PDI - Resultado de Búsqueda

Cristian Adrián Sandoval Acuña

Académico

Universidad de La Frontera

Temuco, Chile

Farmacología del Cancer, Metabolismo mitocondrial, Metabolismo intracelular de Hierro, Resistencia tumoral, Metabolismo de Aminoácidos

Farmacología, UNIVERSIDAD DE CHILE. Chile, 2016
Bioquímica, mención Toxicología y Diagnóstico Molecular, UNIVERSIDAD DE CHILE. Chile, 2011
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2011

Profesor Encargado de Biotecnología Other

Universidad Central de Chile

Facultad de Medicina y Ciencias de la Salud

Santiago, Chile

2015 - 2016
Profesional Docente Full Time

UNIVERSIDAD DE LA FRONTERA

Facultad de Medicina

Temuco, Chile

2025 - At present

Investigador Asociado Full Time

Instituto de Biotecnología, Academia Checa de Ciencias

Praga, Rep. Checa

2021 - 2024
Investigador Postdoctoral Full Time

Instituto de Biotecnología, Academia Checa de Ciencias

Praga, Rep. Checa

2016 - 2021

Universidad de Carlos, Praga, República Checa

Tesis de Magister

Co-director, Mgr. Michaela Vondrá?ková, Tumor suppressor NDRG1 and its regulation by iron chelators. Tesis defendida en Septiembre 2021.
Co-director, Mgr. Petra Potomová, The role of iron in the regulation of proteins connected with tamoxifen-resistance. Tesis defendida en Septiembre 2023.

Tesis de Doctorado

Co-director, Sukanya Jadhav PhD, Iron and Mitochondria as an anti-cancer target. Tesis defendida en Septiembre 2024.
Co-director, Veronika Tomková PhD, Molecular mechanisms of tamoxifen resistance in breast cancer. Tesis defendida en Junio 2020.
Co-director, Mgr. Petra Potomová, Non-conventional iron chelators as modulators of aminoacid metabolism in anti-cancer therapy. Tesis iniciada en Octubre 2023.
Co-director, Ing. Jana Psotová, Molecular Mechanisms of Cancer Resistance to Taxanes and Mitochondrially Targeted Drugs. Tesis iniciada en Octubre 2022.
Co-director, MSc. Yaiza Pacior, Molecular Mechanisms of Cancer Resistance: The Role of Mitochondria. Tesis iniciada en Marzo 2023.

Young Investigator Award

Society for Free Radical Research-Europe

Portugal, 2018

Premio a la mejor presentación de poster durante el 19th SFRR?I Biennial Meeting 2018
Support of Perspective Human Sources: Financial support of Postdoctoral Fellows

Academica Checa de Ciencias

Rep. Checa, 2017

Distinción a Investigadores Postdoctorales de Excelencia dentro de la Academia Checa de Ciencias


Ultradeformable liposomal delivery of vismodegib modulates its biological activity in melanoma cells Calienni, Maria Natalia; Sandoval-Acuna, Cristian; Potomova, Petra; Ybarra, David Emanuel; Truksa, Jaroslav; Montanari, Jorge Article ISI FRONTIERS IN MEDICAL TECHNOLOGY (2026)
NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation Jadhav, Sukanya B.; Vondrackova, Michaela; Potomova, Petra; Sandoval-Acuna, Cristian; Smigova, Jana; Klanicova, Kristyna; Rosel, Daniel; Brabek, Jan; Stursa, Jan; Werner, Lukas; et al. Article ISI FRONTIERS IN PHARMACOLOGY (2024)
Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma Sychra, Tomas; Spalenkova, Alzbeta; Balatka, Stepan; Vaclavikova, Radka; Seborova, Karolina; Ehrlichova, Marie; Truksa, Jaroslav; Sandoval-Acuna, Cristian; Nemcova, Vlasta; Szabo, Arpad; et al. Article ISI ISCIENCE (2024)
Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model Seborova, Karolina; Koucka, Kamila; Spalenkova, Alzbeta; Holy, Petr; Ehrlichova, Marie; Sychra, Tomas; Chen, Lei; Bendale, Hersh; Ojima, Iwao; Sandoval-Acuna, Cristian; et al. Article ISI FRONTIERS IN PHARMACOLOGY (2022)
Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene Novakova, Zora; Milosevic, Mirko; Kutil, Zsofia; Ondrakova, Marketa; Havlinova, Barbora; Kasparek, Petr; Sandoval-Acuna, Cristian; Korandova, Zuzana; Truksa, Jaroslav; Vrbacky, Marek; et al. Article ISI SCIENTIFIC REPORTS (2022)
Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy Sandoval-Acuna, Cristian; Torrealba, Natalia; Tomkova, Veronika; Jadhav, Sukanya B.; Blazkova, Kristyna; Merta, Ladislav; Lettlova, Sandra; Adamcova, Miroslava K.; Rosel, Daniel; Brabek, Jan; et al. Article ISI CANCER RESEARCH (2021)
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells Truksa J.; Urra F.A. Article ISI SCOPUS Cells (2020)
Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines Rojas, Diego; Pavani, Mario Article ISI SCOPUS Toxicology in Vitro (2020)
Mitochondrial fragmentation, elevated mitochondrial superoxide and respiratory supercomplexes disassembly is connected with the tamoxifen-resistant phenotype of breast cancer cells Tomkova, Veronika; Sandoval-Acuna, Cristian; Torrealba, Natalia; Truksa, Jaroslav Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2019)
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; Hubackova, Sona; Endaya, Berwini; Judasova, Kristyna; et al. Article ISI CELL METABOLISM (2019)
Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model of mammary adenocarcinoma Peredo-Silva, Liliana; Fuentes-Retamal, Sebasti?n; Sandoval-Acu?a, Cristian; Madrid-Rojas, Mat?as; Rebolledo, Solange Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates Sandoval-Acuna, Cristian; Fuentes-Retamal, Sebastián; Guzmán-Rivera, Daniela; Peredo-Silva, Liliana; Madrid-Rojas, Matías; Rebolledo, Solange Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Cu(II)-disulfide complexes display simultaneous superoxide dismutase- and catalase-like activities Andrade-Acuna, D; Lopez-Alarcon, C; Sandoval-Acuna C; Speisky H. Article ISI SCOPUS Journal of Inorganic Biochemistry (2013)
First Web-Based Database on Total Phenolics and Oxygen Radical Absorbance Capacity (ORAC) of Fruits Produced and Consumed within the South Andes Region of South America Speisky H.; Lopez-Alarcon, C; Gomez, M.; Fuentes J,; Sandoval-Acuna C Article ISI SCOPUS Journal of Agricultural and Food Chemistry (2012)
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action Sandoval-Acuna C; Lopez-Alarcon, C; Aliaga M.E.; Speisky H. Article ISI SCOPUS Chemico-Biological Interactions (2012)
Stimulation of cytosolic and mitochondrial calcium mobilization by indomethacin in Caco-2 cells: Modulation by the polyphenols quercetin, resveratrol and rutin Carrasco-Pozo, Catalina; Pastene, Edgar; Vergara, Carola; Zapata, Moises; Sandoval, Cristian; Gotteland, Martin Article ISI SCOPUS Biochimica et Biophysica Acta - General Subjects (2012)
Role of Superoxide Anions in the Redox Changes Affecting the Physiologically Occurring Cu(I)-Glutathione Complex Speisky H.; Lopez-Alarcon, C; Olea Azar C.; Sandoval-Acuna C Article ISI SCOPUS Bioinorganic Chemistry and Applications (2011)


Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions Sandoval-Acuna C; Ferreira J.; Speisky H. Review ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)