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Stephanie Braun Galleani

Profesora Asociada

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

Investigación en diferentes sistemas biológicos, particularmente levaduras, para la producción de proteínas recombinantes, incorporando disciplinas de ingeniería de procesos, biología molecular e ingeniería genética.

Biochemical Engineering, University College London. Reino Unido, 2014
Ingeniero Civil Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2008

Profesora Asociada Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Ingeniería

Valparaíso, Chile

2022 - A la fecha
Investigador Postdoctoral Full Time

University College Dublin

Irlanda

2016 - 2018
Investigador Postdoctoral Full Time

University College London

Reino Unido

2014 - 2016

- Tesis de pregrado “Generación y caracterización de una cepa de Komagataella phaffii productora de beta-glucosidasa”. Finalizada
- Tesis de pregrado “Sobreexpresión del gen IRA1 en Komagataella phaffii y evaluación de su efecto en la producción de beta-glucosidasa”. Finalizada
- Proyecto de título "Evaluación de la actividad cinética de beta-glucosidasa para la síntesis de oligosacáridos prebióticos". Finalizada
- Tesis de pregrado "Evaluación técnico-económica de la producción de un preparado comercial probiótico a partir de la levadura Saccharomyces boulardii". En curso
- Tesis de Magíster "Efecto de la temperatura en la producción de la proteína recombinante beta-glucosidasa en Komagataella phaffii S467". En curso
- Tesis de Magíster "Producción de vesículas extracelulares en Komagataella phaffii para uso en biomedicina". En curso

Beca Excelencia Académica DAAD

DEUTSCHE AKADEMISCHE AUSTAUSCHDIENST

Alemania, 2005

Beca de Intercambio Académico por un año en Universidad Técnica de Berlín. Programa de Ingeniería DAAD (Servicio Alemán de Intercambio Académico)
Becas Chile Doctorado

ANID

Chile, 2010

Beca Doctorado para realizar PhD en University College London - Reino Unido


Immobilization of Naringinase onto Polydopamine-Coated Magnetic Iron Oxide Nanoparticles for Juice Debittering Applications Kimmins, Scott D.; Henriquez, Antonella; Torres, Celia; Wilson, Lorena; Flores, Marcos; Pio, Edgar; Jullian, Domingo; Urbano, Bruno; Braun-Galleani, Stephanie; Ottone, Carminna; et al. Article ISI POLYMERS (2024)
Advances in Cell Engineering of the Komagataella phaffii Platform for Recombinant Protein Production Berrios, Julio Article ISI METABOLITES (2022)
Identification of genetic variants of the industrial yeast Komagataella phaffii (Pichia pastoris) that contribute to increased yields of secreted heterologous proteins Venkatesh, Anjan; Casey, William T.; O'Connor, Kevin E. Article WoS PLOS BIOLOGY (2022)
The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family Coughlan, Aisling Y.; Lombardi, Lisa; Braun-Galleani, Stephanie; Martos, Alexandre A. R.; Galeote, Virginie; Bigey, Frederic; Byrne, Kevin P.; Wolfe, Kenneth H. Article ISI ELIFE (2020)
Whole cell biosynthetic activity of Komagataella phaffii (Pichia pastoris) GS115 strains engineered with transgenes encoding Chromobacterium violaceum omega-transaminase alone or combined with native transketolase Henriquez, Maria-Jose; Nesbeth, Darren N. Article ISI BIOTECHNOLOGY PROGRESS (2020)
Genomic diversity and meiotic recombination among isolates of the biotech yeast Komagataella phaffii (Pichia pastoris) Dias, Julie A.; Ryan, Adam P. Article ISI MICROBIAL CELL FACTORIES (2019)
Origin of Lactose Fermentation in Kluyveromyces lactis by Interspecies Transfer of a Neo-functionalized Gene Cluster during Domestication Varela, Javier A.; Puricelli, Martina; Ortiz-Merino, Raul A.; Giacomobono, Romina; Morrissey, John P. Article ISI CURRENT BIOLOGY (2019)
Whole cell biosynthesis of 1-methyl-3-phenylpropylamine and 2-amino-1,3,4-butanetriol using Komagataella phaffii (Pichia pastoris) strain BG-10 engineered with a transgene encoding Chromobacterium violaceum omega-transaminase Article ISI HELIYON (2019)
Biotransformation of -hydroxypyruvate and glycolaldehyde to l-erythrulose by Pichia pastoris strain GS115 overexpressing native transketolase Wei, Yu-Chia; Bandara, Sahan; Nesbeth, Darren Article ISI BIOTECHNOLOGY PROGRESS (2018)
Population genomics shows no distinction between pathogenic Candida krusei and environmental Pichia kudriavzevii: One species, four names Douglass, Alexander P.; Offei, Benjamin Article ISI PLOS PATHOGENS (2018)
Zygosaccharomyces pseudobailii, another yeast interspecies hybrid that regained fertility by damaging one of its MAT loci Wu, Qun Article ISI FEMS YEAST RESEARCH (2018)
Evolutionary restoration of fertility in an interspecies hybrid yeast, by whole-genome duplication after a failed mating-type switch Kuanyshev, Nurzhan; Porro, Danilo; Branduardi, Paola Article ISI PLOS BIOLOGY (2017)
Improving recombinant protein production in the Chlamydomonas reinhardtii chloroplast using vivid Verde Fluorescent Protein as a reporter Baganz, Frank; Purton, Saul Article ISI BIOTECHNOLOGY JOURNAL (2015)


Cell engineering for bioprocess applications to enhance recombinant protein secretion in Komagataella phaffii ConferencePoster (2024)
Ingeniería genética aplicada a bioprocesos para mejorar la expresión de proteínas recombinantes en Komagataella phaffii ConferencePoster (2023)
The methylotrophic yeast Pichia pastoris as a chassis to produce chiral amino-alcohols using biodiesel waste ConferencePoster (2016)
Chiral amino-alcohol synthesis from biodiesel waste glycerol in Pichia pastoris ConferencePoster (2015)
Recombinant protein expression in the chloroplast of the green microalga Chlamydomonas reinhardtii ConferencePoster (2014)
Expression of a novel fluorescent protein in the Chlamydomonas reinhardtii chloroplast: a new marker for recombinant protein production ConferencePoster (2013)
Recombinant protein expression in the chloroplast of the green microalga Chlamydomonas reinhardtii: a case study using a novel green fluorescent protein as a reporter ConferencePoster (2013)
Exploring the potential for therapeutic protein production in algae ConferencePoster (2012)
Expression of a novel fluorescent protein (VFP) in the Chlamydomonas reinhardtii chloroplast: a new marker for recombinant protein production in microalgae ConferencePoster (2012)


Enhancing Komagataella phaffii Resilience: A hypoxia-based stressostat for adaptive evolution in harsh large-scale conditions Edgar Velastegui Proyecto (2025)
Fueling a new sustainable industry in Chile via integrated and intensified bio-electro-chemical processes for CO2 upcycling using green hydrogen and renewable energy for alleviating climate change Alberto Vergara Fernández Proyecto (2022)
Cell and Bioprocess Engineering to improve/enhance recombinant protein production in Komagataella phaffii: overexpression of genes identified by QTL mapping, and improvement of cultivation conditions Proyecto (2020)
Sexual cycles, genomics and mating-type switching in non-conventional yeast species Proyecto (2015)
Integrated process and cell refactoring systems (IPCRES) for enhanced industrial biotechnology Biotechnology and Biological Sciences Research Council (BBSRC) (BB/M004880/1) Proyecto 2014-2017 Postdoctorado
Desarrollo de un proceso biotecnológico para la revalorización de descartes de la industria de procesamiento de berries FONDEF (D07I1045) Proyecto 2008-2011 Personal técnico y/o de apoyo
Effect of concentration of different carbon sources and low temperatures on metabolic flux distribution, specific productivity and quality of tPA in Chinese hamster ovary cells FONDECYT (1070337) Proyecto 2007-2010 Tesista
Recuperación y purificación de alcoholes alifáticos de cadena larga de los residuos del proceso Kraft de pulpeo de la celulosa para su uso en la industria farmacéutica FONDEF (D04I1007) Proyecto 2005-2009 Investigador(a)