PDI - Resultado de Búsqueda

Cristian Adrián Sandoval Acuña

Profesor

I can IB

Praga, Chile

Farmacología del Cancer, Metabolismo mitocondrial, Metabolismo intracelular de Hierro, Resistencia tumoral

Farmacología, UNIVERSIDAD DE CHILE. Chile, 2016
Bioquímica, mención Toxicología y Diagnóstico Molecular, UNIVERSIDAD DE CHILE. Chile, 2011
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2011

Profesor Encargado de Biotecnología Other

Universidad Central de Chile

Facultad de Medicina y Ciencias de la Salud

Santiago, Chile

2015 - 2016

Investigador Asociado Full Time

Instituto de Biotecnología, Academia Checa de Ciencias

Praga, Rep. Checa

2021 - 2024
Investigador Postdoctoral Full Time

Instituto de Biotecnología, Academia Checa de Ciencias

Praga, Rep. Checa

2016 - 2021

Young Investigator Award

Society for Free Radical Research-Europe

Portugal, 2018

Premio a la mejor presentación de poster durante el 19th SFRR?I Biennial Meeting 2018
Support of Perspective Human Sources: Financial support of Postdoctoral Fellows

Academica Checa de Ciencias

Rep. Checa, 2017

Distinción a Investigadores Postdoctorales de Excelencia dentro de la Academia Checa de Ciencias


NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation Jadhav, Sukanya B.; Vondrackova, Michaela; Potomova, Petra; Sandoval-Acuna, Cristian; Smigova, Jana; Klanicova, Kristyna; Rosel, Daniel; Brabek, Jan; Stursa, Jan; Werner, Lukas; et al. Article ISI FRONTIERS IN PHARMACOLOGY (2024)
Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma Sychra, Tomas; Spalenkova, Alzbeta; Balatka, Stepan; Vaclavikova, Radka; Seborova, Karolina; Ehrlichova, Marie; Truksa, Jaroslav; Sandoval-Acuna, Cristian; Nemcova, Vlasta; Szabo, Arpad; et al. Article ISI ISCIENCE (2024)
Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model Seborova, Karolina; Koucka, Kamila; Spalenkova, Alzbeta; Holy, Petr; Ehrlichova, Marie; Sychra, Tomas; Chen, Lei; Bendale, Hersh; Ojima, Iwao; Sandoval-Acuna, Cristian; et al. Article ISI FRONTIERS IN PHARMACOLOGY (2022)
Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene Novakova, Zora; Milosevic, Mirko; Kutil, Zsofia; Ondrakova, Marketa; Havlinova, Barbora; Kasparek, Petr; Sandoval-Acuna, Cristian; Korandova, Zuzana; Truksa, Jaroslav; Vrbacky, Marek; et al. Article ISI Scientific Reports (2022)
Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy Sandoval-Acuna, Cristian; Torrealba, Natalia; Tomkova, Veronika; Jadhav, Sukanya B.; Blazkova, Kristyna; Merta, Ladislav; Lettlova, Sandra; Adamcova, Miroslava K.; Rosel, Daniel; Brabek, Jan; et al. Article ISI CANCER RESEARCH (2021)
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells Truksa, J; Urra, FA Article ISI CELLS (2020)
Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines Rojas, Diego; Pavani, Mario Article ISI SCOPUS Toxicology in Vitro (2020)
Mitochondrial fragmentation, elevated mitochondrial superoxide and respiratory supercomplexes disassembly is connected with the tamoxifen-resistant phenotype of breast cancer cells Tomkova, Veronika; Sandoval-Acuna, Cristian; Torrealba, Natalia; Truksa, Jaroslav Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2019)
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; Hubackova, Sona; Endaya, Berwini; Judasova, Kristyna; et al. Article ISI CELL METABOLISM (2019)
Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model of mammary adenocarcinoma Peredo-Silva, Liliana; Fuentes-Retamal, Sebasti?n; Sandoval-Acu?a, Cristian; Madrid-Rojas, Mat?as; Rebolledo, Solange Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
Mitochondriotropic agents induce an uncoupling effect, triggering selective apoptosis in human colorectal cancer cell lines Jara JA., Rojas D.; Fuentes-Retamal S., Sandoval-Acuña C.; Castro.Castillo V., Rebolledo S.; Pavani M., Maya JD.; Ferreira J., Catalán M. Article Molecular Pharmaceutics (2017)
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates Sandoval-Acuna, Cristian; Fuentes-Retamal, Sebastián; Guzmán-Rivera, Daniela; Peredo-Silva, Liliana; Madrid-Rojas, Matías; Rebolledo, Solange Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Cu(II)-disulfide complexes with superoxide dismutase- and catalase-like activities protect mitochondria and whole cells against oxidative stress Aliaga ME., Sandoval-Acuña C.; López-Alarcón C., Fuentes J. Article Free Radic Biol Med (2014)
Cu(II)-disulfide complexes display simultaneous superoxide dismutase- and catalase-like activities Aliaga ME. , Andrade-Acuña D.; López-Alarcón C., Sandoval-Acuña C. Article J Inorg Biochem. (2013)
First web-based database on total phenolics and oxygen radical absorbance capacity (ORAC) of fruits produced and consumed within the south Andes region of South America Speisky H, López-Alarcón C; Gómez M, Fuentes J Article J Agric Food Chem (2012)
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action Sandoval-Acuña C, Lopez-Alarcón C; Aliaga ME, Speisky H Article Chem Biol Interact (2012)
Stimulation of cytosolic and mitochondrial calcium mobilization by indomethacin in Caco-2 cells=> Modulation by the polyphenols quercetin, resveratrol and rutin Carrasco-Pozo C., Gotteland M.; Pastene E., Sandoval C.; VERGARA, C Article Elsevier BV (2012)
Role of superoxide anions in the redox changes affecting the physiologically-occurring Cu(I)-Glutathione complex. Speisky H., López-Alarcón C.; Olea-Azar C., Sandoval-Acuña C. Article Bioinorg Chem App (2011)


Desarrollo de Productos Nutra-Cosméticos con Acción Anti-Envejecimiento en Base a Nuevos Compuestos Bio-Activos FONDEF (VIU110015) Proyecto 2012-2013 Director(a)


Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions Sandoval-Acuna C; Ferreira J.; Speisky, H Review ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)

2

Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

3

Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

1

HERNAN SPEISKY

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

2

Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

2

José Jara

Assistant Professor

Research Institute of Dental Sciences

Universidad de Chile

Santiago, Chile

1

Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1

Gloria Calaf

Jefe Laboratorio Biología del Cáncer

Universidad de Tarapacá

Arica, Chile

4

Sebastián Fuentes

Investigador Postdoctoral

Institulo de Ciencias Biomédicas - Instituto de investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

12

Cristian Sandoval

Profesor

I can IB

Praga, Chile

1

Daniela Guzmán

Docente

Escuela de Química y Farmacia

Universidad Andrés Bello

Santiago, Chile