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Rene Michael Botnar

Full Professor

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

Líneas de Investigación


Cardiac MRI, Coronary MRI, Atherosclerosis, Molecular Imaging, Contrast Agent Development

Educación

  •  Electrical Engineering, SWISS FEDERAL INSTITUTE OF TECHNOLOGY-ZURICH. Suiza, 1997
  •  Physics, UNIVERSITAT FRIDERICIANA KARLSRUHE. Alemania, 1992
  •  Physics, UNIVERSITAT FRIDERICIANA KARLSRUHE. Alemania, 1989

Experiencia Académica

  •   Research Associate Full Time

    UNIVERSITY OF ZURICH

    Zurich, Suiza

    1996 - 1997

  •   Clinical Scientist Full Time

    HARVARD UNIVERSITY

    Boston, Estados Unidos

    1997 - 2003

  •   Instructor Full Time

    HARVARD UNIVERSITY

    Boston, Estados Unidos

    2003 - 2004

  •   Assistant Professor Full Time

    HARVARD UNIVERSITY

    Boston, Estados Unidos

    2004 - 2004

  •   Full Professor Full Time

    UNIVERSITAT MUNICH

    Munich, Alemania

    2004 - 2007

  •   Full Professor and Chair Full Time

    KING'S COLLEGE LONDON

    Life Sciences and Medicine

    London, Reino Unido

    2007 - At present

  •   Head of Department Full Time

    KING'S COLLEGE LONDON

    Life Sciences and Medicine

    London, Reino Unido

    2015 - At present

  •   Scientific Director Cardiac MR Center Full Time

    BETH ISRAEL DEACONESS MEDICAL CENTER

    Boston, Estados Unidos

    2003 - 2004

  •   Full Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Institute for Biological and Medical Engineering

    Santiago de Chile, Chile

    2014 - At present

Experiencia Profesional

  •   Clinical Scientist Full Time

    Philips Medical Systems

    Boston, Estados Unidos

    1997 - 2003

Formación de Capital Humano


Teaching
1989-92 Physics for Engineers
1992-96 Statistical Methods in Biomedical Engineering
1997-04 Cardiovascular MR physics
2004-04 Non-invasive Cardiac Imaging
2006-07 Cardiovascular Imaging Seminar
2009-16 SSC in clinical and preclinical MRI, module lead (15 credits)
2014- 7MIGEP43 Medical Imaging Acquisition, module lead (15 credits)
2009- 7MIGEP14 Introduction to Medical Imaging Sciences, lecturer (15 credits)
2015- 7MIGEP09 Medical Imaging with Non-Ionising Radiation, lecturer (15 credits)
2015- 7MIGEP27 Further Medical Imaging with Non-Ionising Radiation, lecturer (15 credits)

Postdocs
2020- Shubhajid Paul, PhD
2018- Haikun Qi, PhD
2018- Thomas Küstner, PhD
2017-19 Aurélien Bustin, PhD
2016-18 Giulia Ginami, PhD
2015-18 Arna van Engelen, PhD
2013-15 Sara Lacerda, PhD
2012- Begoña, Lavin-Plaza, PhD
2012-13 Sarah Peel, PhD
2012-15 Markus Henningsson, PhD
2012-16 Silvia, Lorrio, PhD
2010-15 Alkystis Phinikaridou, PhD
2010-13 André Salomon, PhD
2008-15 Andrea Protti, PhD

PhD students
2020- Ioannis Valasakis, BS
2019- Nadia Chaher, BS
2019- Reza Hajhosseiny, MD
2019- Alina Psenicny, BS
2018- Mueez Aizaz, MSc
2018- Hannah, Perry, MRes
2017- Ryan McNally, MRes
2017- Giorgia Milotta, MRes
2016-20 Marta Dazzi, MRes
2016-20 Rhiannon Evans, MRes
2016- Karina Lopez, MRes
2015-19 Giovanna Nordio, MRes
2014-17 Isabel Ramos, MSc
2013-17 Maryam Nezafat, MSc
2011-16 Pierre Gebhardt, MSc
2011-15 Dirk Kruger, MSc
2009-12 Tarique Hussain, MD
2009-12 Sarah Peel, BS
2008-13 Eirini Karamariti, MS
2008-12 Marcelo Andia, MS MD
2008-12 Gabriella Passacquale, MD
2008-15 Markus Henningsson, BS
2007-10 Marcus Makowski, MD

Master students
2019-19 Ivna Branquinho, BS
2017-18 Margo van Gent, BS
2017-17 Jean Cupe Chacalcaje, BS
2017-17 Jasmin Breitenstein, BS
2016-16 Filipa Silva, BS
2016-16 Suzanne Franklin, BS
2016-16 Mateusz Florkow, BS
2016-16 Aurelien Robbe, BS
2015-15 Tom Bruijnen, BS
2015-15 Rob Holtackers, BS
2016-16 Almut Glitzer, BS
2014-14 Melissa van de Steeg, BS
2014-15 Joao Tourais, BS
2013-13 Frank Eschbach, BS
2012-12 Jules, Nelissen, BS
2010-10 Tom van Rooij, BS
2009-09 Rene Verhaart, BS
2008-08 Miriam Lagemaat, BS
2004-05 Roger Fischer, BS
2005-06 Sinan Uygur, BS
2002-02 Christoph Barmet, BS
2000-01 Michael Schär, BS
2000-01 Alex Etienne, BS
1998-99 David Hengesbach, BS
1999-00 Florian Wiesinger, BS
1998-99 Michael Huber, BS
1996-97 Harald Quick, BS
1995-96 Sebastian Kozerke, BS
1994-95 Daniel Frey, BS
1993-94 Oliver Weber, BS

Clinical fellows
2020- Alina, Hua, MD
2019- Reza Hajhosseiny, MD
2016-19 Imran Rashid, MD
2010-12 Britta Butzbach, MD
2010-12 Boris Bigalke, MD
2009-12 Andreas Indermuehle, MD
2009-12 Tarique Hussain, MD
2007-09 Christian Jansen, MD
2004-04 Marcus Katoh, MD
2002-03 Tim Leiner, MD
2001-02 David Maintz, MD
2000-01 Won Y Kim, MD
1999-00 Elmar Spüntrup, MD
1996-97 Benjamin Dubno, MD


Difusión y Transferencia


Selected invited and keynote lectures (last 5 years)

2016 Academic Vascular Surgery, KCL
Invited Lecture
Molecular Imaging of Atherosclerosis
London, UK

2016 CMR Techniques for the Assessment of Coronary Plaques and Stenosis
Invited Lecture
Society for Cardiovascular Magnetic Resonance (SCMR)
Los Angeles, CA

2016 MRI of Coronary Plaque: Are We There Yet?
Invited Lecture
Society for Cardiovascular Magnetic Resonance (SCMR)
Los Angeles, CA

2017 CVMR Retreat
Keynote Lecture
MR in Bed with PET
Annecy, France

2017 Siemens Customer Event
Invited Lecture
3D quantitative and multiparametric whole heart MRI
Barcelona, Spain

2017 Edinburgh Cardiovascular Imaging Seminar
Invited Lecture
3D quantitative and multiparametric whole heart MRI
Edinburgh, UK

2017 Motion Compensation: Pulse Sequence & Reconstruction Strategies
Invited Lecture
International Society for Magnetic Resonance in Medicine (ISMRM)
Honolulu, HI

2018 Society for Cardiovascular Magnetic Resonance
Invited Lecture
3D multiparametric whole heart MRI: get all in one
Barcelona, Spain

2018 Universidad de Los Andes
Invited Lecture
Cardiovascular Magnetic Resonance Imaging: Technical developments and clinical applications
Santiago de Chile, Chile

2018 European Society for Molecular Imaging
Invited Lecture
Cardiovascular Molecular Imaging with PET and MRI
San Sebastian, Spain

2018 British Cardiovascular Imaging Meeting
Invited Lecture
Coronary MR Angiography: are we there yet?
Edinburgh, UK

2018 International Society for Magnetic Resonance in Medicine
Invited Lecture
Clinical Translation and Applications of Molecular MRI in Cardiovascular Diseases
Paris, France

2018 Vulnerable Patient Meeting (VPM)
Invited Lecture
Coronary MRA: how far are we from its use in assessing coronary artery anatomy
Stresa, Italy

2018 CVMR Retreat
Keynote Lecture
Multi Spectral MRI of the Heart
Annecy, France

2018 Society for Magnetic Resonance Angiography
Invited Lecture
Vessel Wall and Plaque Imaging
Glasgow, UK

2019 International Symposium on Biomechanics and Vascular Biology
Invited Lecture
Molecular MR Imaging of Advanced Plaques
London, UK

2019 British Heart Foundation Centre of Excellence Annual Symposium
Invited Lecture
Comprehensive diagnosis of heart disease with multi-parametric MRI
London, UK

2019 Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Invited Lecture
Comprehensive diagnosis of heart disease with multi-parametric MRI
Madrid, Spain

2019 Synergistic Reconstruction Symposium
Invited Lecture
Multiparametric Cardiovascular Magnetic Resonance Imaging
Chester, UK

2019 Vascular Inflammation: Novel Approaches
Invited Lecture
Society for Cardiovascular Magnetic Resonance (SCMR)
Seattle, WA

2019 Comprehensive diagnosis of heart disease with multi-parametric MRI
Invited Lecture
Department of Radiology, UT Southwestern Medical Center
Dallas, TX

2020 Physikalisch Technische Bundesanstalt (PTB)
Invited Lecture
Multiparametric Cardiovascular Magnetic Resonance Imaging
Berlin, Germany

2020 Free-breathing Relaxometry: Is 3D Worth It?
Invited Lecture
Society for Cardiovascular Magnetic Resonance (SCMR)
Orlando, FL

2020 Robust Myocardial T1, T2, T2*, and ECV Mapping: the Good, the Bad and the Future
Invited Lecture
International Society for Magnetic Resonance in Medicine (ISMRM)
Paris, France

Patents
1. Stuber M, Botnar RM. Magnetic resonance imaging method and system with adaptively selected flip angles (US Patent 6,230,039).
2. Manning WJ, Botnar RM, Stuber M. Combined use of ECG and PPU signals for triggering medical imaging (US Patent 6,501,979).
3. Wiethoff AJ, Parsons EC, Botnar RM, Spuentrup E. Methods of cardiothoracic imaging. (Serial Number 10/888,833)
4. Wiethoff AJ, Parsons EC, Botnar RM, Spuentrup E. Stationary target imaging. (Provisional Serial Number 60/543,875; Provisional Serial Number 60/486,833)
5. Botnar RM. Phinikaridou A. Materials and methods relating to cardiovascular imaging. (WO/2012/107725 / PCT/GB2012/000133)
6. Prieto C, Ginami G, Neji R, Botnar RM. BOOST: A Method of Performing Magnetic Resonance Imaging and a Magnetic Resonance Apparatus. Application number: GB1713442.0
7. Prieto C, Bustin A, Neji R, Botnar RM. PROST: Method of Reconstructing Magnetic Resonance Image Data. Application number GB1807623.2
8. Prieto C, Correia T, Neji R, Botnar RM. ORCCA: Method of Reconstructing Magnetic Resonance Image Data. Application number GB1806025.1
9. Prieto C, Correia T, Neji R, Botnar RM. HD-PROST: High-Dimensionality Undersampled Patch-Based Reconstruction (HD-PROST) for Accelerated Multi-Contrast Magnetic Resonance Imaging. Application number. Joint patent with Siemens Healthineers.

Clinical translation
Developed pre-product software (WIP1111) for coronary MR angiography on Siemens MR scanner (2020)
Developed pre-product software (WIP1427) for multi-contrast whole heart cardiac MRI on Siemens MR scanner (2020)
Performed multicentre study for clinical evaluation of coronary MR angiography, published in the New England Journal of Medicine (2001)


Premios y Distinciones

  •   James E. Muller Vulnerable Plaque New Investigator Prize For Clinical Research

    Association for Eradication of Heart Attack

    Estados Unidos, 2002

    For the development of magnetic resonance coronary plaque imaging

  •   Fellow Award

    International Society for Magnetic Resonance in Medicine

    Australia, 2012

    For achievements in MRI research

  •   Outstanding Teacher Award

    International Society for Magnetic Resonance in Medicine

    Australia, 2012

    For outstanding teaching

  •   Fellow Award

    Society for Cardiovascular Magnetic Resonance

    Estados Unidos, 2019

    For achievements in cardiovascular magnetic resonance research

  •   Associate Editor

    Journal of Cardiovascular Magnetic Resonance

    Estados Unidos, 2017

    Assigns manuscripts to reviewers and discusses those manuscripts at editorial board meeting

  •   Council Member

    European Society for Molecular Imaging

    Reino Unido, 2020

    Member of the European Society for Molecular Imaging council that manages the society and organises the annual meetings

  •   Board Member

    Society for Cardiovascular Magnetic Resonance

    Estados Unidos, 2008

    Member of the board of the Society for Cardiovascular Magnetic Resonance, which manages the societies activities and organises the annual scientific meeting

  •   Senior Editor

    Journal of Molecular Imaging and Biology

    Reino Unido, 2020

    Senior editor assigns reviewers and makes decisions on acceptance or rejection of peer reviewed manuscripts

  •   Gold Medal Committee member

    Society for Cardiovascular Magnetic Resonance

    Estados Unidos, 2012

    Committee of senior accomplished members of the society selects the winner of the annual Gold Medal

  •   Young Investigator Award committee

    International Society for Magnetic Resonance in Medicine

    Estados Unidos, 2012

    Member of the Young Investigator Award committee of the ISMRM that selects the candidates for the annual Rabi and Moore award


 

Article (191)

3D Whole-heart free-breathing qBOOST-T2 mapping
3D whole-heart isotropic sub-millimeter resolution coronary magnetic resonance angiography with non-rigid motion-compensated PROST
3D whole‐heart isotropic‐resolution motion‐compensated joint T 1 /T 2 mapping and water/fat imaging
A multi-scale variational neural network for accelerating motion-compensated whole-heart 3D coronary MR angiography
Accelerated free-breathing whole-heart 3D T-2 mapping with high isotropic resolution
Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures
Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization
Faster 3D saturation-recovery based myocardial T1 mapping using a reduced number of saturation points and denoising
Free-running cardiac magnetic resonance fingerprinting: Joint T1/T2 map and Cine imaging
From Compressed-Sensing to Artificial Intelligence-Based Cardiac MRI Reconstruction
Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy
Isotropic 3D Cartesian single breath-hold CINE MRI with multi-bin patch-based low-rank reconstruction
Multi‐parametric liver tissue characterization using MR fingerprinting: Simultaneous T 1 , T 2 , , and fat fraction mapping
Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
Respiratory motion-compensated high-resolution 3D whole-heart T1 rho mapping
Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation
Water-fat Dixon cardiac magnetic resonance fingerprinting
Whole-heart T1 mapping using a 2D fat image navigator for respiratory motion compensation
3D SASHA myocardial T1 mapping with high accuracy and improved precision
Accelerated 3D T(2)w-imaging of the prostate with 1-millimeter isotropic resolution in less than 3 minutes
Accelerated 3D T-2 mapping with dictionary-based matching for prostate imaging
Automatic CNN-based detection of cardiac MR motion artefacts using k-space data augmentation and curriculum learning
Clinical value of dark-blood late gadolinium enhancement cardiovascular magnetic resonance without additional magnetization preparation
Concurrent Molecular Magnetic Resonance Imaging of Inflammatory Activity and Extracellular Matrix Degradation for the Prediction of Aneurysm Rupture
Dual-probe molecular MRI for the in vivo characterization of atherosclerosis in a mouse model: Simultaneous assessment of plaque inflammation and extracellular-matrix remodeling
Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis
Five-minute whole-heart coronary MRA with sub-millimeter isotropic resolution, 100% respiratory scan efficiency, and 3D-PROST reconstruction
Free-running 3D whole heart myocardial T-1 mapping with isotropic spatial resolution
Free-running simultaneous myocardial T1/T2 mapping and cine imaging with 3D whole-heart coverage and isotropic spatial resolution
High-dimensionality undersampled patch-based reconstruction (HD-PROST) for accelerated multi-contrast MRI
Imaging sequence for joint myocardial T-1 mapping and fat/water separation
Molecular and Nonmolecular Magnetic Resonance Coronary and Carotid Imaging
Motion corrected water/fat whole-heart coronary MR angiography with 100% respiratory efficiency
Non-contrast enhanced simultaneous 3D whole-heart bright-blood pulmonary veins visualization and black-blood quantification of atrial wall thickness
Noninvasive Imaging of Endothelial Damage in Patients With Different HbA(1c) Levels: A Proof-of-Concept Study
Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T CMR Imaging With an Albumin-Binding Probe
Respiratory- and cardiac motion-corrected simultaneous whole-heart PET and dual phase coronary MR angiography
Rigid motion-corrected magnetic resonance fingerprinting
Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T(2)prep-IR
Sparsity and locally low rank regularization for MR fingerprinting
Cardiac MR Motion Artefact Correction from K-space Using Deep Learning-Based Reconstruction
Contrast-Enhanced Magnetic Resonance Angiography Using a Novel Elastin-Specific Molecular Probe in an Experimental Animal Model
Correction to: 3D SASHA myocardial T1 mapping with high accuracy and improved precision (Magnetic Resonance Materials in Physics, Biology and Medicine, (2018), 10.1007/s10334-018-0703-y)
Dual-phase whole-heart imaging using image navigation in congenital heart disease
Improved coronary magnetic resonance angiography using gadobenate dimeglumine in pediatric congenital heart disease
Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation
MRI with gadofosveset: A potential marker for permeability in myocardial infarction
Optimized respiratory-resolved motion-compensated 3D Cartesian coronary MR angiography
Simultaneous Assessment of Cardiac Inflammation and Extracellular Matrix Remodeling after Myocardial Infarction
Simultaneous bright- and black-blood whole-heart MRI for noncontrast enhanced coronary lumen and thrombus visualization
Tropoelastin: A Novel Marker for Plaque Progression and Instability
Highly efficient nonrigid motion-corrected 3D whole-heart coronary vessel wall imaging
Coronary MR angiography at 3T: fat suppression versus water-fat separation
Combined coronary lumen and vessel wall magnetic resonance imaging with i-T2prep: influence of nitroglycerin.
Highly Efficient Respiratory Motion Compensated Free-Breathing Coronary MRA Using Golden-Step Cartesian Acquisition
100% Efficient three-dimensional coronary MR angiography with two-dimensional beat-to-beat translational and bin-to-bin affine motion correction
A new framework for interleaved scanning in cardiovascular MR: Application to image-based respiratory motion correction in coronary MR angiography
Assessment of Myocardial Infarction and Postinfarction Scar Remodeling With an Elastin-Specific Magnetic Resonance Agent
Combined coronary lumen and vessel wall magnetic resonance imaging with i-T2prep: influence of nitroglycerin
Contrast-enhanced cardiovascular magnetic resonance imaging of coronary vessel wall: state of art
Coronary Vessel Wall Contrast Enhancement Imaging as a Potential Direct Marker of Coronary Involvement
Fibrin-Targeted Magnetic Resonance Imaging Allows In Vivo Quantification of Thrombus Fibrin Content and Identifies Thrombi Amenable for Thrombolysis
Gd-containing conjugated polymer nanoparticles: bimodal nanoparticles for fluorescence and MRI imaging
High-frequency speckle tracking echocardiography in the assessment of left ventricular function and remodeling after murine myocardial infarction
In Vivo Assessment of Aortic Aneurysm Wall Integrity Using Elastin-Specific Molecular Magnetic Resonance Imaging
Individualized cardiovascular risk assessment by cardiovascular magnetic resonance
Molecular imaging of myocardial infarction
PET/CT and MR imaging biomarker of lipid-rich plaques using [Cu-64]-labeled scavenger receptor (CD68-Fc)
Plaque Trek
Rats Fed Diets with Different Energy Contribution from Fat Do Not Differ in Adiposity
Role of miR-195 in Aortic Aneurysmal Disease
Vascular Remodeling and Plaque Vulnerability in a Rabbit Model of Atherosclerosis: Comparison of Delayed-Enhancement MR Imaging with an Elastin-specific Contrast Agent and Unenhanced Black-Blood MR Imaging
Whole-Heart Coronary MRA with 3D Affine Motion Correction Using 3D Image-Based Navigation
Advanced Respiratory Motion Compensation for Coronary MR Angiography
Bisphosphonate-Anchored PEGylation and Radiolabeling of Superparamagnetic Iron Oxide: Long-Circulating Nanoparticles for in Vivo Multimodal (T1 MRI-SPECT) Imaging
Contrast-enhanced specific absorption rate-efficient 3D cardiac cine with respiratory-triggered radiofrequency gating
Detection and Grading of Coronary Allograft Vasculopathy in Children With Contrast-Enhanced Magnetic Resonance Imaging of the Coronary Vessel Wall
Detection of coronary plaques using MR coronary vessel wall imaging: validation of findings with intravascular ultrasound
Elastin-based molecular MRI of liver fibrosis
Flow-independent 3D whole-heart vessel wall imaging using an interleaved T2-preparation acquisition
Hyperemic stress myocardial perfusion cardiovascular magnetic resonance in mice at 3 Tesla: initial experience and validation against microspheres
In Vivo Magnetization Transfer and Diffusion-Weighted Magnetic Resonance Imaging Detects Thrombus Composition in a Mouse Model of Deep Vein Thrombosis
Left-sided Pulmonary Venous Pathway Obstruction after Mustard Operation
Magnetic Resonance Coronary Angiography: Where Are We Today?
Magnetic Resonance T-1 Relaxation Time of Venous Thrombus Is Determined by Iron Processing and Predicts Susceptibility to Lysis
MR Imaging of the Arterial Vessel Wall: Molecular Imaging from Bench to Bedside
Multimodality Imaging of Subclinical Aortic Atherosclerosis Relation of Aortic Stiffness to Calcification and Plaque in Female Twins
Noninvasive MRI Monitoring of the Effect of Interventions on Endothelial Permeability in Murine Atherosclerosis Using an Albumin-Binding Contrast Agent
Prospective respiratory motion correction for coronary MR angiography using a 2D image navigator
Protein kinase G oxidation is a major cause of injury during sepsis
The emerging role of cardiovascular magnetic resonance in the evaluation of Kawasaki disease
Accelerating three-dimensional molecular cardiovascular MR imaging using compressed sensing
Advances in Molecular Imaging of Atherosclerosis and Myocardial Infarction: Shedding New Light on In-vivo Cardiovascular Biology
Arterial spin labeling angiography using a triple inversion recovery prepulse
Contrast Enhancement Imaging in Coronary Arteries in SLE
Cross-sectional and In-plane coronary vessel wall imaging using a local inversion prepulse and spiral read-out: A comparison between 1.5 and 3 tesla
Dual Inversion-Recovery MR Imaging Sequence for Reduced Blood Signal on Late Gadolinium-enhanced Images of Myocardial Scar
Evaluation of phase-sensitive versus magnitude reconstructed inversion recovery imaging for the assessment of myocardial infarction in mice with a clinical magnetic resonance scanner
Ex vivo imaging of injured arteries in rabbits using fluorescence-labelled glycoprotein VI-Fc
Green Fluorescent Protein (GFP) Color Reporter Gene Visualizes Parvovirus B19 Non-Structural Segment 1 (NS1) Transfected Endothelial Modification
In vivo assessment of intraplaque and endothelial fibrin in ApoE−/− mice by molecular MRI
Mid-regional pro-atrial natriuretic peptide as a prognostic marker for all-cause mortality in patients with symptomatic coronary artery disease
Molecular Imaging of Early  v 3 Integrin Expression Predicts Long-Term Left-Ventricle Remodeling After Myocardial Infarction in Rats
Molecular MRI of Atherosclerosis Burden
MRI of atherosclerosis: from mouse to man
MRI-based prediction of adverse cardiac remodeling after murine myocardial infarction
Noninvasive Magnetic Resonance Imaging Evaluation of Endothelial Permeability in Murine Atherosclerosis Using an Albumin-Binding Contrast Agent
Single breath-hold assessment of cardiac function using an accelerated 3D single breath-hold acquisition technique - comparison of an intravascular and extravascular contrast agent
Three-dimensional dual-phase whole-heart MR imaging: clinical implications for congenital heart disease.
Three-Dimensional Imaging of the Aortic Vessel Wall Using an Elastin-Specific Magnetic Resonance Contrast Agent
Whole-heart coronary MR angiography with 2D self-navigated image reconstruction
Accelerated aortic imaging using small field of view imaging and electrocardiogram-triggered quadruple inversion recovery magnetization preparation
Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent
Cardiac MRI to investigate myocardial scar and coronary venous anatomy using a slow infusion of dimeglumine gadobenate in patients undergoing assessment for cardiac resynchronization therapy
Characterization of carotid artery plaques with USPIO-enhanced MRI: assessment of inflammation and vascularity as in vivo imaging biomarkers for plaque vulnerability
Congenital Heart Disease in Children: Coronary MR Angiography during Systole and Diastole with Dual Cardiac Phase Whole-Heart Imaging
Congenital Heart Disease: Cardiovascular MR Imaging by Using an Intravascular Blood Pool Contrast Agent
Coronary Imaging With Cardiovascular Magnetic Resonance: Current State of the Art
Detection of Coronary Artery Anomalies in Infants and Young Children with Congenital Heart Disease by Using MR Imaging
Detection of Intracoronary Thrombus by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction
Imaging of injured and atherosclerotic arteries in mice using fluorescence-labeled glycoprotein VI-Fc
MRI of Coronary Wall Remodeling in a Swine Model of Coronary Injury Using an Elastin-Binding Contrast Agent
Noninvasive Assessment of Atherosclerotic Plaque Progression in ApoE-/- Mice Using Susceptibility Gradient Mapping
Reference region-based pharmacokinetic modeling in quantitative dynamic contract-enhanced MRI allows robust treatment monitoring in a rat liver tumor model despite cardiovascular changes
Right Atrial Scar Detection after Catheter Ablation
Sandwich Immunoassay for Soluble Glycoprotein VI in Patients with Symptomatic Coronary Artery Disease
Zoom imaging for rapid aortic vessel wall imaging and cardiovascular risk assessment
Cardiovascular MRI in small animals
Constitutive glycogen synthase kinase-3 /  activity protects against chronic  -adrenergic remodelling of the heart
First-pass contrast-enhanced myocardial perfusion MRI in mice on a 3-T clinical MR scanner
High Spatial Resolution and High Contrast Visualization of Brain Arteries and Veins: Impact of Blood Pool Contrast Agent and Water-Selective Excitation Imaging at 3T
Late gadolinium enhancement of acute myocardial infarction in mice at 7T: Cine-FLASH versus inversion recovery
Local erythropoietin and endothelial progenitor cells improve regional cardiac function in acute myocardial infarction
Magnetic Conjugated Polymer Nanoparticles as Bimodal Imaging Agents
MR Imaging of Lymph Nodes using Gadofluorine M: Feasibility in a Swine Model at 1.5 and 3T
T1-weighted MRI for the detection of coronary artery plaque haemorrhage
Visualization of Coronary Wall Atherosclerosis in Asymptomatic Subjects and Patients with Coronary Artery Disease Using Magnetic Resonance Imaging
Combined Reporter Gene PET and Iron Oxide MRI for Monitoring Survival and Localization of Transplanted Cells in the Rat Heart
Coronary Plaque Characterization by T1-Weighted Cardiac Magnetic Resonance
Flow Targeted 3D Steady-State Free-Precession Coronary MR Angiography
Flow-Targeted Inversion-Prepared b-TFE Coronary MR Angiography: Initial Results in Patients
Molecular Imaging With Targeted Contrast Agents
Molecular Magnetic Resonance Imaging of Myocardial Perfusion With EP-3600, a Collagen-Specific Contrast Agent: Initial Feasibility Study in a Swine Model
MRI of subclinical coronary atherosclerosis
Serial Contrast-Enhanced Cardiac Magnetic Resonance Imaging Demonstrates Regression of Hyperenhancement Within the Coronary Artery Wall in Patients After Acute Myocardial Infarction
Utilizing different methods for visualizing susceptibility from a single multi-gradient echo dataset
A New 18F-Labeled Myocardial PET Tracer: Myocardial Uptake After Permanent and Transient Coronary Occlusion in Rats
MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients
Relation of Left Ventricular Function, Mass, and Volume to NT-proBNP in Type 1 Diabetic Patients
Structural and functional imaging by MRI
Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki disease
Delayed-Enhancement Cardiovascular Magnetic Resonance Coronary Artery Wall Imaging
Detection of Pulmonary Vein and Left Atrial Scar after Catheter Ablation with Three-dimensional Navigator-gated Delayed Enhancement MR Imaging: Initial Experience 1
Differential Impact of Age, Sex, and Hypertension on Aortic Atherosclerosis: The Framingham Heart Study
Dual cardiac–respiratory gated PET: implementation and results from a feasibility study
Intraindividual Comparison of 3D Coronary MR Angiography and Coronary CT Angiography
Molecular Coronary MR Imaging of Human Thrombi using EP-2104R, a Fibrin-Targeted Contrast Agent: Experimental Study in a Swine Model
Subacute Thrombotic Occlusion and Spontaneous Recanalization of the Right Coronary Artery After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction Visualized by Coronary Angiography and Cardiac Magnetic Resonance Imaging
Usefulness of MRI to Demonstrate the Mechanisms of Myocardial Ischemia in Hypertrophic Cardiomyopathy with Myocardial Bridge
Whole-Heart Coronary Magnetic Resonance Angiography: Value for the Detection of Coronary Artery Stenoses in Comparison to Multislice Computed Tomography Angiography
Analysis of residual coronary artery motion for breath hold and navigator approaches using real-time coronary MRI
Characterizing radial undersampling artifacts for cardiac applications
Coronary magnetic resonance imaging: visualization of the vessel lumen and the vessel wall and molecular imaging of arteriothrombosis
Inversion recovery radial MRI with interleaved projection sets
MR coronary vessel wall imaging: Comparison between radial and spiral k-space sampling
Radiofrequency ablation of right ventricular outflow tract tachycardia using a magnetic resonance 3D model for interactive catheter guidance
Subclinical Coronary and Aortic Atherosclerosis Detected by Magnetic Resonance Imaging in Type 1 Diabetes With and Without Diabetic Nephropathy
Whole-Heart-MR-Koronarangiographie - erste Ergebnisse
Cardiovascular magnetic resonance imaging of coronary atherothrombosis
Correction for heart rate variability improves coronary magnetic resonance angiography
Inherently self-calibrating non-cartesian parallel imaging
Inversion Prepared Coronary MR Angiography: Direct Visualization of Coronary Blood Flow
Magnetic resonance imaging of atherosclerosis
Molecular Magnetic Resonance Imaging of Pulmonary Emboli with a Fibrin-specific Contrast Agent
Free-breathing 3D Steady-State Free Precession Coronary MR Angiography with Radial k-Space Sampling: Comparison with Cartesian k-Space Sampling and Cartesian Gradient-Echo Coronary MR Angiography—Pilot Study1
In Vivo Magnetic Resonance Imaging of Coronary Thrombosis Using a Fibrin-Binding Molecular Magnetic Resonance Contrast Agent
In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent
Comparison of aortic elasticity determined by cardiovascular magnetic resonance imaging in obese versus lean adults
Coronary Magnetic Resonance Angiography
Quantitative Assessment of Left Ventricular Function with Interactive Real-Time Spiral and Radial MR Imaging1
Renal Arteries: Navigator-gated Balanced Fast Field-Echo Projection MR Angiography with Aortic Spin Labeling: Initial Experience1
Technische Aspekte der MR-Koronarangiographie
Coronary Magnetic Resonance Angiography for the Detection of Coronary Stenoses
Free-Breathing Black-Blood Coronary MR Angiography: Initial Results1
In Vivo Magnetic Resonance Imaging of Experimental Thrombosis in a Rabbit Model
Hemodynamics in the carotid artery bifurcation:
Noninvasive Coronary Vessel Wall and Plaque Imaging With Magnetic Resonance Imaging
Double-oblique free-breathing high resolution three-dimensional coronary magnetic resonance angiography
Improved Coronary Artery Definition With T2-Weighted, Free-Breathing, Three-Dimensional Coronary MRA
Submillimeter Three-dimensional Coronary MR Angiography with Real-time Navigator Correction: Comparison of Navigator Locations1
Radio-frequency-induced thermoablation: monitoring with T1-weighted and proton-frequency-shift MR imaging in an interventional 0.5-T environment.

Abstract (3)

MAGNETIC RESONANCE MULTI-SEQUENCE THROMBUS IMAGING (MSTI) PREDICTS THROMBUS LYSABILITY IN PATIENTS WITH ACUTE ILIOFEMORAL DEEP VEIN THROMBOSIS (DVT)
FOCAL VASCULAR INJURY CAUSES SUSTAINED REMOTE ENDOTHELIAL DYSFUNCTION AND ATHEROSCLEROTIC PLAQUE PROGRESSION: AN IN VIVO MURINE MRI STUDY
PRAVASTATIN AND MINOCYCLINE TREATMENT AFFECTS VESSEL WALL REMODELING IN A MURINE MODEL OF VASCULAR INJURY

EditorialMaterial (1)

Coronary Magnetic Resonance Angiography in Heterotopic Heart Transplant Recipient

Errata (1)

3D SASHA myocardial T1 mapping with high accuracy and improved precision (vol 32, pg 281, 2019)

Proyecto (40)

Detection of High-Risk Plaque with tropoelastin-specific and multicontrast coronary MRI
Multi-parametric tissue characterisation of myocardial inflammation in autoimmune rheumatic diseases using cardiovascular magnetic resonance imaging
Quantification and modulation of vascular inflammatory activity for the detection and treatment of high-risk atherosclerotic plaque
King's College London BHF Centre of Research Excellence
Wellcome EPSRC Centre for Medical Engineering
Comprehensive Assessment of Coronary and Myocardial Disease with Self-gated 3D Magnetic Resonance Imaging
Self-Navigated Multi-Contrast And Quantitative Whole Heart 3D Magnetic Resonance Imaging
SmartHeart - Next-generation cardiovascular healthcare via integrated image acquisition, reconstruction, analysis and learning
3.0T Magnetic Resonance Delayed Enhancement Vessel Wall Imaging in Patients with Type 1 and 2 Diabetes
BHF Centre of Research Excellence
Atherosclerosis stratification using advanced imaging and computer- based models
Firmware-based design for a PET detector data acquisition and processing chain and RF interference reduction techniques for simultaneous PET/MR imaging
Molecular imaging of inflammation and extracellular matrix remodelling after MI
A study using elastin-specific MRI contrast agent to quantify renal fibrosis
High resolution three dimensional MRI of the heart and intrathoracic vessels in patients with congenital heart disease
Molecular imaging of dysfunctional matrix remodelling in arterial disease
Defining the mechanism by which vasodilator drugs selectively reduce central pulse pressure through a reduction in pressure augmentation
Detection and grading of coronary allograft vasculopathy in children using Magnetic Resonance Imaging
Magnetic resonance imaging for follow up of Paediatric Heart Transplant
MultiFunctional Nanotechnology for Selective Detection and Treatment of Cancer
MRI of intraplaque albumin as marker for plaque neovascularisation
Monocyte-platelet aggregates in the circulation=> a novel biomarker for atherosclerosis
MRI of inflammation and extracellular matrix formation in atherosclerosis and vascular injury
Pretargeting nanoparticle strategies for multimodal imaging of tumours
Project 3=> Simultaneous PET/MR imaging of atherosclerosis using novel molecular and cellular contrast agents
Three-dimensional whole heart perfusion MR imaging
ARTerial Inflammation, STIffening and Calification ARTISTIC
BHF research excellence clinical fellowship
Dose finding study for CP1174 in a pig model of coronary injury
MR perfusion imaging to guide management of patients with stable coronary artery disease
Non-invasive assessment of arterial integrity using an elastin specific MRI contrast agent
Small Animal MRI
Fluid structure interaction in hemodynamics
Coronary plaque imaging in a swine model of in- stent stenosis using a plaque specific MR contrast agent
MAGIC=> Magnetic Particle Imaging for Cardiovascular Applications
A phase II feasibility study to evaluate the safety and efficacy of EP-2104R for magnetic resonance imaging of thrombi in the arterial vasculature and cardiac chambers
Cardiac MRI with 3D Undersampled Radial Imaging
Delayed enhancement coronary vessel wall imaging in patients with unstable coronary artery disease using Gadovist
Development of target specific contrast agents for image guided diagnosis and therapy of cancer
Coronary MRA and myocardial perfusion using an intravascular MR contrast agent

Review (5)

Cardiac Magnetic Resonance Fingerprinting: Technical Developments and Initial Clinical Validation
Molecular Imaging in Ischemic Heart Disease
Molecular imaging of cardiac remodelling after myocardial infarction
Molecular MRI of Atherosclerosis
Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology
207
Rene Botnar

Full Professor

Institute for Biological and Medical Engineering

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

35
Claudia Prieto

Associate Professor

Electrical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

20
Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

2
Cristian Tejos

Professor

Department of Electrical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile