-Miranda, D. and Gallardo-Escárate, C. Disentangling sea lice responses to antiparisitic drugs: emerging role from non-coding rnas. 12th international sea lice conference dreams hotel - Punta Arenas - chile. 04-08 noviembre 2018.
12. Gallardo-Escárate, C., Valenzuela-Muñoz, V., Nuñez-Acuña, G. and Valenzuela-Miranda, D. Reverse vaccinology applied to the development of new vaccines against Caligus rogercresseyi. 12TH INTERNATIONAL SEA LICE CONFERENCE Dreams Hotel - PUNTA ARENAS - CHILE. 04-08 noviembre 2018.
13. Valenzuela-Muñoz, V., Valenzuela-Miranda, D. and Gallardo-Escárate, C. Salmon non-coding RNAs repertoire and their modulation during C. rogercresseyi infestation. 12TH INTERNATIONAL SEA LICE CONFERENCE Dreams Hotel - PUNTA ARENAS - CHILE. 04-08 noviembre 2018.
2017
14. Tarifeño-Saldivia, E., Valenzuela-Miranda, D., Gallardo-Escárate, C. Transcriptional cytoskeleton reorganization of Atlantic salmon infected with the intracellular bacterium Piscirickettsia salmonis suggests modulation through non-coding RNAs. Biotecnología Habana 2017, Varadero, Cuba. 03-06 diciembre 2017.
15. Valenzuela-Miranda, D., Tarifeño, E., Gallardo-Escárate, C. Dual RNA-Seq approach reveals metabolic dependency of the intracellular bacterium Piscirickettsia salmonis on the Atlantic salmon (Salmo salar) amino acids. Biotecnología Habana 2017, Varadero, Cuba. 03-06 diciembre 2017.
16. Gallardo-Escárate, C.,Valenzuela-Muñoz, V., Nuñez-Acuña, G., Valenzuela-Miranda, D., Gonçalves, AT. Functional genomics applied to the development of new vaccines against the sea louse Caligus rogercresseyi. Biotecnología Habana 2017, Varadero, Cuba. 03-06 diciembre 2017.
17. Cristian Gallardo-Escárate, Valentina Valenzuela-Muñoz, Sebastián Boltaña, Gustavo Núñez-Acuña, Diego Valenzuela-Miranda, Ana T. Gonçalves, Camille Détrée, Estefanía Tarifeño-Silva, Rodolfo Farlora, Steven Roberts, H.M. Putnam. The Caligus rogercresseyi miRnome: discovery and transcriptome profiling during the sea lice ontogeny, European Aquaculture Society Conference 2017, CROACIA, Dubrovnik, 18 – 20 October.
18. Cristian Gallardo-Escárate, Valentina Valenzuela-Muñoz, Gustavo Núñez-Acuña, Diego Valenzuela-Miranda. Functional genomics applied to the development of new vaccines against the sea louse Caligus rogercresseyi, European Aquaculture Society Conference 2017, CROACIA, Dubrovnik, 18 – 20 October.
19. Valenzuela-Miranda, D., Valenzuela-Muñoz, V., Gallardo-Escárate, C. Uncovering the role of non-coding rnas in atlantic salmon during the infection with the intracellular bacterium Piscirickettsia salmonis. Aquaculture Europe 2017. Dubrovnik, Croacia, 17-20 octubre 2017.
20. V. Valenzuela-Muñoz, D. Valenzuela-Miranda, C. Gallardo-Escárate. Comparative transcriptome analysis of long non-coding rnas (Lncrna) between two salmon species and their role during sea lice infestation. Aquaculture Europe 2017 Dubrovnik-Croacia.
2016
21. Valenzuela-Miranda, D., Gallardo-Escárate, C. Long non-coding RNAs: unexplored players during drug metabolism in the sea lice Caligus rogercresseyi. The 11th International Sea Lice Conference. Westport, Ireland. 26-28 September 2016.
22. Valenzuela-Muñoz, V., Núñez-Acuña, G., Valenzuela-Miranda, D., Gonçalves, A.T., Boltaña, S., Gallardo-Escárate, C. Uncovering species-specific iron regulation patterns in Atlantic and Coho salmon during the infection with the sea louse Caligus rogercresseyi. The 11th International Sea Lice Conference. Westport, Ireland. 26-28 September 2016.
23. Núñez-Acuña, G., Pino-Marambio, J., Wadsworth, S., Valenzuela-Muñoz, V., Boltaña, S., Valenzuela-Miranda, D. Gonçalves, A.T., Gallardo-Escárate, C., Discovering of key molecules involved in host recognition mechanisms in the salmon louse Caligus rogercresseyi. The 11th International Sea Lice Conference. Westport, Ireland. 26-28 September 2016.
24. Gallardo-Escárate, C., Valenzuela-Muñoz, V., Núñez-Acuña, G., Valenzuela-Miranda, D., Gonçalves, A.T., Boltaña, S. The emerging role of non-coding RNAs in the host/sea lice interaction. The 11th International Sea Lice Conference. Westport, Ireland. 26-28 September 2016.
25. Valenzuela-Muñoz, V., Núñez-Acuña, G., Valenzuela-Miranda, D., Gonçalves, A.T., Boltaña, S., Gallardo-Escárate, C. MicroRNA expression profiles in Atlantic salmon infected with Caligus rogercresseyi. The 11th International Sea Lice Conference. Westport, Ireland. 26-28 September 2016.
2015
26. Valenzuela-Miranda, D., Del Río-Portilla, MA., Gallardo-Escárate, C. 05-10 October 2015. Growth-related transcriptome of the red abalone, Haliotis rufescens Swainson, 1822. IAS2015, 9th International Abalone Symposium, Yeosu, Korea.
27. Valenzuela­Miranda, D., Segovia, C., Valderrama, K., Almarza, O., Gallardo-Escárate, C., Santander, J. 23 - 26 August 2015. Molecular mechanisms orchestrating iron uptake in Piscirickettsia salmonis. Aquaculture 2015. Le Corum, Montpellier, France.
28. Valenzuela, D., Boltaña, S., Gallardo-Escárate, C. 30th March 2015. RNA-seq analysis unravels the mechanisms of ISAV-induced a divergent tissue regulation in Atlantic salmon (Salmo salar). 13th International Society of Developmental & Comparative Immunology, Murcia, Spain.
2014
29. Gallardo-Escárate, C., V. Valenzuela-Muñoz, G. Núñez-Acuña, J. Chávez-Mardones, W. Maldonado-Aguayo, A.T. Gonçalves, R. Farlora, D. Valenzuela-Miranda. “Caligus rogercresseyi transcriptome: Novel insights for key biological processes during the lifecycle of the salmon louse”. Sea Lice 2014. August 31st to September 5th. Portland, Maine, USA.



 

Article (40)

Effects of Microbiota on the Soiling Process of PV Modules in Arid Zones of the Atacama Desert
Environmental influence on the Atlantic salmon transcriptome and methylome during sea lice infestations
Hypoxia in the Blue Mussel <i>Mytilus chilensis</i> Induces a Transcriptome Shift Associated with Endoplasmic Reticulum Stress, Metabolism, and Immune Response
The Atlantic salmon microbiome infected with the sea louse Caligus rogercresseyi reveals tissue-specific functional dysbiosis
Atlantic Salmon (<i>Salmo salar</i>) Transfer to Seawater by Gradual Salinity Changes Exhibited an Increase in The Intestinal Microbial Abundance and Richness
Chromosome-Level Genome Assembly of the Blue Mussel Mytilus chilensis Reveals Molecular Signatures Facing the Marine Environment
Transcriptome Signatures of Atlantic Salmon-Resistant Phenotypes against Sea Lice Infestation Are Associated with Tissue Repair
Whole-genome resequencing in the sea louse <i>Caligus rogercresseyi</i> uncovers gene duplications and copy number variants associated with pesticide resistance
Author Correction: Proximity ligation strategy for the genomic reconstruction of microbial communities associated with the ectoparasite Caligus rogercresseyi (Scientific Reports, (2022), 12, 1, (783), 10.1038/s41598-021-04485-0)
Competing endogenous RNA-networks reveal key regulatory microRNAs involved in the response of Atlantic salmon to a novel orthomyxovirus
Exploring Sea Lice Vaccines against Early Stages of Infestation in Atlantic Salmon (<i>Salmo salar</i>)
Nanopore sequencing evidenced the presence of fish bacterial pathogens in the sea louse (Caligus rogercresseyi) microbiota collected from distant salmon farms in Chile
Proximity ligation strategy for the genomic reconstruction of microbial communities associated with the ectoparasite Caligus rogercresseyi
Whole-Genome Transcript Expression Profiling Reveals Novel Insights into Transposon Genes and Non-Coding RNAs during Atlantic Salmon Seawater Adaptation
Chromosome-scale genome assembly of the sea louse <i>Caligus rogercresseyi</i> by SMRT sequencing and Hi-C analysis
Comprehensive Transcriptome Analyses in Sea Louse Reveal Novel Delousing Drug Responses Through MicroRNA regulation
The wastewater microbiome: A novel insight for COVID-19 surveillance
Transcriptome and morphological analysis in<i> Caligus</i><i> rogercresseyi</i> uncover the effects of Atlantic salmon vaccination with IPath®
Trypsin Genes Are Regulated through the miRNA Bantam and Associated with Drug Sensitivity in the Sea Louse <i>Caligus rogercresseyi</i>
Induced?iron overdose modulate the immune response in Atlantic salmon increasing the susceptibility to Piscirickettsia salmonis infection
Long-term serial culture of <i>Piscirickettsia salmonis</i> leads to a genomic and transcriptomic reorganization affecting bacterial virulence
Nanopore sequencing of microbial communities reveals the potential role of sea lice as a reservoir for fish pathogens
Tackling the Molecular Drug Sensitivity in the Sea Louse<i>Caligus rogercresseyi</i>Based on mRNA and lncRNA Interactions
Catching the complexity of salmon-louse interactions
Comparative analysis of long non-coding RNAs in Atlantic and Coho salmon reveals divergent transcriptome responses associated with immunity and tissue repair during sea lice infestation
Dual RNA-Seq uncovers metabolic amino acids dependency of the intracellular bacterium Piscirickettsia salmonis Infecting Atlantic salmon
In the shadow: The emerging role of long non-coding RNAs in the immune response of Atlantic salmon
Long noncoding RNAs=> Unexplored players in the drug response of the sea louse Caligus rogercresseyi
MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis
The Caligus rogercresseyi miRNome: Discovery and transcriptome profiling during the sea lice ontogeny
Caligus rogercresseyi serine proteases: Transcriptomic analysis in response to delousing drugs treatments
Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar)
Novel insights into the response of Atlantic salmon (Salmo salar) to Piscirickettsia salmonis: Interplay of coding genes and lncRNAs during bacterial infection
Characterization of the growth-related transcriptome in California red abalone (Haliotis rufescens) through RNA-Seq analysis
From the viral perspective: Infectious salmon anemia virus (ISAV) transcriptome during the infective process in Atlantic salmon (Salmo salar)
High-throughput transcriptome analysis of ISAV-infected Atlantic salmon Salmo salar unravels divergent immune responses associated to head-kidney, liver and gills tissues
Identification of microRNAs Associated With Sexual Maturity in Rainbow Trout Brain and Testis Through Small RNA Deep Sequencing
MicroRNA biogenesis pathway from the salmon louse (Caligus rogercresseyi): Emerging role in delousing drug response
Caligus-SEQ=> Avances, desafíos y perspectivas sobre proyecto de secuenciación masiva de última generación en Caligus rogercresseyi
Sex-dependent transcriptome analysis and single nucleotide polymorphism (SNP) discovery in the brine shrimp Artemia franciscana

Abstract (2)

Genomics for the understanding of the host-pathogen interaction: the case of the Atlantic salmon and Piscirickettsia salmonis
Iron overload alters the immune response in Atlantic salmon and increases the susceptibility to Piscirickettsia salmonis infection

ConferencePaper (1)

The race between host and sea lice in the Chilean salmon farming: a genomic approach

Proyecto (8)

Herramienta molecular para el monitoreo de la sensibilidad farmacológica de productos antiparasitarios contra el piojo de mar en la industria salmonera
Centro de investigación interdisciplinario para la acuicultura sustentable (INCAR)
Untangling the sea lice microbiome: A potential threat for Chilean salmon farming
Programa para la Gestión Sanitaria en la Acuicultura. CaligusLIFE: Investigación científica de excelencia para la comprensión de la biología de Caligus rogercresseyi y su aplicación en estrategias de control de la caligidosis en la industria del salmón
Centro Interdisciplinario para la Investigación Acuícola (INCAR)
Desarrollo y Validación de un Chip de Snps para la Determinación de las Bases Moleculares y el Mejoramientogenético de la Resistencia a Enfermedades en Samo Salar
Insights into innate immune response of bivalves challenged to Alexandrum catenella=> Comparative transcriptome analysis by 454 pyrosequencing
Reducción del impacto de enfermedades en la industria salmonera=> sistema de evaluación y monitoreo de su condición sanitaria
26
Cristian Gallardo

Profesor Titular

Departamento de Oceanografía

Universidad de Concepción

Concepcion, Chile

1
Homero Urrutia

Profesor titular

Facultad de Ciencias Biológicas

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Gonzalo Gajardo

profesor titular

Departamento de Ciencias Básicas y Biodiversidad

UNIVERSIDADA DE LOS LAGOS. LABORATORIO DE GENÉTICA, ACUICULTURA & ACUICULTURA

Osorno, Chile

1
Ruben Avendaño

Full Professor

UNIVERSIDAD ANDRÉS BELLO

Viña del Mar, Chile

1
Juan Valdés

Head lab

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Edward Fuentealba

Executive Director

Electrical Engineering

Universidad de Antofagasta

Antofagasta, Chile

3
Rodolfo Farlora

Full time professor

Instituto de Biología

Universidad de Valparaíso

Valparaiso, Chile

3
Sebastian Boltana

Profesor Asociado

Occeanografia

Universidad de Concepcion

Concpecion, Chile

1
Ana Fachadas Gato

Investigador

Centro de Biotecnologia

Universidad de Concepción

ConcepciónConcepción, Chile

2
Jose Yañez

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Estefanía Tarifeño

Assistant professor

Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

45
Diego Valenzuela

PostDoc

Universidad de Concepción

Concepción, Chile

6
Valentina Valenzuela

Investigador Asociado

Centro de Biotecnologia

Universidad de Concepción

Concepción, Chile

1
Luis Rojas

Profesor Planta Oficial

Química

Universidad Católica del Norte

Antofagasta, Chile

5
Gustavo Núñez

Investigador Postdoctoral

Vicerrectoría de Investigación y Desarrollo

Universidad de Concepción

Concepción, Chile

1
Marco Yévenes

Profesional

Ciencias Biológicas y Biodiversidad

Universidad de Los Lagos

Osorno, Chile